Virus Protein and Nucleoprotein Complexes

442 Pages·2018·22.003 MB·English

by  J. Robin Harris, David Bhella

Subcellular Biochemistry 88
J. Robin Harris · David Bhella Editors
Virus
Protein and
Nucleoprotein
Complexes
Subcellular Biochemistry
Volume 88
Series editor
J. Robin Harris
Institute of Zoology, University of Mainz, Mainz, Germany
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Series Editor
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International Advisory Editorial Board
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S. Rottem, The Hebrew University, Jerusalem, Israel
X. Wang, Jiangnan University, Wuxi, China
More information about this series at http://www.springer.com/series/6515
J. Robin Harris • David Bhella
Editors
Virus Protein and
Nucleoprotein Complexes
Editors
J. Robin Harris David Bhella
Institute of Zoology MRC-University of Glasgow Centre
University of Mainz for Virus Research
Mainz, Germany Glasgow, United Kingdom
ISSN 0306-0225
Subcellular Biochemistry
ISBN 978-981-10-8455-3 ISBN 978-981-10-8456-0 (eBook)
https://doi.org/10.1007/978-981-10-8456-0
Library of Congress Control Number: 2018937669
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Preface
This volume of the Springer Subcellular Biochemistry Series, entitled Virus Protein
and Nucleoprotein Complexes, follows on from the previous volumes dealing with
soluble Macromolecular Protein Complexes (Volume 83) and Membrane Protein
Complexes (Volume 87). Unlike Volume 68 of the series Structure and Physics of
Viruses, emphasis in the present volume is upon the components of viruses rather
than their intact structure. As in the previous volumes on Complexes, a diverse col-
lection of interesting chapter topics is included, within which there is both structural
and functional emphasis. All topics are under current investigation by active scien-
tists. The 17 chapters included in the book cover many but not all of the relevant
virus-related topics; as is inevitable with multi-author books some chapters have
been lost during the preparation period, thus leaving open the possibility of a future
related volume.
The book commences with a broad overview that places emphasis on virus
assembly, followed by the capsid proteins of spherical viruses, helical virus nucleo-
capsids and viral envelope fusion. Then this book includes 16 more specific chap-
ters dealing with the following: the ribonucleoprotein complex of negative-sense
single-stranded RNA viruses; the viral RNA-dependent RNA polymerases; the filo-
virus filament proteins; influenza virus RNP; the nucleoproteins of single-s tranded
RNA viruses; Zika virus envelope protein and antibody complexes; the retrovirus
capsid core; nucleoprotein intermediates in HIV-1 DNA integration; the oligomer-
ization of retrovirus integrases; the human respiratory syncytial virus M2–1 protein;
the filamentous bacteriophage proteins and their assembly; protein- RNA interac-
tions in the single-stranded RNA bacteriophages; the bacteriophage head-to-tail
interface; protein-protein interactions involving viroporins; protein complexes and
virus-like particle technology; and finally the role of flaviviral proteins in the induc-
tion of innate immunity.
The diversity of information given in these chapters provides an in-depth insight
into the present-day molecular virology, from a structural and functional perspec-
tive. The data from high-resolution cryo-electron microscopy and X-ray crystallog-
v
vi Preface
raphy can be seen to provide a powerful contribution to structural virology. Whilst
some important chapter topics were lost due to authors backing out, it is thought that
the content of the book remains strong and it is hoped it will be of interest to many.
Indeed, the theme of macromolecular complexes, introduced in Volume 83 of the
series, is greatly extended within the present volume.
Mainz, Germany J. Robin Harris
Glasgow, UK David Bhella
December, 2017
Contents
1 Virus Proteins and Nucleoproteins: An Overview ............................... 1
David Bhella
2 A Structural View of Negative-Sense RNA Virus
Nucleocapsid Protein and Its Functions Beyond .................................. 19
Zhiyong Lou
3 Viral RNA-Dependent RNA Polymerases:
A Structural Overview............................................................................ 39
Diego Ferrero, Cristina Ferrer-Orta, and Núria Verdaguer
4 Filovirus Filament Proteins .................................................................... 73
Daniel R. Beniac, Lindsey L. Lamboo, and Timothy F. Booth
5 Structure and Function of Influenza Virus Ribonucleoprotein .......... 95
Chun-Yeung Lo, Yun-Sang Tang, and Pang-Chui Shaw
6 Structural Homology Between Nucleoproteins
of ssRNA Viruses ..................................................................................... 129
Mikel Valle
7 Zika Virus Envelope Protein and Antibody Complexes ...................... 147
Lianpan Dai, Qihui Wang, Hao Song, and George Fu Gao
8 The Retrovirus Capsid Core .................................................................. 169
Wei Zhang, Luiza Mendonça, and Louis L. Mansky
9 Nucleoprotein Intermediates in HIV-1 DNA Integration:
Structure and Function of HIV-1 Intasomes ........................................ 189
Robert Craigie
10 Oligomerization of Retrovirus Integrases ............................................. 211
Duane P. Grandgenett and Hideki Aihara
vii
viii Contents
11 Structure and Function of the Human Respiratory
Syncytial Virus M2–1 Protein ................................................................ 245
Selvaraj Muniyandi, Georgia Pangratiou, Thomas A. Edwards,
and John N. Barr
12 Filamentous Bacteriophage Proteins and Assembly ............................ 261
Suzana K. Straus and Htet E. Bo
13 Protein-RNA Interactions in the Single- Stranded
RNA Bacteriophages ............................................................................... 281
Jānis Rūmnieks and Kaspars Tārs
14 The Bacteriophage Head-to-Tail Interface ........................................... 305
Paulo Tavares
15 Beyond Channel Activity: Protein-Protein Interactions
Involving Viroporins ............................................................................... 329
Janet To and Jaume Torres
16 Protein Complexes and Virus-Like Particle Technology ..................... 379
Andris Zeltins
17 The Role of Flaviviral Proteins in the Induction
of Innate Immunity ................................................................................. 407
L. Cedillo-Barrón, J. García-Cordero, G. Shrivastava,
S. Carrillo- Halfon, M. León-Juárez, J. Bustos Arriaga,
Pc León Valenzuela, and B. Gutiérrez Castañeda
Chapter 1
Virus Proteins and Nucleoproteins:
An Overview
David Bhella
Introduction
Viruses are by far the most abundant of life forms on the planet Earth. Studies of
viral diversity in the marine environment have led to estimates that there are around
1031 virus particles (virions) in the biosphere (Paez-Espino et al. 2016). Recent
metagenomic studies of the viromes of diverse ecological niches indicate similarly
staggering levels of genetic diversity (Breitbart and Rohwer 2005).
To set out to write an authoritative text on the proteins of all viruses, a subject
matter so inconceivably vast might therefore be viewed as foolhardy to say the least.
Detailed knowledge of the structure and function of viral proteins is however com-
paratively modest. Our understanding of viral replication strategies is largely
derived from detailed studies of a small number of viruses: those that infect humans,
economically important animal and plant species as well as bacteriophages, the
study of which has been historically more tractable. These have informed our under-
standing of many critical viral functions nonetheless, as well as providing surprising
insights into viral evolution.
Viral replication strategies are intimately linked with the biology of the host.
They are characterised by a finely balanced interplay between viral and host factors,
regulating both viral expression and host responses to infection. All viruses, regard-
less of how their genomes are encoded, must achieve certain fundamental functions
to perpetuate themselves. This chapter will therefore describe proteins that enable
some of these functions, the structural components of viruses. Subsequent chapters
will focus on specific aspects of virus biology in greater detail, to reveal how viruses
have evolved exquisite mechanisms to ensure their continued survival and success.
D. Bhella (*)
MRC-University of Glasgow Centre for Virus Research, Scotland, UK
e-mail: [email protected]
© Springer Nature Singapore Pte Ltd. 2018 1
J. R. Harris, D. Bhella (eds.), Virus Protein and Nucleoprotein Complexes,
Subcellular Biochemistry 88, https://doi.org/10.1007/978-981-10-8456-0_1