Table Of ContentAdvances in Experimental Medicine and Biology 892
José Ramos
Hana Sychrová
Maik Kschischo E ditors
Yeast
Membrane
Transport
Advances in Experimental Medicine and Biology
Volume 892
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José Ramos • Hana Sychrová • Maik Kschischo
Editors
Yeast Membrane Transport
123
Editors
JoséRamos HanaSychrová
DepartmentofMicrobiology DepartmentofMembraneTransport
UniversityofCórdoba InstituteofPhysiology
Córdoba,Spain TheCzechAcademyofSciences
Prague,CzechRepublic
MaikKschischo
DepartmentofMathematicsandTechnology
UniversityofAppliedSciences
Koblenz,Remagen,Germany
ISSN0065-2598 ISSN2214-8019 (electronic)
AdvancesinExperimentalMedicineandBiology
ISBN978-3-319-25302-2 ISBN978-3-319-25304-6 (eBook)
DOI10.1007/978-3-319-25304-6
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Preface
All cells need to communicate with their environment, which means exchange
informationandmaterialacrosstheirmembranes.Toensuretheuptakeofnutrients
and other necessary compoundsor to extrude toxic metabolites, metabolic waste,
orchemicalsignals,cellsusetransportsystemsconsistingofoneormoreproteins
embedded in the cell membranes. The significance of transport in organisms and
theircellswassummarizedbyDanielC.TostesonwhowroteinhisbookMembrane
Transport: People and Ideas (Tosteson 1989): “I conjure a picture of a living
organismasanextraordinarilycomplex,self-replicating,self-assembling,dynamic,
open, physicochemical system maintained near the steady state by the continual
entry and exit of matter and energy.”Thoughthe indispensability and complexity
of cell membrane transport have attracted researchers for more than 100 years,
researchonmembranetransporthasmadecontinuousprogressinthe last decades
andremainsanactivefieldofscientificinvestigation.Yeasts,andmainlythemodel
organism Saccharomyces cerevisiae, are among the favorite cells for researchers
studying all aspects of transport systems and their mechanisms. However, an
importantamountof knowledge has been obtained when employingthe so-called
non-conventional and pathogenic yeasts, especially because of their peculiarities
and,insomecases,specifictransportsystems.Thetransportersmediatinguptakeof
nutrients,fluxesofcationsandanions,ortheextrusionoftoxiccompoundsacross
theplasmamembranearediscussedtogetherwiththetransportsystemslocalizedin
themembranesofcellorganelles.Eachchaptersummarizesourcurrentknowledge
on importanttransportprocessesin yeasts, and as it is based on the experienceof
theexpertsworkinginthefieldformanyyears,itprovidesbothageneraloverview
ofthemaintransportcharacteristicsforaspecificsubstrateoragroupofsubstrates
anduniquedetailsthatonlyanexpertworkinginthefieldisabletotransmittothe
reader.
Córdoba,Spain JoséRamos
Remagen,Germany MaikKschischo
Prague,CzechRepublic HanaSychrová
v
Contents
1 MembraneTransportinYeast,AnIntroduction........................ 1
MaikKschischo,JoséRamos,andHanaSychrová
2 Cell Surface Interference with Plasma Membrane
andTransportProcessesinYeasts........................................ 11
JeanMarieFrancois
3 ProtonTransportandpHControlinFungi............................. 33
PatriciaM.Kane
4 Function and Regulation of Fungal Amino Acid
Transporters:InsightsfromPredictedStructure....................... 69
ChristosGournas,MartinePrévost,Eva-MariaKrammer,
andBrunoAndré
5 WaterTransportinYeasts................................................. 107
FarzanaSabir,CatarinaPrista,AnaMadeira,TeresaMoura,
MariaC.Loureiro-Dias,andGraçaSoveral
6 SugarandGlycerolTransportinSaccharomycescerevisiae........... 125
LindaF.Bisson,QingwenFan,andGordonA.Walker
7 TheCRaZyCalciumCycle................................................ 169
EduardoA.Espeso
8 PotassiumandSodiumTransportinYeast .............................. 187
LynneYenush
9 Carboxylic Acids Plasma Membrane Transporters
inSaccharomycescerevisiae ............................................... 229
MargaridaCasal,OdíliaQueirós,GabrielTalaia,DavidRibas,
andSandraPaiva
10 InorganicPhosphateandSulfateTransportinS.cerevisiae........... 253
D.R.SamynandB.L.Persson
vii
viii Contents
11 InteractionsBetweenMonovalentCationsandNutrient
Homeostasis................................................................. 271
DavidCanadellandJoaquínAriño
12 Mathematical Modelling of Cation Transport
andRegulationinYeast.................................................... 291
MatthiaséKahmandMaikKschischo
13 TransportSystemsinHalophilicFungi.................................. 307
Ana Plemenitaš, Tilen Konte, Cene Gostincˇar,
andNinaGundeCimerman
14 Antifungals:MechanismofActionandDrugResistance.............. 327
Rajendra Prasad, Abdul Haseeb Shah,
andManpreetKaurRawal
15 CandidaEffluxATPasesandAntiportersinClinicalDrug
Resistance.................................................................... 351
Rajendra Prasad, Manpreet Kaur Rawal,
andAbdulHaseebShah
Index............................................................................... 377
Chapter 1
Membrane Transport in Yeast, An Introduction
MaikKschischo,JoséRamos,andHanaSychrová
Abstract Research on membrane transport has made continuous progress in the
last decades and remains an active field of scientific investigation. In the case of
yeast, most of the research has been conducted for the model organism Saccha-
romycescerevisiae,butalsotheso-callednon-conventionalyeastsarebeingstudied,
especially because of their peculiarities and, in some cases, specific transport
systems. This book is based on the experience of several experts summarizing
thecurrentknowledgeaboutimportantsubstratetransportprocessesinyeast.Each
chapterprovidesbothageneraloverviewofthemaintransportcharacteristicsofa
specific substrate or groupof substrates andthe uniquedetails thatonlyan expert
workinginthefieldisabletotransmittothereader.
Keywords Yeast • Membrane • Transport
1.1 Importance ofMembrane TransportProcesses
A cell’s existence depends on its membrane. Although membranes were first
consideredjustasphysicalboundaries,theirfunctionasapermeabilitybarrierwas
quicklyrealized.Lateron,thecrucialsensingfunctionsofmembranestofacilitate
information exchange between the external and internal milieu were discovered.
In addition to the plasma membrane, eukaryotic cells contain systems of internal
M.Kschischo
DepartmentofMathematicsandTechnology,UniversityofAppliedSciencesKoblenz,
RheinAhrCampus,Remagen,Germany
e-mail:[email protected]
J.Ramos((cid:2))
DepartmentofMicrobiology,UniversityofCórdoba,Córdoba,Spain
e-mail:[email protected]
H.Sychrová
DepartmentofMembraneTransport,InstituteofPhysiology,TheCzechAcademyofSciences,
Prague,CzechRepublic
e-mail:[email protected]
©SpringerInternationalPublishingSwitzerland2016 1
J.Ramosetal.(eds.),YeastMembraneTransport,AdvancesinExperimental
MedicineandBiology892,DOI10.1007/978-3-319-25304-6_1
