The American Psychiatric Publishing Textbook of Schizophrenia

455 Pages·2006·8.29 MB·English

by  Jeffrey A. Lieberman

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The American Psychiatric Publishing
Textbook of Schizophrenia
EDITORIAL BOARD
Nancy C. Andreasen, M.D., Ph.D.
William T. Carpenter Jr., M.D.
Robert E. Drake, M.D., Ph.D.
Wayne S. Fenton, M.D.
Robert Freedman, M.D.
Raquel Gur, M.D., Ph.D.
Dilip V. Jeste, M.D.
Anthony F. Lehman, M.D., M.S.P.H.
David A. Lewis, M.D.
Stephen R. Marder, M.D.
Carol A. Tamminga, M.D.
Ming T. Tsuang, M.D., Ph.D., D.Sc.
The American Psychiatric Publishing
Textbook of Schizophrenia
E D I T E D B Y
JEFFREY A. LIEBERMAN, M.D.
T. SCOTT STROUP, M.D., M.P.H.
DIANA O. PERKINS, M.D., M.P.H.
Washington, DC
London, England
Note: The authors have worked to ensure that all information in this book is accurate at the time of publication and
consistent with general psychiatric and medical standards, and that information concerning drug dosages, schedules,
and routes of administration is accurate at the time of publication and consistent with standards set by the U.S. Food
and Drug Administration and the general medical community. As medical research and practice continue to advance,
however, therapeutic standards may change. Moreover, specific situations may require a specific therapeutic response
not included in this book. For these reasons and because human and mechanical errors sometimes occur, we recommend
that readers follow the advice of physicians directly involved in their care or the care of a member of their family.
Books published by American Psychiatric Publishing, Inc., represent the views and opinions of the individual authors
and do not necessarily represent the policies and opinions of APPI or the American Psychiatric Association.
If you would like to buy between 25 and 99 copies of this or any other APPI title, you are eligible for a 20% discount;
please contact APPI Customer Service at [email protected] or 800-368-5777. If you wish to buy 100 or more copies of
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Copyright © 2006 American Psychiatric Publishing, Inc.
ALL RIGHTS RESERVED
Manufactured in the United States of America on acid-free paper
10 09 08 07 06 5 4 3 2 1
First Edition
Typeset in Adobe’s Frutiger and Janson Text.
American Psychiatric Publishing, Inc.
1000 Wilson Boulevard
Arlington, VA 22209-3901
www.appi.org
Library of Congress Cataloging-in-Publication Data
The American Psychiatric Publishing textbook of schizophrenia / edited by Jeffrey A. Lieberman, T. Scott Stroup,
Diana O. Perkins.—1st ed.
p. ; cm.
Includes bibliographical references and index.
ISBN 1-58562-191-9 (hardcover : alk. paper)
1. Schizophrenia. I. Lieberman, Jeffrey A., 1948–. II. Stroup, T. Scott, 1960–. III. Perkins, Diana O., 1958–.
IV. American Psychiatric Publishing. V. Title: Textbook of schizophrenia. VI. Title: Schizophrenia.
[DNLM: 1. Schizophrenia—physiopathology. 2. Schizophrenic Psychology. 3. Brain—physiopathology.
4. Schizophrenia—complications. 5. Schizophrenia—therapy. WM 203 A5123 2006]
RC514.A442 2006
616.89′8—dc22
2005035241
British Library Cataloguing in Publication Data
A CIP record is available from the British Library.
To our patients for their courage and for their assistance
in the search for the causes of and cure for their illness.
To my family in gratitude for their love, support, and patience—J.A.L.
To Thelma, Meg, Lib, and Paul—T.S.S.
With appreciation to my husband, Clark, for his intellectual and emotional support,
and to my children, Chris, Nick, and Katie, for their tolerance and love—D.O.P.
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CONTENTS
Contributors. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . xi
Foreword . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .xv
David A. Lewis, M.D.
Preface . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .xvii
Jeffrey A. Lieberman, M.D.
T. Scott Stroup, M.D., M.P.H.
Diana O. Perkins, M.D., M.P.H.
1
History of Schizophrenia and Its Antecedents . . . . . . . . . .1
Michael H. Stone, M.D.
2
Epidemiology. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .17
William W. Eaton, Ph.D.
Chuan-Yu Chen, Ph.D.
3
Genetics . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .39
Patrick F. Sullivan, M.D., F.R.A.N.Z.C.P.
Michael J. Owen, Ph.D., F.R.C.Psych., F.Med.Sci.
Michael C. O’Donovan, Ph.D., F.R.C.Psych.
Robert Freedman, M.D.
4
Prenatal and Perinatal Factors . . . . . . . . . . . . . . . . . . . . . .55
John H. Gilmore, M.D.
Robin M. Murray, M.D.
5
Neurodevelopmental Theories. . . . . . . . . . . . . . . . . . . . . .69
Matcheri S. Keshavan, M.D.
Andrew R. Gilbert, M.D.
Vaibhav A. Diwadkar, Ph.D.
6
Neurochemical Theories . . . . . . . . . . . . . . . . . . . . . . . . . . .85
Daniel C. Javitt, M.D., Ph.D.
Marc Laruelle, M.D.
7
Phospholipids in Schizophrenia. . . . . . . . . . . . . . . . . . . . 117
Sahebarao P. Mahadik, Ph.D.
Jeffrey K. Yao, Ph.D., F.A.C.B.
8
Neuroprogressive Theories . . . . . . . . . . . . . . . . . . . . . . . 137
L. Fredrik Jarskog, M.D.
John H. Gilmore, M.D.
9
Neuropathology and Neural Circuits
Implicated in Schizophrenia. . . . . . . . . . . . . . . . . . . . . . . 151
L. Fredrik Jarskog, M.D.
Trevor W. Robbins, Ph.D.
10
Structural and Functional Neuroanatomy . . . . . . . . . . . 167
Aysenil Belger, Ph.D.
Gabriel Dichter, Ph.D.
11
Psychopathology. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 187
J. P. Lindenmayer, M.D.
Anzalee Khan, M.S.
12
Co-occurring Substance Use and
Other Psychiatric Disorders . . . . . . . . . . . . . . . . . . . . . . . 223
Mary F. Brunette, M.D.
Douglas L. Noordsy, M.D.
Alan I. Green, M.D.
13
Neurocognitive Impairments. . . . . . . . . . . . . . . . . . . . . . 245
Richard S.E. Keefe, Ph.D.
Charles E. Eesley, B.S.
14
Social Cognitive Impairments . . . . . . . . . . . . . . . . . . . . . 261
David L. Penn, Ph.D.
Jean Addington, Ph.D.
Amy Pinkham, M.A.
15
Social and Vocational Impairments. . . . . . . . . . . . . . . . . 275
Kim T. Mueser, Ph.D.
Shirley M. Glynn, Ph.D.
Susan R. McGurk, Ph.D.