Table Of ContentVanadium Compounds
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In Vanadium Compounds; Tracey, A., et al.;
ACS Symposium Series; American Chemical Society: Washington, DC, 1998.
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In Vanadium Compounds; Tracey, A., et al.;
ACS Symposium Series; American Chemical Society: Washington, DC, 1998.
ACS SYMPOSIUM SERIES 711
Vanadium Compounds
Chemistry, Biochemistry, and
1 Therapeutic Applications
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p://pu1998-
1, 2012 | htt10.1021/bk- Alan S. Tracey, EDITOR
October 3998 | doi: Simon Fraser University
2 on 10, 1 Debbie C. Crans, EDITOR
5.4er Colorado State University
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American Chemical Society, Washington, DC
In Vanadium Compounds; Tracey, A., et al.;
ACS Symposium Series; American Chemical Society: Washington, DC, 1998.
Library of Congress Cataloging-in-Publication Data
Vanadium compounds : biochemistry; chemistry, and therapeutic applications /
Alan S. Tracey, Debbie C. Crans, editors.
p. cm.—(ACS symposium series ; ISSN 0097-6156 ; 711)
Includes bibliographical references and index.
ISBN 0-8412-3589-9
1
org w00 1. Vanadium—Physiological effect—Congresses. 2. Vanadium—
cs.1.f Therapeutic use—Congresses. 3. Vanadium—Congresses.
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2 on 10, 1 Copyright © 1998 American Chemical Society
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PRINTED IN THE UNITED STATES OF AMERICA
In Vanadium Compounds; Tracey, A., et al.;
ACS Symposium Series; American Chemical Society: Washington, DC, 1998.
Advisory Board
ACS Symposium Series
Mary E. Castellion Omkaram Nalamasu
ChemEdit Company AT&T Bell Laboratories
Arthur B. Ellis Kinam Park
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org w00 University of Wisconsin at Madison Purdue University
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In Vanadium Compounds; Tracey, A., et al.;
ACS Symposium Series; American Chemical Society: Washington, DC, 1998.
Foreword
lHE ACS SYMPOSIUM SERIES was first published in 1974 to provide
a mechanism for publishing symposia quickly in book form. The pur
pose of the series is to publish timely, comprehensive books devel
oped from ACS sponsored symposia based on current scientific re
search. Occasionally, books are developed from symposia sponsored
1
org w00 by other organizations when the topic is of keen interest to the chem
cs.1.f istry audience.
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bs.07 Before agreeing to publish a book, the proposed table of contents
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In Vanadium Compounds; Tracey, A., et al.;
ACS Symposium Series; American Chemical Society: Washington, DC, 1998.
Preface
Louring the past 15 years an explosive growth has occurred in the chemistry
and biochemistry of vanadium compounds. Much of this interest had been fu
1 eled by the various roles that vanadium plays as a phosphate mimic in bio
cs.org 1.pr00 cmheetmabiocalilz isnygs teemnzsy, meeitsh earc caocrtidviantgi ntgo othr ei nrhoilbe ittihnagt ap hlaorsgpeh antuem pblaeyr s oifn pthhoosspeh asytes-
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1, 2012 | http://pubs.10.1021/bk-1998-07 ontomeffi mturvvcosahag.nn eoaanHdfda iotisuhuewmems e.-e -vdacAeeroprlsn,i e etwenarq diiwlnuel inaonbltrge lky .e s cinemoezmnyp mopfroretouasmn,n dt t hstih ene n vspoearwo nP marodoouicuttisemnterg-di dpitenshp giestsh n, iednt hetaeneir tme usssht eaaswl onaadpsn e drat ohsaxepp iidrdpaalitissicceoaosnt vsio aennorysdf
October 3998 | doi: caoqmuepPoouruosng darenss ds h oairsng agsnerievcae trmlayle dasitraiem.a suT laohtfee dtph aetp heea rpsep xldipeclsaoctriroaibntieso dn a inondf thpviraso npvaeodrlituuiemms e ocwhf eevmreai nsdatredyvi ueimln
2 on 10, 1 oped from the Symposium entitled "Chemistry, Biochemistry, and Therapeutic
9.163.35.4December Acpaaplr ptCilcioicpnaagtniroetsns ssi not hft ahVti sat onsoaykdm ipuplmoasc Cieu omimn rpCeoapunrnecsduesnn", t heNdeol dvm eaamtn ybth eewr 5o1tr0hl- d1Nw4oi, drt1eh 9 gA9r7om.u epArsi,lc tnahnoo tuC aghlhel mathcie
by 8ate: tive areas of vanadium chemistry or vanadium life science were present. A few
d D additional contributions were solicited to provide the proceedings with a slightly
ownloadeblication bvraonaaddeiru msc socpiee.n cPe rhioadr tboe ethni sh eslydm apnods isuomm,e oothf etrh ossyem mpeoestiian gosn rveasruiloteuds ains pseycmtsp oo f
Du sium proceedings (7-2). In addition, three monologues have recently been pub
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lished (3-5). For those readers interested in the growth of this general field, we
have provided a summary of those meetings below. To our knowledge the first
meeting in Vanadium science was entitled "Role of Vanadium in Biology" and
was held in 1986 at the Federation of American Societies for Experimental Bi
ology meeting. A synopsis from this Symposium was reported in the Federation
Proceedings (7). A second symposium with a chemical emphasis entitled
"Biochemistry of Vanadium" was held at the 45th American Chemical Society
Southeast Regional Meeting in Johnson City, Tennessee, in 1993. A third sym
posium with a pharmacological emphasis was held in 1994 in Montreal entitled
"Vanadium: Biochemistry, Physiology, and Potential Use in Diabetes Therapy"
and the symposium proceeding from this meeting resulted in a special volume of
Molecular and Cellular Biochemistry (2). Recently, vanadium chemistry for the
xi
In Vanadium Compounds; Tracey, A., et al.;
ACS Symposium Series; American Chemical Society: Washington, DC, 1998.
first time was given a session at the 8th International Conference for Bioinor-
ganic Chemistry in Yokohama, Japan, in 1997. That meeting was followed by
the Symposium from which this Proceedings was developed. In this sympo
sium, vanadium chemistry and biochemistry were closely coupled with thera
peutic applications of vanadium compounds. Its timeliness and success is not
only reflected in the quality of the contributions in this volume, but also in the
fact that sequels for the symposium are in the planning stages.
This Symposium Proceedings is divided into three sections, each of which
is proceeded by an introduction and a brief general review of the area. The first
section consists of 12 chapters that describe research in aqueous and non
aqueous vanadium chemistry. The introductory chapter for the chemistry sec
1 tion of the proceedings reviews the simple aqueous vanadium chemistry of di
acs.org 11.pr00 rmecotd reel lecvhaenmcies ttroy bainodl oogtihcearl nstound-iaeqs.e uIonu asd cdhiteimonis, tirty p nroovt iddeess csroibmeed iinnf odremtaailt iionn tohne
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October 3998 | doi: ptsherenortvaeipdde euast ti act hbear pispeyfl imcreapvtoiioseniwus moo.ff vtThaehn eac duiinrurtemron tdc uoscmtatitpoeon u ontfo d tsht.he e Tafrhitn e ainfl i ntshaelev ecpnoh nactrrhmiabpauctteoirolson gsiyen c ttahinoidsn
2 on 10, 1 section, Chapter 28, describes the effects of vanadium administered as oral tab
9.163.35.4December cleutrsr etAon std ilwaebvaese lt iocob fvh uiuonmudase nrasstt. a nthdei nSg ymofp tohsei uvma naanddi ufmro mch ecmhaispttreyr sa nind tthhies vmoelcuhmaen,i stmhes
by 8ate: of action in biology has increased vastly in the past decade. The recent ad
d D vances in understanding the aqueous chemistry of vanadium, in some sense cor
ownloadeblication raensdp omnedds ictoi naa ls haisfpt efcrotsm o fa ptoudraeyly. inAolrtghaonuicg hf oncouts atlol ac uermrepnht asstius doiens thme abyi olleoagdi ctaol
Du successful applications, the increased interest in not only the simple vanadium
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salts but also organic vanadium derivatives, suggests that at some future time,
vanadium compounds with reduced toxicity and increased therapeutic value will
be identified. The symposium giving rise to these proceedings focused attention
on the importance of understanding the interrelationships between the aqueous
chemistry, the biochemistry, and therapeutic utilization of vanadium com
pounds. The details available in many of the following chapters will directly or
indirectly emphasize those relationships.
xii
In Vanadium Compounds; Tracey, A., et al.;
ACS Symposium Series; American Chemical Society: Washington, DC, 1998.
References
1. Nechay, B. R.; Nanninga, L. B.; Nechay, P. S. E.; Post, R. L.; Grantham, J.
J.; Macara, I. G.; Kubena, L. FI.; Philips, T. D.; Nielsen, F. H. FASEB Fed.
Proc. 1986, 45, 123-132.
2. Vanadium Compounds: Biochemical and Therapeutic Applications; Srivas
tava, A. K.; Chiasson, J.-L., Eds; Focused issue in Mol. Cell. Biochem. 1995,
153.
3. "Vanadium in the Environment." In Adv. Environ. Science Technol.Nriagu,
J. O., Ed.; John Wiley & Sons, Inc: New York, 1998; Vol. 23, Parts 1 and 2.
4. Vanadium and Its Role for Life; Metal Ions in Biological Systems, Sigel, H.;
Sigel, A., Eds.; Marcel Dekker, Inc.: New York, 1995; Vol. 31.
1
cs.org 1.pr00 5. PVuabnlisahdeirus:m D oinrd Breicohlto, gNiectahle rSlayndsste, m19s9;0 . Chasteen, N. D., Ed.; Kluwer Academic
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October 3998 | doi: BSCIUAMRNONANAD AFBR YA, SBERRI TUISNHIV CEORLSUITMYB IA V5A 1S6
2 on 10, 1
9.163.35.4December DDCEEOBPLABOIRRETA MCD.EO NC STRT AOANFTS E C UHNEIMVIESRTRSIYT Y
by 8ate: FT. COLLINS, CO 80523-1872
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In Vanadium Compounds; Tracey, A., et al.;
ACS Symposium Series; American Chemical Society: Washington, DC, 1998.
