Table Of ContentUNDERSTANDING GLIAL CELLS
UNDERSTANDING GLIAL CELLS
edited by
Bernardo Castellano, Ph.D.
Department of Cell Biology and Physiology
Universitat Autdnoma Barcelona
Berta Gonzälez, Ph.D.
Department of Cell Biology and Physiology
Universitat Autonoma Barcelona
Manuel Nieto-Sampedro, Ph.D.
Cajal Institute
c.,
C. S.I. Madrid
~.
"
SPRINGER SCIENCE+BUSINESS MEDIA, LLC
Library of Congress Cataloging-in-Publication Data
Understanding glial cells / edited by Bernardo Castellano, Berta
Gonzalez, Manuel Nieto-Sampedro.
p. cm.
Includes bibliographical references and index.
ISBN 978-1-4613-7628-6 ISBN 978-1-4615-5737-1 (eBook)
DOI 10.1007/978-1-4615-5737-1
1. Neuroglia. I. Castellano, Bernardo, 1957- 11. Gonzalez,
Berta, 1955- . 111. Nieto-Sampedro, Manuel, 1944-
QP363.2.U53 1998
573.8'636-dc21 98-12006
CIP
Copyright © 1998 by Springer Science+Business Media New York
Originally published by Kluwer Academic Publishers in 1998
Softcover reprint ofthe hardcover 1st edition 1998
All rights reserved. No part of this publication may be reproduced, stored in a
retrieval system or transmitted in any form or by any means, mechanical, photo
copying, recording, or otherwise, without the prior written permission of the
publisher, Springer Science+Business Media, LLC.
Printed on acid-free paper.
CONTENTS
List of contributors ix
Preface xvii
Acknowledgments xix
I. MORPHOLOGY AND ONTOGENY
1. Characterization of the glial cells in the teleost visual pathway 3
Juan M Lara, Almudena Velasco, Concepcion Lillo,
David Jimeno and Jose Aijon
2. The macroglia ofteleosts: characterization, distribution 19
and development
Sofia Diaz-Regueira and Ramon Anadon
3. Organization and function ofastrocytes in the human retina 47
Jose M Ramirez, Alberto TriviflO, Ana 1. Ramirez
and Juan J. Salazar
4. Astroglial architecture of the human optic nerve: functional 63
role of astrocytes
Alberto Triviflo, Jose M Ramirez, Juan J. Salazar
and Ana 1. Ramirez
5. Glial cells ontogeny in the telencephalon and mesencephalon 79
of the lizard Gallotia galloti
Maximina Monzon-Mayor, Carmen M Yanes,
Maria M Romero-Alemim, Jean de Barry, Robert R. Sturrock
and Giorgio Gombos
6. Role of thyroid hormone on the oligodendrocyte 111
type 2-astrocyte lineage
Angeles Rodriguez-Pena, Nieves Ibarrola and Sonia Vega
vi
II. MOLECULAR AND BIOCHEMICAL PROPERTIES
7. Characterization of rat neural stem cells from embryonic striatum 133
and mesencephalon during in vitro differentiation
Eulalia Bazem, Miguel A. Lopez-Toledano, Carolina Redondo,
Alberto Alcazar, Maria Angeles Mena, Carlos L. Paino
and Antonio S. Herranz
8. Expression of neurotrophins and their receptors within glial cells 149
of retina and optic nerve
Elena Vecino, Elena Caminos, Elena Becker,
Dionisio Martin-Zanca and Neville N. Osborne
9. Expression and function of neurotransmitter receptors in 167
glial cells of the central nervous system
Carlos Matute, David Fogarty, Jose Maria Garcia-Barcina,
Miroslav Gottlieb, Maria Jose Moran
and Maria Victoria Sanchez-Gomez
10. Role of astroglia in the neural effects of sex hormones and 185
neuroactive steroids
Maria del Carmen Fernandez-Galaz, Julie Ann Chowen
and Luis Miguel Garcia-Segura
11. Cytokines and astroglial cells: functions and mechanisms of action 195
Francisco Molina-Holgado, Eduardo Molina-Holgado,
Alberto Lledo and Carmen Guaza
12. The critical factor for L-DOPA toxicity on dopamine neurons is glia 213
Maria Angeles Mena, Maria Jose Casarejos, Alberto Alcazar,
Antonio S. Herranz, Carlos L. Paino and Justo Garcia de Yebenes
III. INVOLVEMENT IN DAMAGE AND REGENERATION
13. Ethanol exposure during brain development alters 233
astrogliogenesis and astrocyte functions
Jaime Renau-Piqueras, Luis Megias and Consuelo Guerri
14. Neuron-glia ensembles and mammalian CNS lesion repair 255
Manuel Nieto-Sampedro
15. Glial response to excitotoxic injury in the immature brain 271
Laia Acarin, Berta Gonzalez, Anthony J. Castro
and Bernardo Castellano
vii
16. Effects of contralateral lesions and aging on the neuronal and 297
glial population of the cerebral cortex of the rat
Maria Angeles Peinado, Maria Jesus Ramirez, Juan Angel Pedrosa,
Manuel Martinez, Adoraci6n Quesada, Maria Luisa del Moral,
Francisco Jose Esteban, Jose Rodrigo and Jose Maria Peinado
17. The role of Schwann cell in nerve regeneration 319
Enrique Verdu and Xavier Navarro
IV. GLiA IN PATHOLOGY
18. Glial abnormalities in genetically determined disorders of myelin 363
Jose Miguel Vela, Ishar Dalmau, Berta Gonzalez
and Bernardo Castellano
19. Glial changes in aging and Alzheimer's disease 385
Maria Asuncion Moran and Pilar Gomez-Ramos
20. Adhesion molecules, angiogenesis and malignant gliomas: 405
implications for tumorigenesis
Blanca Conde, Elena Sinues, Ana Gascon, Angela Alcala
and Mercedes Ruidiaz
LIST OF CONTRIBUTORS
Laia Acarin Ramon Anadon
Unitat Histologia, Facultat de Medicina Departmento de Biologia Fundamental
Departament Biologia CeLlular i Universidad Santiago de Compostela
Fisiologia 15706 Santiago de Compostela, Spain.
Universitat Autonoma Barcelona
08193 Bellaterra, Spain. Jean de Barry
Laboratoire de Neurobiologie Cellulaire
Jose Aijon (UPR 9009 CNRS)
Departamento de Biologia Celular y Centre de Neurochimie
Patologia Universite Louis Pasteur
Universidad de Salamanca Strasbourg, France.
37007 Salamanca, Spain.
Eulalia Bazan
Angela Alcala Servicio de Bioquimica
Departamento Ciencias Morfologicas. Departamento de Investigacion
Facultad de Medicina Hospital Ramon y Cajal
Universidad de Zaragoza INSALUD
50009 Zaragoza, Spain. 28034 Madrid, Spain.
Alberto Alcazar Elena Becker
Servicio de Bioquimica Departamento de Microbiologia
Departamento de Investigacion y Genetica
Hospital Ramon y Cajal, INSALUD C.S.I.C., Universidad de Salamanca
28034 Madrid, Spain. 37007 Salamanca, Spain.
x
Elena Caminos Ishar Dalmau
Departamento de Biologia Celular Unitat Histologia, Facultat de Medicina
y Patologia Departament Biologia Cel.lular i
Facultad de Medicina Fisiologia
Universidad de Salamanca Universitat Autonoma Barcelona
37007 Salamanca, Spain. 08193 Bellaterra, Spain.
Maria Jose Casarejos Sofia M. Dlaz-Regueira
Departamento de Investigaci6n Departmento de Biologfa Celular
Hospital Ram6n y Cajal y Molecular
INSALUD Universidad de La Coruna
28034 Madrid, Spain. 15071 La Corufia, Spain.
Bernardo Castellano Francisco Jose Esteban
Unitat Histologia, Departmento de Biologia Celular
Facultat de Medicina Facultad de Ciencias Experimentales
Departament Biologia Cel.lular i Universidad de Jaen
Fisiologia 23071 Jaen, Spain.
Universitat Autonoma Barcelona
08193 Bellaterra, Spain. Marla del Carmen Fernandez-Galaz
Instituto Cajal, C.S.I.C.
Anthony J. Castro 28002 Madrid, Spain.
Department of Cell Biology,
Neurobiology and Anatomy, David J. Fogarty
Stritch School of Medicine Departamento de Neurociencias
Loyola University Chicago Universidad del Pais Vasco
Maywood {lL 60153, U.S.A. 48940 Leioa, Vizcaya, Spain.
Julie Ann Chowen Jose Marla Garcla-Barcina
Instituto Cajal, C.S.I.C. Departamento de Neurociencias
28002 Madrid, Spain. Universidad del Pais Vasco
48940 Leioa, Vizcaya, Spain.
Blanca Conde
Departamento Ciencias Morfol6gicas Justo Garcia de Yebenes
Facultad de Medicina Servicio de Neurologfa
Universidad de Zaragoza Fundaci6n Jimenez Diaz
50009 Zaragoza, Spain. Madrid, Spain.
xi
Luis Miguel Garcia-Segura Carmen Guaza
Instituto Cajal, C.S.I.C. Grupo de Psicobiologia
28002 Madrid, Spain. Unidad de Plasticidad Neural
Instituto Cajal, C.S.I.C.
Ana Gascon 28002 Madrid, Spain
Departamento Ciencias Morfol6gicas
Facultad de Medicina Consuelo Guerri
Universidad de Zaragoza Instituto de Investigaciones Citol6gicas
50009 Zaragoza, Spain. (F.I.B.)
46010 Valencia, Spain.
Giorgio Gombos
Laboratoire de Neurobiologie Cellulaire Antonio S. Herranz
(UPR 9009 CNRS) Servicio de Neurobiologia
Centre de Neurochimie Departamento de Investigaci6n
Universite Louis Pasteur Hospital Ram6n y Cajal, INSALUD
Strasbourg, France. 28034 Madrid, Spain.
Pilar Gomez-Ramos Nieves [barrola
Departamento de Morfologia Instituto Investigaciones Biomedicas
Facultad de Medicina C.S.I.C., Madrid, Spain.
Universidad Aut6noma de Madrid
28029 Madrid, Spain. David Jimeno
Dpto. de Biologia Celular y Patologia
Berta Gonzalez Universidad de Salamanca
Unitat Histologia, 37007 Salamanca, Spain.
Facultat de Medicina
Departament Biologia Cel.lular i Juan M. Lara
Fisiologia Dpto. de Biologia Celular y Patologia
Universitat Autonoma Barcelona Universidad de Salamanca
08193 Bellaterra, Spain. 37007 Salamanca, Spain.
Miroslav Gottlieb Concepcion Lillo
Departamento de N eurociencias Dpto. de Biologia Celular y Patologia
Universidad del Pais Vasco Universidad de Salamanca
48940 Leioa, Vizcaya, Spain. 37007 Salamanca, Spain.
xii
Alberto Lledo Maria Angeles Mena
Grupo de Psicobiologia Servicio de Neurobiologia
Unidad de Plasticidad Neural Departamento de Investigacion
Instituto Cajal Hospital Ramon y Cajal, INSALUD
C.S.I.C. 28034 Madrid, Spain.
28002 Madrid, Spain
Francisco Molina-Holgado
Miguel A. Lopez-Toledano Grupo de Psicobiologia
Servicio de Neurobiologia Unidad de Plasticidad Neural
Departamento de Investigacion Instituto Cajal, C.S.I.C.
Hospital Ramon y Cajal, 28002 Madrid, Spain
INSALUD
28034 Madrid, Spain. Eduardo Molina-Holgado
Grupo de Psicobiologia
Dionisio Martin-Zanca Unidad de Plasticidad Neural,
Departamento de Microbiologia Instituto Cajal
y Genetica, C.S.I.C., 28002 Madrid, Spain
C.S.I.C.
Universidad de Salamanca Maximina Monzon-Mayor
37007 Salamanca, Spain. Dept. de Morfologia y Biologia Celular
Facultad de Ciencias de la Salud
Manuel Martinez Universidad de Las Palmas
Departmento de Biologia Celular de Gran Canaria
Facultad de Ciencias Experimentales 35080 Islas Canarias, Spain.
Universidad de Jaen
23071 Jaen, Spain. Maria Luisa del Moral
Departmento de Biologia Celular
Carlos Matute Facultad de Ciencias Experimentales
Departamento de Neurociencias Universidad de Jaen
Universidad del Pais Vasco 23071 Jaen, Spain.
48940 Leioa, Vizcaya, Spain.
Maria Asuncion Moran
Luis Megias Departamento de Morfologia
Departamento Ciencias Morfologicas Facultad de Medicina
Universidad de Granada Universidad Autonoma de Madrid
18071 Granada, Spain. 28029 Madrid, Spain.
