Table Of ContentDOUBLE ISSUE JAN. 18 / JAN. 25, 2021
Democracy Under Attack
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Politics Among Nations: The Struggle for Power & Peace
By Hans Morgenthau
For certain adults with newly diagnosed metastatic non-small cell lung cancer (NSCLC) that tests positive for PD-L1
=
A CHANCE FOR MORE
SNUGGLY SUNDAYS
A Chance to Live Longer™
THE 1ST AND ONLY FDA-APPROVED CHEMO-FREE COMBINATION
OF 2 IMMUNOTHERAPIES THAT WORKS DIFFERENTLY
In a study of newly diagnosed advanced NSCLC patients, half of those on OPDIVO + YERVOY were alive at 17.1 months versus
14.9 months on platinum-based chemotherapy.
Results may vary. OPDIVO® + YERVOY® is not approved for patients younger than 18 years of age.
Indication & Important Safety Information for OPDIVO (nivolumab) • H ormone gland problems: headaches that will not go away or
+ YERVOY (ipilimumab) unusual headaches; eye sensitivity to light; eye problems; rapid
heartbeat; increased sweating; extreme tiredness; weight gain or
Only your healthcare professional knows the specifics of your
weight loss; feeling more hungry or thirsty than usual; urinating
condition and how OPDIVO in combination with YERVOY may fit into
more often than usual; hair loss; feeling cold; constipation; your
your overall therapy. The information below does not take the place
voice gets deeper; dizziness or fainting; changes in mood or behavior,
of talking with your healthcare professional, so talk to them if you
such as decreased sex drive, irritability, or forgetfulness
have any questions.
• K idney problems: decrease in the amount of urine; blood in your
What are OPDIVO and YERVOY?
urine; swelling in your ankles; loss of appetite
OPDIVO and YERVOY are prescription medicines used to treat people
• S kin problems: rash; itching; skin blistering or peeling; painful sores
with a type of advanced stage lung cancer called non-small cell lung
or ulcers in mouth or nose, throat, or genital area
cancer (NSCLC). OPDIVO may be used in combination with YERVOY as
your first treatment for NSCLC when your lung cancer has spread to • E ye problems: blurry vision, double vision, or other vision problems;
other parts of your body (metastatic) and your tumors are positive for eye pain or redness
PD-L1, but do not have an abnormal EGFR or ALK gene.
Problems can also happen in other organs and tissues. These are
It is not known if OPDIVO and YERVOY are safe and effective when not all of the signs and symptoms of immune system problems that
used in children younger than 18 years of age. can happen with OPDIVO and YERVOY. Call or see your healthcare
provider right away for any new or worsening signs or symptoms,
What is the most important information I should know about
which may include:
OPDIVO and YERVOY?
• C hest pain; irregular heartbeat; shortness of breath; swelling of
OPDIVO and YERVOY are medicines that may treat certain cancers by
ankles
working with your immune system. OPDIVO and YERVOY can cause
• C onfusion; sleepiness; memory problems; changes in mood or
your immune system to attack normal organs and tissues in any
behavior; stiff neck; balance problems; tingling or numbness of the
area of your body and can affect the way they work. These problems
arms or legs
can sometimes become serious or life-threatening and can lead
• D ouble vision; blurry vision; sensitivity to light; eye pain; changes in
to death and may happen anytime during treatment or even after
eye sight
your treatment has ended. You may have more than one of these
• P ersistent or severe muscle pain or weakness; muscle cramps
problems at the same time. Some of these problems may happen
• L ow red blood cells; bruising
more often when OPDIVO is used in combination with YERVOY.
Getting medical help right away may help keep these problems
Call or see your healthcare provider right away if you develop any
from becoming more serious. Your healthcare team will check
new or worse signs or symptoms, including
you for these problems during treatment and may treat you with
• L ung problems: new or worsening cough; shortness of breath; chest corticosteroid or hormone replacement medicines. Your healthcare
pain team may also need to delay or completely stop your treatment if you
• I ntestinal problems: diarrhea (loose stools) or more frequent have severe side effects.
bowel movements than usual; stools that are black, tarry, sticky, What should I tell my healthcare provider before receiving OPDIVO
or have blood or mucus; severe stomach-area (abdominal) pain or and YERVOY? Before you receive OPDIVO and YERVOY, tell your
tenderness healthcare provider about all of your medical conditions, including
• L iver problems: yellowing of your skin or the whites of your eyes; if you:
severe nausea or vomiting; pain on the right side of your stomach • h ave immune system problems such as Crohn’s disease, ulcerative
area (abdomen); dark urine (tea colored); bleeding or bruising more colitis, or lupus
easily than normal
• h ave received an organ transplant
Talk to your doctor about OPDIVO + YERVOY
www.OPDIVOYERVOY.com 1-855-OPDIVOYERVOY
• h ave received or plan to receive a stem cell transplant that uses • C omplications, including graft-versus-host disease (GVHD),
donor stem cells (allogeneic) of bone marrow (stem cell) transplant that uses donor stem
cells (allogeneic). These complications can be severe and can
• h ave received radiation treatment to your chest area in the past
lead to death. These complications may happen if you underwent
and have received other medicines that are like OPDIVO
transplantation either before or after being treated with OPDIVO
• h ave a condition that affects your nervous system, such as
or YERVOY. Your healthcare provider will monitor you for these
myasthenia gravis or Guillain-Barré syndrome
complications.
• a re pregnant or plan to become pregnant. OPDIVO and YERVOY
The most common side effects of OPDIVO when used in combination
can harm your unborn baby
with YERVOY include: feeling tired; diarrhea; rash; itching; nausea;
• a re breastfeeding or plan to breastfeed. It is not known if OPDIVO pain in muscles, bones, and joints; fever; cough; decreased appetite;
or YERVOY passes into your breast milk. Do not breastfeed during vomiting; stomach-area (abdominal) pain; shortness of breath; upper
treatment with OPDIVO or YERVOY and for 5 months after the last respiratory tract infection; headache; low thyroid hormone levels
dose of OPDIVO or YERVOY (hypothyroidism); decreased weight; and dizziness.
Females who are able to become pregnant: Your healthcare These are not all the possible side effects of OPDIVO and YERVOY.
provider should do a pregnancy test before you start receiving Call your doctor for medical advice about side effects.
OPDIVO or YERVOY.
You are encouraged to report side effects of prescription drugs to
• Y ou should use an effective method of birth control during your the FDA. Call 1-800-FDA-1088.
treatment and for at least 5 months after your last dose of OPDIVO (10 mg/mL) and YERVOY (5 mg/mL) are injections for
OPDIVO or YERVOY. Talk to your healthcare provider about birth intravenous (IV) use.
control methods that you can use during this time.
• T ell your healthcare provider right away if you become pregnant or
This is a brief summary of the most important information about
think you are pregnant during treatment with OPDIVO or YERVOY.
OPDIVO and YERVOY. For more information, talk with your healthcare
You or your healthcare provider should contact Bristol Myers Squibb
providers, call 1-855-673-4861, or go to www.OPDIVO.com.
at 1-844-593-7869 as soon as you become aware of the pregnancy.
Tell your healthcare provider about all the medicines you take,
including prescription and over-the-counter medicines, vitamins,
and herbal supplements.
Know the medicines you take. Keep a list of them to show your
healthcare providers and pharmacist when you get a new medicine.
What are the possible side effects of OPDIVO and YERVOY?
OPDIVO and YERVOY can cause serious side effects, including:
• S ee “What is the most important information I should know
about OPDIVO + YERVOY?”
• S evere infusion reactions. Tell your healthcare team or nurse right
away if you get these symptoms during an infusion of OPDIVO or
YERVOY: chills or shaking; itching or rash; flushing; shortness of
© 2020 Bristol-Myers Squibb Company. All rights reserved. OPDIVO®, YERVOY®,
breath or wheezing; dizziness; feel like passing out; fever; back or
and the related logos are trademarks of Bristol-Myers Squibb Company.
neck pain
7356US2002303-03-01 12/20
VOL. 197, NOS. 1–2 | 2021
4 | Conversation
6 | For the Record
The Brief
News from the U.S.
and around the world
7 | Trump’s assault
on institutions
made visible
18 | The extreme
climate of 2020
19 | Milestones:
Pierre Cardin and
Brian Urquhart
The View
Ideas, opinion,
innovations
21 | Ian Bremmer
on the risks of 2021 The Olympic logo
at Tokyo’s National
23 | Nayomi
Stadium on Dec. 16
Munaweera on
Photograph by Kenji
reconnecting
Chiga for TIME
Time Off
Features
What to watch, read,
see and do
The Year Ahead The Antisocial
ON THE
91 | After a national COVERS:
Network
THE MOLECULE: Behind the vaccines
trauma, people
By Walter Isaacson 26 A heavily armed white-
crave escapism
PLUS: Why it’s safe By Heidi J. Larson supremacist militia went
94 | Post-Trump, The rollout fiasco By Alice Park global using Facebook
artists can
By Simon Shuster
unclench
THE DOCTOR WILL REALLY SEE YOU: and Billy Perrigo 74
96 | Open season Medical schools are changing with the times Photograph by
on The Great Dina Litovsky
By Jamie Ducharme 38
The Kindness
Gatsby for TIME
of Strangers
98 | Movies: OLYMPIAN RISK: Tokyo says it can
Desperate families
Wonder Woman safely mount the Summer Games
crowdfund funerals for
1984 lacks wonder
By Charlie Campbell 44
victims of COVID-19
PLUS: The athletes improvise
104 | 7 Questions By Melissa Chan 82
for Planned By Sean Gregory
Parenthood chief
Alexis McGill Rich Tangle Capitol Police
HEIRS TO THE ARAB SPRING: The fight
guard the House
Johnson
of Life
for dignity goes on By Joseph Hincks 54 Chamber
A partner with cancer, a
Photogragh
20,000 SEEDS UNDER THE SEA: A Spanish new baby, a pandemic and, by Drew
Angerer—
chef’s bold plan to harvest rice from the ocean somehow, joy
Getty Images
floor By Matt Goulding 62 By Rebekah Taussig 86
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