The Zebrafish: Disease Models and Chemical Screens (Methods in Cell Biology, Volume 105)

409 Pages·8.264 MB·English

by  Detrich III Y.W., Westerfield M., Zon L.I. (Eds.)

Methods in Cell Biology
VOLUME 105
The Zebrafish: Disease Models and Chemical Screens
3rd Edition
Series Editors
Leslie Wilson
DepartmentofMolecular,CellularandDevelopmentalBiology
UniversityofCalifornia
SantaBarbara,California
Paul Matsudaira
DepartmentofBiologicalSciences
NationalUniversityofSingapore
Singapore
Methods in Cell Biology
VOLUME 105
The Zebrafish: Disease Models and Chemical Screens
3rd Edition
Edited by
H. William Detrich III
DepartmentofBiology,NortheasternUniversity,Boston,MA,USA
Monte Westerfield
InstituteofNeuroscience,UniversityofOregon,Eugene,OR,USA
Leonard I. Zon
DivisionofHematology/Oncology,Children’sHospitalofBoson
DepartmentofPediatricsandHowardHughesMedicalInstitute
HarvardMedicalSchool,Boston,MA,USA
AMSTERDAM (cid:1) BOSTON (cid:1) HEIDELBERG (cid:1) LONDON
NEWYORK (cid:1) OXFORD (cid:1) PARIS (cid:1) SANDIEGO
SANFRANCISCO (cid:1) SINGAPORE (cid:1) SYDNEY (cid:1) TOKYO
AcademicPressisanimprintofElsevier
AcademicPressisanimprintofElsevier
225WymanStreet,Waltham,MA02451,USA
525BStreet,Suite1900,SanDiego,CA92101-4495,USA
32,JamestownRoad,LondonNW17BY,UK
LinacreHouse,JordanHill,OxfordOX28DP,UK
Thirdedition2011
Copyright#2011ElsevierInc.Allrightsreserved
Nopartofthispublicationmaybereproduced,storedinaretrievalsystem
ortransmittedinanyformorbyanymeanselectronic,mechanical,photocopying,
recordingorotherwisewithoutthepriorwrittenpermissionofthepublisher
PermissionsmaybesoughtdirectlyfromElsevier’sScience&TechnologyRights
DepartmentinOxford,UK:phone[phone];fax[phone];
email:[e-mail]tyourrequestonlineby
visitingtheElsevierwebsiteathttp://elsevier.com/locate/permissions,andselecting
ObtainingpermissiontouseElseviermaterial
Notice
Noresponsibilityisassumedbythepublisherforanyinjuryand/ordamagetopersons
orpropertyasamatterofproductsliability,negligenceorotherwise,orfromanyuseor
operationofanymethods,products,instructionsorideascontainedinthematerialherein.
Becauseofrapidadvancesinthemedicalsciences,inparticular,independentverification
ofdiagnosesanddrugdosagesshouldbemade
ISBN:978-0-12-381320-6
ISSN:0091-679X
For information on all Academic Press publications
visitourwebsiteatelsevierdirect.com
PrintedandboundinUSA
11121314 10987654321
DEDICATION
DedicationtoMethodsinCellBiology–TheZebrafish,3rdEdition
We dedicate the Third Edition of Methods in Cell Biology: The Zebrafish to
Wolfgang Driever, Mark C. Fishman, Charles Kimmel, and Christiane Nu€sslein-
Volhard.Throughtheirforesightedembraceofthezebrafishasamodelvertebrate
and their pursuit of genetic screens to illuminate vertebrate development, they
fosteredtheemergenceofthevibrantzebrafishresearchcommunity.
CONTRIBUTORS
Numbersinparenthesesindicatethepagesonwhichtheauthor’scontributionsbegin.
JamesF.Amatruda(3),DepartmentofPediatrics,UniversityofTexasSouthwestern
MedicalCenter,Dallas,Texas,USA;DepartmentofMolecularBiology,University
ofTexasSouthwesternMedicalCenter,Dallas,Texas,USA;DepartmentofInternal
Medicine,UniversityofTexasSouthwesternMedicalCenter,Dallas,Texas,USA
AlexanderApschner(239),HubrechtInstitute-KNAW&UMCUtrecht,Utrecht,
TheNetherlands
Erica L. Benard (273), Institute of Biology, Leiden University, Leiden, The
Netherlands
Wilhelm Bloch (191), Institute of Cardiologyand Sports Medicine, German Sport
University Cologne, Cologne, Germany; Cologne Excellence Clusteron Cellular
Stress Responses in Aging-Associated Diseases, University of Cologne, Cologne,
Germany
Matthew G. Butler (137), Program in the Genomics of Differentiation, National
InstituteofChildHealthandDevelopment,NationalInstitutesofHealth,Bethesda,
Maryland,USA
Jeremy R. Charette (87), Department of Molecular & Biomedical Sciences,
UniversityofMaine,Orono,Maine,USA
EleanorY.Chen(383),MolecularPathologyUnit,MassachusettsGeneralHospital,
Charlestown, MA, USA; Department of Pathology, Brigham and Women’s
Hospital,HarvardMedicalSchool,Boston,MA,USA
ChaoCui(273),InstituteofBiology,LeidenUniversity,Leiden,TheNetherlands
Tim Czopka (25), Centre for Neuroregeneration, University of Edinburgh,
Chancellor’s Building, 49 Little France Crescent, Edinburgh, UK; Centre for
Regenerative Medicine, University of Edinburgh, Edinburgh, UK; Centre for
MultipleSclerosisResearch,UniversityofEdinburgh,Edinburgh,UK
VanessaDamoulis(3),DepartmentofPediatrics,UniversityofTexasSouthwestern
MedicalCenter,Dallas,Texas,USA;DepartmentofMolecularBiology,University
ofTexasSouthwesternMedicalCenter,Dallas,Texas,USA
FredericusvanEeden(163),MRC-CDBG/BMS,UniversityofSheffield,Western
Bank,Sheffield,UnitedKingdom
JuliaEtchin(309),DepartmentofPediatricOncology,Dana-FarberCancerInstitute
andChildren’sHospital,Boston,Massachusetts,USA
Natália Martins Feitosa (191), Institute of Developmental Biology, University of
Cologne,Cologne,Germany;CenterforMolecularMedicineCologne,University
ofCologne,Cologne,Germany
xv
xvi Contributors
Mark C. Fishman (525), Novartis Institutes for Biomedical Research, Cambridge,
Massachusetts02139,USA
RachelGiles(163),DepartmentofNephrology,UniversityMedicalCenterUtrecht,
Universiteitsweg100,3584CG,Utrecht,TheNetherlands
Wolfram Goessling (117), Genetics Division, Brigham and Women’s Hospital,
Harvard Medical School, Boston, Massachusetts, USA; Harvard Stem Cell
Institute,Cambridge,Massachusetts,USA
AniketV.Gore(137),ProgramintheGenomicsofDifferentiation,NationalInstitute
of Child Health and Development, National Institutes of Health, Bethesda,
Maryland,USA
Karen Guillemin (87), Institute of Molecular Biology, University of Oregon,
Eugene,Oregon,USA
MatthiasHammerschmidt(191),InstituteofDevelopmentalBiology,Universityof
Cologne,Cologne,Germany;CenterforMolecularMedicineCologne,University
of Cologne, Cologne, Germany; Cologne Excellence Cluster on Cellular Stress
ResponsesinAging-AssociatedDiseases,UniversityofCologne,Cologne,Germany
Myron S. Ignatius (437), Molecular Pathology Unit, Massachusetts General
Hospital, Charlestown, Massachusetts, USA; Center of Cancer Research,
Massachusetts General Hospital Cancer Center, Charlestown, Massachusetts,
USA;HarvardStemCellInstitute,Boston,Massachusetts,USA
John P. Kanki (309), Department of Pediatric Oncology, Dana-Farber Cancer
InstituteandChildren’sHospital,Boston,Massachusetts,USA
Zakia Kanwal (273), Institute of Biology, Leiden University, Leiden, The
Netherlands
TerhiKarpanen(223),HubrechtInstitute-KNAWandUniversityMedicalCenter
Utrecht,Uppsalalaan8,Utrecht,TheNetherlands
NicholasKatsanis(257),CenterforHumanDiseaseModeling,DepartmentsofCell
BiologyandPediatrics,DukeUniversityMedicalCenter,Durham,NorthCarolina,
USA
CarolH.Kim(87),DepartmentofMolecular&BiomedicalSciences,Universityof
Maine,Orono,Maine,USA;GraduateSchoolofBiomedicalSciences,Universityof
Maine,Orono,Maine,USA
David Kokel (517), Cardiovascular Research Center and Division of Cardiology,
Department of Medicine, Massachusetts General Hospital, Harvard Medical
School, Charlestown, Massachusetts, USA and Broad Institute, 7 Cambridge
Center,Cambridge,Massachusetts,USA
D. Lai (419), Molecular, Cellular and Developmental Biology Group, School of
BiologicalSciences,UniversityofAuckland,Auckland,NewZealand
C.-C.Lan(419),Molecular,CellularandDevelopmentalBiologyGroup,Schoolof
BiologicalSciences,UniversityofAuckland,Auckland,NewZealand
DavidM.Langenau(383, 437),Molecular PathologyUnit,Massachusetts General
Hospital, Charlestown, MA, USA; Center of Cancer Research, Massachusetts
General Hospital, Charlestown, MA, USA; Harvard Stem Cell Institute, Boston,
MA,USA
Contributors xvii
StevenD.Leach(367),DepartmentofSurgeryandtheMcKusick-NathansInstitute
of Genetic Medicine, Johns Hopkins University School of Medicine, Maryland,
Baltimore
I.U.S.Leong(419),Molecular,CellularandDevelopmentalBiologyGroup,School
ofBiologicalSciences,UniversityofAuckland,Auckland,NewZealand;Diagnostic
Genetics,LabPlus,AucklandCityHospital,Auckland,NewZealand
PulinLi(403),HarvardMedicalSchool,HowardHughesMedicalInstitute,Harvard
StemCellInstitute,Children’sHospitalBoston,Boston,Massachusetts,USA
KateLillard(3),DepartmentofPediatrics,UniversityofTexasSouthwesternMedical
Center,Dallas,Texas,USA;DepartmentofMolecularBiology,UniversityofTexas
SouthwesternMedicalCenter,Dallas,Texas,USA
Shu Liu (367), Department of Surgery and the McKusick-Nathans Institute of
Genetic Medicine, Johns Hopkins University School of Medicine, Maryland,
Baltimore
Ive Logister (163), Department of Medical Oncology, University Medical Center,
Universiteitsweg 100, Utrecht, The Netherlands; Hubrecht Institute for
Developmental Biologyand Stem Cell Research, KNAWand University Medical
CenterUtrecht,Uppsalalaan8,Utrecht,TheNetherlands
A. Thomas Look (309), Department of Pediatric Oncology, Dana-Farber Cancer
InstituteandChildren’sHospital,Boston,Massachusetts,USA
D.R.Love(419),Molecular,CellularandDevelopmentalBiologyGroup,Schoolof
Biological Sciences, Universityof Auckland, Auckland, New Zealand; Diagnostic
Genetics,LabPlus,AucklandCityHospital,Auckland,NewZealand
David A. Lyons (25), Centre for Neuroregeneration, University of Edinburgh,
Chancellor’s Building, 49 Little France Crescent, Edinburgh, UK; Centre for
MultipleSclerosisResearch,UniversityofEdinburgh,Edinburgh,UK
Marie E. Mathers (339), Department of Pathology, Western General Hospital,
Edinburgh,EH42XU,Scotland,UK
Annemarie H. Meijer (273), Institute of Biology, Leiden University, Leiden, The
Netherlands
KathrynMilligan-Myhre(87),InstituteofMolecularBiology,UniversityofOregon,
Eugene,Oregon,USA
JamesE.N.Minchin(63),DepartmentofCellandMolecularPhysiology,University
ofNorthCarolinaatChapelHill,ChapelHill,NorthCarolina,USA
TristaE.North(117),HarvardStemCellInstitute,Cambridge,Massachusetts,USA;
DepartmentofPathology,BethIsraelDeaconessMedicalCenter,HarvardMedical
School,Boston,Massachusetts,USA
JoanieC.Neumann(3),DepartmentofPediatrics,UniversityofTexasSouthwestern
MedicalCenter,Dallas,Texas,USA;DepartmentofMolecularBiology,University
ofTexasSouthwesternMedicalCenter,Dallas,Texas,USA
E. Elizabeth Patton (339), MRC Human Genetics Unit & Edinburgh Cancer
ResearchCentre,TheUniversityofEdinburgh,Edinburgh,EH42XR,Scotland,UK
Randall T. Peterson (517, 525), Cardiovascular Research Center and Division of
Cardiology, Department of Medicine, Massachusetts General Hospital, Harvard
xviii Contributors
Medical School, Charlestown, Massachusetts, USA and Broad Institute, 7
CambridgeCenter,Cambridge,Massachusetts,USA
Ryan T. Phennicie (87), Department of Molecular & Biomedical Sciences,
UniversityofMaine,Orono,Maine,USA
John H. Postlethwait (461), University of Oregon, Institute of Neuroscience,
Eugene,Oregon,USA
JohnF.Rawls(63,87),DepartmentofCellandMolecularPhysiology,Universityof
NorthCarolinaatChapelHill,ChapelHill,NorthCarolina,USA;Departmentof
Microbiology and Immunology, University of North Carolina at Chapel Hill,
ChapelHill,NorthCarolina,USA
Rebecca Richardson (191), Institute of Developmental Biology, University of
Cologne, Cologne, Germany; Center for Molecular Medicine Cologne,
UniversityofCologne,Cologne,Germany
Adriana Rodr(cid:1)ıguez-Mar(cid:1)ı (461), University of Oregon, Institute of Neuroscience,
Eugene,Oregon,USA
Ellen van Rooijen (163), Department of Medical Oncology, University Medical
Center, Universiteitsweg 100, Utrecht, The Netherlands; Hubrecht Institute for
Developmental Biologyand Stem Cell Research, KNAWand University Medical
Center Utrecht, Uppsalalaan 8, Utrecht, The Netherlands; Present address:
Children’s Hospital Boston and Harvard Medical School, 1 Blackfan Circle,
Boston,MA02115,UnitedStates
Kirankumar Santhakumar (163), MRC-CDBG/BMS, University of Sheffield,
WesternBank,Sheffield,UnitedKingdom
Manfred Schartl (339), University of Wuerzburg, Physiological Chemistry I,
Biocenter,AmHubland,Wu€rzburg97074,Germany
Stefan Schulte-Merker (163, 223, 239), Hubrecht Institute for Developmental
Biology and Stem Cell Research, KNAW and University Medical Center
Utrecht,Uppsalalaan8,Utrecht,TheNetherlands
Herman P. Spaink (273), Institute of Biology, Leiden University, Leiden, The
Netherlands
OliverW.Stockhammer(273),InstituteofBiology,LeidenUniversity,Leiden,The
Netherlands
W.ZacStephens(87),InstituteofMolecularBiology,UniversityofOregon,Eugene,
Oregon,USA
JustinL.Tan(493),Stem Cell ProgramandDivision ofHematologyandOncology,
Children’sHospitalBoston,Dana-FarberCancerInstitute,HowardHughesMedical
InstituteandHarvardMedicalSchool,1BlackfanCircle,Boston,Massachusetts,USA
Michiel van der Vaart (273), Institute of Biology, Leiden University, Leiden, The
Netherlands
Emile Voest (163), Department of Medical Oncology, University Medical Center,
Universiteitsweg100,Utrecht,TheNetherlands
Brant M. Weinstein (137), Program in the Genomics of Differentiation, National
InstituteofChildHealthandDevelopment,NationalInstitutesofHealth,Bethesda,
Maryland,USA