Table Of ContentTrace Amines
Experimental and Clinical Neuroscience
Trace Amines: Comparative and Clinical Neurobiology,
edited by A. A. Boulton, A. V. luorio,
and R. G. H. Downer, 1988
Neuropsychopharmacology of the Trace Amines,
edited by A. A. Boulton, P. R. Bieck, L. Maitre,
and P. Riederer, 1985
Neurobiology of the Trace Amines, edited by
A. A. Boulton, G. B. Baker, W. G. Dewhurst,
and M. Sandler, 1984
Neural Membranes, edited by Grace Y. Sun,
Nicolas Bazan, lang-Yen Wu, Giuseppe Porcellati,
and Albert Y. Sun, 1983
Trace Amines
Comparative and Clinical Neurobiology
Edited by
A. A. Boulton and A. V. Juorio
University of Saskatchewan, Saskatoon, Saskatchewan, Canada
and
R. G. H. Downer
University of Waterloo, Waterloo, Ontario, Canada
Humana Press • Clifton, New Jersey
© Copyright 1988 by The Humana Press Inc.
Softcover reprint of the hardcover 1st edition
Crescent Manor
PO Box 2148
Clifton, NJ 07015
All rights of any nature whatsoever reserved.
No part of this book may be reproduced, stored in a retrieval sytem, or transmitted
in any form or by any means, including electronic, mechanical, photocopying,
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Library of COngress cataloglng-In-Publlcatlon Data
Trace amines: comparative and clinical neurobiology 1 edited by A.A. Boulton,
A.V. Juorio, and R.G.H. Downer
760 p. cm.-(Experimental and Clinical Neuroscience)
Based on the proceedings of a conference held May 28-30, 1987 in Isla
Margarita, Venezuela as a satellite of the 11th International Society for Neuro
chemistry Meeting.
Sponsored by the International Society for Neurochemistry.
Includes bibliographies and index.
ISBN-13: 978-1-4612-8945-6 e-ISBN-13: 978-1-4612-4602-2
001: 10.1007/978-1-4612-4602-2
1. Biogenic amines-Physiological effect-Congresses. 2. Biogenic
amines-Metabolism--Congresses. 3. Neurobiology-Congresses.
I. Boulton, A. A. (Alan A.) II. Juorio, A. V. (Augusto V.) III. Downer, Roger G.
H. IV. Intemational Society for Neurochemistry. Meeting. (11th: 1987: La
Guaira, Distrito Federal, Venezuela) V. International Society for Neurochemistry.
VI. Series.
[DNLM: 1. Amines-congresses. 2. Neurobiology-congresses.
QU 60 T759 1987]
QP801.B66T73 1988
591'.0188-dc19 88-6847
CIP
Preface
This is the third Proceedings book to arise from biennial conferen
ces on the Trace Amines. Since our first meeting in 1983 in Edmonton,
Canada, progress has been brisk and, as will be seen from the ensuing
pages, it is now possible to include major contributions from inverte
brate neurobiologists as well as receptorologists. In the opening ses
sion we heard about the distribution of the trace amines-now clear
ly a misnomer-in insects and the pharmacological, receptor, and syn
aptic characteristics of octopamine and tryptamine as well as the pos
sibility of monoamines in general being targets for insecticide discov
ery.
In mammalian brain the distribution and characterization of the
tryptamine receptor has proceeded to the point where two types have
been described as well as novel agonists and antagonists, and, for the
first time, a binding site for p-tyramine has been described. The com
bination of lesions and pharmacological and metabolic manipulations
now permits the mapping of trace aminergic pathways, and the rap
idly accumulating evidence from releasing drugs, in situ microdialy
sis, iontophoresis, and second messenger systems lends credence to
the claim that the trace amines possess neuromodulatory functions.
Although drugs with specific actions on trace aminergic systems are
still required, it is interesting to note that prodrugs of phenylethyla
mine have now been synthesized and that intriguing new condensa
tion adducts have been identified following interaction between trace
and other amines and cigaret smoke constituents and alcohol metabo
lites. Some of these latter substances are capable of interacting with
some receptors and enzymes.
As biological markers of stress, migraine, depression, schizophre
nia, and tardive dyskinesia, the trace amines or their acidic metabo
lites or their associated enzymes seem particularly good candidates.
Alan A. Boulton
Augusto V. Juorio
Roger G. H. Downer
v
Acknowledgments
This book is based on the Proceedings of the Trace Amines: Their
Comparative and Clinical Neurobiology conference which was held
May 28th to 30th, 1987 at the Hotel Bella Vista, Isla Margarita, Venez
uela. The meeting was also arranged as a Satellite of the 11 th Interna
tional Society for Neurochemistry Meeting and we are grateful to the
ISN for their sponsorship and also for a financial contribution. In addi
tion we are grateful to the following pharmaceutical companies for
their financial support:
American Cyanamid Company, Princeton, New Jersey, USA
Boehringer Ingelheim (Canada) Ltd., Burlington, Ontario, Canada
Ciba-Geigy AG, Basel, Switzerland
Ciba-Geigy Canada Ltd., Mississauga, Ontario, Canada
Ciba-Geigy Ltd., Summit, New Jersey, USA
Hoechst Roussel Pharmaceuticals Inc., Somerville, New Jersey, USA
Lilly Research Laboratories, Indianapolis,lndiana, USA
Pfizer Canada Inc., Pointe Claire, Dorval, Quebec, Canada
Rhone-Poulenc Pharma Inc., Montreal, Quebec
Stauffer Chemical Company, Richmond, California, USA
Upjohn Company of Canada, Don Mills, Ontario, Canada
Warner-Lambert Company (Parke-Davis Canada Inc.), Scarborough,
Ontario, Canada
Contributors
BAKER, GLEN B. • Department of Psychiatry, University of Al
berta, 1st Floor, Clinical Sciences Building, Edmonton, Alberta, Can
ada T6G2G3
BlECK, PETERR. • Humanpharmakologisches Institut Ciba-Geigy
GMBH, Ob dem Himmelreich 9, D-7400 Tiibingen, Germany
BOULTON, ALAN A.. Neuropsychiatric Research Division,A114
CMR Building, University of Saskatchewan, Saskatoon, Saskatchew
an, Canada S7N OWO
CELUCH, STELLA M. • Neuropsychiatric Research Division, CMR
Building, University of Saskatchewan, Saskatoon, Saskatchewan,
Canada S7N OWO
CIPRIAN-OLUVIER, JORGE • Francisco de Vittoria 2322/24,
Buenos Aires, Argentina 1425
COLLINS, MICHAEL A. • Department of Biochemistry, Loyola
University Stritch School of Medicine, Maywood, IL 60153, USA
COOPER, THOMAS B. • Analytical Psychopharmacology Lab,
Nathan S. Kline Institute, Orangeburg, NY 10962, USA
DIAMOND, BRUCE I. • Department of Psychiatry, Medical Col
lege of Georgia, 1515 Pope Avenue, Augusta, GA 30912, USA
DOWNER, ROGER G. H. • Department of Biology, University of
Waterloo, Waterloo, Ontario, Canada N2L 3G1
DURDEN, DAVID A. • Neuropsychiatric Research Division, CMR
Building, University of Saskatchewan, Saskatoon, Saskatchewan,
Canada S7N OWO
DYCK, ULUAN E. • Neuropsychiatric Research Division, CMR
Building, University of Saskatchewan, Saskatoon, Saskatchewan,
Canada S7N OWO
EVANS, PETER D. • Department of Zoology, University of
Cambridge, Downing Street, Cambridge, England CB13EJ, UK
FARAJ, BAHJAT • Department of Radiology, 467 Woodruff
Memorial Building, Emory University School of Medicine, Atlanta,
GA 30322, USA
vii
viii Contributors
FLETCHER, PAUL J. • Neuropsychiatric Research Division, CMR
Building, University of Saskatchewan, Saskatoon, Saskatchewan,
Canada S7N OWO
GREENSHAW,ANDREW J. • Department of Psychiatry, Univers
ity of Alberta, 1st Floor, Clinical Sciences Building, Edmonton, Al
berta, Canada T6G 2G3
HARRIS, JOSEPH • Department of Chemistry, Arizona State Uni
versity, Tempe, AZ 85287, USA
HENRY, DAVID P. • Lilly Laboratory for Clinical Research, Uni
versity of Indiana, School of Medicine, Indianapolis, IN 46202 USA
46202
JENNINGS, KENT R. • Insecticide Discovery Department, Ameri
can Cyanamid Co., PO Box 400, Princeton, NJ 08540, USA
JUORIO, AUGUSTO V. • Neuropsychiatric Research Division,
CMR Building, University of Saskatchewan, Saskatoon, Saskatche
wan, Canada S7N OWO
KIENZL, EUZABET • LBI for Clinical Neurobiology, Lainz Hospi
tal, Vienna, Austria
LANGE, ANGELA B. • Department of Zoology, University of
Toronto, Toronto, Ontario, Canada M5S lA8
LANGER, SALOMON Z .• Departement de Recherche Biologique,
Laboratoires d'Etudes et de Recherches Synthelabo, 58 rue de la
Glaciere, 75013 Paris, France
LARSON, ALICE A. • Department of Vet Biology, University of
Minnesota, College of Veterinary Medicine, 295 AnSci/Vet Med.
Building, 1988 Fitch Avenue, St. Paul, MN 55108, USA
MIDGLEY, JOHN • Nuclear Medicine Center, Veterans Admini
stration Medical Center, 1601 Archer Road, Gainesville, FL 32602,
USA
NATHANSON, JAMES A. • Department of Neurology, Massachu
setts General Hospital, Boston, MA 02114, USA
NGUYEN, TUONG VAN. Neuropsychiatric Research Division,
CMR Building, University of Saskatchewan, Saskatoon, Saskatchew
an, Canada S7N OWO
ORIKASA, SHUZO • Neuropsychiatric Research Division, CMR
Building University of Saskatchewan, Saskatoon, Saskatchewan,
Canada S7N OWO
OSBORNE, NEVILLE N. • Nuffield Laboratory of Ophthalmol
ogy, University of Oxford, Walton Street, Oxford, 0X2 6AW, UK
Contributors ix
PATERSON, I. ALICK • Neuropsychiatric Research Division, CMR
Building, University of Saskatchewan, Saskatoon, Saskatchewan,
Canada S7N OWO
PERRY, DAVID C. • Department of Pharmacology, George Wash
ington University School of Medicine, 2300 Eye Street, NW, Washing
ton, DC 20037, USA
READER, TOMAS A. • Centre de Recherche en Sciences Neuro
logiques, Universite de Montreal, Case Postale 6128, succursale A,
Montreal, Quebec, Canada H3C 3J7
RICHARDSON, MARY ANN • Clinical Research Division, The
Nathan S. Kline Institute for Psychiatric Research, Orangeburg, NY
10962, USA
SANDLER, MERTON • Department of Chemical Pathology, Queen
Charlotte's Hospital, Goldhawk Road, London W6 OXG, UK
SARPER, RAUF • Nuclear Medicine, VA Medical Center, 1670
Clairmont Road, Decatur, GA 30033, USA
SATOH, NOBUNORI • Department of Pharmacology, Tohoku
College of Pharmacy, 4-4-1, Komatsushima, Sendai 983, Japan
SLOLEY, B. DUFF • Neuropsychiatric Research Division, CMR
Building, University of Saskatchewan, Saskatoon, Saskatchewan,
Canada S7N OWO
TIPTON, KEITH F. • Biochemistry Department, Trinity College,
University of Dublin, Dublin 2, Ireland, UK
VA CCARI, ANDREA • Instituto di Farmacologia, via Porcell,
90100 Cagliari, Italy
WHIM, MATTHEW • Department of Zoology, University of Cam
bridge, Downing Street, Cambridge, CB2 3EJ, UK
WILSON, JOHN X. • Department of Physiology, Health Sciences
Center, University ofW estern Ontario, London, Ontario, CanadaN6A
5Cl
WOOD, PAUL L. • Department of Neuropharmacology, Neuro
science Research, Ciba-Geigy Ltd., 556 Morris Avenue, Summit, NJ
07901, USA
YU, PETER • Neuropsychiatric Research Division, CMR Building,
University of Saskatchewan, Saskatoon, Saskatchewan, Canada S7N
OWO
Contents
v Preface
vi Acknowledgments
vii Contributors
xi Contents
xvii Abbreviations
Neurobiology: Invertebrates
Invited Contributions
3 Pharmacological Characteristics of Octopamine-Sensitive
Adenylate Cyclase and N-Acetyl Octopamine Transferase in
Insects, R. G. H. Downer, J. W. D. Gole, R. J. Martin,
and G. L. Orr
17 Octopamine Receptors on Locust Skeletal Muscle, P. D. Evans
33 The Firefly Light Organ: A Model for a Trace Amine
Synapse, J. A. Nathanson
41 The Regulation of Insect Visceral Muscle by Octopamine,
I. Orchard and A. B. Lange
53 Monoamines as Targets for Insecticide Discovery,
K. R. Jennings, D. G. Kuhn, S. Trotta, and W. K. Whitney
Submitted Contributions
65 N-AcetyI5-Hydroxytryptamine and N-Acetyl Dopamine in the
Cockroach (Periplaneta americana), B. D. Sioley
and R. G. H. Downer
xi
