The Neuroimmunological Basis of Behavior and Mental Disorders

437 Pages·2009·5.49 MB·English

by  William A. Banks

The Neuroimmunological Basis of Behavior
and Mental Disorders
Allan Siegel (cid:129) Steven S. Zalcman
Editors
The Neuroimmunological
Basis of Behavior and
Mental Disorders
1 23
Editors
Allan Siegel Steven S. Zalcman
Departments of Neurology and Neuroscience University of Medicine and Dentistry
and Psychiatry of New Jersey — NJ Medical School,
University of Medicine and Dentistry of New Newark, NJ 07103, USA
Jersey — NJ Medical School, [email protected]
Newark, NJ 07103, USA
[email protected]
ISBN: 978-0-387-84850-1 e-ISBN: 978-0-387-84851-8
DOI 10.1007/978-0-387-84851-8
Library of Congress Control Number: 2008937579
© Springer Science+Business Media, LLC 2009
All rights reserved. This work may not be translated or copied in whole or in part without the written
permission of the publisher (Springer Science+Business Media, LLC, 233 Spring Street, New York,
NY 10013, USA), except for brief excerpts in connection with reviews or scholarly analysis. Use in
connection with any form of information storage and retrieval, electronic adaptation, computer software,
or by similar or dissimilar methodology now known or hereafter developed is forbidden.
The use in this publication of trade names, trademarks, service marks, and similar terms, even if they are
not identifi ed as such, is not to be taken as an expression of opinion as to whether or not they are subject to
proprietary rights.
Printed on acid-free paper
springer.com
For Carla Siegel, and Anna and Mier Zalcman
“Who is wise? One who learns from every person.”
Contents
Part I Neuroimmune Interactions .................................................................. 1
Cytokines and the Blood–Brain Barrier ........................................................... 3
William A. Banks, Jessica L. Lynch, and Tulin O. Price
Neurochemical and Endocrine Responses to Immune Activation:
the Role of Cytokines ........................................................................................ 19
Adrian J. Dunn
Neural Pathways Mediating Behavioral Changes Associated
with Immunological Challenge ........................................................................ 35
Lisa E. Goehler and Ron P.A. Gaykema
Molecular Basis of Cytokine Function ............................................................ 59
Pranela Rameshwar and Arlene Bardaguez
Interferon-α, Molecular Signaling Pathways and Behavior ......................... 71
Jianping Wang
Exercise and Stress Resistance: Neural-Immune Mechanisms .................... 87
Monika Fleshner, Sarah L. Kennedy, John D. Johnson,
Heidi E. W. Day, and Benjamin N. Greenwood
Part II Neuroimmunological Basis of Behavior ........................................ 109
Alteration of Neurodevelopment and Behavior by
Maternal Immune Activation ......................................................................... 111
Stephen E.P. Smith and Paul H. Patterson
vii
viii Contents
Interleukin-2 and Septohippocampal Neurons:
Neurodevelopment and Autoimmunity ......................................................... 131
John M. Petitto, Zhi Huang, Grace K. Ha, and Daniel Dauer
Cytokine-Induced Sickness Behavior and Depression ................................ 145
Q. Chang, S.S. Szegedi, J.C. O’Connor, R. Dantzer, and K.W. Kelley
Effect of Systemic Challenge with Bacterial Toxins on
Behaviors Relevant to Mood, Anxiety and Cognition .................................. 183
Rachel A. Kohman, Joanne M. Hash-Converse, and Alexander W. Kusnecov
Cytokines, Immunity and Sleep ..................................................................... 209
Francesca Baracchi and Mark R. Opp
Cytokines and Aggressive Behavior .............................................................. 235
Allan Siegel, Suresh Bhatt, Rekha Bhatt, and Steven S. Zalcman
Neurochemical and Behavioral Changes Induced by
Interleukin-2 and Soluble Interleukin-2 Receptors ..................................... 261
Steven S. Zalcman, Randall T. Woodruff, Ruchika Mohla, and Allan Siegel
Part III Neuroimmunological Basis of Mental Disorders ........................ 285
Immunity and Depression: A Clinical Perspective ...................................... 287
Steven J. Schleifer
Cytokines, Immunity and Schizophrenia with Emphasis
on Underlying Neurochemical Mechanisms ................................................. 307
Norbert Müller and Markus J. Schwarz
Immunobiological and Neural Substrates of Cancer-Related
Neurocognitive Defi cits ................................................................................... 327
Martin Klein
Autoimmunity and Brain Dysfunction .......................................................... 341
Steven A. Hoffman and Boris Sakic
Viruses and Psychiatric Disorders ................................................................. 383
Bradley D. Pearce
Microglial Cells and Infl ammatory Cytokines in the Aged Brain .............. 411
Amy F. Richwine and Rodney W. Johnson
Index ................................................................................................................. 425
Contributors
William A. Banks Departments of Internal Medicine, Geriatric Division and
Pharmacological and Physiological Science, Saint Louis University School of
Medicine, 1402 South Grand Blvd, St. Louis, MO 63104, [email protected]
Francesca Baracchi Department of Anesthesiology, 7422 Medical Sciences
Building I, 1150 West Medical enter Drive, University of Michigan, Ann Arbor,
MI 48109–5615, USA
Arlene Bardeguez Department of Obstretrics, UMDNJ – NJ Medical School 185
South Orange Avenue, Newark, NJ 07103, USA
Rekha Bhatt Departments of Neurology & Neuroscience and Psychiatry,
UMDNJ – New Jersey Medical School, MSB Room H-512, 185 South Orange
Avenue, Newark, NJ 07103, USA
Suresh Bhatt Departments of Neurology & Neuroscience and Psychiatry,
UMDNJ – New Jersey Medical School, MSB Room H-512, 185 South Orange
Avenue, Newark, NJ 07103, USA
Q. Chang Integrative Immunology and Behavior Program, Department of Animal
Sciences, College of Medicine, University of Illinois at Urbana-Champaign, 212
Edward R. Madigan Laboratory, 1201 West Gregory Drive, Urbana, IL 61801, USA
Robert Dantzer Integrative Immunology and Behavior Program, Department
of Animal Sciences, College of Medicine, University of Illinois at Urbana-
Champaign, 212 Edward R. Madigan Laboratory, 1201 West Gregory Drive,
Urbana, IL 61801, USA
Daniel Dauer McKnight Brain Institute, Departments of Psychiatry,
Neuroscience, and Pharmacology & Therapeutics, College of Medicine,
University of Florida, Box 100256, Gainesville, FL 32610–0256, USA
Heidi E.W. Day Department of Integrative Physiology, Center for Neuroscience,
University of Colorado-Boulder, Clare Small Building, Boulder, CO 80309–0354, USA
Adrian J. Dunn Department of Psychology, Pacifi c Biosciences Research Center,
University of Hawaii, 1993 East-West Road, Honolulu, HI 96822–2321, USA,
[email protected]
ix
x Contributors
Monika Fleshner Department of Integrative Physiology, Center for
Neuroscience, University of Colorado-Boulder, Clare Small Building, Boulder,
CO 80309–0354, USA, fl [email protected]
Ron P.A. Gaykema Laboratory of Neuroimmunology & Behavior Program in
Sensory and Systems Neuroscience, Department of Psychology & Neuroscience
Graduate Program, University of Virginia, 102 Gilmer Hall, P.O. Box 400400,
Charlottesville, VA 22904–4400, USA
Lisa E. Goehler Laboratory of Neuroimmunology and Behavior, Center for
the Study of Complementary and Alternative Therapies, School of Nursing,
University of Viginia, Charlottesville, VA 22908, USA, [email protected]
Benjamin N. Greenwood Department of Integrative Physiology, Center for
Neuroscience, University of Colorado-Boulder, Clare Small Building, Boulder,
CO 80309–0354, USA
Grace K. Ha McKnight Brain Institute, Departments of Psychiatry,
Neuroscience, and Pharmacology & Therapeutics, College of Medicine,
University of Florida, Box 100256, Gainesville, FL 32610–0256, USA
Joanne M. Hash-Converse Behavioral Neuroscience Program, Department of
Psychology, Rutgers University, Piscataway, NJ 08855, USA
Steven A. Hoffman. Neuroimmunology Labs, School of Life Sciences, College
of Liberal Arts and Sciences, Arizona State University, P.O. Box 874501, Tempe,
AZ 85287–4501, USA, [email protected]
Zhi Huang McKnight Brain Institute, Departments of Psychiatry, Neuroscience,
and Pharmacology & Therapeutics, College of Medicine, University of Florida,
Box 100256, Gainesville, FL 32610–0256, USA
John D. Johnson Department of Integrative Physiology, Center for Neuroscience,
University of Colorado-Boulder, Clare Small Building, Boulder, CO 80309–0354, USA
Rodney W. Johnson Integrative Immunology and Behavior Program,
Department of Animal Sciences, University of Illinois, 1207 West Gregory Drive,
Urbana, IL 61801, USA, [email protected]
Keith W. Kelley Integrative Immunology and Behavior Program, Department
of Animal Sciences, College of ACES, Department of Pathology, College of
Medicine, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA,
[email protected]
Sarah L. Kennedy Department of Integrative Physiology, Center for Neuroscience,
University of Colorado-Boulder, Clare Small Building, Boulder, CO 80309–0354, USA
Martin Klein Department of Medical Psychology – D349, VU University
Medical Center, Van der Boechorststraat 7, 1081 BT Amsterdam, The Netherlands,
[email protected]
Contributors xi
Rachel A. Kohman Joint Graduate Training Program in Toxicology, Department
of Psychology, Rutgers University and University of Medicine and Dentistry of
New Jersey, 152 Frelinghuysen Road, Piscataway, NJ 08855, USA
Alexander W. Kusnecov Joint Graduate Training Program in Toxicology,
Rutgers University and University of Medicine and Dentistry of New Jersey,
152 Frelinghuysen Road, Piscataway, NJ 08855, USA; Behavioral Neuroscience
Program, Department of Psychology, Rutgers University, Piscataway, NJ 08855,
USA, [email protected]
Jessica L. Lynch Departments of Internal Medicine, Geriatric Division and
Pharmacological and Physiological Science, Saint Louis University School of
Medicine, 1402 South Grand Blvd, St. Louis, MO 63104
Ruchika Mohla Department of Psychiatry, UMDNJ – New Jersey Medical
School, Behavioral Health Science Building, Room F-1559, 183 South Orange
Avenue, Newark, NJ 07103, USA
Norbert Müller Department of Psychiatry and Psychotherapy, Ludwig-
Maximilians-University Munich, Nussbaumstrasse 7, D-80336 Munich-Germany,
[email protected]
J.C. O’Conner Integrative Immunology and Behavior Program, Department
of Animal Sciences, College of Medicine, University of Illinois at
Urbana-Champaign, 212 Edward R. Madigan Laboratory, 1201 West Gregory
Drive, Urbana, IL 61801, USA
Mark R. Opp Department of Anesthesiology, University of Michigan, 7422
Medical Sciences Building I, 1150 West Medical enter Drive, Ann Arbor, MI
48109–5615, USA; Department of Molecular & Integrative Physiology, University
of Michigan, 7422 Medical Sciences Building I, 1150 West Medical enter Drive,
Ann Arbor, MI 48109–5615, USA; Neuroscience Graduate Program, University of
Michigan, 7422 Medical Sciences Building I, 1150 West Medical enter Drive, Ann
Arbor, MI 48109–5615, USA, [email protected]
Paul H. Patterson Biology Division, California Institute of Technology, 216–76,
Caltech Pasadena, CA 91125, USA, [email protected]
Bradley D. Pearce Department of Psychology, Emory University, 532 North
Kilgo Circle, Atlanta, GA 30322, USA, [email protected]
John M. Petitto McKnight Brain Institute, Departments of Psychiatry,
Neuroscience, and Pharmacology & Therapeutics, College of Medicine,
University of Florida, Box 100256, Gainesville, FL 32610–0256, USA, jpetitto@
UFL.EDU
Tulin O. Price Departments of Internal Medicine, Geriatric Division and
Pharmacological and Physiological Science, Saint Louis University School of
Medicine, 1402 South Grand Blvd, St. Louis, MO 63104