Table Of ContentTHE STRESSED HEART
DEVELOPMENTS IN CARDIOVASCULAR MEDICINE
Lancee, C.T., ed.: Echocardiology. 1979. ISBN ')0-247-2209-8.
Baan, J, Arntzenius, A. c., Yellin, E.L., eds.: Cardiac dynamics. 1980. ISBN 90-247-2212-8.
Thalen, H.J.T., Meere, c.c., eds.: Fundamentals of cardiac pacing. 1970. ISBN 90-247-2245-4.
Kulbertus, H.E., Wellens, H.JJ., cds.: Sudden death. 1980. ISBN 90-247-2290-X.
Dreifus, L.S., Brest, A.N., eds.: Clinical applications of cardiovascular drugs. 1980. ISBN 90-::!47-2295-0.
Spencer, M. P., Reid, J. M., cds. : Cerebrovascular evaluation with Doppler ultrasound. 1981. ISBN
90-247-2348-1.
Zipes, D. P., Bailey, J. c., Elharrer, V., cds.: The slow inward current and cardiac arrhythmias. 1980.
ISBN 90-247-2380-9.
Kesteloot, H., Joossens, J. V., eds.: Epidemiology of arterial blood pressure. 1980. ISBN 90-247-2386-8.
Wackers, F.J. T., ed.: Thallium-2ot and technetium-99m-pyrophosphate myocardial imaging in the coronary
care unit. 1980. ISBN 90-247-2396-5.
Maseri, A., Marchesi, c., Chierchia, S., Trivella, M.G., eds.: Coronary care units. 1981. IBSN 90-247-2456-2.
Morganroth, J., Moore, E.N., Dreifus, L.S., Michelson, E. L., eds.: The evaluation of new anti-arrhythmic
drugs. 1981. ISBN 90-247-2474-0.
Alboni, P.: Intraventricular conduction disturbances. 1981. ISBN 90-247-2483-X.
Rijsterborgh, H., ed.: Echocardiology. 1981. ISBN 90-247-2491-0.
Wagner, G.S., ed.: Myocardial infarction. Measurement and intervention. 1982. ISBN 90-247-2513-5.
Meltzer, R. S., Roelandt, J., eds.: Contrast echocardiography. 1982. ISBN 90-247-2531-3.
Amery, A., Fagard, R., Lijnen, R., Staessen, J., eds.: Hypertensive cardiovascular disease; pathophysiology
and treatment. 1982. ISBN 90-247-2534-8.
Bouman, L. N., Jongsma, H.J., eds.: Cardiac rate and rhythm. 1982. ISBN 90-247-2626-3.
Morganroth,J., Moore, E.N., eds.: The evaluation of beta blocker and calcium antagonist drugs. 1982.
ISBN 90-247-2642-5.
Rosenbaum, M.B., ed.: Frontiers of cardiac electrophysiology. 1982. ISBN 90-247-2663-8.
Roelandt, J., Hugenholtz, P. G., eds.: Long-term ambulatory electrocardiography. 1982. ISBN 90-247-2664-8.
Adgey, A.J., ed.: Acute phase of ischemic heart disease and myocardial infarction. 1982. ISBN 90-247-2675-1.
Hanrath, P., Bleifeld, W., Souquet, eds.: Cardiovascular diagnosis by ultrasound. Transcsophageal,
computerized, contrast, Dopplerechocardiography. 1982. ISBN 90-247-2692-1.
Roelandt, J., ed.: The practice of M-mode and two-dimensional echocardiography. 1983. ISBN 90-247-2745-6.
Meyer, J., Schweizer, P., Erbel, R., eds.: Advances in noninvasive cardiology. 1983. ISBN 0-89838-576-8.
Morganroth,Joel, Moore, E.N., eds.: Sudden cardiac death and congestive heart failure: Diagnosis and
treatment. 1983. ISBN 0-89838-580-6.
Perry, H.M., ed.: Lifelong management of hypertension. ISBN 0-89838-582-2.
Jaffe, E. A., ed.: Biology of endothelial cells. ISBN 0-89838-587-3.
Surawicz, B., Reddy c.P., Prystowsky, E.N., eds.: Tachycardias. 1984. ISBN 0-89838-588-1.
Spencer, M.P., ed.: Cardiac Doppler diagnosis. ISBN 0-89838-591-1.
Villareal, H. V., Sambhi, M. P., eds.: Topics in pathophysiology of hypertension. ISBN 0-89838-595-4.
Messerli, F.H., ed.: Cardiovascular disease in the elderly. 1984. ISBN 0-89838-596-2.
Simoons, M.L., Reiber, I.H.C., eds.: Nuclear imaging in clinical cardiology. ISBN 0-89838-599-7.
Ter Keurs, H. E. D.J., Schipperheym, J.J., eds.: Cardiac left ventricular hypertrophy. ISBN 0-89838-612-8.
Sperelakis, N., ed.: Physiology and pathophysiology of the heart. ISBN 0-89838-615-2.
Messerli, F.H., ed.: Kidney in essential hypertension. 1983. ISBN 0-89838-616-0.
Sambhi, M.P., ed.: Fundamental fault in hypertension. ISBN 0-89838-638-1.
Marchesi, D., ed.: Ambulatory monitoring: Cardiovascular system and allied applications. ISBN
0-89838-642-X.
Kupper, W., Macalpin, R.N., B1eifeld, W., eds.: Coronary tone in ischemic heart disease. ISBN
0-89838-646-2.
Sperelakis, N., Caulfield, J. B., eds.: Calcium antagonists: Mechanisms of action on cardiac muscle and vascular
smooth muscle. ISBN 0-89838-655-1.
Godfraind, T., Herman, A. S., Wellens, D., eds.: Entry blockers in cardiovascular and cerebral dysfunctions.
ISBN 0-89838-658-6.
Morganroth, J., Moore, E. N., eds.: Interventions in the acute phase of myocardial infarction. ISBN
0-89838-659-4.
Abel, F.L., Newman, W.H., eds.: Functional aspects of the normal, hypertrophied, and failing heart.
ISBN 0-89838-665-9.
Sideman, S., and Beyar, R., eds.: Simulation and imaging of the cardiac system. ISBN 0-89838-687-X.
van de Wall, E., Lie, K.I., eds.: Recent views on hypertrophic cardiomyopathy. ISBN 0-89838-694-2.
Beamish, R.E., Singal, P.K., Dhalla, N.S., eds.: Stress and heart disease. ISBN 089838-709-4.
Beamish, R.E., Panagia, V., Dhalla, N.S., eds.: Pathogenesis of stress-induced heart disease. ISBN
0-89838-710-8.
Morganroth, J., Moore, E. N., eds.: Cardiac arrhythmias: New therapeutic drugs and devices.
ISBN 0-89838-716-7.
Mathes, P., ed.: Secondary prevention in coronary artery disease and myocardial infarction. ISBN
0-89838-736-1.
Stone, H. Lowell, Weglicki, W.B., eds.: Pathology of cardiovascular injury. ISBN 0-89838-743-4.
Meyer, J., Erbel, R., Rupprecht, H.J., eds.: Improvement of myocardial perfusion. ISBN 0-89838-748-5.
Reiber, J. H. c., Serruys, P. W., Slager, c.].: Quantitative coronary and left ventricular cineangiography.
ISBN 0-89838-760-4.
Fagard, R.H., Bekaert, I.E., eds.: Sports Cardiology. ISBN 0-89838-782-5.
Reiber, J.H.C., Serruys, P.W., eds.: State of the art in quantitative coronary arteriography. ISBN
0-89838-804-X.
Roelandt, J., ed.: Color doppler flow imaging. ISBN 0-89838-806-6.
van der Wall, E.E., ed.: Noninvasive imaging of cardiac metabolism. ISBN 0-89838-812-0.
Liebman, J., Plonsey, R., Rudy, Y., eds., Pediatric and fundamental electrocardiography. ISBN 0-89838-815-5.
Hilger, H., Hombach, V., eds., Invasive cardiovascular therapy. ISBN 0-89838-818-X.
THE STRESSED HEART
EDITED BY MARIANNE]. LEGATO, M.D.
Associate Professor of Clinical Medicine
Columbia University College of Physicians and Surgeons
MARTINUS NIJHOFF PUBLISHING
A Member of the Kluwer Academic Publishers Group
Boston/Dordrecht/Lancaster
©
1987 by Martinus NijhoffPublishing, Boston.
Softcover reprint of the hardcover 1s t edition 2007
All rights reserved. No part of this publication may be reproduced, stored in a retrieval system, or
transmitted in any form or by any means, mechanical, photocopying, recording, or otherwise,
without the prior written permission of the publishers.
Martinus NijhoffPublishing, 101 Philip Drive, Assinippi Park, Norwell, MA 02061
Distributors
for the United States and Canada: Kluwer Academic Publishers, 101 Philip Drive, Assinippi Park,
Norwell, MA 02061
for the UK and Ireland: Kluwer Academic Publishers, MTP Press Limited, Falcon House, Queen
Square, Lancaster LAI IRN, UK
for all other countries: Kluwer Academic Publishers Group, Distribution Centre, P.O. Box 322,
3300 AH Dordrecht. The Netherlands
Library of Congress Cataloging-in-Publication Data
The Stressed heart.
(Developments in cardiovascular medicine; (62)
Includes index.
\. Heart-Hypertrophy-Etiology. 2. Stress
(Physiology) 3. Heart-Diseases. 4. Physiology,
Pathological. I. Legato, Marianne J.. 1935-
II. Series: Developments in cardiovascular medicine;
v. 62. [DNLM: 1. Heart-physiopathology. 2. Heart
Enlargment-physiopathology. WI DE997VME v. 62/
WG200S914]
RC685.H9S771987 616.1'2071 86-28474
ISBN-13: 978-1-4612-9214-2 e-ISBN-13: 978-1-4613-2041-8
DOl: 10.1007/978-1-4613-2041-8
For Michael R. Rosen, M.D.
In recognition of his lively intelligence, his unswerving integrity, and his
qualities ofleadership. They have illuminated and expanded investigative
cardiology for us all.
CONTENTS
1. Regulation of gene expression in the normal and overloaded heart
JEAN MARIE MOALIC and BERNARD SWYNGHEDAUW
2. Cell stress and the initiation of growth 21
GRAEME L. HAMMOND
3. Subcellular growth of cardiocytes during hypertrophy 49
ROBERT J. TOMANEK and CRAIG A. CANBY
4. Capillarity and the distribution of capillaries and mitochondria in cardiac
growth 67
NATALIO BANCHERO
5. The coronary vasculature during myocardial hypertrophy 87
WILLIAM M. CHILIAN, ROBERT J. TOMANEK and MELVIN L. MARCUS
6. Microcirculation in the stressed heart 107
KAREL RAKUSAN
7. Pathology and pathophysiology of the coronary microcirculation in myocardial
ischemia 125
STEPHEN M. FACTOR
8. The biochemistry of myocardial failure 149
LOUIS A. SORDAHL and CLAUDE R. BENEDICT
9. Force-interval relationship and activator calcium availability: similarities of
sympathetic stimulation and hypertrophy and heart failure 169
PAGE A. W. ANDERSON
vii
viii Contents
10. Right atrial ultrastructure in coronary artery disease: characterization of chronic
ischemia 219
JOHN J. FENOGLIO, JR. and TUAN DUC PH AM
11. Connective tissue in the normal and hypertrophied heart 235
THOMAS F. ROBINSON
12. Myocardial hypertrophy and cardiac failure: a complex interrelationship 253
BARRY M. MASSIE
13. The regression of cardiac hypertrophy: functional, anatomic, and hemodynamic
considerations 275
GEORGE COOPER, IV
14. Regression ofleft ventricular hypertrophy: clinical considerations 289
ANTHONY P. GOLDMAN and MORRIS N. KOTLER
15. The cardiocyte in senescence 311
ROBERT J. TOMANEK
16. Stress and sudden death 323
EDWARD M. DWYER, JR.
CONTRIBUTING AUTHORS
Page Anderson, M.D.
Professor of Pediatrics
Duke University School of Medicine
Durham, NC 27710
Natalio Banchero, M.D.
Professor of Physiology
University of Colorado Health Sciences Center
4200 East 9th A venue
Denver, Colorado 80262
Claude R. Benedict, M.D.
Assistant Professor of Medicine
University of Texas Medical Branch
Galveston, Texas 77550
Craig A. Canby, M.D.
Graduate Student
Department of Anatomy
University oflowa Cardiovascular Center
Iowa City, Iowa 52242
x Contributing Authors
William M. Chilian, Ph.D.
Department of Medical Physiology
Texas A & M University College of Medicine
College Station, Texas 77843
George Cooper, IV, M.D.
Professor of Medicine and Physiology
Medical University of South Carolina
Cardiology Section, Department of Medicine
V A Medical Center
109 B Street
Charleston, South Carolina 29403
EdwardM. Dwyer,jr., M.D.
Professor of Clinical Medicine
Columbia University College of Physicians and Surgeons
St. Luke's-Roosevelt Hospital Center
428 West 59th Street
New York, New York 10019
Stephen Factor, M.D.
Professor of Pathology and Associate Professor of Medicine
Albert Einstein College of Medicine
1300 Morris Park A venue
Bronx, New York 10461
john Fenoglio, j r., M. D.
Professor and Chairman, Department of Pathology
Columbia University College of Physicians and Surgeons
622 West 168th Street
New York, New York 10032
Anthony P. Goldman, M.D.
Assistant Professor of Medicine
Temple University School of Medicine
Albert Einstein Medical Center
York and Tabor Roads
Philadelphia, Pennsylvania 19141
Graeme L. Hammond, M.D.
Professor of Cardiothoracic Surgery
Acting Chief, Cardiothoracic Surgery
Yale University School of Medicine
New Haven, Connecticut 06510
xi
Morris N. Kotler, M.D.
Professor of Medicine
Temple University School of Medicine
Albert Einstein Medical Center
York and Tabor Roads
Philadelphia, Pennsylvania 19141
Melvin L. Marcus, M.D.
Professor of Medicine
University ofIowa Cardiovascular Center
Iowa City, Iowa 52242
Barry M. Massie, M.D.
Associate Professor of Medicine
University of California, San Francisco
Cardiology Division (111 C)
VA Hospital
4150 Clement Street
San Francisco, California 94121
Jean Marie Moalic, Ph.D.
INSERM U 127
Hopital Lariboisicre
41 Boulevard de la Chapelle
75010
Paris, France
Karel Rakusan, M.D., Ph.D.
Professor of Physiology
University of Ottawa College of Medicine
Ottawa, Ontario Canada
Thomas F. Robinson, Ph.D.
Associate Professor of Medicine and Physiology and Biophysics
Albert Einstein College of Medicine
1300 Morris Park A venue
Bronx, New York 10461
Bernard Swynghedauw, M.D.
INSERM U 127
Hopital Lariboisicre
41 Boulevard de la Chapelle
75010
Paris, France
