Update in Pediatric Neuro-Oncology

140 Pages·9.322 MB·English

by  Natasha Pillay Smiley, Soumen Khatua

bioengineering
Update in
Pediatric
Neuro-Oncology
Edited by
Soumen Khatua and Natasha Pillay Smiley
Printed Edition of the Special Issue Published in Bioengineering
www.mdpi.com/journal/bioengineering
Update in Pediatric Neuro-Oncology

Update in Pediatric Neuro-Oncology
SpecialIssueEditors
SoumenKhatua
NatashaPillaySmiley
MDPI•Basel•Beijing•Wuhan•Barcelona•Belgrade
SpecialIssueEditors
SoumenKhatua
TheUniversityofTexasMDAndersonCancerCenter
USA
Natasha Pillay Smiley
Ann and Robert H. Lurie Children’s Hospital
USA
EditorialOffice
MDPI
St.Alban-Anlage66
4052Basel,Switzerland
This is a reprint of articles from the Special Issue published online in the open access
journal Bioengineering (ISSN 2306-5354) in 2018 (available at: https://www.mdpi.com/journal/
bioengineering/specialissues/pediatrneurooncol)
Forcitationpurposes,citeeacharticleindependentlyasindicatedonthearticlepageonlineandas
indicatedbelow:
LastName,A.A.; LastName,B.B.; LastName,C.C.ArticleTitle. JournalNameYear,ArticleNumber,
PageRange.
ISBN978-3-03897-539-7(Pbk)
ISBN978-3-03897-540-3(PDF)
CoverimagecourtesyofNatashaPillaySmiley.
(cid:2)c 2019bytheauthors. ArticlesinthisbookareOpenAccessanddistributedundertheCreative
Commons Attribution (CC BY) license, which allows users to download, copy and build upon
publishedarticles,aslongastheauthorandpublisherareproperlycredited,whichensuresmaximum
disseminationandawiderimpactofourpublications.
ThebookasawholeisdistributedbyMDPIunderthetermsandconditionsoftheCreativeCommons
licenseCCBY-NC-ND.
Contents
AbouttheSpecialIssueEditors . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . vii
Prefaceto”UpdateinPediatricNeuro-Oncology”. . . . . . . . . . . . . . . . . . . . . . . . . . . ix
NatashaPillaySmileyandSoumenKhatua
IntroductiontotheSpecialIssueonPediatricNeuro-Oncology
Reprintedfrom:Bioengineering2018,5,109,doi:10.3390/bioengineering5040109 . . . . . . . . . . 1
Anders W. Bailey, Amreena Suri, Pauline M. Chou, Tatiana Pundy, Samantha Gadd,
Stacey L. Raimondi, Tadanori Tomita and Simone Treiger Sredni
Polo-Like Kinase 4 (PLK4) Is Overexpressed in Central Nervous System Neuroblastoma
(CNS-NB)
Reprintedfrom:Bioengineering2018,5,96,doi:10.3390/bioengineering5040096. . . . . . . . . . . 5
AmerM.Najjar,JasonM.JohnsonandDawidSchellingerhout
TheEmergingRoleofAminoAcidPETinNeuro-Oncology
Reprintedfrom:Bioengineering2018,5,104,doi:10.3390/bioengineering5040104 . . . . . . . . . . 18
EthanB.Ludmir,DavidR.GrosshansandKristinaD.Woodhouse
RadiotherapyAdvancesinPediatricNeuro-Oncology
Reprintedfrom:Bioengineering2018,5,97,doi:10.3390/bioengineering5040097. . . . . . . . . . . 33
CavanP.Bailey,MaryFigueroa,SanaMohiuddin,WafikZakyandJoyaChandra
CuttingEdgeTherapeuticInsightsDerivedfromMolecularBiologyofPediatricHigh-Grade
GliomaandDiffuseIntrinsicPontineGlioma(DIPG)
Reprintedfrom:Bioengineering2018,5,88,doi:10.3390/bioengineering5040088. . . . . . . . . . . 49
PeterH.BaenzigerandKarenMoody
PalliativeCareforChildrenwithCentralNervousSystemMalignancies
Reprintedfrom:Bioengineering2018,5,85,doi:10.3390/bioengineering5040085. . . . . . . . . . . 65
TaraH.W.DobsonandVidyaGopalakrishnan
PreclinicalModelsofPediatricBrainTumors—ForgingAhead
Reprintedfrom:Bioengineering2018,5,81,doi:10.3390/bioengineering5040081. . . . . . . . . . . 83
David E. Kram, Jacob J. Henderson, Muhammad Baig, Diya Chakraborty,
Morgan A. Gardner, Subhasree Biswas and Soumen Khatua
Embryonal Tumors of the Central Nervous System in Children: The Era of
Targeted Therapeutics
Reprintedfrom:Bioengineering2018,5,78,doi:10.3390/bioengineering5040078. . . . . . . . . . . 96
Peter L. Stavinoha, Martha A. Askins, Stephanie K. Powell, Natasha Pillay Smiley and
RhondaS.Robert
NeurocognitiveandPsychosocialOutcomesinPediatricBrainTumorSurvivors
Reprintedfrom:Bioengineering2018,5,73,doi:10.3390/bioengineering5030073. . . . . . . . . . . 112
v

About the Special Issue Editors
Soumen Khatua is an Associate Professor and a pediatric Neuro-Oncologist at M.D. Anderson
Cancer Center. He completed a pediatric Hematology-Oncology fellowship at the Children’s
National Medical Center, Washington DC and a Neuro-Oncology fellowship at the Children’s
Hospital Los Angeles. His research efforts are directed towards developing clinical trials using
targetedtherapyinpediatricbraintumors. Dr. Khatua’sareasofinterestandfocusarehigh-grade
glioma,diffusepontinegliomaandintracranialgermcelltumors.
NatashaPillaySmileyisapediatricNeuro-OncologistatAnn&RobertH.LurieinChicago,Illinois.
Inadditiontotakingcareofnewlydiagnosedchildrenwithbrainandspinalcordtumors,sheserves
asthedirectorofthePediatricBrainTumorSurvivorshipProgramandisamemberoftheCancer
PredispositionclinicandtheNF-1Neuro-OncologyClinic.ShealsocurrentlyservesastheAssistant
Hematology/Oncology/SCTFellowshipDirectorandtheNeuro-OncologyFellowshipDirector.
vii

Preface to ”Update in Pediatric Neuro-Oncology”
PediatricNeuro-Oncologyisahighlyspecializedfieldencompassingmolecularbiology,clinical
acumen, evidence-basedmedicine, cancergenetics, andneuropsychologicalcareforthediagnosis
and treatment of children with central nervous system (CNS) tumors. In this Special Edition of
Bioengineering, we hope to demonstrate the wide breath of science and medicine that occurs in
thefieldofpediatricneuro-oncology. Facedwithsubstantialmortalityinchildrenwithaggressive
tumorsaswellassignificantmorbidityofsurvivors,wearealwayschallengedtolearnmoreabout
thesediseaseentitiesandimprovetheoutcomesofthesechildren.Topicsthatarediscussedfurtherin
thiseditionare: Molecularbiologyinpediatricgliomas,theclinicalrelevanceofpreclinicalmodels,
updatesonradiationtherapyforpediatricCNStumors,molecularneuro-imaging,embryonaltumors
and targeted therapeutics, and neurocognitive and psychosocial outcomes and palliative care in
childrenwithcentralnervoussystemmalignancies.
SoumenKhatua,NatashaPillaySmiley
SpecialIssueEditors
ix