Table Of ContentLab Animal Science Silverman
Suckow
Murthy
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“For the experienced reader and novice alike, this book provides a wealth
The
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of useful information and insight into the collective experience and wisdom
of the numerous expert editors and authors. Both NIH/OLAW and APHIS/AC
commend the authors and editors for their outstanding efforts and for
moving the biomedical research community forward in its formulation of
I ACUC
best practices and commonly accepted professional guidance in this C
complex arena.”
—From the Introduction by
Dr. Patricia A. Brown, Director of the Office of Laboratory Animal Welfare
Dr. Chester A. Gipson, Deputy Administrator, USDA/APHIS/Animal Care U
Ever since its establishment by USDA regulation in the mid-1980s, the
Institutional Animal Care and Use Committee (IACUC) has evolved as the HANDBOOK
premier instrument of animal welfare oversight within research institutions in
C
the United States. As biomedical research continuously grows, the role and
impact of the IACUC has increased in scope and complexity. The IACUC
Handbook has become “the Bible” for individuals when the time comes for
Third Edition
them to serve on their institution’s IACUC. It provides a foundation for under-
standing and implementing the many and varied responsibilities of this
committee. H
This Third Edition comprehensively addresses the significant changes in the A
pertinent regulatory environment and interpretation of applicable federal laws,
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regulations, and policies. It provides multiple references and commentary on
the new edition of the Guide for the Care and Use of Laboratory Animals, the D
new AVMA Guidelines for the Euthanasia of Animals: 2013 Edition, and the
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Office of Laboratory Animal Welfare’s Frequently Asked Questions. The Third
Edition also features an updated survey of IACUC practices from institutions O
around the United States, offering wisdom gained from their experience. In
addition, it includes a chapter that provides an international perspective on O Edited by
how animal welfare reviews can function in other countries.
K Jerald Silverman
Mark A. Suckow
Third
Sreekant Murthy
Edition
K15383
The
I ACUC
HANDBOOK
Third Edition
The
I ACUC
HANDBOOK
Third Edition
Edited by
Jerald Silverman
Mark A. Suckow
Sreekant Murthy
Boca Raton London New York
CRC Press is an imprint of the
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Contents
1. Origins of the IACUC ............................................................................................................1
Harry Rozmiarek
2. Circumstances Requiring an IACUC ...............................................................................11
Marcy Brown and Mary Jo Shepherd
3. Creation of an IACUC ..........................................................................................................23
Marcy Brown and Mary Jo Shepherd
4. Reporting Lines of the IACUC ..........................................................................................39
Marcy Brown and Mary Jo Shepherd
5. General Composition of the IACUC and Specific Roles of the IACUC Members .......45
Christian E. Newcomer and William G. Greer
6. Frequency and Conduct of Regular IACUC Meetings .................................................73
Sreekant Murthy
7. General Format of IACUC Protocol Forms .....................................................................97
Christian E. Newcomer and William G. Greer
8. Submission and Maintenance of IACUC Protocols ....................................................111
Kathy Laber and Alison C. Smith
9. General Concepts of Protocol Review ............................................................................139
Ernest D. Prentice, Gwenn S. F. Oki, and Michael D. Mann
10. Amending IACUC Protocols ............................................................................................177
Angela M. Mexas and Diane J. Gaertner
11. Continuing Review of Protocols .....................................................................................199
Gwenn S. F. Oki and Ernest D. Prentice
12. Justification for the Use of Animals ...............................................................................211
Larry Carbone
13. Justification of the Number of Animals to Be Used ....................................................237
Ed J. Gracely
14. Animal Acquisition and Disposition .............................................................................253
Michael J. Huerkamp, Larry Iten, and David R. Archer
15. Animal Housing, Use Sites, and Transportation .........................................................299
Robert M. Bigsby and Robin Crisler
16. Pain and Distress ................................................................................................................317
Alicia Z. Karas and Jerald Silverman
17. Euthanasia ............................................................................................................................377
Peggy J. Danneman
18. Surgery ..................................................................................................................................417
Lester L. Rolf Jr.
19. Antigens, Antibodies, and Blood Collection ................................................................447
Harold F. Stills Jr.
20. Occupational Health and Safety .....................................................................................461
Robin Lyn Trundy and Susan Stein Cook
21. Personnel Training .............................................................................................................483
Howard G. Rush and Melissa C. Dyson
22. Confidential and Proprietary Information ...................................................................503
Marilyn J. Chimes and Priya Sankar
23. General Concepts of the Program Review and Facility Inspection .........................539
Joseph D. Thulin and Kenneth P. Allen
24. Inspection of Animal Housing Areas ............................................................................573
Christine A. Boehm and Debra L. Hickman
25. Inspection of Individual Laboratories ...........................................................................591
Neil S. Lipman and Scott E. Perkins
26. Inspection of Surgery Areas.............................................................................................603
Scott E. Perkins and Neil S. Lipman
27. Assessment of Veterinary Care .......................................................................................617
Mark A. Suckow and Bernard J. Doerning
28. Laboratory Animal Enrichment ......................................................................................657
Kathryn Bayne and Jennifer N. Camacho
29. Animal Mistreatment and Protocol Noncompliance ..................................................685
Jerald Silverman
30. Postapproval Monitoring ..................................................................................................719
Ron E. Banks
31. The European Ethical Review Framework: Collaborative Issues ............................751
Javier Guillén
