Translational Research in Pain and Itch

154 Pages·2016·2.56 MB·English

by  Chao Ma

Advances in Experimental Medicine and Biology 904
Chao Ma
Yuguang Huang Editors
Translational
Research in
Pain and Itch
Advances in Experimental Medicine and
Biology
Volume 904
Editorial Board
Irun R. Cohen, The Weizmann Institute of Science, Rehovot, Israel
N.S. Abel Lajtha, Kline Institute for Psychiatric Research, Orangeburg, NY, USA
John D. Lambris, University of Pennsylvania, Philadelphia, PA, USA
Rodolfo Paoletti, University of Milan, Milan, Italy
More information about this series at h ttp://www.springer.com/series/5584
Chao Ma (cid:129) Yuguang Huang
Editors
Translational Research
in Pain and Itch
Editors
Chao Ma Yuguang Huang
Department of Anatomy, Histology and Department of Anesthesiology, Peking
Embryology, Institute of Basic Medical Union Medical College Hospital, Peking
Sciences, Neuroscience Center, School Union Medical College
of Basic Medicine, Peking Union Chinese Academy of Medical Sciences
Medical College Beijing , China
Chinese Academy of Medical Sciences
Beijing , China
ISSN 0065-2598 ISSN 2214-8019 (electronic)
Advances in Experimental Medicine and Biology
ISBN 978-94-017-7535-9 ISBN 978-94-017-7537-3 (eBook)
DOI 10.1007/978-94-017-7537-3
Library of Congress Control Number: 2016932496
© Springer Science+Business Media Dordrecht 2016
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Pref ace
The past decade has witnessed exciting advances in the basic research of pain and
itch – both are our most basic yet still mysterious sensations. Clinically, the treat-
ment of prolonged and intractable pain (chronic pain) and itch (pruritus) cost bil-
lions of dollars every year worldwide while the results are often unsatisfying or
accompanied with serious side effects. Despite the slow progress in drug discovery,
scientists all over the world have recently acquired more insights into the mecha-
nisms underlying pain and itch in both physiological and pathological conditions.
The gaps between basic research and clinical application are eagerly waiting to be
fi lled by translational research.
T his book provides a comprehensive review of recent advances in the transla-
tional research on pain and itch. The contributing authors are world-renowned sci-
entists and have made important discoveries in the relevant fi eld of research. Their
fi ndings not only shed light on the mechanisms but also pave the way for develop-
ing novel strategies for the effective and safe treatment of chronic pain and pruritus.
Hopefully not long from now, medical practitioners can be more confi dent and
patients can be more optimistic when facing these annoying (and often terrible)
conditions.
W e sincerely appreciate all the contributing authors, our editorial team from the
Joint Laboratory of Anesthesiology and Pain in Peking Union Medical College, and
the Springer publisher. This book would not be possible without their time and
effort.
Beijing, China Chao Ma
Yuguang Huang
v

Contents
1 Assessment of Itch and Pain in Animal Models
and Human Subjects ............................................................................... 1
Tangmi Yuan , Juan Li , Le Shen , Wanying Zhang , Tao Wang ,
Yinyan Xu , Jie Zhu , Yuguang Huang , and Chao Ma
2 Allergic Contact Dermatitis: A Model of Inflammatory Itch
and Pain in Human and Mouse ............................................................. 23
Robert H. LaMotte
3 Modulation of C-nociceptive Activities by Inputs
from Myelinated Fibers .......................................................................... 33
Duan Wan-Ru and Xie Yi-Kuan
4 New Mechanism of Bone Cancer Pain: Tumor Tissue-Derived
Endogenous Formaldehyde Induced Bone Cancer
Pain via TRPV1 Activation .................................................................... 41
You Wan
5 Neuropathic Pain: Sensory Nerve Injury
or Motor Nerve Injury? .......................................................................... 59
Xian-Guo Liu , Rui-Ping Pang , Li-Jun Zhou , Xu-Hong Wei ,
and Ying Zang
6 Peripheral Nociceptors as Immune Sensors
in the Development of Pain and Itch ..................................................... 77
Tao Wang and Chao Ma
7 Mas-Related G Protein-Coupled Receptors Offer Potential
New Targets for Pain Therapy ............................................................... 87
Vineeta Tiwari , Vinod Tiwari , Shaoqiu He , Tong Zhang ,
Srinivasa N. Raja , Xinzhong Dong , and Yun Guan
vii
viii Contents
8 Pain Modulation and the Transition from Acute
to Chronic Pain ........................................................................................ 105
Mary M. Heinricher
9 Advances in the Treatment of Neuropathic Pain ................................. 117
Li Xu , Yuguan Zhang , and Yuguang Huang
10 Integrated, Team-Based Chronic Pain Management: Bridges
from Theory and Research to High Quality Patient Care .................. 131
Mary A. Driscoll and Robert D. Kerns
Contributors
Xinzhong Dong D ivision of Pain Medicine, Department of Anesthesiology and
Critical Care Medicine, School of Medicine, J ohns Hopkins University, B altimore,
MD , USA
Mary A. Driscoll VA Connecticut Healthcare System , West Haven , CT , USA
Yale University School of Medicine , New Haven , CT , USA
Yun Guan Division of Pain Medicine, Department of Anesthesiology and Critical
Care Medicine, School of Medicine , Johns Hopkins University , Baltimore , MD ,
USA
Shaoqiu He D ivision of Pain Medicine, Department of Anesthesiology and
Critical Care Medicine, School of Medicine, J ohns Hopkins University, B altimore,
MD , USA
Mary M. Heinricher D ept. Neurological Surgery, O regon Health & Science
University , Portland , USA
Yuguang Huang Department of Anesthesiology, Peking Union Medical College
Hospital, Peking Union Medical College , Chinese Academy of Medical Sciences ,
Beijing , China
Robert D. Kerns VA Connecticut Healthcare System , West Haven , CT , USA
Yale University School of Medicine , New Haven , CT , USA
Robert H. LaMotte Department of Anesthesiology , Yale University School of
Medicine , New Haven , CT , USA
Juan Li Department of Anesthesiology , Peking Union Medical College Hospital ,
Beijing , China
Department of Anatomy, Histology and Embryology, Institute of Basic Medical
Sciences, Neuroscience Center, Chinese Academy of Medical Sciences, School of
Basic Medicine , Peking Union Medical College , Beijing , China
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