Thyroid Hormone Disruption and Neurodevelopment

207 Pages·2016·4.93 MB·English

by  Noriyuki Koibuchi

Contemporary Clinical Neuroscience
Noriyuki Koibuchi
Paul M. Yen Editors
Thyroid Hormone
Disruption and
Neurodevelopment
123
Contemporary Clinical Neuroscience
More information about this series at h ttp://www.springer.com/series/7678
Noriyuki Koibuchi • Paul M. Yen
Editors
Thyroid Hormone Disruption
and Neurodevelopment
Editors
Noriyuki Koibuchi Paul M. Yen
Department of Integrative Physiology Laboratory of Hormonal Regulation
Gunma University Graduate School of Cardiovascular and Metabolic Disorders
Medicine Program
Maebashi , Gunma , Japan Duke-NUS Graduate Medical School
Singapore , Singapore
Contemporary Clinical Neuroscience
ISBN 978-1-4939-3735-6 ISBN 978-1-4939-3737-0 (eBook)
DOI 10.1007/978-1-4939-3737-0
Library of Congress Control Number: 2016940093
© Springer Science+Business Media New York 2016
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Contents
Part I Disruption of Thyroid Hormone Action at Molecular Level
1 Mechanisms for Thyroid Hormone Action in the CNS ....................... 3
Rohit Anthony Sinha and Paul. M. Yen
2 Deiodinase and Brain Development ...................................................... 23
Masami Murakami
3 Brominated Organohalogens and Neurodevelopment:
Different Mechanisms, Same Consequence .......................................... 33
Kingsley Ibhazehiebo , Toshiharu Iwasaki , and Noriyuki Koibuchi
4 Perinatal Infection-Associated Changes in Thyroid
Hormone Status, Gut Microbiome, and Thyroid
Hormone-Mediated Neurodevelopment ............................................... 51
E. M. Sajdel-Sulkowska , M. Bialy , and R. Zabielski
5 Disruption of Feedback Regulation of Thyroid Hormone
Synthesis/Secretion and Brain Development ........................................ 69
Sumiyasu Ishii and Masanobu Yamada
Part II Animal Models to Study Thyroid Hormone
Disruption on Neurodevelopment
6 Animal Models to Study Thyroid Hormone Action
in Neurodevelopment .............................................................................. 85
Noriaki Shimokawa and Noriyuki Koibuchi
7 Thyroid Hormone Receptor Mutation and Neurodevelopment ......... 103
Jens Mittag
8 Using Mouse Genetics to Investigate Thyroid Hormone
Signaling in the Developing and Adult Brain ....................................... 119
F. Chatonnet , S. Richard , and F. Flamant
v
vi Contents
9 Disruption of Auditory Function by Thyroid Hormone
Receptor Mutations................................................................................. 133
David S. Sharlin
Part III Thyroid Hormone Disruption and Neurodevelopment:
Human Studies
10 The Impact of Maternal Thyrotoxicosis and Antithyroid
Drug Exposure on Fetal/Neonatal Brain Development ....................... 153
Ines Donangelo and Gregory A. Brent
11 Deficit in Thyroid Hormone Transporters
and Brain Development .......................................................................... 169
Takehiro S uzuki and Takaaki Abe
12 Syndromes of Resistance to Thyroid Hormone
and Brain Development .......................................................................... 183
Irene Campi and Paolo Beck-Peccoz
Index ................................................................................................................. 205
Contributors
Takaaki A be Division of Nephrology, Endocrinology, and Vascular Medicine,
Department of Medicine , Tohoku University Graduate School of Medicine , Sendai ,
Miyagi , Japan
Division of Medical Science , Tohoku University Graduate School of Biomedical
Engineering , Sendai , Miyagi , Japan
D epartment of Clinical Biology and Hormonal Regulation, T ohoku University
Graduate School of Medicine , Sendai , Miyagi , Japan
Paolo Beck-Peccoz Department of Clinical Sciences and Community Health ,
University of Milan, Fondazione IRCCS Cà Granda Ospedale Maggiore , Milan , Italy
M. Bialy Department of Experimental and Clinical Physiology, Laboratory of
Center for Preclinical Research , Medical University of Warsaw , Warsaw , Poland
Gregory A. Brent D epartment of Medicine, D avid Geffen School of Medicine at
UCLA , Los Angeles , CA , USA
Irene Campi D epartment of Clinical Sciences and Community Health, U niversity
of Milan, Fondazione IRCCS Cà Granda Ospedale Maggiore , Milan , Italy
F. Chatonnet I nstitut de Génomique Fonctionnelle de Lyon, Université de Lyon,
Université Lyon, INRA, CNRS, Ecole Normale Supérieure de Lyon, L yon, C edex, F rance
Ines Donangelo Endocrinology Division , Allegheny General Hospital , Pittsburgh ,
PA , USA
F. Flamant Institut de Génomique Fonctionnelle de Lyon, Université de Lyon, Université
Lyon, INRA, CNRS, Ecole Normale Supérieure de Lyon , Lyon , Cedex , France
Kingsley Ibhazehiebo Department of Integrative Physiology , Gunma University
Graduate School of Medicine , Maebashi , Gunma , Japan
Sumiyasu Ishii D epartment of Medicine and Molecular Science, G unma
University Graduate School of Medicine , Maebashi , Gunma , Japan
vii
viii Contributors
Toshiharu Iwasaki Department of Integrative Physiology , Gunma University
Graduate School of Medicine , Maebashi , Gunma , Japan
Noriyuki Koibuchi Department of Integrative Physiology, Gunma University
Graduate School of Medicine , Maebashi , Gunma , Japan
Jens Mittag C enter of Brain Behavior and Metabolism, University of Lübeck,
Lübeck , Germany
Masami Murakami Department of Clinical Laboratory Medicine , Gunma
University Graduate School of Medicine , Maebashi , Japan
S. Richard Institut de Génomique Fonctionnelle de Lyon, Université de Lyon,
Université Lyon, INRA, CNRS, Ecole Normale Supérieure de Lyon , Lyon , Cedex ,
France
E. M. Sajdel-Sulkowska D epartment of Psychiatry, H arvard Medical School and
Brigham and Women’s Hospital , Boston , MA , USA
Department of Experimental and Clinical Physiology, Laboratory of Center for
Preclinical Research , Medical University of Warsaw , Warsaw , Poland
Department of Physiological Sciences , Warsaw University of Life Sciences,
Warsaw , Poland
David S. Sharlin D epartment of Biological Sciences, M innesota State University,
Mankato , MN , USA
Noriaki Shimokawa Department of Integrative physiology , Gunma University
Graduate School of Medicine , Maebashi , Gunma , Japan
Rohit Anthony Sinha Laboratory of Hormonal Regulation, Cardiovascular and
Metabolic Disorders Program, D uke-NUS Graduate Medical School, S ingapore,
Singapore
Takehiro Suzuki Division of Nephrology, Endocrinology, and Vascular Medicine,
Department of Medicine , Tohoku University Graduate School of Medicine , Sendai ,
Miyagi , Japan
D epartment of Medical Science, T ohoku University Graduate School of Biomedical
Engineering , Sendai , Miyagi , Japan
Masanobu Yamada Department of Medicine and Molecular Science , Gunma
University Graduate School of Medicine , Maebashi , Gunma , Japan
Paul M. Yen Laboratory of Hormonal Regulation, Cardiovascular and Metabolic
Disorders Program , Duke-NUS Graduate Medical School , Singapore , Singapore
R. Zabielski D epartment of Physiological Sciences, W arsaw University of Life
Sciences , Warsaw , Poland
Part I
Disruption of Thyroid Hormone
Action at Molecular Level
Chapter 1
Mechanisms for Thyroid Hormone Action
in the CNS
Rohit Anthony Sinha and Paul M. Yen
Abstract T his chapter aims to summarize our recent understanding about the
action of thyroid hormone (TH) in the CNS. The topics will include the molecular
action of TH at genomic and non-genomic levels and its impact on the physiology
of brain.
Keywords Thyroid hormone (TH) • Thyroid hormone receptors (TR) • Brain
• Neurons • Epigenetic • Deiodinases
1.1 Introduction
Thyroid hormones (THs) mediate important physiological processes such as devel-
opment, growth, and metabolism in virtually all tissues of the body (Brent 2 012 ;
Cheng et al. 2 010 ; Oetting and Yen 2007 ). There are two major THs secreted by the
thyroid gland, levothyroxine (T ) and triiodothyronine (T ), with the latter serving
4 3
as the more biologically active form. Their serum concentrations are tightly regu-
lated by the hypothalamic/pituitary/thyroid (HPT) axis. THs are transported by spe-
cifi c proteins via the circulation to tissues throughout the body and also must pass
the blood/brain barrier for delivery to the CNS. Intracellular uptake of TH occurs by
specifi c TH transporters, and the intracellular concentration of TH is further regu-
lated by intracellular deiodinases that convert T to T to increase the TH activity or
4 3
transform the THs to inert metabolites to reduce it. Intracellular TH then binds to
nuclear thyroid hormone receptors (TRs), members of the nuclear receptor super-
family, that are ligand-dependent transcription factors to regulate positive or nega-
tive transcription of target genes. There are two major isoforms, TRα and TRβ,
which each has different tissue distributions. TRs typically form heterodimers with
another member of the nuclear receptor superfamily, RXR, and bind to specifi c
R. A. Sinha , Ph.D. (*) • P. M. Yen , M.D.
Laboratory of Hormonal Regulation, Cardiovascular and Metabolic Disorders Program ,
Duke-NUS Graduate Medical School , 8 College Road , Singapore 169857 , Singapore
e-mail: [email protected]; [email protected]
© Springer Science+Business Media New York 2016 3
N. Koibuchi, P.M. Yen (eds.), Thyroid Hormone Disruption and Neurodevelopment,
Contemporary Clinical Neuroscience, DOI 10.1007/978-1-4939-3737-0_1