The Endometrium: Molecular, Cellular and Clinical Perspectives, Second Edition

922 Pages·2008·17.638 MB·\922

by  John D. Aplin (Editor), Asgerally T Fazleabas (Editor), Stanley R Glasser (Editor), Linda C Giudice (Editor)

The endometrium fin:The endometrium fin 22/1/08 11:33 Page 1
SECOND EDITION
The
G A
Endometrium
l p
a
l
S E C O N D E D I T I O N s in
s

e (cid:127)
r F

(cid:127) a

G z
l
i e
u The
a
d
i b Endometrium
c a
Edited by Journal of Fertility and Sterilityreviewing the first edition: e s
S E C O N D E D I T I O N
John D Aplin MA PhD "an impressive international list of authoritative
Maternal and Fetal Health authors who are leaders in their respective fields ... a
Research Group
unique reference tool for students and investigators"
University of Manchester
Manchester, UK E
The first edition of The Endometrium was a landmark Molecular, Cellular, and Clinical Perspectives
Asgerally T Fazleabas PhD HCLD T
publishing event in reproductive biology and medicine. Many n
Department of Obstetrics and
important developments have occurred in the field, and this h
Gynecology, Center for Women’s
new edition has been substantially updated and expanded to de
Health and Reproduction
University of Illinois at Chicago include new topics with an improved format.
o
Chicago, IL, USA
With the addition of several new authors and topics, the m
Stanley R Glasser PhD second edition of The Endometrium has developed new
Institute of Biosciences and coverage of transcriptomics, stem cells, genetics and in-utero
Technology, Texas A&M University programming. Other new areas strengthen to include; e
System Health Sciences Center
placentology in human and animal models, taking account of
t
Houston, TX, USA
the tremendous current interest in the maternal-fetal interface
r
and its role in pregnancy pathology, neonatal and adult health.
Linda C Giudice MD PhD i
The layout has also been improved in order to aid browsing
Department of Obstetrics, u
and cross-referencing.
Gynecology, and Reproductive
Sciences m
This is an invaluable up-to-date innovative text that will appeal
University of California
San Francisco, CA, USA to a worldwide spectrum of academic and professional readers
including postgraduate and postdoctoral researchers in
reproductive biology. As well as trainees and health care
professionals in obstetrics and gynecology and allied
disciplines such as assisted reproduction and oncology.
Edited by
A panel of internationally respected authors has been carefully
chosen for their insight, clear, fair writing style and scholarly John D Aplin, Asgerally T Fazleabas
perspective.
Stanley R Glasser, Linda C Giudice
ISBN 978-0-41538-583-1
www.informahealthcare.com 9 780415 385831
Prelims-Aplin-8035.qxd 1/21/2008 7:05 PM Page i
THE ENDOMETRIUM
Prelims-Aplin-8035.qxd 1/21/2008 7:05 PM Page ii
REPRODUCTIVE MEDICINE & ASSISTED REPRODUCTIVE TECHNIQUES SERIES
Series Editors
David K Gardner DPhil
Colorado Center for Reproductive Medicine,Englewood,CO,USA
Jan Gerris MD PhD
Professor of Gynecology,University Hospital Gheni,Ghent,Belgium
Zeev Shoham MD
Director,Infertility Unit,Kaplan Hospital,Rehovot,Israel
Published Titles
Gerris,Delvigne and Olivennes,Ovarian Hyperstimulation Syndrome
ISBN 9781842143285
Sutcliffe,Health and Welfare of ART Children
ISBN 9780415379304
Tan,Chian and Buckett,In-vitro Maturation of Human Oocytes
ISBN 9781842143322
Keck,Tempfer and Hugues,Conservation Infertility Management
ISBN 9780415384513
Pellicer and Simon,Stem Cells in Human Reproduction
ISBN 9780415397773
Elder and Cohen,Human Preimplantation Embryo Solution
ISBN 9780415399739
Tucker and Liebermann Vitrification in Assisted Reproduction
ISBN 9780415408820
Forthcoming Titles
Balen,Infertility in Practice,3rd Edition
ISBN 9780415450676
Gardner,Howles,Weissman and Shoham,Textbook of ART 3rd Edition
ISBN:9780415448949
Prelims-Aplin-8035.qxd 1/21/2008 7:05 PM Page iii
THE ENDOMETRIUM
Molecular, Cellular, and Clinical Perspectives
Second Edition
Edited by
John D Aplin
MA PhD
Maternal and Fetal Health Research Group
University of Manchester
Manchester
UK
Asgerally T Fazleabas
PhD HCLD
Department of Obstetrics and Gynecology, Center for Women’s
Health and Reproduction
University of Illinois at Chicago
Chicago, IL
USA
Stanley R Glasser
PhD
Institute of Biosciences and Technology
Texas A&M University System Health Sciences Center
Houston,TX
USA
Linda C Giudice
MD PhD MSc
Department of Obstetrics,
Gynecology,and Reproductive Sciences
University of California
San Francisco, CA
USA
Prelims-Aplin-8035.qxd 1/21/2008 7:05 PM Page iv
© 2008 Informa UK Ltd
First edition published in the United Kingdom in 2002
Second edition published in the United Kingdom in 2008 by Informa Healthcare,Telephone House,69–77 Paul
Street,London EC2A 4LQ.Informa Healthcare is a trading division of Informa UK Ltd.Registered Office:37/41
Mortimer Street,London W1T 3JH.Registered in England and Wales number 1072954.
Tel:[phone]
Fax:[phone]
Website:www.informahealthcare.com
All rights reserved.No part of this publication may be reproduced,stored in a retrieval system,or transmitted,in
any form or by any means,electronic,mechanical,photocopying,recording,or otherwise,without the prior per-
mission of the publisher or in accordance with the provisions of the Copyright,Designs and Patents Act 1988 or
under the terms of any licence permitting limited copying issued by the Copyright Licensing Agency, 90
Tottenham Court Road,London W1P 0LP.
Although every effort has been made to ensure that all owners of copyright material have been acknowledged in
this publication,we would be glad to acknowledge in subsequent reprints or editions any omissions brought to our
attention.
Although every effort has been made to ensure that drug doses and other information are presented accurately in
this publication, the ultimate responsibility rests with the prescribing physician. Neither the publishers nor the
authors can be held responsible for errors or for any consequences arising from the use of information contained
herein. For detailed prescribing information or instructions on the use of any product or procedure discussed
herein,please consult the prescribing information or instructional material issued by the manufacturer.
A CIP record for this book is available from the British Library.
Library of Congress Cataloging-in-Publication Data
Data available on application
ISBN 10:0 415 38583 0
ISBN 13:978 0 415 38583 1
Distributed in North and South America by
Taylor & Francis
6000 Broken Sound Parkway,NW,(Suite 300)
Boca Raton,FL 33487,USA
Within Continental USA
Tel:[phone];Fax:[phone]
Outside Continental USA
Tel:[phone];Fax:[phone]
Email:[email protected]
Distributed in the rest of the world by
Cengage Learning Services Limited
Cheriton House
North Way
Andover,Hampshire SP10 5BE,UK
Tel:[phone]
Email:[email protected]
Composition by C&M Digitals (P) Ltd,Chennai,India
Printed and bound in India by Replika Press Pvt.Ltd
Prelims-Aplin-8035.qxd 1/21/2008 7:05 PM Page v
Contents
List of contributors ix
Preface to the first edition xvii
Preface to the second edition xxi
Color plates xxiii
SECTION I:DEVELOPMENT
1. Embryology of the uterus 1
Takeshi Kurita and Hisae Nakamura
2. Puberty,menarche and the endometrium 19
Joseph S Sanfilippo and Mary Anne Jamieson
SECTION II:MATURE FEMALE REPRODUCTIVE TRACT
3. Menstrual and estrous cycles 25
Lois A Salamonsen
4. The fine structure of the mature human endometrium 46
Peter Dockery and Marcella J Burke
5. The cytoskeleton of uterine epithelial and stromal cells 66
Laura A Lindsay and Christopher R Murphy
6. Endometrial angiogenesis,arteriogenesis,and lymphangiogenesis 76
Jane E Girling and Peter AW Rogers
7. Endometrial imaging 93
Julie Lukic and Seang Lin Tan
8. Estrogen and progesterone regulation of cell proliferation in the
endometrium of muridae and humans 99
Wei Tong,Andrea Niklaus,Liyin Zhu,Haiyan Pan,Bo Chen,Mira Aubuchon,
Nanette Santoro,and Jeffrey W Pollard
9. Progesterone antagonists and the non-human primate endometrium 123
Robert M Brenner and Ov D Slayden
SECTION III:REGULATORY BIOLOGY
10. Endometrial stem cells 135
Caroline E Gargett
11. Transgenic models of uterine biology 154
Indrani C Bagchi and Milan K Bagchi
12. Estrogen-regulated genes in the endometrium 162
Sylvia C Hewitt and Kenneth S Korach
13. Progesterone-regulated genes in the endometrium 176
Kevin Lee,Jinrong Wang,and Francesco DeMayo
14. Transcriptomics 193
Linda C Giudice,Said Talbi,Amy Hamilton,and Bruce A Lessey
15. Paracrine mediators of endometrial growth and differentiation 223
Robert M Bigsby and Kathleen E Bethin
16. A comparative view of prostaglandin action in the uterus 245
Flavia L Lopes,Joëlle Desmarais,and Bruce D Murphy
Prelims-Aplin-8035.qxd 1/21/2008 7:05 PM Page vi
vi CONTENTS
SECTION IV:ESTABLISHMENT OF PREGNANCY
17. Maternal recognition of pregnancy 260
Fuller W Bazer,Thomas E Spencer,Troy L Ott,and Gregory A Johnson
18. Chorionic gonadotropin signaling at the maternal–fetal interface 286
J Robert A Sherwin,Andrew M Sharkey,and Asgerally T Fazleabas
19. Embryo–endometrial signaling 296
Francisco Domínguez and Carlos Simón
20. Endometrial receptivity 305
Bruce A Lessey and Stanley R Glasser
21. Connexins:indicators for hormonal and blastocyst-mediated
endometrial differentiation 319
Ruth Grümmer and Elke Winterhager
22. Blastocyst implantation:the adhesion cascade 331
Susan J Kimber
23. The prolactin family:regulators of uterine biology 352
Michael J Soares,SM Khorshed Alam,Toshihiro Konno,and Rupasri Ain
SECTION V:THE ENDOMETRIAL STROMA
24. Endometrial extracellular matrix 364
John D Aplin
25. Signaling and transcription factor networks in the human endometrial stroma 379
Birgit Gellersen and Jan Brosens
26. Human endometrial hemostasis during the menstrual cycle and gestation 397
Charles J Lockwood,Graciela Krikun,and Frederick Schatz
27. Uterine stromal cell differentiation in non-decidualizing species 409
Gregory A Johnson
SECTION VI:PLACENTATION
28a. Implantation of the blastocyst:I.Comparative studies 422
FB Peter Wooding
28b. Implantation of the blastocyst:II.Implantation in primates 432
Allen C Enders
29. Human placental development 441
John D Aplin and Carolyn JP Jones
30. Differentiation of the invasive cytotrophoblast lineage in normal
pregnancy and in preeclampsia 454
Virginia D Winn,Kristy Red-Horse and Susan J Fisher
31. Mechanisms of trophoblast differentiation and maternal–fetal
interactions in the mouse 466
James C Cross
32. Epitheliochorial and endotheliochorial placentas 476
Vibeke Danzter,Rudolf Leiser,and Christiane Pfarrer
SECTION VII:IMMUNOBIOLOGY
33. Innate and adaptive immunity in the human female reproductive tract:
influence of the menstrual cycle and menopause on the mucosal immune
system in the uterus 493
Charles R Wira,John V Fahey,Todd M Schaefer,Patricia A Pioli,
Charles L Sentman,and Li Shen
34. Molecular immunology of the maternal–fetal interface 524
Joan S Hunt and Margaret G Petroff
Prelims-Aplin-8035.qxd 1/21/2008 7:05 PM Page vii
CONTENTS vii
35. Cytokine and chemokine regulation of endometrial immunobiology 546
Sarah A Robertson
36. Endometrial complement:physiology and pathophysiology 570
Steven L Young
SECTION VIII:PHARMACOLOGICAL MODELS AND GENE THERAPY
37. Endometrial paradigms 581
Kathy L Sharpe-Timms,Breton F Barrier,and Susan C Nagel
38. Endometrial effects of hormonal contraception 601
Hilary OD Critchley and David T Baird
39. Endometrial effects of selective progesterone receptor modulators 613
Kristof Chwalisz,Alistair Williams,and Robert Brenner
40. In-utero gene transfer:promises and problems 623
Gaurang S Daftary and Hugh S Taylor
SECTION IX:ASSISTED REPRODUCTIVE TECHNOLOGY
41. Gamete quality and assisted reproductive technologies 637
Catherine MH Combelles and Catherine Racowsky
42. Unanswered questions and proposed solutions in
assisted reproductive technologies 657
Jose M Navarro,Hey-Joo Kang,
Glenn Schattman,and Zev Rosenwaks
43. Clinical relevance of endometrial assessment 669
Aimee Seungdamrong and Peter G McGovern
44. Reproductive freedom and access to assisted reproductive technologies 678
Vardit Ravitsky and Art Caplan
SECTION X:PATHOLOGY AND THERAPY
45. The endometrium of polycystic ovary syndrome 683
Linda C Giudice and Bruce A Lessey
46. Endometriosis 691
Erkut Attar and Serdar Bulun
47. The pathophysiology of dysfunctional uterine bleeding 711
Romana A Nowak
48. Colonization and infection of the endometrium 727
David A Eschenbach
49. Ectopic pregnancy 731
John E Buster
50. Preeclampsia and intrauterine growth restriction 745
Alexander EP Heazell,Justine Nugent,Rebecca L Jones,
Lynda K Harris,and Philip N Baker
51. Aging of the endometrium 761
David F Archer
52. The effects of hormone therapy and botanicals and
dietary supplements on the endometrium 771
Stacie E Geller and Laura Studee
53. Uterine disease in midlife and beyond:the menopausal
transition and postmenopause 785
Alex Polotsky and Nanette Santoro
54. Benign uterine disease:leiomyomata and benign polyps 797
Marcy Maguire and James H Segars
Prelims-Aplin-8035.qxd 1/21/2008 7:05 PM Page viii
viii CONTENTS
55. Models of endometrial carcinogenesis 813
Mark E Sherman and James V Lacey Jr
56. Malignancy 832
Jean A Hurteau,BJ Rimel,Amy Hakim,and Yvonne Collins
Index 849
Prelims-Aplin-8035.qxd 1/21/2008 7:05 PM Page ix
Contributors
Rupasri Ain PhD David T Baird MD DSc
Institute of Maternal–Fetal Biology Division of Reproductive and Developmental Sciences
The University of Kansas Medical Center University of Edinburgh
Kansas City,KS Centre for Reproductive Biology
USA The Queen’s Medical Research Institute
Edinburgh,Scotland
John D Aplin MA PhD UK
Maternal and Fetal Health Research Group
University of Manchester Philip N Baker DM FRCOG
Manchester Maternal and Fetal Health Research Centre
UK St Mary’s Hospital
Manchester
David F Archer MD UK
Department of Obstetrics and Gynecology
Eastern Virginia Medical School Breton F Barrier MD
Norfolk,VA Department of Obstetrics,Gynecology
USA and Women’s Health
University of Missouri-Columbia
Erkut Attar MD Columbia,MO
Istanbul Medical School USA
Department of Obstetrics and Gynecology
Istanbul Fuller W Bazer PhD
Turkey Department of Animal Science
Center for Animal Biotechnology
Mira Aubuchon and Genomics
Department of Obstetrics and Gynecology Texas A&M University
University of Cincinatti College Station,TX
Cincinatti,OH USA
USA
Kathleen E Bethin MD PhD
Indrani C Bagchi PhD Department of Pediatrics and Herman B Wells
Department of Veterinary Bioscience Center for Pediatric Research
University of Illinois at Champaign-Urbana Indiana University School of Medicine
Urbana,IL Riley Hospital for Children
USA Indianapolis,IN
USA
Milan K Bagchi PhD
Department of Molecular Integrative Physiology Robert M Bigsby PhD
University of Illinois at Champaign-Urbana Indiana University School of Medicine
Urbana,IL Indianapolis,IN
USA USA