The Antibiotic Resistance Laboratory Network

88 Pages·2017·4.12 MB·English

New Efforts in Combating
Antibiotic Resistance – The
Antibiotic Resistance Laboratory
Network
Paula Snippes Vagnone MT(ASCP)
July 11, 2017
MN Laboratory System Webinar Series
Objectives
Describe the ARLN, including Minnesota’s role and
•
testing capacity as a regional lab
Outline the goals of the ARLN
•
Review laboratory methods for the detection of
•
carbapenemases
Describe bacterial and fungal resistance threats
•
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Overview of CDC’s New
Antibiotic Resistance Laboratory Network
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Problem: Gaps in State, Regional & National Lab Capacity
• Limited state capacity to detect and respond to known or emerging forms of resistance
• CDC acts as one of the few sentinel surveillance programs for emerging resistance
 Highly reliant on an informed laboratorian or clinician to flag unusual resistance
• When AR mechanism testing does happen, it is performed at CDC, some state public
health labs or at academic/corporate entities that are not connected to public health
action
• Increasing reliance on culture independent diagnostic testing in clinical labs will limit
public health detection of AR
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Problem: Gaps in State, Regional & National Lab Capacity
CARB Action Plan Outlines Milestones to Improve Laboratory Capacity
Sub-Objective 2.1.1: Create a regional public health laboratory network that uses
standardized testing platforms to expand the availability of reference testing
services, characterize emerging resistance patterns and bacterial strains
obtained from outbreaks and other sources, and facilitate rapid data analysis
and dissemination of information.
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CDC Antibiotic Resistance Threat Report,
September 16, 2013
http://www.cdc.gov/drugresistance/threat-report-2013/pdf/ar-threats-2013-508.pdf#page=14
CDC Antibiotic Resistance Threat Report
ESBL
CRPA
CRE
CRA
MRSA
Microorganisms with a threat level of URGENT:
Clostridium difficile, drug-resistant Neisseria gonorrhoeae, and CRE
Solution: CDC’s AR Laboratory Network (ARLN)
• Transform the national lab infrastructure with
regional laboratories and local labs with gold-
standard methods and technology
• Enhanced testing capacity in all 50 states and
five local jurisdictions
• Faster detection for rapid and improved public
health response
• Communication channels to engage clinical
laboratory partners
• Real-time, actionable data to combat AR
threats
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AR Solutions at Every Level
The ARLN ensures more consistent and
improved communication, coordination,
Healthcare Labs
and tracking at all levels every time.
• When resistance threats are detected
State & Local Health
within healthcare facilities or state/local
Departments
labs, regional labs can provide support to
characterize, support response, and track
these discoveries.
Regional Labs
• Flexibility in surveillance testing to focus
on the next emerging threat.
• CDC’s ARLN team and Programs provide
CDC
logistics support, subject matter expertise,
and tailored solutions.
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