Table Of ContentTHE AGEING BRAIN
THE AGEING BRAIN
THE NEUROBIOLOGY AND
NEUROPSYCHIATRY OF AGEING
Edited by
PERMINDER S. SACHDEV
This edition published in the Taylor & Francis e-Library, 2005.
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Published by: Swets & Zeitlinger Publishers
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ISBN 0-203-97097-7 Master e-book ISBN
ISBN 90 265 1943 5(Print Edition)
Contents
ACKNOWLEDGEMENTS ix
Section I Introduction 1
CHAPTER 1: THE AGEING BRAIN 3
Perminder S Sachdev
CHAPTER 2 POPULATION AGEING, HUMAN LIFESPAN AND
NEURODEGENERATIVE DISORDERS: A FIFTH EPIDEMIOLOGIC
TRANSITION 11
G Anthony Broe
Section II Characteristics of the ageing brain 33
CHAPTER 3 STRUCTURAL CHANGES IN THE AGEING HUMAN BRAIN 35
Jillian J Kril
CHAPTER 4 STRUCTURAL NEUROIMAGING OF THE AGEING BRAIN 49
Jeffrey CL Looi and Perminder S Sachdev
CHAPTER 5 NEUROPHYSIOLOGICAL, SENSORY AND MOTOR CHANGES
WITH AGEING 63
Stephen R Lord and Rebecca St George
CHAPTER 6 COGNITIVE CHANGES AND THE AGEING BRAIN 75
Helen Christensen and Rajeev Kumar
CHAPTER 7 AGEING OF THE HUMAN BRAIN AS STUDIED BY
FUNCTIONAL NEUROIMAGING 97
Julian N Trollor and Perminder S Sachdev
vi CONTENTS vii
CHAPTER 8 NEUROENDOCRINE ASPECTS OF BRAIN AGEING 139
George A Smythe
CHAPTER 9 CEREBROVASCULAR SYSTEM AND THE AGEING BRAIN 153
Valendai K Srikanth and Geoffrey A Donnan
Section III Factors influencing brain ageing 171
CHAPTER 10 THE MOLECULAR BASIS OF ALZHEIMER’S DISEASE
AND FRONTOTEMPORAL DEMENTIA 173
John BJ Kwok and Peter R Schofield
CHAPTER 11 OXIDATIVE AND FREE RADICAL MECHANISMS IN BRAIN
AGEING 187
Judy de Haan, Rocco C Iannello, Peter J Crack, Paul Hertzog and
Ismail Kola
CHAPTER 12 THE ROLE OF NUTRITIONAL FACTORS IN COGNITIVE
AGEING 205
Janet Bryan
CHAPTER 13 THE BRAIN RESERVE HYPOTHESIS 223
Peter W Schofield
Section IV Clinical interface 241
CHAPTER 14 WILL WE ALL DEMENT IF WE LIVE LONG ENOUGH? 243
Carol Brayne
CHAPTER 15 DETECTING ALZHEIMER’S DISEASE AT THE
PRE-SYMPTOMATIC STAGE 259
Gary W Small
CHAPTER 16 PARKINSONISM AND AGEING 275
John GL Morris, Mariese A Hely and Glenda M Halliday
CHAPTER 17 AGE VARIATION IN THE PREVALENCE OF DEPRESSION:
ARE STUDY FINDINGS MEANINGFUL? 283
John Snowdon
CHAPTER 18 VASCULAR DEMENTIA 299
Perminder S Sachdev
vi CONTENTS vii
CHAPTER 19 CONCLUSION 323
Perminder S Sachdev
CONTRIBUTORS ADDRESS LIST 327
SUBJECT INDEX 333
AUTHOR INDEX
Acknowledgements
The seed for this book was sown with the formation of The Ageing Brain
Program at the University of New South Wales in 1998, and the early sprout
appeared in 2000 at the International Conference on the Ageing Brain held at
the Scientia, University of New South Wales, Sydney. The book is, of course,
more than the Conference, and its diverse foliage is the dedicated work of
many scientists and scholars. I am extremely grateful to all the authors for
that extra effort that made each of the chapters a significant contribution.
The editing of a book is a labour of love that demands doggedness and com-
pulsive persistence. The latter qualities were brought to this work with meas-
ured good humour by Angela Russell, who undertook the tasks of editing and
compiling. If she sometimes annoyed the contributors with her deadlines and
diligent proofreading, the final manuscript will more than compensate for it.
She was assisted in this task by the quiet and behind-the-scenes contribution
of Wanda Schinke. The flair of Joanna Christie was an important determinant
of the success of the Conference.
The planning of this book, and its intellectual content, were influenced by
many colleagues to whom I am extremely grateful. I would like to make
particular mention of Sam Aroni, Henry Brodaty, Tony Broe, Felicia Hup-
pert, Jeffrey Looi, Gary Small, Julian Trollor, Michael Valenzuela and Xing
Li Wang who were generous with their suggestions and time. I found, in the
publishers of this book, a rather indulgent group of professionals, led by
Arnout Jacobs, who let many deadlines go past with little more than gentle
reminders.
For the undisturbed small hours of the morning that the writing took me
into, I am in debt of my family — my beautiful wife Jagdeep and our lovely
daughters Nupur and Sonal. They have provided the environment which has
continued to nurture me through all my academic travails.
My research into neuropsychiatric disorders of the elderly has been supported
generously by the University of New South Wales and the National Health
