The Controversial Climacteric: The workshop moderators’ reports presented at the Third International Congress on the Menopause, held in Ostend, Belgium, in June 1981, under the auspices of the International Menopause Society

187 Pages·1982·2.158 MB·English

by  P. A. van Keep, W. H. Utian, A. Vermeulen (auth.), P. A. van Keep, W. H. Utian, A. Vermeulen (eds.)

THE
CONTROVERSIAL
CLIMACTERIC
THE
CONTROVERSIAL
CLIMACTERIC
The workshop moderators' reports
presented at the
Third International Congress on the Menopause,
held in Ostend, Belgium, in June 1981,
under the auspices of the
International Menopause Society.
Edited by
P. A. van Keep, W. H. Utian
and A. Vermeulen
The editors were assisted by Pamela Freebody
MTaUMITED
LANCASTER· BOSTON· THE HAGUE
International Medical Publisher
Published in the UK and Europe by
MTP Press Limited
Falcon House
Lancaster, England
British Library Cataloguing in Publication Data
International Congress on the Menopause (3rd: 1981: Ostend)
The controversial climacteric.
1. Climacteric - Congresses
I. Title II. Keep, P.A. van III. Utian, W.H. IV. Vermeulen, A.
V. International Menopause Society
612 '.665 RC884
ISBN-13: 978-94-011-7255-4 e-ISBN-13: 978-94-011-7253-0
DOl: 10.1007/978-94-011-7253-0
Published in the USA by
MTP Press
A division of Kluwer Boston Inc
190 Old Derby Street
Hingham, MA 02043, USA
Library of Congress Cataloging in Publication Data
International Congress on the Menopause (3rd: 1981 : Ostend, Belgium)
The controversial climacteric.
Includes index.
1. Menopause-Congresses. I. Keep, Pieter A. van. II. Utian, Wulf H., 1939-
III. Vermeulen, A. (Alex), 1927- IV. International Menopause Society.
V. Title. [DNLM: 1. Climacteric-Congresses. W3 IN667 3rd 1981s/WP 580 161 1981c
RG186.I57 1981 618.1'75 82-256
ISBN-13: 978-94-011-7255-4 AACR2
Copyright © 1982 MTP Press Limited
Softcover reprint of the hardcover 1st edition 1982
All rights reserved. No part of this publication may be reproduced, stored in a retrieval
system, or transmitted in any form or by any means, electronic, mechanical,
photocopying, recording or otherwise, witho.ut prior permission from the publishers.
Typeset by Swiftpages Ltd., Liverpool
iv
Contents
Principal contributors vii
Preface xv
1 Gonadal function in the ageing male
K. D. Voigt 1
2 The pre-menopause
H. P. G. Schneider 9
3 Sociological aspects of mid-life
M. Hepworth 19
4 Some biochemical consequences of post-menopausal
hormone replacement treatment
U. Larsson-Cohn 29
5 Psycho-sexual aspects of mid-life
A. A. Haspe/s and H. Musaph 39
6 The breast
J. McQueen 51
7 Neuroendocrine changes in the peri-menopause
U. J. Gaspard and P. Franchimont 61
v
THE CONTROVERSIAL CLIMACTERIC
8 Hysterectomy
E. V. van Hall 73
9 Androgens in post-menopausal women
A. Vermeulen 81
10 The peri-menopause at the cellular level
J. H. H. Thijssen 87
11 Osteoporosis
O. L. M. Bijvoet 95
12 Potency and hepato-cellular effects of oestrogens
after oral, percutaneous, and subcutaneous adminis
tration
S. Campbell and M. I. Whitehead 103
13 Progestins in the peri-menopause
M. Notelovitz 127
14 Epidemiologic aspects of the benefits and risks of
oestrogen therapy
D. Cramer 137
15 Menopause clinics: purpose, function, and inter
national comparisons
W. H. Utian 147
Other communications
Free communications 163
Posters 172
Index 175
VI
Principal contributors
T. Abe O. l. M. Bijvoet
Tohoku University School of Medicine, Academisch Ziekenhuis Leiden,
Department of Obstetrics and Afdeling Klinische Endocrinologie,
Gynaecology, Rijnsburgerweg 10,
1-1 Seiryo-machi, 2333 AA Leiden, The Netherlands
Sendai 980, Japan
J. Botella Llusia
Universidad Complutense de Madrid,
P. Aschheim Departamento de Obstetricia y
INSERM, U. 118, Ginecologia,
Unite de Recherches Gerontologiques, Planta 5° Norte,
29 rue Wilhem, Ciudad Universitaria,
75016 Paris, France Madrid 3, Spain
F. Bottiglioni
s. Universita di Bologna,
Ballinger
Istituto di Patologia Ostetrica e
University of Sydney,
Ginecologica,
Department of Behavioural Sciences,
Policlinico S. Orsola,
Sydney, NSW 2006, Australia
Via Massarenti 13,
40138 Bologna, Italy
F. Bayard J. P. Bourguignon
INSERM, U. 168, Universite de Liege,
Laboratoire d'Endocrinologie Clinique Pediatrique,
Experimentale, 66 boulevard de la Constitution,
C.H.U. Rangueil, 4020 Liege, Belgium
Chemin du Vallon,
31054 Toulouse Cedex, France P. F. Brenner
University of Southern California School
of Medicine,
E. W. Bergink Department of Obstetrics and
Organon International B. V., Gynecology,
Scientific Development Group, Women's Hospital,
P.O. Box 20, 1240 North Mission Road,
534{) BH Oss, The Netherlands Los Angeles, CA 90033, USA
VB
THE CONTROVERSIAL CLIMACTERIC
R. D. Bulbrook A. Demoulin
Imperial Cancer Research Fund Universite de Liege,
Laboratories, Clinique Gynecologique et Obstetricale,
Department of Clinical Endocrinology, 81 boulevard de la Constitution,
P.O. Box 123, 4020 Liege, Belgium
Lincoln's Inn Fields,
London WC2A 3PX, UK
L. Dennerstein
University of Melbourne,
P. M. H. G. Buytaert
Department of Psychiatry,
Universitaire Instelling Antwerpen,
Clinical Sciences Building,
Afdeling Obstetrie en Gynaecologie,
c/o P.O. Royal Melbourne Hospitals,
2000 Antwerpen, Belgium
Melbourne, Victoria 3050, Australia
S. Campbell
King's College Hospital Medical School, J. G. van Dijk
Department of Obstetrics and Academisch Ziekenhuis Leiden,
Gynaecology, Vrouwenkliniek,
Denmark Hill, Gebouw35 A,
London SE5 8RX, UK Rijnsburgerweg 10,
2333 AA Leiden, The Netherlands
E. Cohen
Hasharon Hospital,
7 Keren-Kayamet-Le-Israel Street, C. D. van der Does
Petah-Tiqva, Israel Diaconessenhuis,
Afdeling Gynaecologie,
A.Collin Houtlaan 55,
Leicester Polytechnic, 2334 CK Leiden, The Netherlands
P.O. Box 143,
Leicester LEl 9BH, UK
N. Dombrowicz
D. Cramer Pepermanstraat 9,
Boston Hospital for Women, 4100 Seraing, Belgium
Division of the Brigham and Women's
Hospital and Harvard Medical School,
J. Donnez
75 Francis Street,
Universite Catholique de Louvain,
Boston, MA 02115, USA
Cliniques Universitaires Saint-Luc,
M. G. Crane Departement de Gynecologie-
Obstetrique,
Loma Linda University,
10 avenue Hippocrate,
Loma Linda, CA 92350, USA
1200 Bruxelles, Belgium
N. Crona
University of Goteborg,
B. Ehret
Department of Obstetrics and
Kliniken am Burggraben,
Gynecology,
Abteilung Gynakologie,
Sahlgrenska Sjukhuset,
Alte Vlothoerstrasse 65,
41345 Goteborg, Sweden
4902 Bad Salzuflen, West Germany
D. A. Davey
University of Cape Town Medical School, F. ~Ikik
Department of Obstetrics and rlopital Broussais,
Gynaecology, Clinique Medicale Propedeutique,
Observatory, 96 rue Didot,
7925 Cape, South Africa 75674 Paris Cedex 14, France
Vlll
PRINCIPAL CONTRIBUTORS
L. FAhraeus A. R. Genazzani
University Hospital, Universita degli Studi di Siena,
Department of Obstetrics and Cattedra di Patologia Ostetrica e
Gynaecology, Ginecologica,
581 85 Linkoping, Sweden Via Pietro Mascagni 4,
53100 Siena, Italy
E. Fairhurst
University of Manchester, C. Gold
Department of Geriatric Medicine, University of Toronto,
University Hospital of South Manchester, Toronto General Hospital,
Nell lane, 1849 Yonge Street, Suite 307,
Manchester M20 8lR, UK Toronto, Canada M4S 1Y2
M. Featherstone l. Goldie
Teesside Polytechnic, The Royal Marsden Hospital (london
Department of Social Studies, and Surrey),
Middlesbrough, Cleveland Bl 3BA, UK Fulham Road,
london SW3 6JJ, UK
M. Flint
R. B. Greenblatt
Montclair State College,
Medical College of Georgia
Department of Anthropology,
School of Medicine,
Upper Montclair, NJ 07043, USA
Department of Endocrinology,
Augusta, GA 30901, USA
G. Forti
Universita di Firenze, M. van Haaften
Scoula di Specializzazione in Academisch Ziekenhuis Utrecht,
Endocrinologia, Afdeling Endocrinologie,
Via Morgagni 85, Catharijnesingel 101,
50134 Firenze, Italy 3500 CG Utrecht, The Netherlands
J. Hailes
P. Franchimont
Royal Women's Hospital,
Universite de Liege,
Menopause Clinic,
Institut de Medecine,
Melbourne, Victoria, Australia
laboratoire de Radioimmunologie,
Tour de Pathologie, E. V. van Hall
C.H.U. - BiUiment B23, Academisch Ziekenhuis leiden,
Sart Tilman par Liege 1, Belgium Rijnsburgerweg 10,
2333 AA leiden, The Netherlands
R. D. Gambrell
A. A. Haspels
Medical College of Georgia,
Academisch Ziekenhuis Utrecht,
Department of Obstetrics and
Universiteitskliniek voor Obstetrie en
Gynecology,
Gynaecologie,
Augusta, GA 30912, USA
Catharijnesingel 101,
3500 CG Utrecht, The Netherlands
U. J. Gaspard
Universite de Liege, R. P. Heaney
Faculte de Medecine, Creighton University,
Clinique Gynecologique et Obstetricale, Department of Medicine,
81 boulevard de la Constitution, 2500 California Street,
4020 Liege, Belgium Omaha, NE 68178, USA
IX
THE CONTROVERSIAL CLIMACTERIC
J. H. C. L. Hendriks P. A. van Keep
Katholieke Universiteit, International Health Foundation,
Sint Radboudziekenhuis, 8 avenue Don Bosco,
Instituut voor Rontgendiagnostiek, 1150 Bruxelles, Belgium
Geert Groteplein Zuid 18,
6500 HB Nijmegen, The Netherlands R. J. B. King
Imperial Cancer Research Fund
M. Hepworth Laboratories,
University of Aberdeen, Department of Hormone Biochemistry,
Department of Sociology, P.O. Box 123,
Edward Wright Building, Lincoln's Inn Fields,
Dunbar Street, London WC2A 3PX, UK
Old Aberdeen AB9 2TY, UK
G. Langer
E. Hirvonen Psychiatrische Universitatsklinik,
University Central Hospital, 14 Lazarettgasse,
Department of Obstetrics and 1097 Wien, Austria
Gynaecology,
00290 Helsinki 29, Finland U. Larsson-Cohn
University Hospital,
F. A. Holstein Department of Obstetrics and
Universitat Hamburg, Gynaecology,
Universitats-Krankenhaus Eppendorf, 581 85 Linkoping, Sweden
Abteilung Mikroskopische Anatomie,
C. Lauritzen
Martinistrasse 52,
Universitat Ulm,
2000 Hamburg 20, West Germany
Frauenklinik,
Prittwitzstrasse 43,
A. Holte
7900 Ulml Donau, West Germany
University of Oslo,
Institute of Psychology, R. F. Lax
P.B. 1094, Blindern,
1185 Park Avenue,
Oslo 3, Norway New York, NY 10028, USA
H. S. Jacobs C. Lecart
St. Mary's Hospital Medical School, Universite Catholique de Louvain,
Paddington, Cliniques Universitaires Saint-Luc,
London W2 1P G, UK Departement de Gynecologie-
Obstetrique,
v. H. T. James 10 avenue Hippocrate,
1200 Bruxelles, Belgium
St. Mary's Hospital Medical School,
Department of Chemical Pathology,
B. de Lignieres
Paddington,
Hopital Necker,
London W2 1P G, UK
Service d'Endocrinologie et de
Gynecologie Medicale,
H. L. Judd 149 rue de Sevres,
University of California, 75730 Paris Cedex 15, France
Los Angeles School of Medicine,
Department of Obstetrics and M. A. Limouzin-Lamothe
Gynecology, Hopital Bichat,
Center for the Health Sciences, 34 avenue Hoche,
Los Angeles, CA 90024, USA 75008 Paris, France
x
PRINCIPAL CONTRIBUTORS
R. Lindsay B. Moore
Helen Hayes Hospital, Dudley Road Hospital,
Regional Bone Center, Department of Obstetrics and
Route9W, Gynaecology,
West Haverstraw, NY 10993, USA Dudley Road,
Birmingham B18 7QH, UK
P. Linkowski
Universite de Bruxelles, H. Musaph
Departement de Psychiatrie, Academisch Ziekenhuis Utrecht,
Hopital Erasme, Universiteitskliniek voor Obstetrie en
808 route de Lennik, Gynaecologie,
1070 Bruxelles, Belgium Catharijnesingel101,
3500 CG Utrecht, The Netherlands
J. McQueen
Beckenham Hospital, J. Need
379 Croydon Road, Flinders Medical Centre,
Beckenham, Kent BR3 3QL, UK Department of Obstetrics and
Gynaecology,
B. Maoz Bedford Park, South Australia 5042,
Ben-Gurion University of the Negev, Australia
Soroka Medical Center,
P.O. Box 151, M. Neves-e-Castro
Beer Sheva 84120, Israel Organon International B.V.,
Scientific Development Group,
F. Michiels P.O. Box 20,
Parklaan 55, 5340 BH Oss, The Netherlands
2700 Sint Niklaas, Belgium
B. E. C. Nordin
A. Mikkelsen
MRC Mineral Metabolism Unit,
University of Oslo, The General Infirmary,
Institute of Behavioural Sciences in Great George Street,
Medicine, Leeds LS1 3EX, UK
P.O. Box 1111, Blindern,
Oslo 3, Norway
M. Notelovitz
The Center for Climacteric Studies,
G. Milhaud
University of Florida,
Hopital Saint Antoine,
The Professional Center,
Service de Medecine Nucleaire,
901 NW 8th Avenue, Suite B-1,
184 rue du Faubourg Saint Antoine,
Gainesville, FL 32601, USA
75571 Paris Cedex 12, France
H. van der Molen J.Ovadia
Erasmus Universiteit, The Beilinson Medical Center,
Afdeling Chemische Endocrinologie, Beilinson Hospital,
P.O. Box 1738, Petah-Tiqva, Israel
3000 DR Rotterdam, The Netherlands
J. R. Pasqualini
H. Molinski C.N.R.S. Steroid Hormone Research
Universitats-Frauenklinik Dusseldorf, Unit,
Psychosomatische Abteilung, Foundation for Hormone Research,
Moorenstrasse 5, 26 boulevard Brune,
4000 Dusseldorf, West Germany 75014 Paris, France
Xl