University of Groningen Anemia and erythropoietin in cardiovascular disease Kleijn, Lennaert

142 Pages·2013·2.71 MB·English

University of Groningen

Anemia and erythropoietin in cardiovascular disease
Kleijn, Lennaert
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Download date: 17-03-2023
Anemia and Erythropoietin in Cardiovascular Disease
Lennaert Kleijn
Financial support by Amgen bv, Boehringer Ingelheim bv, Bayer Healthcare
Pharmaceuticals bv, Graduate School of Medical Sciences, Servier Nederland
Farma bv, Rijksuniversiteit Groningen, St. Jude Medical Nederland bv, Chipsoft bv,

Roche Nederland bv, Vifor Pharma bv for the publication of this thesis is gratefully

acknowledged.
Copyright 2013 Lennaert Kleijn
All rights reserved. No part of this publication may be reproduced or transmitted in any
form or by any means without written permission of the author and, when appropri-
ate, the publisher holding the copyrights of the published articles.
ISBN: 978-90-367-6713-2
ISBN: 978-90-367-6714-9 (e-pub)
Cover design and layout by Claudia Gonzalez Arevalo
[email protected]
http://cmgonzalezarevalo.wix.com/layout
Printed by Grafimedia Facilitair bedrijf RUG
Anemia and erythropoietin in
cardiovascular disease
Proefschrift
ter verkrijging van de graad van doctor aan de
Rijksuniversiteit Groningen
op gezag van de
rector magnificus, prof. dr. E. Sterken
en volgens besluit van het College voor Promoties.
De openbare verdediging zal plaatsvinden op
maandag 3 februari 2014 om 14:30 uur
door
Lennaert Kleijn
geboren op 9 oktober 1985
te Nagele
Promotor:
Prof. dr. D.J. van Veldhuisen
Copromotores:
Dr. P. Van der Meer
Dr. B.D. Westenbrink
Beoordelingscommissie:
Prof. dr. C.A.J.M. Gaillard
Prof. dr. D. Swinkels
Prof. dr. H.L. Hillege
Paranimfen:
W.T. Ruifrok
F. Imhann
Financial support by the Dutch Heart Foundation for the publication of this thesis is
gratefully acknowledged.

Table of contents
Chapter 1 Introduction and aim of the thesis
Part 1 I Anemia in cardiovascular disease
Chapter 2 Anemia and its association with hemodynamics in a
broad spectrum of cardiovascular patients
Under revision
Chapter 3 Inflammation and anemia in a broad spectrum of patients
with heart failure
Heart. 2012 Aug;98(16):1237-41
Chapter 4 Impact of postoperative anemia on cardiovascular
outcome after Coronary artery bypass graft surgery;
insights from the IMAGINE trial
Heart. 2011 Oct;97(19):1590-6
Chapter 5 Impaired erythropoiesis after coronary artery bypass
grafting is associated with an increased inflammatory
response
Submitted
Part 2 I Erythropoietin in cardiovascular disease
Chapter 6 Should erythropoietin treatment in chronic heart failure
be hemoglobin targeted?
Eur J Heart Fail. 2010 Mar;12(3):215-6
Chapter 7 Long term effects of epoetin alfa in patients with
ST- elevation myocardial infarction
Cardiovasc Drugs Ther. 2013 Oct;27(5):433-9
Chapter 8 Erythropoietin and heart failure: the end of a promise?
Eur J Heart Fail. 2013 May;15(5):479-81
Chaper 9 Summary, conclusions and future directions
Appendices Nederlandse samenvatting
Dankwoord
Bibliography
Curriculum Vitae

Introduction and aim
1
of the thesis
Chapter