The Adhesion Molecule Factsbook

325 Pages·1993·48.08 MB·English

by  Rod Pigott Christine Power

THE
ADHESION
MOLECULE
FactsBook
Second Edition
THE
ADHESION
MOLECULE
FactsBook
Second Edition
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Grahame Hardie and Steven Hanks
The Protein Kinase FactsBook
The Protein Kinase FactsBook CD-Rom
Edward C. Conley
The Ion Channel FactsBook
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The Ion Channel FactsBook
Ih Intracellular Ligand-Gated Channels
Edward C. Conley and William J. Brammar
The Ion Channel FactsBook
IV: Voltage-gated Channels
Kris Vaddi, Margaret Keller and Robert Newton
The Chemokine FactsBook
Marion E. Reid and Christine Lomas-Francis
The Blood Group Antigen FactsBook
A. Neil Barclay, Marion H. Brown, S.K. Alex Law, Andrew J. McKnight,
Michael G. Tomlinson and P. Anton van der Merwe
The Leucocyte Antigen FactsBook, 2nd edn
Robin Hesketh
The Oncogene and Tumour Suppressor Gene FactsBook, 2nd edn
Jeffrey K. Griffith and Clare E. Sansom
The Transporter FactsBook
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and Mary Saunders
The Gene Knockout FactsBook
Bernard J. Morley and Mark J. Walport
The Complement FactsBook
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The HLA FactsBook
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The Leukemia-Lymphoma Cell Line FactsBook
THE
A D H E S I O N
MOLECULE
FactsBook
Second Edition
Clare M. Isacke
Imperial College of Science, Technology and Medicine,
London, UK
Michael A. Horton
University College London, London, UK
ACADEMIC PRESS
A Harcourt Science and Technology Company
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Copyright (cid:14)9 2000 by ACADEMIC PRESS
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ISBN 0-12-356505-7
Library of Congress Catalog Card Number: 00-104879
A catalogue for this book is available from the British Library
Typeset by Mackreth Media Services, Hemel Hempstead, UK
Printed in Great Britain by Redwood Books, Trowbridge, Wiltshire
00 01 02 03 04 05 RB 9 8 7 6 5 4 3 2 1
Preface vii
...
Abbreviations Vlll
Chapter 1
Introduction 2
Chapter 2
Adhesion Molecule Families 7
Chapter 3
Accessing Information on the World Wide Web 33
Cadherins CD33 ....................................... 97
E-Cadherin ................................. 43
N-Cadherin ................................. 46
P-Cadherin CEACAM family ..................... 103
R-Cadherin ................................. 5 1 Contactin- 1 108
VE-Cadherin .............................. 53 ICAM- 1 .................................... 111
ICAM-2 .................................... 114
.......................... 57 ICAM-3 .................................... 116
OB-Cadherin .............................. 59 ICAM-4 ...................
Cadherin- 14 ..........
Ksp-Cadherin .............................. 69
.............. 133
Desmocollin 3 ........................... 78 Sialoadhesin .............................. 138
Desmoglein 1 ....... 80
Desmoglein 2 .............................. 83
Desmoglein 3 .............................. 85
Integrins
Immunoglobulin superfamily Integrin aL. ................................ 149
ALCAM .................................... 89 Integrin aM .............................. 152
CD22a and p .............................. 9 1 Integrin ax .............................. 155
CD31 ....................................... 94 Integrin a” .............................. 157
Integrin a1. ................................ 159 CD6 .................. 23 7
CD23 ....................................... 239
Integrin a3. ...............
CD39 ....................................... 247
Integrin ah. ................................ 173
Integrin a, ................................. 176
Integrin a8. ... CD42c .................................... 254
Integrin ag. ...
Integrin a, .............................. 182 CD43 ...........
Integrin aIlb. ............................. 184
Integrin av 187 CD57 ....................................... 264
Integrin aE. ................................ 190
Integrin PI ................................. 192
Integrin PI ................................. 195 Claudin-1 ................................. 271
Integrin P3 ................................. 198 Claudin-3 273
Integrin P4. ................................ 20 1 Claudin-4 ................................. 275
Integrin P, ................................. 208 Collagen type XI11 (a1c hain) ......2 80
Integrin Ps 210 Collagen type XVII (a1 chain)
Dystroglycan .....................
Selectins E48 .......................................... 288
E-Selectin ...... 21s ESL- 1 290
L-Selectin ................................. 218 Galectin 3 ................................. 292
P-Selectin ................................. 220 GlyCAM-1 .............................. 294
HSA ....................................... 296
Sy ndecans
LYVE- 1 298
Syndecan-1 .............................. 225
Occludin ................................. 300
Syndecan-2 .......... 227 PCLPl .................................... 302
Syndecan-3 .............................. 229
PSGL- 1 304
Syndecan-4 23 1
VAP-1 .................................... 307
Other molecules
AMOG ..................2 35 Index ....................................... 309
The authors acknowledge all those who have helped in the completion of this
book. In particular we would like to thank Chau Chong for excellent secretarial
help, our laboratories for their patience while the book was being written and
members of the UK Adhesion Group who filled in questionnaires suggesting
molecules that should be included. Many colleagues were invaluable in checking
entries and providing unpublished information. We would particularly like to
thank Ann Ager, Chris Buckley, Paul Crocker, Pat Doherty, Kurt Drickamer,
Nancy Hog, Gudrun Ihrke, David Jackson, Sirpa Jalltanen, Clive Landis, Tony
Magee, Fiona Watt, Sue Watt and Lisa Williams. Writing this book was greatly
helped by the recent publication of The Leucocyte Antigen FactsBook, and we
would like to acknowledge Neil Barclay, Marion Brown, Alex Law, Andrew
McKnight, Michael Tomlinson and Anton van der Merwe whose hard work made
our task much easier.
With the published literature on adhesion molecules increasing by several
thousand papers per annum and the various mammalian genome projects
sequencing apace, a book will inevitably contain omissions and inaccuracies, and
the references have a danger of being superseded. For this we apologize. However,
with access to electronic databases on the World Wide Web (see Chapter 3),t his is
relatively easy to remedy and the reader is asked to bear with us and make their
own updates relating to a favourite molecule.
AIDS Acquired immunodeficiency syndrome
B B lymphocyte
BCR B cell antigen receptor
CCP Complement control protein
CD Cluster of differentiation
CNR Cadherin-related neuronal receptor
cs Chondroitin sulphate
ECM Extracellular matrix
EGF Epidermal growth factor
ERM Ezrin/radixin/moesin
ES Embryonic stem
EST Expressed sequence tag
FAK Focal adhesion kinase
FGF Fibroblast growth factor
GAG Gly cosaminoglycan
GalNAc N-A cetylgalactosamine
GlcNAc N-A cetylglucosamine
GPI Gly cosyl-phosphatidylinositol
GSK Glycogen synthase kinase
HEV High endothelial venule
IFN Interferon
Ig Immunoglobulin
IgSF Immunoglobulin superfamily
IL Interleukin
ITIM Immunoreceptor tyrosine-based inhibitory motif
kb Kilobase pairs
kDa Kilodalton
LAD Leucocyte adhesion deficiency
LPS Lipopoly saccharide
LRR Leucine-rich repeat
MAPK Mitogen-activated protein kinase
MGI Mouse Genome Informatics
MHC Major histocompatibility complex
NK Natural killer
NMR Nuclear magnetic resonance
OMIM Online Mendelian Inheritance in Man
PI Phosphatidylinositol
SDS-PAGE Polyacrylamide gel electrophoresis in sodium dodecyl sulphate
SH2 Src homology domain 2
SH3 Src homology domain 3
sLeA Sialyl-Lewis*
sLeX Sialyl-LewisX
T T lymphocyte
TM Transmembrane
TM4SF Tetraspan supcrfamily
TNF Tumour nccrosis factor
WFl Wingless
www Wnrld Widc Wch
Size Type Size
(approximate (approximate
amino acids) 8 amino acids)
D
Cadherin T 10 Lectin C-type 120
repeat
h Galccrin or 140
Collagennus Vatisblc Lectin S-type
domain length
a
0 LRR repeats
24
Complement "r'
control protein 60
(CCPF Link 90
p+
Drsrnoglein @ 30 70-90
repeat
Scavenger 110
Epidermal p receptor
growth 40
factor (EGF)
OTHER SYMBOLS USED
N-g Iy cory lation si teP h
Fihronectin
type 111 /FnN Q-linked glymwlation /
Glrcmoam inoglvcan -SJ
-
GPI anchor in
lipid hilayer
Jrn munoglohulin Site of propeptide cleavage
(Ig) C2 set [c.R.i n cad herins!
Unknown nr unclear molecular
7
cnnfnrrnation nr membrane
attnchrnent/linkajy
Figure 1 Icons used for the protein domains and repeats that are present in
adhesion molecules.