Table Of ContentTHE BASAL
GANGLIA III
ADVANCES IN BEHAVIORAL BIOLOGY
Editorial Board
Jan Bures Institute of Physiology, Prague, Czechoslovakia
Irwin Kopin National Institute of Mental Health, Bethesda, Maryland
Bruce McEwen Rockefeller University, New York, New York
James McGaugh University of California, Irvine, California
Karl Prlbram Stanford University School of Medicine, Stanford, California
Jay Rosenblatt Rutgers University, Newark, New Jersey
Lawrence Welskrantz University of Oxford, Oxford, England
Recent Volumes in this Series
Volume 27 THE BASAL GANGLIA: Structure and Function
Edited by John S. McKenzie, Robert E. Kemm,
and Lynette N. Wilcock
Volume 28 BRAIN PLASTICITY, LEARNING, AND MEMORY
Edited by B. E. Will, P. Schmitt, and
J. C. Dalrymple-Alford
Volume 29 ALZHEIMER'S AND PARKINSON'S DISEASES: Strategies
for Research and Development
Edited by Abraham Fisher, Israel Hanin, and Chaim Lachman
Volume 30 DYNAMICS OF CHOLINERGIC FUNCTION
Edited by Israel Hanin
Volume 31 TOBACCO SMOKING AND NICOTINE: A Neurobiological Approach
Edited by William R. Martin, Glen R. Van Loon, Edgar T. Iwamoto, and
Lay ten Davis
Volume 32 THE BASAL GANGLIA II: Structure and Function-Current Concepts
Edited by Malcolm B. Carpenter and A. Jayaraman
Volume 33 LECITHIN: Technological, Biological, and Therapeutic Aspects
Edited by Israel Hanin and G. Brian Ansell
Volume 34 ALTERATIONS IN THE NEURONAL CYTOSKELETON IN
ALZHEIMER' DISEASE
Edited by George P. Perry
Volume 35 MECHANISMS OF CEREBRAL HYPOXIA AND STROKE
Edited by George Somjen
Volume 36 NOVEL APPROACHES TO THE TREATMENT OF ALZHEIMER'S DISEASE
Edited by Edwin M. Meyer, James W. Simpkins, and Jyunji Yamamoto
Volume 37 KINDLING 4
Edited by Juhn A. Wada
Volume 38A BASIC, CLINICAL, AND THERAPEUTIC ASPECTS OF
ALZHEIMER'S AND PARKINSON'S DISEASES
Volume 1
Edited by Toshiharu Nagatsu, Abraham Fisher, and Mitsuo Yoshida
Volume 38B BASIC, CLINICAL, AND THERAPEUTIC ASPECTS OF
ALZHEIMER'S AND PARKINSON'S DISEASES
Volume 2
Edited by Toshiharu Nagatsu, Abraham Fisher, and Mitsuo Yoshida
Volume 39 THE BASAL GANGLIA '"
Edited by Giorgio Bernardi, Malcolm B. Carpenter, Gaetano Di Chiara,
Micaela Morelli, and Paolo Stanzione
A Continuation Order Plan is available for this series. A continuation order will bring delivery of each new
volume immediately upon publication. Volumes are billed only upon actual shipment. For further infonnation
please contact the publisher.
THE BASAL
GANGLIA III
Edited by
Giorgio Bernardi
Second University of Rome
Rome, Italy
Malcolm B. Carpenter
Uniformed Services University of the Health Sciences
Bethesda, Maryland
Gaetano Di Chiara
University of Gagliari
Gagliari, Italy
Micaela Morelli
University of Gagllarl
Gagliari, Italy
and
Paolo Stanzione
Second University of Rome
Rome, Italy
PLENUM PRESS • NEW YORK AND LONDON
Library of Congress Cataloging in Publication Data
International Basal Ganglia Society. Symposium (3rd: 1989: Cagliari, Italy)
The basal ganglia III 1 edited by Giorgio Bernardi ... let al.].
p. cm.-(Advances in behavioral biology; v. 39)
"Proceedings of the Third Triennial Meeting of the International Basal Ganglia Society,
held June 10-13, 1989, in Cagliari, Italy"-T.p. verso.
Includes bibliographical references and index.
ISBN 978-1-4684-5873-2 ISBN 978-1-4684-5871-8 (eBook)
DOI 10.1007/978-1-4684-5871-8
1. Basal ganglia-Physiology-Congresses. 2. Basal ganglia-Diseases-Congres
ses. I. Bernardi, Giorgio. II. Title. III. Title: Basal ganglia 3. IV. Series.
[DNLM: 1. Basal Ganglia-congresses. WL 307 1605b 1989]
QP383.3.158 1989
599l 0188-dc20
DNLM/DLC 90-14329
for Library of Congress CIP
Proceedings of the Third Triennial Meeting of the International Basal
Ganglia Society, held June 10-13, 1989, in Cagliari, Italy
© 1991 Plenum Press, New York
Softcover reprint of the hardcover 1s t edition 1 991
A Division of Plenum Publishing Corporation
233 Spring Street, New York, N.Y. 10013
All rights reserved
No part of this book may be reproduced, stored in a retrieval system, or transmitted
in any form or by any means, electronic, mechanical, photocopying, microfilming,
recording, or otherwise, without written permission from the Publisher
INTERNATIONAL BASAL GANGLIA SOCIETY (IBAGS)
OFFICERS
PRESIDENT
G. Bernardi, Italy
PAST PRESIDENT
TREASURER
M. B. Carpenter, U.S.A.
PRESIDENT ELECT
G. Percheron, France
SECRETARY
G. Di Chiara, Italy
PROGRAM COMMITTEE
A. Y. Agid, France
M. R. Delong, U.S.A.
I. Divac, Denmark
M. Yoshida, Japan
COUNCIL
D. Albe-Fessard, France
R. L. M. Faull, New Zealand
C. Ohye, Japan
A. Parent, Canada
E. T. Rolls, U.K.
K. H. Sontag, Germany
PREFACE
This volume represents the collected papers presented at
the Third Triennial Symposium of the International Basal
Ganglia society (IBAGS) held at Capo Boi, Italy, June
10-13, 1989. About 300 members of the society and
participants attended the symposium which was held in a
delightful environment conducive to the formal and
informal exchange of scientific thought. The
interdisciplinary nature of the symposium was unique in
its coverage of the neurosciences from molecular biology
to clinical and behavioural studies. The 80 papers
collected here reflect the wide spectrum and the depth
of studies on virtually all aspects of the basal
ganglia.
Unfortunately, this book does not capture the cordial
and congenial atmosphere which has characterized this,
and all prior symposia of the Society. Any cooperative
endeavour of this kind requires a tremendous effort and
dedication, usually by a small number of individuals.
The Society is especially pleased to acknowledge the
support and encouragement of the "Italian Ministry of
university and Scientific Research" and the "Italian
National. Research Council". In addition the society
received financial support from numerous Foundations and
corporations, which are listed separately under
acknowledgements.
Finally the Editors are pleased that Plenum Press, which
has published the two previous symposia, has accepted
this program for publication. It is our hope that vast
scientific efforts reflected in these pages will be
widely disseminated and further encourage every kind of
research related to the basal ganglia.
Giorgio Bernardi
Malcolm Carpenter
Gaetano Di Chiara
Micaela Morelli
Paolo Stanzione
ACKNOWLEDGEMENTS
The following Organizations and Institutions are
gratefully acknowledged:
Comune di Cagliari (Italy)
Comune di Villasimius (Italy)
Ente Provinciale per il Turismo (Italy)
Ente Sardo Industrie Turistiche (Italy)
Assessorato al Turismo, Regione Sardegna (Italy)
Ass. Pubblica Istruzione, Regione Sardegna (Italy)
Ministero Pubblica Istruzione (Italy)
consiglio Nazionale delle Ricerche (Italy)
Credito Industriale Sardo (Italy)
Banca d'Italia (Italy)
American Parkinson Disease Association (USA)
National Parkinson Foundation (USA)
Parkinson's Disease Foundation (USA)
United Parkinson Foundation (USA)
Aziende Chimiche Riunite Angelini Francesco (Italy)
Du Punt de Nemours (USA)
E.Lilly & Co. (USA)
FIDIA Research Laboratories (Italy)
Hoffman-La Roche (Switzerland)
Idma (Italy)
ISF S.p.a. (Italy)
Merck Sharp and Dohme Research Laboratories (USA)
Polifarma S.p.a. (Italy)
Proter S.p.a. (Italy)
Sandoz (Italy)
Sandoz (Switzerland)
sigma-Tau S.p.a. (Italy)
Zambon S.p.a. (Italy)
CONTENTS
ANATOMICAL ORGANIZATION AND CHEMICAL NEUROANATOMY OF THE
BASAL GANGLIA
striosomes and matrisomes.............................. 3
Graybiel A.M., Flaherty A.W. and Gimenez-Amaya J.M.
The development of striatal compartmentalization:
the role of mitotic and postmitotic events............. 13
Johnston J.G., Fishell G., Krushel L.A. and
Van der Kooy D.
correlated light and electron microscopy of
golgi-impregnated neostriatal neurons
after 6-hydroxydopamine lesions in the rat ............. 21
Ingham C.A., Hood S.H. and Arbuthnott G.W.
coexpression of neuropeptides and glutamic
acid decarboxylase in cat striatal neurons:
dependence on striosomal compartmentation .............. 29
Besson M.J., Graybiel A.M. and Quinn B.
organization of cholinergic perikarya in
the caudate nucleus of the cat with
respect to heterogeneities in enkephalin
and substance P staining ............................... 39
Martone M.E., Young S.J., Armstrong D.M. and
Groves P.M.
Neuropeptide Y neurons in the striatal network.
Functional adaptive responses to impairment
of stria tal inputs..................................... 49
Kerkerian Le Goff L., Salin P., vuillet J., and
Nieoullon A.
Topographical organization of the thalamostriatal
projections in the Japanese monkey, macaca fuscata,
with special reference to the centromedian
parafascicular and motor thalamic
nuclei. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 63
Nakano K., Hasegawa Y., Kayahara T. and Kuga Y.
Complementarity of the two pallidal segments
in the primate......................................... 73
Filion M., Tremblay L., and Chockkan v.
The pallidum as a dual structure in primates ........... 81
Parent A., Hazrati L.N. and Lavoie B.
xi
The connections of the medial part of the
subthalamic nucleus in the rat: evidence
for a parallel organization ............................ 89
Berendse H.W. and Groenewegen H.J.
The subthalamic nucleus: new data, new questions ....... 99
Feger J., Robledo P. and Renwart N.
Subthalamic nucleus afferents: anatomical
and immunocytochemical features ........................ 109
Carpenter M.B. and Jayaraman A.
Characterization of the synaptic inputs to
dopaminergic neurones in the rat substantia nigra ...... 119
Bolam P. and smith Y.
Multi-collateralization of the dopaminergic
nigrotectal projections in the rat ..................... 133
Takada M., Campbell K.J. and Hattori T.
Convergent projections from substantia nigra
and cerebellum on pontine reticular formation
of rat................................................. 143
Berretta s. and Perciavalle v.
Involvement of the nucleus tegmenti
pedunculopontinus in the descending pathways of
the basal ganglia in the rat ........................... 157
Grofova I., Spann B.M. and Bruce K.
synaptic organization of nucleus accumbens
(ventral striatum)..................................... 167
Meredith G.E. and Wouterlood F.G.
The primate central complex as one of the
basal ganglia .......................................... 177
Percheron G., Francois C., Parent A.,
Sadikot A.F., Fenelon G. and Yelnik J.
The ultrastructural chemoanatomy of the
basal ganglia: 1984-1989. I. The neostriatum ........... 187
Pasik P., Pasik T. and Holstein G.R.
The ultrastructural chemoanatomy of the
basal ganglia: 1984-1989. II. The pallidum,
substantia nigra and substhalamic nucleus .............. 199
Pasik. P., Pasik T. and Holstein G.R.
PHYSIOLOGY OF BASAL GANGLIA COMPONENTS
Dye-coupling in the neostriatum of the rat ............. 213
Cepeda C., Walsh J.P., Hull C.D.,
Buchwald N.A. and Levine M.S.
Neurophysiological changes in aged striatal
neurons in rats........................................ 221
Levine M.S. and Cepeda C.
xii
Short-term plasticity in the ventral striatum:
a comparison between in vivo and in
vitro measurements ..•....•..............•.............• 231
Boeijinga P.H., Lopes da Silva F.H. and
Pennartz C.M.A.
Spontaneous depolarizing synaptic potentials
in the neostriatum ..........................•.......•.. 239
Calabresi P., Mercuri N.B., De Murtas M.,
Stefani A. and Bernardi G.
Dopamine D1 receptors and terminal
excitability in the striatonigral
and nigrostriatal systems ..............•............... 249
Diana M., Ryan L.J., Young S.J. and Groves P.M.
In vivo development of the spontaneous
activity of rat nigrostriatal dopaminergic neurons ..... 259
Tepper J.M., Trent F. and Nakamura S.
Characterization of gaba and glycine
actions on substantia nigra zona compacta neurons ...... 269
Mercuri N.B., Calabresi P., stefani A.,
De Murtas M. and Bernardi G.
Cholinergic excitation of A9 and A10
dopaminergic neurones in vitro through
both nicotinic and muscarinic receptors ................ 275
Lacey M.G., Calabresi P. and North R.A.
Inward rectifying properties of
nucleus accumbens neurones in vitro .................... 285
Uchimura N., Cherubini E. and North R.A.
The glutamatergic and gabaergic transmitter
system in the rat nucleus accumbens:
an electrophysiological in vitro study ................. 293
Pennartz C.M.A., Boeijinga P.H. and
Lopes da silva F.H.
A comparison of single unit activity
in primate caudate nucleus and putamen
in a sensory cued motor task ........................... 303
Aldrigde J.W., Jaeger D. and Gilman S.
PHARMACOLOGY OF DOPAMINE AND RELATIONSHIPS WITH OTHER
NEUROTRANSMITTERS
comparative distribution of D1 receptors
and mu opiate receptors in the neonatal
rat striatum: effects of an early lesion of
dopaminergic fibers .....................•.............. 313
Rogard M., caboche J. and Besson M.J.
Dopaminergic and muscarinic cholinergic receptor
subtypes: localization to neurotransmitters
specific components of the striatum •..............••... 321
Wamsley J.K. and Hunt M.A.
xiii
