the study on: effect of cigarette smoking on hematological parameters and pulmonary function tests

115 Pages·2013·1.55 MB·English

by  Mohammed Arzoo

THE STUDY ON: EFFECT OF CIGARETTE SMOKING ON
HEMATOLOGICAL PARAMETERS AND PULMONARY
FUNCTION TESTS
By
Dr. NADERA YASMEEN
M.B.B.S.
Dissertation submitted to the
Rajiv Gandhi University of health sciences, Karnataka, Bangalore
In partial fulfillment of
the requirements for the degree of

DOCTOR OF MEDICINE
in
PHYSIOLOGY
Under the guidance of
Dr. R.B. PATIL
M.D
Associate Professor

Department of Physiology
M.R. Medical College
Gulbarga
2014
i
Rajiv Gandhi University of Health Sciences, Karnataka, Bangalore

DECLARATION BY THE CANDIDATE

I hereby declare that this dissertation entitled “The study on: Effect of cigarette
smoking on hematological parameters and pulmonary function tests” is a
bonafide and genuine research work carried out by me under the guidance of Dr. R.B.
Patil Associate Professor, Department of Physiology, M.R. Medical College,
M.D.
Gulbarga.

Date: / / 2013
Place: Gulbarga Dr. Nadera Yasmeen

ii
Rajiv Gandhi University of Health Sciences, Karnataka, Bangalore

CERTIFICATE BY THE GUIDE

This is to certify that the dissertation entitled “The study on: Effect of cigarette
smoking on hematological parameters and pulmonary function tests” is a
bonafide research work done by Dr. Nadera Yasmeen in partial fulfillment of the
requirement for the degree of M.D.(Physiology).

Signature of the Guide
Date: / / 2013
Place: Gulbarga Dr. R.B. Patil
M.D.
Associate Professor
Department of Physiology
M.R. Medical College,
Gulbarga

iii
Rajiv Gandhi University of Health Sciences, Karnataka, Bangalore

CERTIFICATE BY THE CO-GUIDE

This is to certify that the dissertation entitled “The study on: Effect of cigarette
smoking on hematological parameters and pulmonary function tests” is a
bonafide research work done by Dr. Nadera Yasmeen in partial fulfillment of the
requirement for the degree of M.D. (Physiology).

Signature of the Co-Guide
Date: / / 2013
Place: Gulbarga Dr. S.N. Patil
M.D.
Associate Professor
Department of Medicine
M. R. Medical College
Gulbarga

iv
Rajiv Gandhi University of Health Sciences, Karnataka, Bangalore

ENDORSEMENT BY THE HOD, PRINCIPAL/HEAD OF THE
INSTITUTION

This is to certify that the dissertation entitled “The study on: Effect of cigarette
smoking on hematological parameters and Pulmonary function tests” is a
bonafide research work done by Dr. NADERA YASMEEN under the guidance of
Dr. R.B. Patil Associate Professor, Department of Physiology, M.R. Medical
M.D.
College, Gulbarga.

Seal and signature of the HOD Seal and signature of the Principal

Dr. B. S. Mali Patil Dr. Mallikarjun B.
M.D. M.D

Professor and Head of the Principal,
Department of Physiology, M.R. Medical College,
M.R. Medical College, Gulbarga.
Gulbarga.

Date: / / 2013 Date: / / 2013
Place: Gulbarga Place: Gulbarga

v
COPY RIGHT

DECLARATION BY THE CANDIDATE

I hereby declare that the Rajiv Gandhi University of Health Sciences, Karnataka, shall
have the rights to preserve, use and disseminate this dissertation / thesis in print or
electronic format for academic / research purpose.

Signature of the Candidate
Date: / / 2013
Place: Gulbarga Dr. NADERA YASMEEN

© Rajiv Gandhi University of Health Sciences, Karnataka

vi
ACKNOWLEDGEMENT
I am extremely grateful to the Almighty for always being with me and guiding me
throughout my life.
It gives me immense pleasure to express my deep and heartfelt gratitude, humble and
sincere thanks to my guide Dr. R.B. Patil Associate Professor, Department of
M.D.
Physiology M. R. Medical College Gulbarga who with his knowledge and expertise
has provided able guidance, valuable advice, constant support and encouragement.
I am very grateful to my co-guide Dr. S.N. Patil Associate Professor, Department
M.D.
of Medicine M. R. Medical College Gulbarga for his valuable suggestions, constant
help and guidance.
It gives me great pleasure to thank my Professor and Head of the department of
Physiology Dr. B.S. Mali Patil for his constant encouragement, support and also
M.D.
for being a constant source of inspiration.
I am extremely thankful to Dr. B. Mallikarjun Dean M.R. Medical College, for
M.D.
his kind permission to take up this work in the Department of Physiology.
I express my sincere thanks to Dr. Ashwini Associate Professor, Department of
M.D.
Physiology for her valuable support.
I am grateful to Dr. Ehtesham Ali Farooqui Dr. Vinod Prabhushetty . and
M.D., M.D
Dr. Roopa Mathapati Asst. Professors, and Dr. Shilpa Patil Tutor,
M.D. M.D.
Department of Physiology for their advice and suggestions.
I am thankful to Shrinivas Reddy for his support and guidance in statistical work.
I am thankful to my fellow postgraduate colleagues for their co-operation and timely
help during my study.
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I am thankful to all the Technical and non-technical staff of the Department of
Physiology, for their co-operation during my study. I thank all the subjects who have
voluntarily participated in this study.
My thanks to Er. Mohammed AA Arzoo for the meticulous computerized laser output
of this dissertation.
My sincere thanks to my parents for their abundant love, endurance support
innumerable sacrifices and unceasing encouragement that has moulded me into a
person I am today.
I am extremely thankful to my children for their love, support, help, encouragement
and co-operation during my study.
I thank all my family members, for their constant encouragement.

Date: / / 2013 Dr. Nadera Yasmeen.
Place: Gulbarga

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LIST OF ABBREVIATIONS USED

BFU-E - Blast forming unit –Erythrocyte
CFU-E - Colony forming unit- Erythrocyte
CFU-MK - Colony forming unit – Megakaryocyte
COPD - Chronic obstructive Pulmonary Disease
ESR - Erythrocyte Sedimentation Rate
FEF - Mean Forced Expiratory Flow during the
25-75%
middle of FVC

FEV1 - Forced Expiratory Volume in 1st sec
FVC - Forced Vital Capacity
G-CSF - Granulocyte-Colony Stimulating Factor
GM-CSF - Granulocyte Macrophage-Colony
stimulating Factor

Hb - Hemoglobin
HDL-C - High Density Lipoprotein Cholesterol
IGF-1 - Insulin like Growth Factor-1
IgE - Immunoglobulin E
IL - Interleukin
LDL - Low Density Lipoprotein
MCV - Mean Corpuscular Volume
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MVV - Maximum Voluntary Ventilation
PCV - Packed Cell Volume
PEFR - Peak Expiratory Flow Rate
RBC - Red blood cell
SE - Standard Error
TLC - Total Leucocyte Count
TNF-α - Tumor Necrosis Factor-α
VC - Vital Capacity

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