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BLUK130-Wang January10,2008 20:48 Ventricular Arrhythmias and Sudden Cardiac Death Ventricular Arrhythmias and Sudden Cardiac Death. Edited by Paul J. Wang, Amin Al-Ahmad, Henry H. Hsia, Paul C. Zei. © 2008 Blackwell Publishing. ISBN: 978-1-4051-6114-5 i BLUK130-Wang January10,2008 20:48 Ventricular Arrhythmias and Sudden Cardiac Death EDITED BY Paul J. Wang, MD CardiacArrhythmiaService StanfordUniversityMedicalCenter Stanford,CA USA Amin Al-Ahmad, MD CardiacArrhythmiaService StanfordUniversityMedicalCenter Stanford,CA USA Henry H. Hsia, MD CardiacArrhythmiaService StanfordUniversityMedicalCenter Stanford,CA USA Paul C. Zei, MD, PhD CardiacArrhythmiaService StanfordUniversityMedicalCenter Stanford,CA USA iii BLUK130-Wang January10,2008 20:48 (cid:2)C 2008byBlackwellPublishing BlackwellFuturaisanimprintofBlackwellPublishing BlackwellPublishing,Inc.,350MainStreet,Malden,Massachusetts02148-5020,USA BlackwellPublishingLtd,9600GarsingtonRoad,OxfordOX42DQ,UK BlackwellScienceAsiaPtyLtd,550SwanstonStreet,Carlton,Victoria3053,Australia Allrightsreserved.Nopartofthispublicationmaybereproducedinanyformorbyanyelectronicormechanicalmeans, includinginformationstorageandretrievalsystems,withoutpermissioninwritingfromthepublisher,exceptbya reviewerwhomayquotebriefpassagesinareview. Firstpublished2008 1 2008 ISBN:978-1-4051-6114-5 LibraryofCongressCataloging-in-PublicationData Ventriculararrhythmiasandsuddencardiacdeath/editedbyPaulJ.Wang...[etal.]. p.;cm. Includesbibliographicalreferencesandindex. ISBN978-1-4051-6114-5(alk.paper) 1.Ventriculartachycardia. 2.Cardiacarrest. 3.Ventriculartachycardia–Treatment. 4.Cardiacarrest–Treatment. I.Wang,PaulJ. [DNLM:1.Tachycardia,Ventricular. 2.Death,Sudden,Cardiac. 3.Tachycardia,Ventricular–therapy. WG330V4657 2008] RC685.T33V432008 616.1(cid:3)23025–dc22 2007031922 AcataloguerecordforthistitleisavailablefromtheBritishLibrary CommissioningEditor:GinaAlmond DevelopmentEditor:KateNewellandFionaPattison EditorialAssistant:VictoriaPitman ProductionController:DebbieWyer Setin9.5/12ptMinionbyAptaraInc.,NewDelhi,India PrintedandboundinSingaporebyMarkonoPrintMediaPteLtd. ForfurtherinformationonBlackwellPublishing,visitourwebsite: www.blackwellcardiology.com Thepublisher’spolicyistousepermanentpaperfrommillsthatoperateasustainableforestrypolicy,andwhichhasbeen manufacturedfrompulpprocessedusingacid-freeandelementarychlorine-freepractices.Furthermore,thepublisher ensuresthatthetextpaperandcoverboardusedhavemetacceptableenvironmentalaccreditationstandards. Designationsusedbycompaniestodistinguishtheirproductsareoftenclaimedastrademarks.Allbrandnamesand productnamesusedinthisbookaretradenames,servicemarks,trademarksorregisteredtrademarksoftheirrespective owners.ThePublisherisnotassociatedwithanyproductorvendormentionedinthisbook. Thecontentsofthisworkareintendedtofurthergeneralscientificresearch,understanding,anddiscussiononlyandare notintendedandshouldnotberelieduponasrecommendingorpromotingaspecificmethod,diagnosis,ortreatment byphysiciansforanyparticularpatient.Thepublisherandtheauthormakenorepresentationsorwarrantieswith respecttotheaccuracyorcompletenessofthecontentsofthisworkandspecificallydisclaimallwarranties,including withoutlimitationanyimpliedwarrantiesoffitnessforaparticularpurpose.Inviewofongoingresearch,equipment modifications,changesingovernmentalregulations,andtheconstantflowofinformationrelatingtotheuseof medicines,equipment,anddevices,thereaderisurgedtoreviewandevaluatetheinformationprovidedinthepackage insertorinstructionsforeachmedicine,equipment,ordevicefor,amongotherthings,anychangesintheinstructionsor indicationofusageandforaddedwarningsandprecautions.Readersshouldconsultwithaspecialistwhereappropriate. ThefactthatanorganizationorWebsiteisreferredtointhisworkasacitationand/orapotentialsourceoffurther informationdoesnotmeanthattheauthororthepublisherendorsestheinformationtheorganizationorWebsitemay provideorrecommendationsitmaymake.Further,readersshouldbeawarethatInternetWebsiteslistedinthiswork mayhavechangedordisappearedbetweenwhenthisworkwaswrittenandwhenitisread.Nowarrantymaybecreated orextendedbyanypromotionalstatementsforthiswork.Neitherthepublishernortheauthorshallbeliableforany damagesarisingherefrom. iv BLUK130-Wang December29,2007 2:58 Contents Listofcontributors, vii Part3 Catheterandsurgical ablation Foreword, xi HeinJ.Wellens 7 Mappingandablationofventricular tachycardiaaftermyocardialinfarction, 76 WilliamG.Stevenson,UshaTedrow Part1 MechanismsofVT 8 Mappingandablationofventricular 1 Theroleofspatialdispersionof tachycardiainnonischemic repolarizationandintramuralreentryin cardiomyopathy, 89 inheritedandacquiredsuddencardiacdeath HenryH.Hsia,PiroozS.Mofrad syndromes, 1 9 Mappingtodefinescarsandisthmuses:anew CharlesAntzelevitch paradigmforguidingventriculartachycardia 2 Mechanismsofventriculartachycardia: ablation, 101 underlyingpathologicalandphysiological KyokoSoejima abnormalities, 18 10 Ablationofidiopathicventricular JacquesMTdeBakker,HaroldVMvanRijen tachycardias, 112 NitishBadhwar,MelvinM.Scheinman 11 Ablationofventricularfibrillation, 128 Part2 Etiologiesandsyndromes KarenP.Phillips,J.DavidBurkhardt, 3 Time-dependentgenderdifferencesinthe RobertA.Schweikert,WalidI.Saliba, clinicalcourseofpatientswiththecongenital AndreaNatale long-QTsyndrome, 28 IlanGoldenberg,ArthurJ.Moss, 12 Ablationofventriculartachycardiain WojciechZareba congenitalheartdisease, 141 GeorgeF.VanHare 4 Geneticsofventriculararrhythmias, 37 ZianH.Tseng,JeffreyOlgin 13 Roleofimagingtechniquesincatheter ablationofventriculartachycardia, 150 5 Arrhythmogenicrightventricular MathewD.Hutchinson,DavidJ.Callans dysplasia/cardiomyopathy, 51 RahulJain,HughCalkins 14 Epicardialablationofventricular tachycardia, 164 6 Riskstratificationandtheimplantable MauricioScanavacca,EduardoSosa defibrillatorforthepreventionof suddendeathinhypertrophic 15 Roleofcathetercontrolsystemsinablation cardiomyopathy, 64 ofventriculartachycardia, 178 BarryJ.Maron MarcoPerez,AminAl-Ahmad v BLUK130-Wang December29,2007 2:58 vi Contents 16 Currentsurgicaltechniquesforischemic Part5 Ventricularfibrillationand ventriculartachycardia, 190 defibrillation RobertJ.Moraca,MarciS.Bailey, 21 Themechanismsofventricular RalphJ.DamianoJr fibrillation, 267 LanS.Chen,Peng-ShengChen,MosheS. Swissa Part4 Epidemiology,riskstratification, andpharmacologicaltherapyfor 22 Mechanismsofdefibrillation, 277 ventriculartachycardia DerekJ.Dosdall,JianHuang,RaymondE. andsuddendeath Ideker 17 Epidemiologyandetiologiesofsudden 23 Automaticexternaldefibrillationandpublic cardiacdeath, 198 accessdefibrillatorresponse, 289 KeaneK.Lee,AminAl-Ahmad,PaulJ.Wang, PaulJ.Wang,AminAl-Ahmad, RobertJ.Myerburg RobertJ.Myerburg 18 Non-invasivetestsforriskstratification 24 Advancesincardiopulmonary inischemicandnon-ischemic rescuscitation, 298 cardiomyopathy, 213 AnuragGupta,AminAl-Ahmad J.ThomasBigger,MarkC.Haigney, 25 Advancesinimplantabledefibrillatortherapy RobertE.Kleiger andtechnologies, 312 PaulJ.Wang,AminAl-Ahmad,HenryH. 19 Riskstratification:whereweareandwhere Hsia,PaulC.Zei dowegofromhere, 240 JeffreyJ.Goldberger 26 ICDleadextraction:when,whyand how?, 327 20 Pharmacologicalmanagementofventricular BruceL.Wilkoff,OussamaWazni arrhythmias, 247 KevinJ.Makati,MuntherHomoud, MarkS.Link,JonathanWeinstock, Index, 335 N.A.MarkEstesIII BLUK130-Wang December29,2007 2:58 Contributors Amin Al-Ahmad, MD David J. Callans, MD CardiacArrhythmiaService UniversityofPennsylvaniaHealthSystem StanfordUniversityMedicalCenter Philadelphia,PA Stanford,CA USA USA Lan S. Chen, MD Charles Antzelevitch, PhD TheDepartmentofNeurology MasonicMedicalResearchLaboratory IndianaUniversitySchoolofMedicine Utica,NY Indianapolis,Indiana USA USA Nitish Badhwar, MBBS,FACC Peng-Sheng Chen, MD SectionofCardiacElectrophysiology TheKrannertInstituteofCardiology UCSF,DivisionofCardiology DivisionofCardiology UniversityofCalifornia DepartmentofMedicine SanFrancisco,CA IndianaUniversitySchoolofMedicine USA Indianapolis,IN USA Marci S. Bailey, RN Ralph J. Damiano, Jr. MD ResearchCoordinator WashingtonUniversitySchoolofMedicine ChiefofCardiothoracicSurgery St.Louis,MO JohnShoenbergProfessorofSurgery USA WashingtonUniversitySchoolofMedicine St.Louis,MO J. Thomas Bigger, MD USA ColumbiaUniversityCollegeofPhysiciansandSurgeons Jacques MT de Bakker, PhD NewYork,NY USA Head,DepartmentofExperimentalCardiologyAcademic MedicalCenter;Amsterdam,TheNetherlands J. David Burkhardt TheCenterofHeartFailureResearch,Departmentof CardiacPacingandElectrophysiology ExperimentalCardiology,AcademicMedicalCenter, DepartmentofCardiovascularMedicine Amsterdam,TheNetherlands ClevelandClinicFoundation TheHeartLungCenter,UniversityMedicalCenterUtrecht, Cleveland,OH TheNetherlands USA TheDepartmentofMedicalPhysiology,UniversityMedical CenterUtrecht,TheNetherlands Hugh Calkins, MD TheInteruniversityCardiologyInstituteoftheNetherlands, ProfessorofMedicine Utrecht DirectoroftheArrhythmiaService TheNetherlands DirectoroftheElectrophysiologyLaboratory DirectoroftheJohnsHopkinsARVD Derek J. Dosdall, PhD ProgramJohnsHopkinsMedicalInstitutions UniversityofAlabamaatBirmingham Baltimore,MD DepartmentofBiomedicalEngineering USA Birmingham,AL USA vii BLUK130-Wang December29,2007 2:58 viii Listofcontributors N.A. Mark Estes III, MD Raymond E. Ideker, MD,PhD ProfessorofMedicine UniversityofAlabamaatBirmingham Director,CardiacArrhythmiaCenter DepartmentsofPhysiologyandBiomedical TuftsUniversitySchoolofMedicine EngineeringMedicine Boston,MA Birmingham,AL USA USA Ilan Goldenberg, MD Rahul Jain, MD TheCardiologyDivision DivisionofCardiology DepartmentofMedicine TheJohnsHopkinsUniversitySchoolof UniversityofRochesterMedicalCenter Medicine Rochester,NY MD USA USA Jeffrey J. Goldberger, MD Robert E. Kleiger, MD TheDivisionofCardiology WashingtonUniversitySchoolofMedicine DepartmentofMedicine St.Louis,MO FeinbergSchoolofMedicine USA NorthwesternUniversity Chicago,IL USA Keane K. Lee, MD StanfordUniversityMedicalCenter Anurag Gupta, MD Stanford,CA StanfordUniversityMedicalCenter USA Stanford,CA USA Mark S. Link, MD Tufts-NewEnglandMedicalCenter Mark C. Haigney, MD Boston,MA UniformedServicesUniversity USA Bethesda,MD USA Kevin J. Makati, MD Tufts-NewEnglandMedicalCenter Munther Homoud, MD Boston,MA Tufts-NewEnglandMedicalCenter USA Boston,MA USA Barry J. Maron, MD Henry H. Hsia, MD HypertrophicCardiomyopathyCenter MinneapolisHeartInstituteFoundation CardiacArrhythmiaService MN StanfordUniversityMedicalCenter USA Stanford,CA USA Pirooz S. Mofrad, MD Jian Huang, MD,PhD StanfordUniversityMedicalCenter UniversityofAlabamaatBirmingham Standford,CA DepartmentsofMedicine USA Birmingham,AL USA Robert J. Moraca, MD FellowinCardiothoracicSurgery Mathew D. Hutchinson, MD WashingtonUniversitySchoolofMedicine UniversityofPennsylvaniaHealthSystem St.Louis,MO Philadelphia,PA USA USA BLUK130-Wang December29,2007 2:58 Listofcontributors ix Arthur J. Moss, MD Melvin M. Scheinman, MD,FACC ProfessorofMedicine(Cardiology) SectionofCardiacElectrophysiology Director,HeartResearchFollow-Up UniversityofCalifornia,SanFrancisco Program SanFrancisco,CA UniversityofRochesterMedicalCenter USA Rochester,NY USA Robert A. Schweikert, MD Director,EPClinicalOperations Robert J. Myerburg, MD,FACC SectionofCardiacElectrophysiologyandPacing ProfessorofMedicineandPhysiology DepartmentofCardiovascularMedicine Chief,DivisionofCardiology ClevelandClinicFoundation UniversityofMiami Cleveland,OH Miami,FL USA USA Kyoko Soejima, MD Andrea Natale, MD AssistantProfessor SectionHead,ElectrophysiologyandPacing DivisionofCardiology DirectoroftheElectrophysiologyLaboratories KeioUniversity TheClevelandClinicFoundation Tokyo Cleveland,OH Japan USA Eduardo Sosa, MD Jeffrey Olgin, MD HeartInstitute SectionofCardiacElectrophysiology UniversityofSaoPauloMedicalSchool DivisionofCardiology SaoPaulo UniversityofCalifornia,SanFrancisco Brazil SanFrancisco,CA USA Moshe S, Swissa, MD DivisionofCardiology Marco Perez, MD DepartmentofMedicine StanfordUniversity KaplanMedicalCenter,Rehovot Stanford,CA TheHebrewUniversity,Jerusalem USA Israel Karen P. Phillips, MB,BS(Hons),FRACP William G. Stevenson, MD ClinicalCardiacElectrophysiologyFellow Director,Clinical,CardiacElectrophysiology,Program DepartmentofCardiovascularMedicine CardiovascularDivision ClevelandClinicFoundation BrighamandWomen’sHospital Cleveland,OH Boston,MA USA USA Walid I. Saliba, MD Usha Tedrow, MD Director,ElectrophysiologyLaboratories AssociateDirector,ClinicalCardiac, SectionofCardiacPacingandElectrophysiology Electrophysiology,Program DepartmentofCardiovascularMedicine CardiovascularDivision ClevelandClinicFoundation BrighamandWomen’sHospital Cleveland,OH Boston,MA USA USA Mauricio Scanavacca, MD Zian H. Tseng, MD HeartInstitute SectionofCardiacElectrophysiology UniversityofSaoPauloMedicalSchool DivisionofCardiology SaoPaulo UniversityofCalifornia,SanFrancisco Brasil SanFrancisco,CA USA BLUK130-Wang December29,2007 2:58 x Listofcontributors George F. Van Hare, MD Jonathan Weinstock, MD ProfessorofPediatrics,ClinicalProfessorofPediatrics; Tufts-NewEnglandMedicalCenter andDirector,PediatricArrhythmiaCenter Boston,MA StanfordUniversitySchoolofMedicineandUCSF USA PaloAlto,CA USa Bruce L. Wilkoff, MD ProfessorofMedicineandDirector,CardiacPacingand Harold VM van Rijen TachyarrhythmiaDevices TheDepartmentofMedicalPhysiology ClevelandClinicFoundation UniversityMedicalCenterUtrecht Cleveland,OH TheNetherlands USA Paul J. Wang, MD Wojciech Zareba, MD,PhD StanfordUniversityMedicalCenter TheCardiologyDivision,DepartmentofMedicine Stanford,CA UniversityofRochesterMedicalCenter USA Rochester,NY USA Oussama Wazni, MD AssociateDirector Paul C. Zei, MD,PhD ClevelandClinicCenterforCardiovascularResearch CardiacArrhythmiaService ClevelandClinic StanfordUniversityMedicalCenter Cleveland,OH Stanford,CA USA USA

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