Traditional Chinese Medicine: Scientific Basis for Its Use

364 Pages·2013·6.601 MB·English

by  James D Adams, Eric J Lien, David E Thurston, David Rotella, David Fox, Ana Martinez, Salvatore Guccione, Robin Ganellin, Eri Oshima, Jeff Wang, Bangyan Stiles, Constance Lay Lay Saw, Tong Yao, Calvin Chen, Jiasheng Tu, Chee Loong Saw, Lita Chew, William CS Cho, Vince Wang, Kuo-Hsiung Lee, Jiangang Shen, Anna Tai, Marcia Babcock, Phil Peplow

Traditional Chinese Medicine
Scientific Basis for Its Use
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RSC Drug Discovery Series
Editor-in-Chief
Professor David Thurston, Kings College, London, UK
Series Editors:
Dr David Fox, Vulpine Science ad Learning, UK
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0 Professor Salvatore Guccione, University of Catania, Italy
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P Professor Ana Martinez, Instituto de Quimica Medica-CSIC, Spain
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2- Professor David Rotella, Northeastern University, USA
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49 Professor Robin Ganellin, University College London, UK
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8 Titles in the Series:
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9/9 1: Metabolism, Pharmacokinetics and Toxicity of Functional Groups
03 2: Emerging Drugs and Targets for Alzheimer’s Disease; Volume 1
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0. 3: Emerging Drugs and Targets for Alzheimer’s Disease; Volume 2
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g | d 5: New Frontiers in Chemical Biology
or 6: Animal Models for Neurodegenerative Disease
3c. 7: Neurodegeneration
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Don 30 1167:: PPhoalyrammaicneeutDicraulgSDaltisscaonvderyCocrystals
d o 18: Proteinases as Drug Targets
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22: Nanostructured Biomaterials for Overcoming Biological Barriers
23: Physico-Chemical and Computational Approaches to Drug Discovery
24: Biomarkers for Traumatic Brain Injury
25: Drug Discovery from Natural Products
26: Anti-Inflammatory Drug Discovery
27: New Therapeutic Strategies for Type 2 Diabetes: Small Molecules
28: Drug Discovery for Psychiatric Disorders
29: Organic Chemistry of Drug Degradation
30: Computational Approaches to Nuclear Receptors
31: Traditional Chinese Medicine
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Traditional Chinese Medicine
ScientificBasisforItsUse
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nloaded on 06 Marcpril 2013 on http://p #AAlplaTrrihtgefhrtRosmoryefsaaelirrSvdeoedcaielitnygofforCthheempuisrtproys2es01o3fresearchfornon-commercialpurposes
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Do30 or for private study, criticism or review, as permitted under the Copyright,
n DesignsandPatentsAct1988andtheCopyrightandRelatedRightsRegulations
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d 2003,thispublicationmaynotbereproduced,storedortransmitted,inanyform
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ubli Chemistry or the copyright owner, or in the case of reproduction in accordance
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reproduction outside the terms stated here should be sent to The Royal Society
of Chemistry at the address printed on this page.
The RSC is not responsible for individual opinions expressed in this work.
Published by The Royal Society of Chemistry,
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For further information see our web site at www.rsc.org
PrintedintheUnitedKingdombyHenryLingLimited,Dorchester,DT11HD,UK
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0.1 ‘‘I believe in the goodness of the American and Chinese people who remain
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or from ‘‘Dr Hua Chuen Mei – May 30, 1925’’ available at
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h 201ubs.rs www.abeduspress.com.
Marcp://p LindaMeiAdams,mywife,isthegrand-daughterofDrHuaChuenMei,who
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Do30 Cantonese. My wife’s grand-mother, Polly Lum, used Traditional Chinese
n Medicine even though her son, son-in-law and grand-son were all Western-
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ed trainedMDs.IamgratefultotheMeiandLumfamiliesforhelpingmelearnthe
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blis utilityofTraditionalChineseMedicine,evenwhenAmericanMedicinemaynot
Pu recognize the utility. I was able to learn the philosophy for using Traditional
Chinese Medicine, which differs greatly from the medicine I learned as a
Graduate Student of Pharmacology at the University of California San
Francisco.Thisphilosophydependsonlivinginbalanceinordertobehealthy.
Iwasalsotaughttheimportanceofspiritualityinhealth,sincehealthrequiresa
healthybody,mindandspirit.Mypoembelowis‘‘bekindtoyourself,bekindto
others, allow God to love you.’’ My Chinese name, below, is Ha Cheen Sing,
SummerThousand Honest,andwasgiventomebymymother-in-law.
跟自己做慈善
跟第二的人做慈善
讓上帝愛你
夏千诚
RSCDrugDiscoverySeriesNo.31
TraditionalChineseMedicine:ScientificBasisforItsUse
EditedbyJamesDavidAdams,Jr.andEricJ.Lien
#TheRoyalSocietyofChemistry2013
PublishedbytheRoyalSocietyofChemistry,www.rsc.org
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vi Preface
I am grateful to Professor Eric Lien for encouraging me to think about the
Science involved in Traditional Chinese Medicine. This has been a great
challenge for me and resulted in this book. I am grateful to all the authors of
the chapters who have applied their great expertise in this book.
05 James David Adams Jr, PhD
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or Doing good deeds brings the most happiness.
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Marcp://p Sustain vitality and youthfulness as long as possible.
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Pu Compounds 11
Eric J. Lien, Linda L. Lien and James D. Adams
2.1 Introduction 11
2.2 Structure–Activity Relationship Analysis 12
2.2.1 FromNaturalSourcestoSyntheticCompounds 12
2.2.2 From Estradiol, Phytoestrogens to Synthetic
Diethylstilbestrol 13
2.3 Medicinal Diet (Yao San) 14
2.4 Immunostimulating (Fu-zhen) Herbs 15
References 16
RSCDrugDiscoverySeriesNo.31
TraditionalChineseMedicine:ScientificBasisforItsUse
EditedbyJamesDavidAdams,Jr.andEricJ.Lien
#TheRoyalSocietyofChemistry2013
PublishedbytheRoyalSocietyofChemistry,www.rsc.org
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viii Contents
Chapter 3 Huang Di Nei Jing and the Treatment of Low Back Pain 17
Minchen Wang (Vince)
3.1 Significance of Low Back Pain (LBP) 17
3.1.1 Prevalence of LBP 17
07 3.1.2 Human Cost 17
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52- 3.2 Scope of the Problem – What Is Involved in LBP? 18
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doi: 3.4 Treatment of LBP According to the Nei Jing 25
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3.7.1 Mapping the Low Back for Point Selection 42
3.7.2 Treatment Guide for LBP 43
3.8 Conclusion 45
References 46
Chapter 4 Understanding Ch’i: The Life-Force Energy that Determines
Vitality, Health and Wellbeing 48
Marcia R. Babcock
4.1 TheOriginoftheUniverse:theCosmologyofCh’iand
Its Manifest Forms as Yin and Yang 48
4.2 Ch’i as Life Force Is Described in Many Cultures 50
4.3 Perceiving and Measuring Ch’i 50
4.4 Historical Measurement of Vital Energy Using
Scientific Methods 51
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Contents ix
4.5 Modern Western Doctors Interested in the Energy
Field Surrounding Human Beings 51
4.6 Comparison of TCM and Ayurveda 52
4.7 Cultivation of Ch’i: Improving the Quality and
Strength of Ch’i Flows 52
07 4.8 Energy Healing Practices Across the World 53
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52- 4.9.1 Traditional Chinese Medicine 53
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5.2 Modernizing Traditional Chinese Medicine for a
Global Stage 62
5.3 TCM in Drug Discovery: Application from the
Molecular Level 63
5.4 Futuristic Drug Discovery: the Top-Down and
Bottom-Up Systematic View 63
5.5 Unleashing the Potential of TCM Through Systems
Biology 66
5.6 An Example of a Systems Approach to TCM Drug
Development 70
5.7 Integration of TCM with Systems Biology: A Long
Way to Go 73
5.7.1 Science Should Be Open Access 73
5.7.2 Pharmacological Data Have Limited
Applicability in Investigating Novel Leads 75
5.7.3 Bigger Is Not Better in Terms of TCM Drug
Compound Screening 75
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5.7.4 Traceback Information Is Critical 75
5.7.5 Modernization of TCM Formulas 76
References 77
7 Chapter 6 Modern Drug Discovery from Chinese Materia Medica Used
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6.4.6 Use as a Chemical Probe 93
6.5 Anisodus tanguticus/Anisodamine and Anisodine 93
6.5.1 Introduction 93
6.5.2 Source Plant and Traditional Uses 94
6.5.3 Chemistry 94
6.5.4 Pharmacology 95
6.5.5 Drug Development 96
6.6 Camptotheca acuminata/Camptothecin 98
6.6.1 Introduction 98
6.6.2 Drug Discovery 98
6.6.3 Lead for New Drug Design 100
6.7 Schisandra chinensis/DDB 100
6.7.1 Introduction 100
6.7.2 Source Plant and Traditional Uses 100
6.7.3 Chemistry 101
6.7.4 Pharmacology 102