Tissue Engineering II: Basics of Tissue Engineering and Tissue Applications

343 Pages·2007·3.633 MB·English

by  Robert J. Fisher, Robert A. Peattie (auth.), Kyongbum Lee, David Kaplan (eds.)

103
Advances in Biochemical
Engineering/Biotechnology
SeriesEditor:T.Scheper
EditorialBoard:
W.Babel·I.Endo·S.-O.Enfors·A.Fiechter·M.Hoare·W.-S.Hu
B.Mattiasson·J.Nielsen·H.Sahm·K.Schügerl·G.Stephanopoulos
U.vonStockar·G.T.Tsao·C.Wandrey·J.-J.Zhong
AdvancesinBiochemicalEngineering/Biotechnology
SeriesEditor:T.Scheper
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Tissue Engineering II
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Volume Editors: Kyongbum Lee · David Kaplan
Withcontributionsby
J.P.Acker·E.S.Ahn·S.T.Andreadis·F.Berthiaume·S.N.Bhatia
R.J.Fisher·J.A.Garlick·Y.Nahmias·R.A.Peattie·V.L.Tsang
T.J.Webster·M.L.Yarmush
123
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DOI10.1007/11749219
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UniversityofHannover
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VolumeEditors
Prof.Dr.KyongbumLee Prof.Dr.DavidKaplan
AssistantProfesssor ProfessorandChair
ChemicalandBiologicalEngineering DepartmentofBiomedicalEngineering
TuftsUniversity ScienceandTechnologyCenter
4ColbyStreet,Room142 Medford,MA02155,USA
Medford,MA02155,USA [email protected]
[email protected]
EditorialBoard
Prof.Dr.W.Babel Prof.Dr.M.Hoare
SectionofEnvironmentalMicrobiology DepartmentofBiochemicalEngineering
Leipzig-HalleGmbH UniversityCollegeLondon
Permoserstraße15 TorringtonPlace
04318Leipzig,Germany London,WC1E7JE,UK
[email protected] [email protected]
Prof.Dr.S.-O.Enfors Prof.Dr.I.Endo
DepartmentofBiochemistryand SaitamaIndustrialTechnologyCenter
Biotechnology 3-12-18,KamiaokiKawaguchi-shi
RoyalInstituteofTechnology Saitama,333-0844,Japan
Teknikringen34, [email protected]
10044Stockholm,Sweden
[email protected] Prof.Dr.A.Fiechter
InstituteofBiotechnology
EidgenössischeTechnischeHochschule
ETH-Hönggerberg
8093Zürich,Switzerland
ae.fi[email protected]
VI EditorialBoard
Prof.Dr.W.-S.Hu Prof.Dr.J.Nielsen
ChemicalEngineering CenterforProcessBiotechnology
andMaterialsScience TechnicalUniversityofDenmark
UniversityofMinnesota Building223
421WashingtonAvenueSE 2800Lyngby,Denmark
Minneapolis,MN55455-0132,USA [email protected]
[email protected]
Prof.Dr.K.Schügerl
Prof.Dr.B.Mattiasson
InstituteofTechnicalChemistry
DepartmentofBiotechnology UniversityofHannover,Callinstraße3
ChemicalCenter,LundUniversity 30167Hannover,Germany
P.O.Box124,22100Lund,Sweden [email protected]
[email protected]
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Prof.Dr.H.Sahm
LaboratoiredeGénieChimiqueet
InstituteofBiotechnolgy
Biologique(LGCB),DépartmentdeChimie
ForschungszentrumJülichGmbH
SwissFederalInstitute
52425Jülich,Germany
ofTechnologyLausanne
[email protected]
1015Lausanne,Switzerland
urs.vonstockar@epfl.ch
Prof.Dr.G.Stephanopoulos
DepartmentofChemicalEngineering Prof.Dr.C.Wandrey
MassachusettsInstituteofTechnology
InstituteofBiotechnology
Cambridge,MA02139-4307,USA
ForschungszentrumJülichGmbH
[email protected]
52425Jülich,Germany
[email protected]
Prof.Dr.G.T.Tsao
ProfessorEmeritus
PurdueUniversity
WestLafayette,IN47907,USA
[email protected]
[email protected]
Prof.Dr.J.-J.Zhong
CollegeofLifeScience&Biotechnology
ShanghaiJiaoTongUniversity
800Dong-ChuanRoad
Minhang,Shanghai200240,China
[email protected]
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Preface
It is our pleasure to present thisspecial volume ontissue engineering in the
series Advances in Biochemical Engineering and Biotechnology. This volume
reflects the emergence of tissue engineering as a core discipline of modern
biomedical engineering, and recognizes the growing synergies between the
technological developments in biotechnology and biomedicine. Along this
vein,thefocusofthisvolumeistoprovideabiotechnologydrivenperspective
oncellengineeringfundamentalswhilehighlightingtheirsignificanceinpro-
ducingfunctionaltissues.Ouraimistopresentanoverviewofthestateofthe
artofaselectionofthesetechnologies,punctuatedwithcurrentapplications
intheresearchanddevelopmentofcell-basedtherapiesforhumandisease.
To prepare this volume, we have solicited contributions fromleaders and
experts in their respective fields, ranging from biomaterials and bioreactors
to gene delivery and metabolic engineering. Particular emphasis was placed
on including reviews that discuss various aspects of the biochemical pro-
cessesunderlyingcellfunction,suchassignaling,growth,differentiation,and
communication. The reviews of research topics cover two main areas: cellu-
larand non-cellularcomponents andassembly; evaluation andoptimization
oftissuefunction;andintegratedreactororimplantsystemdevelopment for
researchandclinicalapplications.Manyofthereviewsillustratehowbiochemi-
calengineeringmethodsareusedtoproduceandcharacterizenovelmaterials
(e.g. genetically engineered natural polymers, synthetic scaffolds with cell-
typespecific attachment sitesorinductive factors),whose unique properties
enable increased levels of control over tissue development and architecture.
Otherreviewsdiscusstheroleofdynamicandsteady-statemodelsandother
informatics tools in designing, evaluating, and optimizing the biochemical
functionsofengineeredtissues.Reviewsthatillustratetheintegrationofthese
methodsandmodelsinconstructingmodel,implant(e.g.skin,cartilage),or
ex-vivosystems(e.g.bio-artificialliver)arealsoincluded.
It is our expectation that the mutual relevance of tissue engineering and
biotechnologywillonlyincreaseinthecomingyears,asourneedsforadvanced
healthcareproductscontinuetogrow.Already,tissuederived cellsconstitute
important production systems for therapeutically and otherwise useful bio-
moleculesthatrequirespecializedpost-translationalprocessingfortheirsafety
andefficacy.Biochemicalengineeringproducts,rangingfromgrowthfactorsto
X Preface
polymerscaffolds,areusedasbuildingblocksorsignalmoleculesatvirtually
every stage of engineered tissue formation. Importantly, the realization of
engineered tissuesas clinicallyuseful andcommercially viableproductswill
at least in part depend on overcoming the same efficiency challenges that
thebiotechnologyindustryhasbeenfacing.Inthislight,weseetheinterface
betweentissueengineeringandvariousotherfieldsofbiochemicalengineering
asaveryexcitingareaforresearchanddevelopmentwithenormouspotential
for cross-disciplinary education. In this regard, we anticipate that this and
othersimilarvolumeswillalsobeusefulassupplementarytextforstudents.
We extend our special thanks to all of the contributing authors as well
as Springer for embarking on this project. We are especially grateful to Dr.
Thomas Scheper and Ulrike Kreusel for their incredible patience and hard
workasourproductioneditors.
Medford,August2006 KyongbumLee,DavidKaplan