Tissue Engineering: From Lab to Clinic

644 Pages·2011·25.74 MB·English

by  Daniela Coutinho

Tissue Engineering
Norbert Pallua • Christoph V. Suschek
Editors
Tissue Engineering
From Lab to Clinic
Editors
Univ.-Prof. Dr. med. Norbert Pallua Prof. Dr. Christoph V. Suschek
Universitätsklinikum, der RWTH Aachen Universitätsklinikum, der RWTH Aachen
Klinik für Plastische Chirurgie, Klinik für Plastische Chirurgie,
Handund Verbrennungschirurgie Handund Verbrennungschirurgie
Pauwelsstr. 30 Pauwelsstr. 30
52074 Aachen 52074 Aachen
Germany Germany
[email protected] [email protected]
Illustrator
Piotr Gusta
6. Rue du Chemin Vert
94500 Champigny sur Marne, France
ISBN 978-3-642-02823-6 e-ISBN 978-3-642-02824-3
DOI 10.1007/978-3-642-02824-3
Springer Heidelberg Dordrecht London New York
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Preface
Although efforts to generate bioartificial tissues and organs for human therapies date
back to the 80s, these efforts have only come closer to reality in the past 10 years. The
possibility of such bioartifical tissues has been fueled by major advances in cell and
molecular biology and the development of more sophisticated cell-culture
technologies. The term Tissue Engineering has come to a broader application in the
last five years and now encompasses the many interdisciplinary fields of knowledge
that are crucial to generate or regenerate tissues or even whole organs. Tissue
engineering has the potential to revolutionize health care, improving the treatment
options and quality of life for millions of people worldwide, yet, saving enormous
financial resources in terms of health care costs. One of its defining characteristics is
that it draws upon and requires close collaboration among scientists in many diverse
specialties. Cell and molecular biologists, biomaterials engineers, advanced imaging
specialists, robotics engineers, and developers of equipment such as bioreactors,
where tissues are grown and nurtured, are all part of the process of tissue engineering.
Another characteristic of tissue engineering is that the field has brought together
researchers worldwide in international collaborative efforts. Tissue engineering as a
promising research is underway in all parts of the globe. The emergence of tissue
engineering has coincided with the emergence of the Internet, making far-reaching
collaborations more possible than ever before.
The topics in Tissue Engineering: From Lab to Clinic, addressed by world-
renowned authorities, were selected to cover the spectrum from basic development
to clinical application. Pertinent information on cell isolation and expansion, both
in animals and humans, provides guidance for the clinical scientists interested in
this area. Written by leading experts in the field, each chapter offers a detailed
state-of-the-art overview of the respective field of research, the author’s visions
regarding his research area, as well as its limitations. This book provides a concep-
tual framework that includes the entire necessary background material in all areas
of tissue engineering.
Tissue Engineering: From Lab to Clinic is intended to be a reference for first-year
to senior-level graduate courses in Tissue Engineering, in departments of bioengi-
neering, and for students who perform research in tissue replacement and restoration.
Additionally, this book attempts to give guidance for students in biology, medicine,
and life-sciences, working with primary and complex cell biology. This book, seeks
to provide both undergraduate and graduate students with the scientific foundation of
v
vi Preface
tissue engineering. We therefore hope to provide a reference to biomedical engineer-
ing students, bioengineers, biological sciences graduate students, as well as their
teachers, to managers and scientists in the biotech industry, and academic
researchers.
Norbert Pallua
Christoph V. Suschek
Contents
Part I Basics and Principles of Tissue Engineering
1 Micro- and Nanotechnology in Tissue Engineering ................................ 3
Daniela Coutinho, Pedro Costa, Nuno Neves,
Manuela E. Gomes, and Rui L. Reis
2 Biomimetic Scaffolds in Tissue Engineering ........................................... 31
Ian O. Smith and Peter X. Ma
3 Natural and Synthetic Scaffolds ............................................................... 41
Patricia S. Wolfe, Scott A. Sell, and Gary L. Bowlin
4 Pluripotent Stem Cells: Sources and Characterization .......................... 69
Sean P. Palecek
5 Adult Stem Cells: Sources and Characterization.................................... 83
Hitoshi Okochi
6 Isolation and Growth of Stem Cells. ......................................................... 93
Jeffrey M. Gimble, Bruce A. Bunnell, Farshid Guilak,
Steven R. Smith, and Adam J. Katz
7 Differentiation and Plasticity of Stem Cells
for Tissue Engineering ............................................................................... 113
Yao-Hua Song, Lukas Prantl, and Eckhard Alt
8 Animal Models for the Evaluation of
Tissue Engineering Constructs ................................................................. 131
Daniel A.W. Oortgiesen, Gert J. Meijer, Rob B.M. de Vries,
X. Frank Walboomers, and John A. Jansen
9 Biomedical Imaging and Image Processing in Tissue Engineering ....... 155
Haiou Shen, Aaron S. Goldstein, and Ge Wang
10 Bioreactors for Tissue Engineering .......................................................... 179
Scott Maxson, David Orr, and Karen J.L. Burg
vii
viii Contents
Part II Tissue Engineering of Organs
11 Issues in Bioartificial Liver Support Therapy
for Acute Liver Failure .............................................................................. 201
John F. Patzer II and Jörg C. Gerlach
12 Central Nervous System ............................................................................ 221
T. Führmann, J. Gerardo-Nava, and G.A. Brook
13 Tissue Engineering for Peripheral Nerve Regeneration ......................... 245
Andrew Hart, Giorgio Terenghi, and Mikael Wiberg
14 Tissue Engineering of Blood Vessels: How to Make a Graft .................. 263
Sajoscha Sorrentino and Hermann Haller
15 Biohybrid Strategies for Vascular Grafts ................................................ 279
Robert van Lith and Guillermo A. Ameer
16 Heart and Cardiovascular Engineering ................................................... 317
Axel Haverich and Mathias Wilhelmi
17 Tissue Engineering of Organs: Eye/Retina .............................................. 335
Stephen Redenti, Henry Klassen, and Michael Young
Part III Tissue Types
18 Engineering of Adipose Tissue .................................................................. 349
Laurence A. Galea, Heidi E. Lilja, Gregory PL. Thomas,
Keren M. Abberton, Jason A. Palmer, and Wayne A. Morrison
19 Blood Substitutes ........................................................................................ 371
Andreas Pape and Oliver Habler
20 Tissue Engineering of Blood Vessels: How to Make a Graft .................. 395
Andrew A. Gassman and Howard P. Greisler
21 Bone Tissue Engineering ........................................................................... 431
J.C. Reichert and D.W. Hutmacher
22 Tissue Engineering of Organs: Brain Tissues ......................................... 457
Deniece Fon, David R. Nisbet, George A. Thouas,
Wei Shen, and John S. Forsythe
23 Engineering Cartilage Tissue .................................................................... 493
Robert L. Mauck and Jason A. Burdick
24 Pancreatic Tissues ...................................................................................... 521
Grace J. Lim and Anthony Atala
Contents ix
25 Tendons: Engineering of Functional Tissues ........................................... 537
D.I. Zeugolis, J.C.Y. Chan, and A. Pandit
26 Tissue Engineering in Oral and Maxillofacial Surgery (OMFS) ........... 573
Wolfgang C. Puelacher
27 Tissue Engineering of Musculoskeletal Tissue ........................................ 597
Lu Zhang and Myron Spector
Index .................................................................................................................... 625