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Transporters as Drug Carriers: Structure, Function, Substrates (Methods and Principles in Medicinal Chemistry) PDF

451 Pages·2009·4.942 MB·English
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About Transporters as Drug Carriers: Structure, Function, Substrates (Methods and Principles in Medicinal Chemistry)

This reference handbook is the first to provide a comprehensive overview, systematically characterizing all known transporters involved in drug elimination and resistance. Combining recent knowledge on all known classes of drug carriers, from microbes to man, it begins with a look at human and mammalian transporters. This is followed by microbial, fungal and parasitic transporters with special attention given to transport across those physiological barriers relevant for drug uptake, distribution and excretion.As a result, this key resource lays the foundations for understanding and investigating the molecular mechanisms for multidrug resistance in cancer cells, microbial resistance to antibiotics and pharmacokinetics in general. For anyone working with antibiotics and cancer chemotherapeutics, as well as being of prime interest to biochemists and biophysicists.

Detailed Information

Author:Gerhard Ecker, Peter Chiba, Raimund Mannhold, Hugo Kubinyi, Gerd Folkers
Publication Year:2009
ISBN:9783527316618
Pages:451
Language:English
File Size:4.942
Format:PDF
Price:FREE
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