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Zelluläre Signaltransduktion II • TGF-ß, der Wachstumsfaktor, der das Wachstum hemmt? Transforming growth factor ß (TGF-ß) Growth factor  Stimulation der Verankerungs-unabhängigen Zellproliferation von Tumorzellen in serum- freiem Medium in Weichagar Transforming  Umwandlung epithelialer Zellen in Zellen mit mesenchymalen Eigenschaften. Epithelial to Mesenchymal Transdifferentiation Transforming growth factor ß (TGF-ß) Growth factor  Stimulation der Verankerungs-unabhängigen Zellproliferation von Tumorzellen in serum- freiem Medium in Weichagar Transforming  Umwandlung epithelialer Zellen in Zellen mit mesenchymalen Eigenschaften. Epithelial to Mesenchymal Transdifferentiation Epithel: Schicht engverbundener, polarisierter Zellen Mesenchym: Gewebe aus locker verbundenen, nicht polarisierten Zellen Transforming Growth Factor-ß-Induced Epithelial to Mesenchymal Transdifferentiation Control TGF-ß Bhowmick et al., Mol Cell Biol 12, 27-36 (2001) Transforming Growth Factor-ß-Induced Epithelial to Mesenchymal Transdifferentiation Link to Cadherins Bhowmick et al., Mol Cell Biol 12, 27-36 (2001) TGFß  ein pleiotropes Cytokin - 3 Isoformen werden von Säugetierzellen exprimiert (TGFß 1-3) - Sequenz in verschiedenen Spezies hoch konserviert - TGFß1: Endotheliale, hämapoetische und Bindegewebszellen - TGFß2: Epitheliale und neuronale Zellen - TGFß3: Mesenchymale Zellen TGF-ß und verwandte Proteine TGF-ß-Familie BMP-Familie TGF-ß BMP2 (bone morphogenic Protein) Activin BMP4 Nodal BMP7 Sekretion von TGF-ß1 als inaktiver Komplex ß1-LAP (80 kDa) TGF-ß1 (25 kDa) S S S S S S LTBP (125-160 kDa) LAP = Latency-associated protein LTBP = Latent TGF-ß-binding protein Sekretion von TGF-ß1 als inaktiver Komplex ß1-LAP (80 kDa) TGF-ß1 (25 kDa) S S S S S S LTBP (125-160 kDa) LAP = Latency-associated protein LTBP = Latent TGF-ß-binding protein Sekretion von TGF-ß1 als inaktiver Komplex ß1-LAP (80 kDa) TGF-ß1 (25 kDa) S S S S S S LTBP (125-160 kDa) LAP = Latency-associated protein LTBP = Latent TGF-ß-binding protein

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Author:	Unknown
Publication Year:	2017
Pages:	99
Language:	English
File Size:	0.77
Format:	PDF
Price:	FREE

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