Table Of ContentThe Manual of Allergy and
Clinical Immunology
The Manual of Allergy and
Clinical Immunology
Edited by
Abeer Feteih, MD, FRCPC
Assistant Professor of Medicine
Clinical Immunologist and Allergist
Department of Internal Medicine, Faculty of Medicine in Rabigh
King Abdulaziz University
Jeddah, Saudi Arabia
Michael Fein, MD, FRCPC
Assistant Professor of Medicine
Division of Clinical Immunology and Allergy
McGill University Health Centre
Montréal, Québec, Canada
Natacha Tardio, MD, FRCPC
Assistant Professor of Medicine
Residency Training Program Director
Division of Clinical Immunology and Allergy
McGill University Health Centre
Montréal, Québec, Canada
First edition published 2022
by CRC Press
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and by CRC Press
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© 2022 selection and editorial matter, Abeer Feteih, Michael Fein and Natacha Tardio; individual chapters, the contributors
CRC Press is an imprint of Taylor & Francis Group, LLC
This book contains information obtained from authentic and highly regarded sources. While all reasonable efforts have
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Library of Congress Cataloging-in-Publication Data
Names: Feteih, Abeer, editor. | Fein, Michael (Michael N.), editor. | Tardio, Natacha, editor.
Title: The manual of allergy and clinical immunology / edited by Abeer Feteih, Michael Fein, Natacha Tardio.
Other titles: Manual of allergy and clinical immunology (Feteih)
Description: First edition. | Boca Raton, FL : CRC Press, 2022. | Includes bibliographical references and
index. | Summary: “This pocketbook provides brief clinical summaries of complex and emerging major
topics encountered in the field of Allergy and Immunology. As knowledge in the specialty is rapidly
evolving, it condenses this material while maintaining an evidence-based approach to the practice. It is a
practical and informative guide for students and clinicians”–Provided by publisher.
Identifiers: LCCN 2021045214 (print) | LCCN 2021045215 (ebook) | ISBN 9781032004464 (hardback) |
ISBN 9781032004457 (paperback) | ISBN 9781003174202 (ebook)
Subjects: MESH: Immune System Diseases | Hypersensitivity | Immunotherapy | Handbook
Classification: LCC RC582 (print) | LCC RC582 (ebook) | NLM QW 539 | DDC 616.07/9–dc23
LC record available at https://lccn.loc.gov/2021045214
LC ebook record available at https://lccn.loc.gov/2021045215
ISBN: 9781032004464 (hbk)
ISBN: 9781032004457 (pbk)
ISBN: 9781003174202 (ebk)
DOI: 10.1201/9781003174202
Typeset in Minion Pro
by KnowledgeWorks Global Ltd.
Dedications
To my beloved supportive husband Mohammed, my precious son Yousef, my parents (Maha and Nizar), and
my dear siblings for all your love and care.
– Abeer Feteih
To my wonderful family for all of their love and support.
– Michael Fein
To my beautiful children Mia and Noah, and wonderful husband Pierre for your inspiration, encouragement
and unconditional love.
– Natacha Tardio
Contents
Preface ix
Editors xi
Contributors xiii
PART 1 RHINOCONJUNCTIVITIS
1 Allergic Rhinitis 3
Abeer Feteih, Hoang Pham, Michael Fein, Geneviève Genest, and Jaime Del Carpio
2 Rhinosinusitis 13
Abeer Feteih, Hoang Pham, Michael Fein, Geneviève Genest, and Jaime Del Carpio
3 Ocular Allergy 23
Fatemah Al-Yaqout and Abeer Feteih
4 Allergen Immunotherapy 31
Abeer Feteih, Walaa Almasri, Geneviève Genest, Hoang Pham, and Phil Gold
PART 2 RESPIRATORY DISORDERS
5 Asthma and Allergic Bronchopulmonary Aspergillosis (ABPA) 41
Hoang Pham, Abeer Feteih, Geneviève Genest, and Jaime Del Carpio
6 Approach to Chronic Cough 57
Hoang Pham and Maxime Cormier
PART 3 CUTANEOUS DISORDERS
7 Atopic Dermatitis (AD) 67
Fatemah Al-Yaqout, Abeer Feteih, Walaa Almasri, Hoang Pham, and Reza Alizadehfar
8 Contact Dermatitis 75
Geneviève Bouvette, Walaa Almasri, Hoang Pham, and Abeer Feteih
9 Urticaria 81
Abeer Feteih, Farida Almarzooqi, Michael Fein, Geneviève Genest, Hoang Pham, and
Moshe Ben-Shoshan
10 Angioedema 91
Abeer Feteih, Farida Almarzooqi, Michael Fein, Geneviève Genest, Hoang Pham, and
Moshe Ben-Shoshan
PART 4 MAST CELL-RELATED DISORDERS/ANAPHYLAXIS (SYSTEMIC ILLNESSES)
11 Mastocytosis and Mast Cell Activation Syndromes 103
Abeer Feteih, Farida Almarzooqi, Geneviève Genest, Michael Fein, Hoang Pham, and
Moshe Ben-Shoshan
vii
viii Contents
12 Anaphylaxis 115
Abeer Feteih, Michael Fein, Natacha Tardio, Geneviève Genest, Lydia Zhang, Hoang
Pham, and Moshe Ben-Shoshan
13 Exercise-Induced Anaphylaxis (EIA) and Food-Dependent EIA (FDEIA) 123
Abeer Feteih, Lydia Zhang, Natacha Tardio, and Michael Fein
14 Stinging Insect Hypersensitivity 127
Abeer Feteih, Hoang Pham, Walaa Almasri, and Geneviève Genest
15 Eosinophilia and Hypereosinophilic Syndrome (HES) 135
Abeer Feteih, Hoang Pham, Geneviève Genest, and Natacha Tardio
PART 5 FOOD ALLERGY
16 Food Allergy 145
Abeer Feteih, Lydia Zhang, Natacha Tardio, Hoang Pham, and Moshe Ben-Shoshan
17 Eosinophilic Esophagitis (EoE) 153
Abeer Feteih, Hoang Pham, Michael Fein, Serge Mayrand, and Natacha Tardio
18 Celiac Disease and Non-Celiac Gluten Sensitivity 159
Stephen Tsoukas, Natacha Tardio, and Waqqas Afif
PART 6 DRUG ALLERGY
19 Drug Allergy 167
Abeer Feteih, Hoang Pham, and Ghislaine Annie Clarisse Isabwe
20 Adverse Reactions to Nonsteroidal Anti-Inflammatory Drugs and Aspirin 177
Abeer Feteih, Lydia Zhang, Geneviève Genest, and Ghislaine Annie Clarisse Isabwe
21 Adverse Reactions to Vaccines 183
Abeer Feteih, Lydia Zhang, and Geneviève Genest
PART 7 CLINICAL IMMUNOLOGY
22 General Approach to Primary Immunodeficiency (PID) in Adults 191
Abeer Feteih, Lydia Zhang, Reza Alizadehfar, and Christos Tsoukas
23 Immunoglobulin Replacement Therapy 199
Abeer Feteih, Farida Almarzooqi, Reza Alizadehfar, and Christos Tsoukas
Index 203
Preface
Allergy and Immunology is a rapidly evolving field University (Montréal, Québec), this work has sig-
with an abundance of growth in medical knowledge. nificantly expanded over the last 5 years to include
Significant advances have been made in the diagnosis the contributions of various experts at the McGill
and treatment of a wide array of allergic and immu- University Health Centre. This includes a collabora-
nologic conditions including respiratory, cutaneous, tive effort among several specialties including allergy,
and systemic allergic disorders. This manual was immunology, respirology, gastroenterology, derma-
created as a practical tool for medical professionals, tology, and pathology. Medical education, research,
residents, and students to quickly access current and clinical innovation, and patient advocacy are com-
concise information on the main pathologies seen in mon objectives of our teaching faculty.
this discipline. Chapters are organized so that mate- We would like to sincerely thank all the authors
rial is easy to grasp and apply in both clinical and as well as the publisher for their help in creating this
non-clinical settings. manual. We hope that it encourages students, sci-
Starting off as a collection of study notes from entists, clinicians, and inquisitive minds to pursue
teaching faculty and senior residents in the Division scholarly work in this fascinating field and to con-
of Clinical Immunology and Allergy at McGill tribute to its advancement.
ix
