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About Why Did NMDA Receptor Antagonists Fail Clinical Trials For Stroke and Traumatic Brain Injury?
NMDA receptor antagonists failed in clinical trials for stroke and traumatic brain injury despite showing neuroprotective effects in animal models. The authors hypothesize that this is because glutamate plays a normal physiological role in promoting neuronal survival after the initial injury period through NMDA receptor-mediated synaptic transmission. Blocking NMDA receptors may therefore hinder neuronal survival in humans. While drug properties and trial design have been cited as reasons for failure, the underlying hypothesis that excitotoxicity drives injury has not been reexamined.
Detailed Information
| Author: | ['a'] |
|---|---|
| Publication Year: | 2020 |
| Pages: | 4 |
| Language: | English |
| Format: | |
| Price: | FREE |
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