Table Of ContentUropathology
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Uropathology
Ming Zhou, MD, PhD
Associate Professor and Director
Surgical Pathology and Urologic Pathology
NYU Medical Center Tisch Hospital
New York City, New York
George J. Netto, MD
Associate Professor of Pathology, Urology and Oncology
Director of Surgical Pathology Molecular Diagnostics
The Johns Hopkins Medical Institutions
Baltimore, Maryland
Jonathan I. Epstein, MD
Professor of Pathology, Urology, Oncology
Reinhard Professor of Urologic Pathology
Director of Surgical Pathology
Department of Pathology
The Johns Hopkins Medical Institutions
Baltimore, Maryland
1600 John F. Kennedy Blvd.
Ste 1800
Philadelphia, PA 19103-2899
UROPATHOLOGY: HIGH-YIELD PATHOLOGY ISBN: 978-1-4377-2523-0
Copyright © 2012 by Saunders, an imprint of Elsevier Inc.
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Notices
Knowledge and best practice in this field are constantly changing. As new research and expe-
rience broaden our understanding, changes in research methods, professional practices, or
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Practitioners and researchers must always rely on their own experience and knowledge
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Library of Congress Cataloging-in-Publication Data
Uropathology : high-yield pathology / [edited by] Ming Zhou, George Netto, Jonathan Epstein.
p. ; cm.
ISBN 978-1-4377-2523-0
I. Zhou, Ming, MD, PhD. II. Netto, George J. III. Epstein, Jonathan I.
[DNLM: 1. Male Urogenital Diseases—pathology. WJ 141]
617.4’6—dc23
2011053082
Executive Content Strategist: William Schmitt
Senior Content Specialist: Katie DeFrancesco
Publishing Services Manager: Anne Altepeter
Senior Project Manager: Doug Turner
Designer: Steve Stave
Printed in the People’s Republic of China
Last digit is the print number: 9 8 7 6 5 4 3 2 1
To my wife, Lan, and daughters, Grace and Rebecca, for their love and support.
Ming Zhou
To my truest friend and anchor—my wife, Ruby!
George Netto
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CONTRIBUTORS
Dilek Baydar, MD Cristina Magi-Galluzzi, MD, PhD
Professor of Pathology Associate Professor
Department of Pathology Department of Anatomic Pathology
Hacettepe University School of Medicine Cleveland Clinic
Ankara, Turkey Cleveland, Ohio
Fadi Brimo, MD Adeboye Osunkoya, MD
Pathologist and Assistant Professor Assistant Professor of Pathology and Urology
Departments of Pathology and Urology Director, Genitourinary Pathology
Montreal General Hospital Department of Pathology
McGill University Health Center Emory University School of Medicine
Montreal, Quebec, Canada Atlanta, Georgia
Alcide Chaux, MD Chin-Chen Pan, MD
Post-Doctoral Research Fellow Professor and Director of General Pathology
Department of Pathology Department of Pathology
The Johns Hopkins Medical Institutions Taipei Veterans General Hospital
Baltimore, Maryland; Taipei, Taiwan
Professor of Pathology
Universidad del Norte Anil Parwani, MD, PhD
Asunción, Paraguay Division Director
Pathology Informatics;
Ying-Bei Chen, MD, PhD Associate Professor
Assistant Attending Pathologist Pathology and Biomedical Informatics
Department of Pathology UPMC Shadyside
Memorial Sloan-Kettering Cancer Center Pittsburgh, Pennsylvania
New York City, New York
Brian D. Robinson, MD
Charles Guo, MD Assistant Professor of Pathology and Laboratory
Assistant Professor Medicine
Department of Pathology Assistant Professor of Pathology in Urology
The University of Texas MD Anderson Weill Medical College of Cornell University
Cancer Center New York City, New York
Houston, Texas
Hemamali Samaratunga, MBBS, LRCP,
Donna Hansel, MD, PhD MRCS, FRCPA
Associate Professor Associate Professor
Department of Anatomic Pathology University of Queensland;
Cleveland Clinic Anatomical Pathologist
Cleveland, Ohio Aquesta Specialized Uropathology
Brisbane, Queensland, Australia
Mathieu Latour, MD, FRCPC
Assistant Professor Puay Hoon Tan, FRCPA
Director, Residency Training Program in Anatomic Head and Senior Consultant
Pathology Department of Pathology
Département de Pathologie et Biologie cellulaire Singapore General Hospital
Centre Hospitalier de l’Université de Montréal Singapore
Montréal, Québec, Canada
Fabio Tavora, MD
Tamara Lotan, MD Director
Assistant Professor Argos Laboratory
Department of Pathology Fortaleza, Brazil;
The Johns Hopkins Medical Institutions Visiting Professor
Baltimore, Maryland Escola Paulista de Medicina
São Paulo, Brazil
vii
viii Contributors
Toyonori Tsuzuki, MD, PhD Huihui Ye, MD
Director Staff Pathologist
Department of Pathology Department of Pathology
Nagoya Daini Red Cross Hospital Beth Israel Deaconess Medical Center
Nagoya, Japan Boston, Massachusetts
Ximing Yang, MD, PhD Ming Zhou, MD, PhD
Professor of Pathology and Chief of Urologic Associate Professor and Director
Pathology Surgical Pathology and Urologic Pathology
Department of Surgical Pathology NYU Medical Center Tisch Hospital
Northwestern Memorial Hospital New York City, New York
Northwestern University Feinberg School
of Medicine
Chicago, Illinois
PREFACE
Today’s pathologists, in practice and in training, all face surgical pathologists who not only understand the issues
a similar challenge: too much to learn but too little time. practicing pathologists face in their daily work but also
When the decision comes to buying a textbook, patholo have a vision for the future of genitourinary pathology.
gists want one that is comprehensive yet easy to read and
features many good images. Acknowledgments
This book fits the bill. It has a unique format. Rather We are enormously grateful to the contributors of this
than combining many topics into one lengthy chapter book. They spent countless hours out of their very busy
that readers have to wade through, each chapter cov schedules to make this textbook possible.
ers one specific disease entity or diagnostic issue, such We thank Margaret LaPlaca for her secretarial assis
as staging and grading. Each chapter provides excel tance. We also want to thank our publisher, Elsevier,
lent images of gross and microscopic pathology, along and executive content strategist, William Schmitt, for
with highly templated and bulleted text. The clinical, his support and encouragement during the production
pathologic, immunohistochemical, and molecular fea of this book. A special thanks is given to Katie
tures of each disease entity are succinctly discussed and DeFrancesco, our content development specialist at
up to date. Emphasis is placed on the pathologic features Elsevier, for her patience and persistence in keeping this
and diagnostic criteria. Pertinent differential diagnoses book on track.
are provided, along with diagnostically important clini
cal, gross, microscopic, and immunohistochemical clues. Ming Zhou, MD, PhD
A book is only as good as its writers. We are very fortu George J. Netto, MD
nate to have assembled a team of internationally known Jonathan I. Epstein, MD
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