Table Of ContentVeterinary
Veterinary Clinical Pathology: A Case-Based Approach presents
200 cases with questions for those interested in improving their skills in
veterinary clinical pathology. It emphasises an understanding of basic
pathophysiologic mechanisms of disease, differential diagnoses and
Clinical
recognition of patterns associated with various diseases or conditions.
Topics discussed include haematology, clinical chemistry, endocrinology,
acid-base and blood gas analysis, haemostasis, urinalysis, biological
variation and quality control. Species covered include the cat, dog and
Pathology
horse, with additional material on ruminants.
Cases vary in difficulty, allowing beginners to improve their clinicopath-
ologic skills while more complicated cases, or cases treating unfamiliar
topics, are included for experienced readers. This book is a helpful
revision aid for those in training as well as for those in practice who are A Case-Based Approach
pursuing continuing education. It is also a valuable resource for veterinary
nurses and technicians.
Edited by
K22449
Kathleen P. Freeman
ISBN: 978-1-4822-2587-7
90000
Stefanie Klenner
9 781482 225877
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Veterinary Clinical Pathology
A Case-Based Approach
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Veterinary Clinical Pathology
A Case-Based Approach
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Veterinary Clinical Pathology
A Case-Based Approach
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Veterinary Clinical Pathology
A Case-Based Approach
Kathleen P. Freeman
DVM, BS, MS, PhD, DipECVCP, FRCPath, MRCVS
RCVS Specialist in Veterinary Pathology (Clinical Pathology)
European Veterinary Specialist in Clinical Pathology
IDEXX Laboratories Ltd., Wetherby, West Yorkshire, United Kingdom
Stefanie Klenner
Dr.med.vet., DipECVCP
European Veterinary Specialist in Clinical Pathology
scil animal care company GmbH
Viernheim, Germany
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CRC Press
Taylor & Francis Group
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© 2015 by Taylor & Francis Group, LLC
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No claim to original U.S. Government works
Version Date: 20150302
International Standard Book Number-13: 978-1-4822-2590-7 (eBook - PDF)
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Contents
Preface vii
Contributors ix
Broad Classification of Cases xi
Abbreviations xiii
Approach to Analysis of Cases xv
Questions 1
Answers 131
Appendices:
1 Conversion Factors 263
2 Biological Variation 264
Index 267
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Preface
This book aims to provide a variety of clinical pathology approach the analysis and interpretation of the data. The
cases covering multiple species and submitted by a format, with general assessment of the laboratory data
selection of clinical pathologists and clinicians. It is not and questions to be answered regarding its interpretation,
meant to cover all possible clinical pathology diagnoses, pathological mechanisms and clinical significance, should
but offers a compilation of cases with clinical pathological be of benefit in tying together the clinical pathology
results encountered by the contributors. The book was results, the pathophysiological base for these results, their
inspired by examples provided to the authors by their interpretation, and further testing or information that may
teachers and mentors when discussing cases and their be of benefit for diagnosis, monitoring and/or prognosis.
thought processes in order to encourage the development When a contributor uses laboratory results to skilfully ‘tell
of their own clinicopathological skills during training. the story’ of the patient and explain the ‘detective work’ of
We were further motivated by the need expressed by many the clinician and its interpretation, it is a joy to read!
veterinary students and trainees in general veterinary We therefore present a collection of cases with a wide
medicine, clinical pathology and internal medicine with variety of clinical pathological abnormalities. Topics
whom we have interacted to have wider experience of the include haematology, clinical chemistry, endocrinology,
thought processes of experienced clinical pathologists and acid–base and blood gas analysis, haemostasis, urinalysis,
clinicians with regard to interpretation of laboratory data. biological variation and quality control. The cases about
It was fascinating to see the systematic approaches that quality control are unique for such a book and reflect our
each contributor has taken with the cases they have elected deep belief that this is an issue of huge importance for
to submit. Although the order of consideration and the all of us. Every laboratory result represents a result with
terminology and phrases used by each contributor may some degree of ‘probability’ associated with it, since all
differ slightly, there are many common threads that will laboratory results contain some degree of inherent error.
be recognised as you read through these cases. You may Knowledge of the nature of such variation (errors) and
find that you have ‘favourite’ contributors whose thought how they may influence our laboratory results helps all
process and approach you admire, and you may seek to of us to become better pathologists and clinicians.
incorporate their style, phrases and approach into your The level of difficulty of the various cases is wide,
own clinical repertoire. giving beginners the possibility to start improving their
The role of clinicians and clinical pathologists in today’s clinicopathological skills, providing more complicated
environment lies in providing context, ‘telling the story’ cases or cases treating unfamiliar topics (e.g. biological
and giving meaning in order to tie together the clinical variation) for the more experienced reader and increasing
presentation and laboratory data and assure the best learning opportunities for the less experienced.
possible patient care. By providing ‘meaning’ for ourselves, We hope that these cases will be of interest to a
the owners and our colleagues we are establishing the basis wide audience and provide a resource for continuing
for ongoing learning and a way to approach cases that will development of expertise in interpretation of laboratory
help all of us to become better practitioners of the art and data. We have endeavoured to ensure that the approaches
science of veterinary medicine and to better communicate and information are accurate and that recommendations
with our clients, owners and colleagues. for Further Reading are provided for many of the topics.
We hope these cases will provide an opportunity for We hope that you will enjoy these cases and the expertise of
students, residents, general practitioners and all veterinarians the contributors in presenting them for you.
who would like to challenge or improve their skills in
veterinary clinical pathology to see various presentations Kathleen P. Freeman
of cases and the ways that the contributors of these cases Stefanie Klenner
vii
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