The Boston IVF Handbook of Infertility

220 Pages·2011·3.3 MB·English

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Edited by
Steven R Bayer
Michael M Alper
Alan S Penzias
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The Boston IVF Handbook
of Infertility
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1-8418-4810-5_CH0000_O.3d][4/10/011/14:38:29][1–12]
REPRODUCTIVE MEDICINE AND ASSISTED REPRODUCTIVE
TECHNIQUES SERIES
Series Editors
David Gardner
University ofMelbourne,Australia
Jan Gerris
UniversityHospital Ghent,Belgium
Zeev Shoham
KaplanHospital, Rehovot,Israel
1. Jan Gerris, Annick Delvigne, Franc¸ois Olivennes Ovarian Hyperstimulation
Syndrome, ISBN: 9781842143285
2. Alastair G Sutcliffe Health and Welfare of ART Children, ISBN: 9780415379304
3. SeangLinTan,Ri-ChenChian,WilliamBuckettInVitroMaturationofHumanOocytes,
ISBN: 9781842143322
4. Christoph Keck, Clemens Tempfer, Jen-Noel Hugues Conservative Infertility
Management, ISBN: 9780415384513
5. Carlos Simon, Antonio Pellicer Stem Cells in Human Reproduction,
ISBN: 9780415397773
6. Kay Elder, Jacques Cohen Human Preimplantation Embryo Selection,
ISBN: 9780415399739
7. Michael Tucker, Juergen Liebermann Vitrification in Assisted Reproduction,
ISBN: 9780415408820
8. John D Aplin, Asgerally T Fazleabas, Stanley R Glasser, Linda C Giudice
The Endometrium, Second Edition, ISBN: 9780415385831
9. Adam H Balen Infertility in Practice, Third Edition, ISBN: 9780415450676
10. Nick Macklon, Ian Greer, Eric Steegers Textbook of Periconceptional Medicine,
ISBN: 9780415458924
11. Carlos Simon, Antonio Pellicer Stem Cells in Human Reproduction, Second Edition,
ISBN: 9780415471718
12. Andrea Borini, Giovanni Coticchio Preservation of Human Oocytes,
ISBN: 9780415476799
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1-8418-4810-5_CH0000_O.3d][4/10/011/14:38:29][1–12]
The Boston IVF Handbook
of Infertility
A Practical Guide for Practitioners
who Care for Infertile Couples
Third Edition
Edited by
Steven R Bayer MD
Michael M Alper MD
Alan S Penzias MD
Boston IVF and Harvard Medical School
Boston, Massachusetts
USA
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1-8418-4810-5_CH0000_O.3d][4/10/011/14:38:29][1–12]
SecondEdition published in2006byInforma UKLtd.
Thiseditionpublishedin2012byInformaHealthcare,TelephoneHouse,69-77PaulStreet,London
EC2A4LQ,UK.
SimultaneouslypublishedintheUSAbyInformaHealthcare,52VanderbiltAvenue,7thFloor,New
York,NY 10017,USA.
InformaHealthcare is atrading divisionofInforma UKLtd. Registered Office: 37–41Mortimer
Street,London W1T3JH, UK.Registered inEngland and Walesnumber1072954.
#2012InformaHealthcare, except asotherwise indicated
Noclaimto original U.S.Government works
Reprintedmaterialisquotedwithpermission.Althougheveryefforthasbeenmadetoensurethat
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reflecttheviews/opinionsofthepublisher.Anyinformationorguidancecontainedinthisbookis
intended foruse solelyby medicalprofessionals strictly as asupplement to themedical
professional’sownjudgement,knowledgeofthepatient’smedicalhistory,relevantmanufacturer’s
instructionsandtheappropriatebestpracticeguidelines.Becauseoftherapidadvancesinmedical
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ISBN-13:9781841848105
ISSN(print): 2158-0197
ISSN(online): 2158-0200
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Library of CongressCataloging-in-Publication Data
The Boston IVF handbook of infertility : a practical guide for practitioners who
careforinfertilecouples/editedbyStevenR.Bayer,MichaelM.Alper,AlanS.
Penzias.--3rded.
p.;cm.-- (Reproductivemedicineandassistedreproductivetechniques
series)
Handbook ofinfertility
Includes bibliographical references andindex.
ISBN 978-1-84184-810-5(pb :alk. paper)
I. Bayer, Steven R. II. Alper, Michael M. III. Penzias, Alan S. IV. Boston
IVF. V.Title: Handbook of infertility. VI. Series: Reproductive medicine &
assisted reproductive techniques series.
[DNLM: 1. Infertility--diagnosis--Handbooks. 2. Infertility--therapy--
Handbooks.3. Reproductive Techniques, Assisted--Handbooks. WP 39]
LC-classification notassigned
618.1’78--dc23
2011029661
For corporate sales pleasecontact: [email protected]
For foreign rightsplease contact: [email protected]
For reprintpermissions pleasecontact: [email protected]
Typeset by MPSLimited, aMacmillan Company.
Printed andboundinthe United Kingdom.
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Contents
Contributors viii
Preface Robert F Casper ix
Acknowledgments x
About Boston IVF xi
Disclaimer xii
1. Overview of infertility 1
Alan S Penzias
2. Factors affecting fertility 11
Steven R Bayer
3. The infertility workup 19
Steven R Bayer and Michael M Alper
4. Preconceptional counseling 35
Steven R Bayer
5. Clinical algorithms 51
Michael M Alper
6. Treatment options I. Ovulation induction 57
Selwyn P Oskowitz
7. Treatment options II. Intrauterine inseminations 65
Steven R Bayer
8. Treatment options III. In vitro fertilization 69
Michael M Alper
9. Treatment options IV. Third party reproduction 83
Brian M Berger
10. Overview of male infertility 93
Stephen A Lazarou
11. Preimplantation genetic screening and diagnosis 107
Khanh-Ha D Nguyen, Alison E Zimon, and Kim L Thornton
12. Polycystic ovary syndrome 117
Rita M Sneeringer and Vasiliki A Moragianni
13. Fertility preservation for cancer patients 127
David A Ryley
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CONTENTS vii
14. Recurrent pregnancy loss 133
Benjamin Lannon and Alison E Zimon
15. Modern management of ectopic pregnancy 143
David A Ryley
16. Integrating quality management into a fertility practice 153
Michael M Alper
17. The true art: How to deliver the best patient care 158
Merle J Berger
18. Medical ethics in reproductive medicine 162
Steven R Bayer and Kim L Thornton
19. The mind/body connection 169
Alice D Domar
20. Infertility counseling and the role of the infertility counselor 176
Jeanie Ungerleider, Terry Chen Rothchild, and Lynn Nichols
21. Insurance and coding issues 184
Steven R Bayer and Karen Parlee
22. Quick reference 191
Index 197
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Contributors
MichaelMAlper Boston IVF, Harvard Medical School, Boston,Massachusetts, USA
StevenRBayer Boston IVF, Harvard Medical School, Boston,Massachusetts, USA
Brian MBerger Boston IVF, Harvard Medical School, Boston,Massachusetts, USA
MerleJ Berger Boston IVF, HarvardMedical School, Boston, Massachusetts, USA
AliceD Domar Boston IVF, Harvard MedicalSchool, Boston, Massachusetts, USA
Benjamin Lannon Boston IVF, Harvard MedicalSchool, Boston, Massachusetts, USA
StephenALazarou Harvard Medical School, Boston,Massachusetts, USA
Vasiliki AMoragianni Harvard MedicalSchool, Boston, Massachusetts, USA
Khanh-HaDNguyen Harvard Medical School, Boston, Massachusetts,USA
LynnNichols Boston IVF,Boston, Massachusetts, USA
SelwynPOskowitz Boston IVF, Harvard MedicalSchool, Boston, Massachusetts, USA
KarenParlee Boston IVF, Waltham, Massachusetts, USA
AlanSPenzias Boston IVF, Harvard MedicalSchool, Boston, Massachusetts, USA
TerryChen Rothchild Boston IVF, Boston, Massachusetts, USA
DavidARyley Boston IVF, HarvardMedical School, Boston, Massachusetts, USA
RitaMSneeringer Boston IVF, Harvard MedicalSchool, Boston,Massachusetts, USA
KimLThornton Boston IVF, Harvard MedicalSchool, Boston, Massachusetts, USA
JeanieUngerleider Boston IVF, Boston, Massachusetts,USA
AlisonEZimon Boston IVF, Harvard Medical School, Boston,Massachusetts, USA
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Preface
ThisisthethirdeditionoftheHandbookofInfertilitybyBostonIVF,oneofthemostrespected
Assisted Reproduction and Women’s Health clinics in the United States. I have had the
privilegetogettoknowwellthetwoseniorauthors,MichaelAlperandAlanPenzias,overthe
lastfewyears.MichaelisarolemodelformanyIVFphysiciansandanexpertinpatientcare,
quality management, and clinical innovation. He is an amazing speaker and writer whose
folksycharmandself-deprecatinghumorbeliesawealthofknowledgeandexperienceinART,
bothclearlyevidentinthisbook.AlanPenziasisasuperbclinicalresearcherandteacherwho
brings to the book critical thinking, technological expertise, as well as his love for medical
history. Together with Steven Bayer and the other physicians and scientists from Boston IVF,
theauthors’personalitiesinfusethetextofthisbookandallowmanyinterestingideastotake
flight. Far from the usual didactic textbook, this book by the staff of Boston IVF is easily
readableandcoversawiderangeofsubjectsinART,rangingfromanintroductoryhistoryof
infertility and its management to the latest scientific advances in preimplantation genetic
diagnosisandembryochromosomalscreening.Thereareuniqueinsightsintofertilityquality
management andexcellence inpatientcare, twoareas thattheseniorauthors havepioneered
andattemptedtoperfectatBostonIVF.Thechapteronmedicalethicsisexceptional,including
practical examplesin the form ofsix casereports. These three chaptersare often neglected in
standardtextsofinfertilityandreflectboththepracticalbusinessmanagementofanARTclinic
as well as the sensibilities and values of the authors in dealing with patients in their daily
practice. I believe this book is valuable for infertility nurses, general obstetricians/
gynecologists, and infertility counselors, and a must-read for first-year fellows and for
residents considering a career in reproductive endocrinology and infertility.
Robert F Casper
Professor,
Division of Reproductive Sciences, University of Toronto,
Camille Dan Family Research Chair in Translational Cell Biology
Senior Scientist,
Samuel Lunenfeld Research Institute,
Mount Sinai Hospital, Toronto,
Medical Director,
Toronto Centre for Advanced Reproductive Technology,
Toronto, Ontario, Canada