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Antibodies as novel tools in myeloma therapy NIELS VAN DE DONK Department of Hematology, VU University Medical Center Amsterdam BHS, Brussels, February 2017 DISCLAIMER • This event is organized and supported by Janssen-Cilag NV • The content and images used in these slides are those of the individual speaker / faculty member(s) and do not necessarily reflect the view of Janssen-Cilag NV • The presentations may include discussions on off-label use of drugs. Myeloma: prognosis VU University Medical Center Bergsagel ASCO 2014 Amsterdam The Netherlands Why new agents in MM ? VU University Medical Center Amsterdam The Netherlands Triple/quadruple refractory Median OS: 5.1 months Double-refractory Median OS: 7.9 months Thus, a great need remains for agents with new MoAs for relapsed/refractory patients Usmani ASH 2015 Abstract 4489 VU University Medical Center Amsterdam The Netherlands Immuno-therapy in multiple myeloma Immunotherapy1,2 Active Passive (Designed to act on the immune system itself) (Designed to act on the tumor) I-O Therapeutic Antitumor Unspecific Adoptive therapies cancer vaccines mAbs • Immune effector cell • Cell-based • Cytokines • Tumor-directed mAbs • Cell therapies modulators • DC-based cancer • Interleukins • Anti-CD38 • Adoptive T-cell • Checkpoint vaccines • Interferons • Anti-SLAMF7 therapy Inhibitors • Single antigen/peptide- • IMiDs • Co-stimulatory based agonists DC, dendritic cell; IMiD, immunomodulatory agent; I-O, immuno-oncology; mAb, monoclonal antibody. 1. Finn OJ. Ann Oncol. 2012;23(suppl 8 ):viii6-viii9. 2. Mellman I et al. Nature. 2011;480:480-489. Monoclonal antibodies in MM 1. Antibodies directed at MM cell surface antigens  2. Checkpoint inhibitors  VU University Medical Center Amsterdam The Netherlands Dara, SAR, ELo 2015/2016 Behring en Ehrlich: magic bullet CD38-targeting antibodies VU University Medical Center Amsterdam The Netherlands DARATUMUMAB VU University Medical Center Van De Donk Blood 2015 Amsterdam The Netherlands

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University Medical Center Amsterdam. BHS, Brussels, February 2017 . Keats Blood 2012;120:1067-1076. Morgan GJ, et al. Nature Rev Cancer

Treatment of Multiple myeloma in the era of monoclonal antibodies PDF

71 Pages·2017·3.74 MB·English

by Heleen Verreijt

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by Heleen Verreijt| 2017| 71 pages| 3.74| English

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University Medical Center Amsterdam. BHS, Brussels, February 2017 . Keats Blood 2012;120:1067-1076. Morgan GJ, et al. Nature Rev Cancer

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Author:	Heleen Verreijt
Publication Year:	2017
Pages:	71
Language:	English
File Size:	3.74
Format:	PDF
Price:	FREE

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