Table Of ContentTHE
CHEMOKINE
FactsBook
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THE
CHEMOKINE
FactsBook
Krishna Vaddi
Genzyme Corporation
Framingham, MA
Margaret Keller
duPont Hospital for Children
Wilmington, DE
Robert C. Newton
The DuPont Merck Pharmaceutical Co
Wilmington, DE
Academic Press
Harcourt Brace & Company, Publishers
SAN DIEGO LONDON BOSTON NEW YORK
SYDNEY TOKYO TORONTO
This book is printed on acid-free paper
Copyright © 1997 by ACADEMIC PRESS
All Rights Reserved.
No part of this publication may be reproduced or transmitted in any form or by any
means, electronic or mechanical, including photocopy, recording, or any information
storage and retrieval system, without permission in writing from the publisher.
Academic Press, Inc.
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http://www.apnet.com
Academic Press Limited
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ISBN 0-12-709905-0
Library of Congress Cataloging-in-Publication Data
Vaddi, Kris.
The chemokine factsbook / by Kris Vaddi, Margaret Keller, Robert
Newton.
p. cm.
ISBN 0-12-709905-0 (alk. paper)
1. Chemokines—Handbooks, manuals, etc. I. Keller, Margaret,
n. Newton, Robert, 1952- . m. Title.
[DNLM: 1. Chemokines—handbooks. QW 539 V122c 1996]
QR185.8.C45V33 1996
616.07'9—dc21
DNLM/DLC
for Library of Congress 96-44883
CIP
A catalogue record for this book is available from the British Library
Typeset in Great Britain by Alden, Oxford, Didcot and Northampton
Printed in Great Britain by WBC, Bridgend, Mid Glamorgan
96 97 98 99 00 01 EB 9 8 7 6 5 4 3 2 1
Contents
Preface vn
Abbreviations DC
Section I THE INTRODUCTORY CHAPTERS
Chapter 1
Introduction
Chapter 2
Organization of the data
Chapter 3
Chemokines: an overview 10
Chapter 4
Chemokine receptors: an overview 18
Section II THE CHEMOKINES
CXC or a family chemokines
IL-8 23
MGSA _ 38
PF4 46
NAP-2 _ 53
IP-10 _ 60
MIP-2 _ 67
ENA-78 73
EMF-1 _ 76
GCP-2 _ 80
SDF-1 _ 82
MIG 84
CC or P family chemokines
MCP-1
MCP-2 _ 99
MCP-3 _ 103
MlP-la _ 107
MIP-li5 _ 118
RANTES 124
1-309 131
Eotaxin _ 135
CIO 138
HCC-1 140
Contents
C or 7 family chemokines
Lymphotac tin 142
SCM-1 144
Section III THE CHEMOKINE RECEPTORS
CXC or a chemokine receptors
IL-8RA 149
IL-8RB 153
CC or j5 chemokine receptors
CCCKR-1 158
CC CKR-2 162
CC CKR-3 164
CC CKR-4 165
Chemoattractant receptors
C5aR 168
FPR/FMLPR 171
Miscellaneous receptors
PAFR 175
DARC 178
Viral chemokine receptors
US28 182
ECRF3 184
Orphan chemokine receptors
LESTR 186
CMK-BRL-1 188
BLR-l/MDR-15 190
V28 193
EBIl 194
Index 197
Preface
We would like to thank Tessa Picknett and Academic Press for their patience and
encouragement during the compilation of this work. We would also like to thank
our spouses, Lakshmi, Grant and Toni, for their understanding and support. Much
appreciation goes to Dr David W. Martin, founder of the DuPont Merck Postdoctoral
program which brought the authors together and supported our interest in
chemokine biology.
Left to right: Robert Newton, Margaret Keller, Krishna Vaddi
This Page Intentionally Left Blank
Abbreviations
ADP Adrenaline activated platelets
AIDS Acquired immune deficiency syndrome
AML Acute myeloid leukemia
AP-1 Activator protein-1
ARDS Adult respiratory distress syndrome
BFU Burst-forming unit
BLR-1 Burkitt's lymphoma receptor 1
Beta thromboglobulin
C/EBP CCAAT/enhancer-binding protein
C5a C5 anaphylatoxin
C5aR C5 anaphylatoxin receptor
cAMP cyclic adenosine monophosphate
CCCKR CC chemokine receptor
CEF Chick embryo fibroblasts
CPU Colony-forming unit
CIDNP Chemically-induced dynamic nuclear polarization
CINC Cytokine-induced neutrophil chemoattractant
CK Chemokine receptors
CMK-BRL-1 Chemokine beta receptor-like 1
CMV Cytomegalovirus
Con A Concanavalin A
CP Capsular polysaccharide
CTAP-m Connective-tissue activating peptide IE
DARC Duffy antigen/chemokine receptor
DMSO Dimethylsulfoxide
DTH Delayed type hypersensitivity
EAE Experimental autoimmune encephalomyelitis
EBI-1 Epstein-Barr induced protein 1
EC50 50% effective concentration
ECM Extracellular matrix
ECRF3 An open reading frame of Herpes virus Saimiri gene
sequence
EDTA Ethylene diamine tetraacetic acid
ELISA Enzyme-linked immunoabsorbent assay
ELR Glutamic acid-leucine-arginine motif
EMF-1 Embryo fibroblast protein 1
ENA-78 Epithelial derived neutrophil attractant 78
ERK-1 Extracellular signal regulated kinase 1
ESP MS Electron spray mass spectroscopy
FGF Fibroblast growth factor
FITC Fluoroscein isothiocyanate
fMLP Formyl-methionyl-leucinyl-phenylalanine
FMLPR N-formyl-methionyl-leucyl-phenylalanine receptor
Description:How do you keep track of basic information on the proteins you work with? Where do you find details of their physicochemical properties, amino acid sequences, gene organization? Are you tired of scanning review articles, primary papers and databases to locate that elusive fact? The Academic Press Fa
