Table Of ContentKewal K. Jain
Textbook of
Personalized
Medicine
Second Edition
T extbook of Personalized Medicine
T extbook of Personalized
Medicine
Second Edition
Kewal K. Jain, MD, FRACS, FFPM
Jain PharmaBiotech, Basel, Switzerland
K ewal K . J ain
J ain PharmaBiotech
B asel, S witzerland
I SBN 978-1-4939-2552-0 ISBN 978-1-4939-2553-7 (eBook)
D OI 10.1007/978-1-4939-2553-7
L ibrary of Congress Control Number: 2015934582
S pringer New York Heidelberg Dordrecht London
© Springer Science+Business Media New York 2 014, 2015
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“ Tonight, I’m launching a new Precision
Medicine Initiative to bring us closer
to curing diseases like cancer
and diabetes — and to give all of us
access to the personalized information
we need to keep ourselves and our families
healthier.”
—President Barack Obama,
State of the Union Address,
20 January 2015, USA
P reface to the S econd Edition
Considerable advances have taken place in technologies used for advancing person-
alized medicine, and it is increasingly applied in clinical use. This has required
expansion and revision of some parts of the fi rst edition published in 2009. The style
has been maintained due to the positive feedback of readers, including scientists,
pharmacists, physicians, and lay persons interested in this topic. The book provides
a concise and comprehensive source of reference for those involved in healthcare
management, planning, and politics. As a single author book, it avoids the overlaps
and missing areas frequently found in multiauthor books. Moreover, the time to
publication is reduced by avoiding the long delays of numerous authors who do not
keep the deadlines.
The book includes 700 references selected from thousands of publications during
the past decade and appended at the end of each chapter. Some of the references
included were prepublication versions at the end of 2014 that will not be formally
published until 2015. The text is supplemented by 31 illustrations and 56 tables.
Algorithms are included as a guide to those involved in the management of important
diseases where decision making is involved due to the multiple choices available.
Finally, I thank the editorial staff of Springer, particularly Patrick Marton and
David Casey, for their help and encouragement in this project.
B asel, Switzerland K ewal K . J ain
vii
P reface to the First Edition
P ersonalized medicine, which simply means selection of treatment best suited for
an individual, involves integration and translation of several new technologies in
clinical care of patients. The scope is much broader than indicated by the term
genomic medicine, because many non-genomic factors are taken into consideration
in developing personalized medicine. Basic technologies for personalized medicine,
of which molecular diagnostics has the biggest share, are mentioned briefl y and
appropriate references are given for further information. Commercial aspects are
discussed briefl y in a chapter and detailed analysis of markets and companies
involved in personalized medicine is presented in a special report on this topic.
There is increasing interest in personalized medicine. Considerable advances have
taken place in molecular biology and biotechnology to make personalized medicine
a viable option, but some misconceptions still exist, both in the academic and in the
commercial sectors. There is lack of a suitable source of information that provides
both the fundamentals as well as applications of personalized medicine. As the lat-
est version of the fi rst monograph on personalized medicine published in 1998, this
volume, Textbook of Personalized Medicine , summarizes the author’s efforts during
the past decade as well as reviews of selected studies done during this period in a
readable format for physicians and scientists. It is hoped that physicians, pharma-
cists, scientists, and interested lay readers with basic scientifi c knowledge will fi nd
this book useful.
B asel, Switzerland K ewal K . J ain
ix
