Understanding Alzheimer's disease / monograph

494 Pages·2013·18.32 MB·English

by  Zerr

UNDERSTANDING
ALZHEIMER'S DISEASE
Edited by Inga Zerr
UNDERSTANDING
ALZHEIMER'S DISEASE
Edited by Inga Zerr
Understanding Alzheimer's Disease
Edited by Inga Zerr
Contributors
Christian Gonzalez-Billault, Daniel A. Borquez, Ismael Palacios-Garcia, Isidre
Ferrer, Jose Luna-Muñoz, Charles R. Harrington, Claude M. Wischik, Paola
Flores-Rodríguez, Jesús Avila, Sergio Zamudio R., Fidel De La Cruz, Raul Mena-
López, Benjamín Florán-Garduño, Takahide Matsushima, Yuhki Saito, Toshiharu
Suzuki, Halil Murat Sen, Sibel Cevizci, Fahri Günes, Elif Karaahmet, Weili Xu,
Camilla Ferrari, Hui-Xin Wang, Francesca Mangialasche, Gordon Glazner,
Brandon Ally, Emily Mason, Manus Donahue, Genaro Ortiz, Fermín Pacheco-
Moisés, L Javier Flores-Alvarado, Miguel A Macías-Islas, Irma E Velázquez-
Brizuela, Ana C Ramírez-Anguiano, Erandis D Tórres-Sánchez, Eddic W Morales-
Sánchez, José A Cruz-Ramos, Genaro E Ortiz-Velázquez, Fernando
CortésEnríquez, Mei Sian Chong, Tih-Shih Lee, Klemens Wild, Ulrike Mueller, Rita
Moretti, Kohzo Nakayama, Lucia Pastorino, Asami Kondo, Kun Ping Lu, Armand
Perret-Liaudet, Aline Dorey, Yannick Tholance, Benoit Dumont, Isabelle Quadrio,
Harish C. Pant
Copyright © 2015 Second Edition
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Notice
Statements and opinions expressed in the chapters are these of the individual
contributors and not necessarily those of the editors or publisher. No responsibility
is accepted for the accuracy of information contained in the published chapters.
The publisher assumes no responsibility for any damage or injury to persons or
property arising out of the use of any materials, instructions, methods or ideas
contained in the book.
First published February, 2013, second - 2015
ISBN-10: 953-51-1009-8
ISBN-13: 978-953-51-1009

Contents
Preface IX
Section 1 Pathogenesis 1
Chapter 1 Structure and Function of the APP Intracellular Domain in
Health and Disease 3
Ulrike Müller and Klemens Wild
Chapter 2 Mechanism of Alzheimer Amyloid β-Protein Precursor
Localization to Membrane Lipid Rafts 23
Yuhki Saito, Takahide Matsushima and Toshiharu Suzuki
Chapter 3 The Amyloidogenic Pathway Meets the Reelin Signaling
Cascade: A Cytoskeleton Bridge Between Neurodevelopment
and Neurodegeneration 39
Daniel A. Bórquez, Ismael Palacios and Christian González-Billault
Chapter 4 γ-Secretase — Regulated Signaling and
Alzheimer's Disease 61
Kohzo Nakayama, Hisashi Nagase, Chang-Sung Koh and Takeshi
Ohkawara
Chapter 5 Phosphorylation of Tau Protein Associated as a Protective
Mechanism in the Presence of Toxic, C-Terminally Truncated
Tau in Alzheimer's Disease 89
José Luna-Muñoz, Charles R. Harrington, Claude M. Wischik, Paola
Flores-Rodríguez, Jesús Avila, Sergio R. Zamudio, Fidel De la Cruz,
Raúl Mena, Marco A. Meraz-Ríos and Benjamin Floran-Garduño
Chapter 6 Pin1 Protects Against Alzheimer's Disease: One Goal, Multiple
Mechanisms 109
Lucia Pastorino, Asami Kondo, Xiao Zhen Zhou and Kun Ping Lu
VI Contents
Chapter 7 Alzheimer Disease and Metabolism: Role of Cholesterol and
Membrane Fluidity 145
Genaro G. Ortiz, Fermín P. Pacheco-Moisés, Luis J. Flores-Alvarado,
Miguel A. Macías-Islas, Irma E. Velázquez-Brizuela, Ana C. Ramírez-
Anguiano, Erandis D. Tórres-Sánchez, Eddic W. Moráles-Sánchez,
José A. Cruz-Ramos, Genaro E Ortiz-Velázquez and Fernando
Cortés-Enríquez
Section 2 Diagnosis 175
Chapter 8 Pre-Analytical and Analytical Critical Factors Influencing the
High Variability of the Concentrations Levels of Alzheimer
Disease Biomarkers in Cerebral Spinal Fluid 177
Armand Perret-Liaudet, Aline Dorey, Yannick Tholance, Benoit
Dumont and Isabelle Quadrio
Chapter 9 Candidate Bio-Markers of Alzheimer’s Disease 193
B.K. Binukumar and Harish C. Pant
Chapter 10 Using Magnetic Resonance Imaging in the Early Detection of
Alzheimer's Disease 225
Emily J. Mason, Manus J. Donahue and Brandon A. Ally
Section 3 Therapy 249
Chapter 11 Potential Therapeutic Strategies to Prevent the Progression of
Alzheimer to Disease States 251
Ester Aso and Isidre Ferrer
Chapter 12 Animal Assisted Therapy and Activities in
Alzheimer's Disease 303
Sibel Cevizci, Halil Murat Sen, Fahri Güneş and Elif Karaahmet
Section 4 Epidemiology, Clinical Presentation and Prevention 327
Chapter 13 Epidemiology of Alzheimer’s Disease 329
Weili Xu, Camilla Ferrari and Hui-Xin Wang
Contents VII
Chapter 14 Apathy as a Key Symptom in Behavior Disorders: Difference
Between Alzheimer’s Disease and Subcortical Vascular
Dementia 359
Rita Moretti, Paola Torre, Francesca Esposito, Enrica Barro, Paola
Tomietto and Rodolfo M. Antonello
Chapter 15 Predicting Cognitive Decline in Alzheimer’s Disease (AD): The
Role of Clinical, Cognitive Characteristics and Biomarkers 375
Mei Sian Chong and Tih-Shih Lee
Chapter 16 Alzheimer’s Disease and Diabetes 409
Brent D. Aulston, Gary L. Odero, Zaid Aboud and Gordon W.
Glazner
Chapter 17 Prevention of Alzheimer’s Disease: Intervention Studies 451
Francesca Mangialasche, Weili Xu and Miia Kivipelto

Preface
This book spans a variety of approaches to address the complex problem of Alzheimer´s
disease - what is the cause, is there a single pathogenetic pathways or are there many of
them, how can we address the whole clinical spectrum of the disease, how can the disease
be diagnosed early and reliable and which perspectives we have for prevention and treat‐
ment. The collection covers actual topics of interest for basic researcher, clinicians, epidemi‐
ologists and provides insight to various aspects of the disease.
Inga Zerr, MD
Department of Neurology
Cliical Dementia Center
Georg August University Göttingen
Germany