Table Of ContentTHE SEPSIS TEXT
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THE SEPSIS TEXT
edited by
Jean-Louis Vincent, M.D.
Department of Intensive Care
Erasme University Hospital
Brussels ,Belgium
Jean Carlet, M.D.
Service de Réanimation Polyvalente
Hôpital Saint-Joseph
Paris, France
Steven M. Opal, M.D.
Division of Infectious Diseases
The Memorial Hospital of Rhode Island
Pawtucket, RI
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CONTENTS
Contributors xi
Introduction
JL Vincent,J Carlet,SOpal xix
GENERALITIES
1. Sepsis: Themagnitude oftheproblem
JL Vincent 1
2. Diagnosis and source of sepsis: The utility of clinical
findings
KCruz, RPDellinger 11
3. Organ failure
R Moreno, RMatos, T Fevereiro 29
4. Markers ofsepsis
H. Redl,ASpittler,W Strohmaier 47
5. Genetic predisposition
F Stüber 67
6. Quantifyingrisk in sepsis: Areview ofillness severity
and organ dysfunction scoring
RS Wax,DCAngus, WKnaus 81
vi
PATHOPHYSIOLOGY
7. The pathogenesis ofGram-negative sepsis
C Papasian, DC Morrison 97
8. The pathophysiology of Gram-positive shock
RK Beaton, J Cohen 117
9. Immunopathogenesis of Gram-negative shock
SM Opal,CEHubert 135
10. Involvement ofpro- and anti-inflammatory cytokines
in sepsis
JM Cavaillon,MAdib-Conquy 159
11. Pathophysiology of immunodepression inICUpatients
HD Volk, CHöflich, GGrütz, WDDöcke,PReinke 197
12. Pathophysiology ofsepsis: the role ofnitric oxide
SJFinney, TWEvans 211
13. Apoptosis and the resolution ofinflammation in sepsis
GJ Bellingan 231
14. Microvascular alterations in sepsis
AW Sielenkämper, P Kvietys, WJ Sibbald 247
15. Cytopathic hypoxia
MP Fink 271
MONITORING SYSTEMS
16. Invasive hemodynamic monitoring
E Huettemann, SG Sakka, K Reinhart 285
17. Value of in sepsis
T Boulain,JL Teboul 309
vii
18. Blood lactate concentrations in sepsis
JA Kruse 323
19. Veno-arterial gradient
V Castelain, JL Teboul 339
20. Gas tonometry
E Silva, LF Poli de Figueiredo 353
GENERAL SUPPORT
21. Generalhemodynamicsupport
SMHollenberg 375
22. Fluid administration
ARWebb 389
23. Bloodtransfusionandsepsis
DNeilipovitz,PCHébert 401
24. Catecholamine therapy
C Martin, JF Dasta, GM Susla 421
25. Regional effects ofcatecholamines
AMeier-Hellmann 445
26. Managementofrespiratorydysfunctionin patients
with severe sepsis
GSMartin, GRBernard 455
27. The roleofnutritionalsupportin sepsis
DKHeyland,JKLukan,SAMcClave 479
MICROBIAL ASPECTS
28. The sources ofsepsis
C Alberti, C Brun-Buisson 491
viii
29. Catheter-related sepsis
JF Timsit 505
30. Control of the source of sepsis
JC Marshall 525
31. Empirical antibiotic therapy for patients with severe
sepsis and septic shock
PY Bochud, MP Glauser, J Carlet, T Calandra 539
32. Candida infections in the intensive care unit
JS Solomkin, EJ Anaissie, BB Albair 559
33. Why, when and how to isolate ICU patients
B Rubinovitch, P Eggimann, D Pittet 581
COMPLICATIONS
34. The lung in sepsis
PM Suter 609
35. The heart in sepsis
B Tavernier, A Mebazaa 619
36. The brain in sepsis
B Philips, D Bennett 633
37. The gut in sepsis
B Vallet 645
38. The kidney in sepsis
MG Vervloet, HA Piepot, ABJ Groeneveld 665
39. The coagulation system in sepsis
CE Hack 687
ix
ANTI-SEPSIS THERAPIES
40. Should fever be treated in sepsis?
BACunha 705
41. Anti-cytokine therapy
EAbraham 719
42. Heat shockproteins and sepsis: Ahot story
JVillar,ASSlutsky 729
43. Immunodepression in the surgical patient and
increased susceptibility to infection
MK Angele, E Faist 743
44. The place ofcorticosteroids
DAnnane,EBellissant 757
45. The place of immunonutrition
BLZarzaur, KAKudsk 769
46. Interferencewith the coagulation system
LGThijs 787
47. Hemofiltration and plasmapheresis
P Rogiers 801
48. Endotoxin analogs in the treatment ofseptic shock
MEAstiz 815
49. Vaccines against bacterial endotoxins
AKBhattacharjee, AS Cross, SM Opal 827
Index 837
