Table Of ContentToxicity of Nanomaterials
Toxicity of Nanomaterials
Environmental and Healthcare Applications
Edited by
Prof. Suresh C. Pillai
Nanotechnology and Bio-Engineering Division, Faculty of Science,
Institute of Technology, Sligo, Ireland
Dr. Yvonne Lang
Nanotechnology and Bio-Engineering Division, Faculty of Science,
Institute of Technology, Sligo, Ireland
CRC Press
Taylor & Francis Group
6000 Broken Sound Parkway NW, Suite 300
Boca Raton, FL 33487-2742
© 2019 by Taylor & Francis Group, LLC
CRC Press is an imprint of Taylor & Francis Group, an Informa business
No claim to original U.S. Government works
Printed on acid-free paper
International Standard Book Number-13: 978-1-138-54430-7 (Hardback)
This book contains information obtained from authentic and highly regarded sources. Reasonable efforts have been made
to publish reliable data and information, but the author and publisher cannot assume responsibility for the validity of all
materials or the consequences of their use. The authors and publishers have attempted to trace the copyright holders of all
material reproduced in this publication and apologize to copyright holders if permission to publish in this form has not been
obtained. If any copyright material has not been acknowledged please write and let us know so we may rectify in any future
reprint.
Except as permitted under U.S. Copyright Law, no part of this book may be reprinted, reproduced, transmitted, or utilized
in any form by any electronic, mechanical, or other means, now known or hereafter invented, including photocopying,
microfilming, and recording, or in any information storage or retrieval system, without written permission from the
publishers.
For permission to photocopy or use material electronically from this work, please access www.copyright.com (http://www.
copyright.com/) or contact the Copyright Clearance Center, Inc. (CCC), 222 Rosewood Drive, Danvers, MA 01923, 978-750-
8400. CCC is a not-for-profit organization that provides licenses and registration for a variety of users. For organizations that
have been granted a photocopy license by the CCC, a separate system of payment has been arranged.
Trademark Notice: Product or corporate names may be trademarks or registered trademarks, and are used only for
identification and explanation without intent to infringe.
Visit the Taylor & Francis Web site at
http://www.taylorandfrancis.com
and the CRC Press Web site at
http://www.crcpress.com
Contents
Editors ......................................................................................................................vii
Contributors .............................................................................................................ix
1 Cytotoxicology Studies of 2-D Nanomaterials .........................................................1
Priyanka Ganguly, Ailish Breen, and Suresh C. Pillai
2 Effects of Nanocrystal Morphologies on Cytotoxicity ...................................................27
Aine M. Whelan
3 Environmental and Cytotoxicity Risks of Graphene Family Nanomaterials .............49
Saoirse Dervin
4 Toxicology Studies of Semiconductor Nanomaterials: Environmental
Applications ......................................................................................................95
T. P. Nisha, Meera Sathyan, M. K. Kavitha, and Honey John
5 Toxicity Analysis of Ag and Au Nanoparticles .....................................................121
Sami Rtimi
6 Designing Smart Nanotherapeutics ....................................................................139
A. Joseph Nathanael, Tae Hwan Oh, and Vignesh Kumaravel
7 Identifying Nanotoxicity at the Cellular Level Using Electron Microscopy .............163
Kerry Thompson, Alanna Stanley, Emma McDermott, Alexander Black,
and Peter Dockery
8 Ecotoxicology of Nanoparticles ..........................................................................191
Iain Murray and Andy Fogarty
9 Lab-on-a-Chip-Based Devices for Rapid and Accurate Measurement of
Nanomaterial Toxicity .......................................................................................215
Mehenur Sarwar, Amirali Nilchian, and Chen-zhong Li
Index ......................................................................................................................243
v
Editors
Suresh C. Pillai obtained his PhD from Trinity College Dublin and then conducted his postdoctoral
research at California Institute of Technology (Caltech), USA. Upon completion of this appointment
he returned to Trinity College Dublin in April 2004 as a Research Fellow before joining CREST-DIT
as a Senior Scientist. He joined IT Sligo in 2013 as a senior lecturer in nanotechnology and currently
heads the Nanotechnology and Bio-Engineering Research Group. He is an elected fellow of the UK’s
Royal Microscopical Society (FRMS) and the Institute of Materials, Minerals and Mining (FIMMM).
Prof. Pillai also completed an executive MBA from Dublin City University in 2009. He was responsible
for acquiring more than €5 million direct R&D funding. He was awarded the 2019 ‘Boyle-Higgins’ award
by the Institute of Chemistry Ireland and received the ‘Industrial Technologies Award 2011’ for licensing
functional coatings to Irish companies. He was also the recipient of the ‘Hothouse Commercialisation
Award 2009’ from the Minister of Science, Technology and Innovation and the ‘Enterprise Ireland
Research Commercialization Award 2009’. He is an editor for the journal Environmental Science and
Pollution Research (ESPR, Springer) and an Editororial Board Member for the Chemical Engineering
Journal and Applied Catalysis B (Elsevier).
Yvonne Lang obtained her PhD from the National University of Ireland, Galway in 2014. Her doctoral
research investigated the use of diatoms to fabricate polymeric structures with a defined geometry. Work
emanating from this research has been published in peer-reviewed journals and has been presented at
several key international conferences. She received the European Society for Biomaterials Julia Polak
Educational Doctorate Award for her doctoral research. Dr. Lang’s postdoctoral research focussed on
varying aspects of nanoparticles including investigation of both therapeutic and environmental appli-
cations of nanoparticles, quantification of nanoparticles in biological samples and exploration of biore-
mediation approaches to detect and capture nanoparticles in environmental samples.
Dr. Lang is currently a lecturer in chemistry at the Institute of Technology, Sligo Ireland. She
is a member of both the Nanotechnology and Bio-Engineering Research Division and the Centre
for Environmental Research, Innovation and Sustainability at IT Sligo. She is a committee member
of the Microscopy Society of Ireland and a past committee member of the Environmental Scientists
Association of Ireland. She is actively involved in the co-ordination and delivery of outreach events
to promote scientific activities to the public. Her research interests include: (1) investigation of diatom
cultures and diatom products as decontamination agents for removal of organic pollutants from water;
(2) interactions of microorganisms and microplastics and (3) impact of outreach activities on attitudes
to habitat, health and well-being.
vii
Contributors
Alexander Black Peter Dockery
Division of Anatomy Division of Anatomy
School of Medicine School of Medicine
College of Medicine, Nursing and Health College of Medicine, Nursing and Health
Sciences Sciences
National University of Ireland Galway National University of Ireland Galway
Galway, Ireland and
Centre for Microscopy and Imaging
National University of Ireland Galway
Ailish Breen
Galway, Ireland
Nanotechnology and Bio-engineering Research
Group
Department of Environmental Science Andy Fogarty
School of Science Department of Life and Physical Sciences
Institute of Technology Sligo Athlone Institute of Technology
and Athlone, Ireland
Centre for Precision Engineering, Materials and
Manufacturing Research (PEM)
Priyanka Ganguly
Institute of Technology Sligo
Nanotechnology and Bio-engineering Research
Sligo, Ireland
Group
Department of Environmental Science
Saoirse Dervin School of Science
Nanotechnology and Bio-Engineering Research Institute of Technology Sligo
Group and
Department of Environmental Science Centre for Precision Engineering, Materials and
Institute of Technology Sligo Manufacturing Research (PEM)
and Institute of Technology Sligo
Centre for Precision Engineering, Materials and Sligo, Ireland
Manufacturing Research (PEM)
Institute of Technology Sligo
Sligo, Ireland
ix