Transplantation and Blood Transfusion: Proceedings of the Eighth Annual Symposium on Blood Transfusion, Groningen 1983, organized by the Red Cross Blood Bank Groningen-Drenthe

227 Pages·1984·20.39 MB·English

by  C.Th. Smit Sibinga, P.C. Das, G. Opelz

TRANSPLANTATION AND BLOOD TRANSFUSION
DEVELOPMENTS IN HEMATOLOGY AND IMMUNOLOGY
Lijnen, H.R., Collen, D. and Verstraete, M., eds: Synthetic Substrates in Clinical Blood
Coagulation Assays. 1980. ISBN 90-247-2409-0
Smit Sibinga, C. Th., Das, P.C. and Forfar, J .0., eds: Paediatrics and Blood Transfusion.
1982. ISBN 90-247-2619-0
Fabris, N., ed: Immunology and Ageing. 1982. ISBN 90-247-2640-9
Homstra, G.: Dietary Fats, Prostanoids and Arterial Thrombosis. 1982.
ISBN 90-247-2667-0
Smit Sibinga, CTh., Das, P.C. and Loghem, van J.J., eds: Blood Transfusion and Prob
lems of Bleeding. 1982. ISBN 90-247-3058-9
Dormandy, J., ed: Red Cell Deformability and Filterability. 1983. ISBN 0-89838-578-4
Smit Sibinga, C.Th., Das, P.C. and Taswell, H.F., eds: Quality Assurance in Blood Bank
ing and Its Clinical Impact. 1984. ISBN 0-89838-618-7
Besselaar, A.M.H.P. van den, Gralnick, H.R. and Lewis, S.M., eds: Thromboplastin
Calibration and Oral Anticoagulant Control. 1984. ISBN 0-89838-637-3.
Fondu, P. and Thijs, 0., eds: Haemostatic Failure in Liver Disease. 1984.
ISBN 0-89838-640-3
Smit Sibinga, C.Th., Das, P.C and Opelz, G., eds: Transplantation and Blood Transfu
sion. 1984. ISBN 0-89838-686-1
Transplantation and Blood
Transfusion
Proceedings of the Eighth Annual Symposium on Blood Transfusion, Groningen
1983, organized by the Red Cross Blood Bank Groningen-Drenthe
edited by
C.TH. SMIT SIBINGA and P.C. DAS
Red Cross Blood Bank Groningen-Drenthe
The Netherlands
G. OPELZ
Ruprecht Karls University
Heide/berg, FRG
1984 SPRINGER-SCIENCE+BUSINESS MEDIA, B.V.
Library of Congress Cataloging in Publication Data
ISBN 978-1-4613-3842-0 ISBN 978-1-4613-3840-6 (eBook)
DOI 10.1007/978-1-4613-3840-6
Copyright
© 1984 by Springer Science+Business Media Dordrecht
Originally published by Martinus NijhoffPublishers, Boston in 1984
AII rights reserved. No part of this publication may be reproduced, stored in a
retrieval system, or transmitted in any form or by any means, mechanical,
photocopying, recording, or otherwise, without the prior written permission of
the publishers,
Springer-Science+Business Media, B.V.
m
TRAVENOl
Acknowledgement
This publication has been made possible through the support of Travenol, which
is gratefully acknowledged.
VII
CONTENTS
Invited speakers IX
Foreword XI
Opening address XIII
1. Principles in transplantation practice
The development of the liver transplantation team in Groningen
(C.H. Gips, R.A.F. Krom) 3
Aspects of grafting and rejection with special reference to the
transplantation of lymphocytes
(W.L. Ford) 9
The DRw6 phenomenon in renal transplantation
(G. F.J. Hendriks) 17
Cryopreservation of platelets, bone marrow and lymphocytes:
application for the transplant recipient
(A.B. Glassman) 23
Discussion 35
II. Supportive hemotherapy
Immune modulation aspects of blood transfusion in transplantation
practice
(G.G. Persijn) 43
Role of lymphocytes in graft-versus-host disease and its prevention
(D. W. van Bekkum) 57
Selective decontamination of the digestive tract as a method of
infection prevention in granulocytopenic patients; a follow-up study
in 102 patients
(H.G. de Vries-Hospers, D.Th. Sleijfer, N.H. Mulder,
H.O. Nieweg, D. van der Waaij) 65
CMV infection and its prevention with specific immunoglobulins
(W.G. Ho, D.J. Winston, R.E. Champlin, R.P. Gale) 73
Characterization of the new cytomygalovirus immunoglobulin
preparation for intravenous use
(R. Schweitzer) 79
The role of interferons in viral infections in immune compromised
patients
(R.T. Schooley, M.S. Hirsch, R.H. Rubin, K. Cantell) 83
VIII
Fundamentals of platelet and granulocyte support in myelo
suppressed leukemia and bone marrow transplant patients
(J.P. Hester, R. Ayyar, M. Keating. K. Dicke) 91
The use of monoclonal antibodies in clinical transplantation
(G. Opelz) 101
Discussion 111
III. Organ preservation
Organization and effectiveness in donor procurement and
transplantation
(R.J. Ploeg) 123
Organization of a hospital bone marrow panel
(D.C.O. James) 131
Developments and limitations in liver preservation
(K. RoBes, R. Y. CaIne) 141
New developments in kidney preservation
(G. Kootstra, B.G. Rijkmans, W.A. Buurman, Th.J.M. Ruers,
J. P. van Hooff) 145
Preservation of hemopoietic stem cells
(J.M. Goldman) 153
Is the basis of cleaning autologous bone marrow transplantation
in leukemia strong enough?
(B. LOwenberg) 161
Discussion 165
IV. Specific organ transplantation
Kidney transplantation - Current perspective
(R.F.M. Wood) 175
Present status of clinical liver transplantation based on a review
of 5 centres: Pittsburgh. Cambridge, Hannover, Innsbruck and
Groningen
(R.A.F. Krom) 185
Allogeneic bone marrow transplantation
(W.G. Ho, D.J. Winston, R.E. Champlin, S.A. Feig, R.P. Gale) 191
Autologous transplantation of blood derived hemopoietic stem cells
(M. Korbling, Th.M. Fliedner) 199
The role of autologous bone marrow transplantation in cancer
treatment
(G.L. Phillips) 205
Evolution of superior immune suppression for heart and heart-lung
transplantation
(B.P. Griffith, R.L. Hardesty, A. Trento, Ann Lee,
H.T. Bahnson) 217
Discussion 227
IX
INVITED SPEAKERS
D.W. van Bekkum - Radiological Institute TNO, Rijswijk, NL
(modera tor)
W.L. Ford - Dept. of Pathology, University of Manchester,
UK
C.H. Gips - Dept. of Internal Medicine, University of Gro
ningen, Groningen, NL
A • B. Glassman - Medical University of South Carolina, Charles
(moderator) ton SC, USA
J. M. Goldman - Royal Postgraduate Medical School, University
of London, London, UK
B. Griffith - Dept. of Surgery, University of Pittsburgh,
Pittsburgh PA, USA
G. F.J. Hendriks - Universital Hospital Leiden, Leiden, NL
J.P. Hester - University of Texas System Cancer Center,
Houston TX, USA
W.G. Ho - UCLA Hospital & Clinics, Los Angeles CA,
USA
D.C.O. James - The Anthony Nolan Bone r-.!arrow Appeal,
London, UK
G. Kootstra - Dept. of General Surgery, University of Lim
burg, Ivlaastricht, NL
M. Korbling - Ruprecht-KarIs-University, Heidelberg, FRG
(modera tor)
R.A.F. Krom - Dept. of Surgery, University of Groningen,
Groningen, NL
B. Lowenberg - Dr. Daniel den Hoed Cancer Centre, Rotter
(moderator) dam, NL
G. Opelz - Ruprecht-Karls-University, Heidelberg, FRG
(chairman)
G. G. Persijn - Eurotransplant Foundation, University of Lei
den, Leiden, N L
G.L. Phillips - Barnard Cancer Center, Washington University,
st. Louis MO, USA
x
R.J. Ploeg - Dept. of Surgery, University of Leiden, Lei
den, NL
K. RolIes - Dept. of Surgery, University of Cambridge
Clinical School, Cambridge, UK
R. T. Schooley - Harvard Medical School, Massachusetts General
Hospital, Boston MA, USA
H. G. de Vries-Hospers - Laboratory for Medical Microbiology, University
of Groningen, Groningen, NL
D. van der Waaij - Laboratory for Medical Microbiology, University
(moderator) of Groningen, Groningen, NL
J. van der Wijk - Dept. of Surgery, University of Groningen,
(moderator) Groningen, NL
R. Wood - Nuffield Dept. of Surgery, University of
Oxford, Oxford, UK