The Boston IVF handbook of infertility

260 Pages·2018·10.87 MB·English

by  Michael M.

The Boston IVF
Handbook of Infertility
A Practical Guide for Practitioners Who Care
for Infertile Couples, Fourth Edition
REPRODUCTIVE MEDICINE AND ASSISTED REPRODUCTIVE
TECHNIQUES SERIES
David Gardner
University of Melbourne, Australia
Zeev Shoham
Kaplan Hospital, Rehovot, Israel
Kay Elder, Jacques Cohen
Human Preimplantation Embryo Selection, ISBN: 9780415399739
John D Aplin, Asgerally T Fazleabas, Stanley R Glasser, Linda C Giudice
The Endometrium, Second Edition, ISBN: 9780415385831
Nick Macklon, Ian Greer, Eric Steegers
Textbook of Periconceptional Medicine, ISBN: 9780415458924
Andrea Borini, Giovanni Coticchio
Preservation of Human Oocytes, ISBN: 9780415476799
Ben Cohlen, Willem Ombelet
Intra-Uterine Insemination: Evidence Based Guidelines for Daily Practice,
ISBN: 9781841849881
Adam H. Balen
Infertility in Practice, Fourth Edition, ISBN: 9781841848495
Nick Macklon
IVF in the Medically Complicated Patient, Second Edition:
A Guide to Management, ISBN: 9781482206692
Michael Tucker, Juergen Liebermann
Vitrification in Assisted Reproduction, ISBN: 9780415408820
Ben J Cohlen, Evert J P van Santbrink, Joop S E Laven
Ovulation Induction: Evidence Based Guidelines for Daily Practice,
ISBN: 9781498704076
Botros Rizk, Markus Montag
Standard Operational Procedures in Reproductive Medicine:
Laboratory and Clinical Practice,
ISBN: 9781498719216
Steven R Bayer, Michael M Alper, Alan S Penzias
The Boston IVF Handbook of Infertility, Fourth Edition,
ISBN: 9781138633025
The Boston IVF
Handbook of Infertility
A Practical Guide for Practitioners Who Care
for Infertile Couples, Fourth Edition
Edited by
Steven R. Bayer, MD
Reproductive Endocrinologist
Boston IVF
Clinical Instructor of Obstetrics, Gynecology and Reproductive Biology
Harvard Medical School
Michael M. Alper, MD
Medical Director and Reproductive Endocrinologist
Boston IVF
Associate Professor of Obstetrics, Gynecology and Reproductive Biology
Harvard Medical School
Alan S. Penzias, MD
Reproductive Endocrinologist
Boston IVF
Associate Professor of Obstetrics, Gynecology and Reproductive Biology
Harvard Medical School
CRC Press
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Contents
Preface .....................................................................................................................................................vii
Acknowledgments ...................................................................................................................................viii
About Boston IVF .....................................................................................................................................ix
Contributors ...............................................................................................................................................x
1. Overview of Infertility .....................................................................................................................1
Alan S. Penzias
2. Factors Affecting Fertility .............................................................................................................12
Steven R. Bayer and Merle J. Berger
3. The Infertility Workup ..................................................................................................................21
Jesse Hade
4. Preconceptional Counseling ..........................................................................................................39
Steven R. Bayer
5. Clinical Algorithms ........................................................................................................................57
Michael M. Alper and Nina Resetkova
6. Treatment Options: I. Ovulation Induction ................................................................................63
Selwyn P. Oskowitz and Alan S. Penzias
7. Treatment Options: II. Intrauterine Insemination.....................................................................72
Sonia Elguero and Marsha Forman
8. Treatment Options: III. In Vitro Fertilization ............................................................................78
Michael M. Alper
9. Treatment Options: IV. Third-Party Reproduction ...................................................................94
Brian M. Berger
10. Fertility Care for the LGBT Community ..................................................................................106
Samuel C. Pang
11. Evaluation and Management of Male Infertility .......................................................................115
Stephen Lazarou
12. Preimplantation Genetic Testing ................................................................................................130
Kim L. Thornton
13. Endometriosis and Infertility .......................................................................................................142
Daniel Griffin
14. Polycystic Ovary Syndrome .........................................................................................................149
Rita M. Sneeringer and Kristen Page Wright
v
vi Contents
15. Recurrent Pregnancy Loss ...........................................................................................................161
Benjamin Lannon and Alison E. Zimon
16. Fertility Preservation for Cancer Patients ..................................................................................173
David A. Ryley
17. Elective Egg Freezing ...................................................................................................................180
Samuel A. Pauli and Kerri L. Luzzo
18. The IVF Laboratory .....................................................................................................................187
Denny Sakkas, C. Brent Barrett, and Kathryn J. Go
19. Tools for Effective Nursing in the Care of the Infertile Patient ..............................................197
Sharon Edwards, Susan Gordon-Pinnell, and Kristin MacCutcheon
20. The Mind/Body Connection ........................................................................................................202
Alice D. Domar
21. Infertility Counseling and the Role of the Infertility Counselor ..............................................211
Jeanie Ungerleider, Terry Chen Rothchild, and Lynn Nichols
22. Medical Ethics in Reproductive Medicine ..................................................................................219
Steven R. Bayer and Kim L. Thornton
23. Integrating Quality Management into a Fertility Practice ......................................................227
Michael M. Alper
24. The True ART: How to Deliver the Best Patient Care .............................................................232
Derek Larkin
Index ......................................................................................................................................................241
Preface
From its early inception over 30 years ago, the field of assisted reproductive technology (ART) and
infertility has been rapidly changing. The field is one of the most innovative and fascinating areas of
medicine. In order to keep up with the latest advances, it is critical for any textbook in the field to be up
to date. Much has changed since our initial edition 15 years ago. Also, much has changed at Boston IVF
as well—our group of fertility specialists has expanded from 4 to now more than 20, resulting in many
more contributors sharing their expertise in the new edition.
In the new edition of the handbook, all of the core topics in the field of infertility have been updated,
and several new chapters have been added. Genetics is playing a more and more important role in our
specialty. The chapter on preimplantation genetic testing highlights the application of genetics in modern-
day ART. The ability to screen embryos for their chromosomal status has led to improved implantation
rates and efficiency in in vitro fertilization (IVF). Endometriosis remains an important cause of infer-
tility, and a new chapter on this topic covers the diagnosis and current treatment paradigm. A chapter
has been added on the treatment options for the LGBT community. Access to effective treatment for
same-sex couples remains difficult in some areas because of legal, cultural, and logistical reasons. Some
treatments for same-sex couples are simple (such as donor insemination for same-sex female couples),
and some may be more involved such as donor egg/gestational surrogacy for same-sex male couples.
The transgender community also deserves special attention to help these individuals pursue their gender
identification and, at the same time, plan for their reproductive options as well. The advent of egg freez-
ing and banking has revolutionized the donor egg field; in fact, vitrification techniques to freeze eggs
is one of the most important advances in our field since intracytoplasmic sperm injection (ICSI) was
introduced more than 20 years ago. A chapter on elective egg freezing presents the application of this
new technology for those women who want to preserve their fertility. Finally, realizing the role of other
key players in the delivery of quality care, we have added chapters highlighting our expertise in the areas
of nursing, the IVF laboratory, and administration.
This fourth edition of The Boston IVF Handbook of Infertility represents the collective efforts of the
many professionals at Boston IVF. It represents 30 years of our company’s efforts to improve the care
that we provide and help our patients resolve their fertility issues. We hope you enjoy our book and it
helps you with the care of your patients.
Michael M. Alper, MD
Medical Director and President, Boston IVF
vii
Acknowledgments
This book is dedicated to our patients, who display the utmost courage and determination in their journey
to one day becoming parents.
viii
About Boston IVF
Boston IVF was established in 1986 as one of the first freestanding IVF centers in the United States.
Since its inception Boston IVF has been a leader in the cutting-edge reproductive technologies. The
unique practice model and commitment to the highest quality medical care has resulted in continued
growth and success of the organization. To this end, Boston IVF has established itself as one of the larg-
est IVF centers in the United States and has been responsible for the birth of more than 30,000 babies.
As a testament to its commitment to quality, Boston IVF became the first IVF center in North America to
become ISO-9001 certified. The strong affiliation of Boston IVF with the Beth Israel Deaconess Medical
Center and the Harvard Medical School has resulted in broad-based clinical and basic science research
that has helped to advance the field of infertility. Boston IVF also has maintained a strong commitment
to education. There is active teaching of nurses, medical students, physicians in training and fellows.
Through its commitment to quality patient care, medical research, and education, Boston IVF is a rec-
ognized world leader in infertility.
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