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APRIL 2016
Contents
THE SCIENTIST THE-SCIENTIST.COM VOLUME 30 NUMBER 4
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U Microbes Meet Cancer A Diff erent Way of The Forces of Cancer
O
E S Understanding cancer’s relationship with Doing Things A tumor’s physical environment fuels its
C
N the human microbiome could transform Cancer cells exhibit altered metabolic growth and causes treatment resistance.
E
SCI immune-modulating therapies. processes that may serve as promising BY LANCE L. MUNN AND RAKESH K. JAIN
/
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C BY KATE YANDELL targets for new therapies.
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©
04.2016 | THE SCIENTIST 3
BioResearch
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APRIL 2016
Department Contents
17 13 FROM THE EDITOR 67 SCIENTIST TO WATCH
Shooting for the Moon Pradeep Chaluvally-Raghavan:
Defeating cancer is many times more Curious about Cancer
difficult than planting a flag on our BY JEF AKST
lunar satellite.
BY MARY BETH ABERLIN 71 LAB TOOLS
Pulling It All Together
17 NOTEBOOK Systems-biology approaches offer
A Tree Takes Root; Putting the Pee new strategies for finding hard-to-
in Pluripotency; The Two Faces of identify drug targets for cancer.
Fish Oil; Cancer Be Damned BY KATE YANDELL
31 CRITICS AT LARGE 75 LAB TOOLS
Pet Scans Written in Blood
Studying tumor development and A tour of evolving strategies for
treatment in dogs and cats could identifying circulating disease
improve the successful translation of biomarkers
new cancer drugs. BY JYOTI MADHUSOODANAN
BY TIMOTHY M. FAN, AMY K.
LEBLANC, AND NICOLA MASON 79 BIO BUSINESS
Banking on Blood Tests
33 ONLINE FIRST How close are liquid biopsies to
Two-Way Traffic replacing current diagnostics?
In mice, malignant cells genetically BY JYOTI MADHUSOODANAN
modified to express an anticancer
EN cytokine home in on tumors and 82 READING FRAMES
Z
EE reduce their growth. Parallel Plagues
H
R BY ANNA AZVOLINSKY Like cancer, ecological scourges
E
ND result from the breakdown of
A
A; S 36 MODUS OPERANDI regulatory processes, and may be
M 58 Tumor-Shrinking Triple-Helices treated with similar logic.
A
Y
KA Making therapeutic microRNAs BY SEAN B. CARROLL
O both stable and sticky
DI 62
TU BY RUTH WILLIAMS 83 CAPSULE REVIEWS
S
/
A BY BOB GRANT
M
YA 58 THE LITERATURE
A
MI K Cancer’s Vanguard 88 FOUNDATIONS
U Exosomes are emerging as key Fighting Cancer with Infection, 1891
K
© I players in metastasis. BY CATHERINE OFFORD
E;
N BY CATHERINE OFFORD
O
RB Plus: Tumor Traps; Cancerous IN EVERY ISSUE
A
E C Conduits 10 CONTRIBUTORS
L
E
H
MIC 62 PROFILE 14 SPEAKING OF SCIENCE
OF Guts and Glory
SY Hans Clevers: From developmental 84 THE GUIDE
E
RT biology to developing organoids
U
CO BY ANNA AZVOLINSKY 87 RECRUITMENT
04.2016 | THE SCIENTIST 5
APRIL 2016
Online Contents
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