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About Vallieres - Simon - MedicalPhysicsUnitMPU - Finalthesis Teza de Master
This document describes a thesis submitted to McGill University investigating dose enhancement in radiotherapy using gold-doxorubicin conjugates. Gold nanoparticles were conjugated with the chemotherapeutic drug doxorubicin and injected into murine melanoma tumors. Mice were then given a single dose of X-rays. Tumor growth inhibition was observed for at least six days post-irradiation, indicating an enhanced radiobiological effect from the gold nanoparticles. However, the gold-doxorubicin conjugates were not as cytotoxic as expected. The small animal irradiator was calibrated and a Monte Carlo model was developed to assess dose uncertainties, showing good agreement with measurements.
Detailed Information
| Author: | ['elvira palariev'] |
|---|---|
| Publication Year: | 2021 |
| Pages: | 125 |
| Language: | English |
| Format: | |
| Price: | FREE |
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