Textbook of Pediatric Rheumatology

971 Pages·2021·112.708 MB·English

by  Ross E Petty MD PhD FRCPC, Ronald Laxer MDCM FRCPC, Carol Lindsley MD FAAP MACR, Lucy Wedderburn MD MA PhD FRCP, Robert C Fuhlbrigge MD PhD, Elizabeth D. Mellins MD

Textbook of
PEDIATRIC
RHEUMATOLOGY
Eighth Edition
Ross E. Petty, MD, PhD, DSc (Hon), FRCPC Lucy R. Wedderburn, MD, MA, PhD, FRCP
Professor Emeritus Professor in Paediatric Rheumatology
Department of Pediatrics UCL GOS Institute of Child Health
University of British Columbia University College London;
Vancouver, British Columbia, Canada Consultant in Paediatric Rheumatology
Great Ormond Street Hospital NHS Trust
London, UK
Ronald M. Laxer, MDCM, FRCPC
Professor of Pediatrics and Medicine
Elizabeth D. Mellins, MD
University of Toronto
Temerty Faculty of Medicine Professor of Pediatrics
Division of Rheumatology Program in Immunology
The Hospital for Sick Children Stanford University
Toronto, Ontario, Canada Stanford, California, USA
Carol B. Lindsley, MD Robert C. Fuhlbrigge, MD, PhD
Professor Emerita Professor of Pediatrics
Pediatrics University of Colorado;
University of Kansas Medical Center Chair of Rheumatology
Kansas City, Kansas, USA Children’s Hospital Colorado
Aurora, Colorado, USA
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TEXTBOOK OF PEDIATRIC RHEUMATOLOGY, EIGHTH EDITION ISBN: 978-0-323-636520
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To Beryl, Edda, Bart, Jerry, Paul, and Anne,
our children and grandchildren,
and to our students, our patients, and their families
who challenge and inspire us.
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P R E FAC E
The first edition of the Textbook of Pediatric Rheumatology, edited Wright, Dr. Nico Wulfraat, and Dr. Francisco Zulian. In the current
by James T. Cassidy and published in 1982, comprised the collective edition, new syndromes have been identified, and although the clinical
contributions of five authors. Subsequent editions have required the features of the diseases that constitute the “core” of a pediatric rheu-
expertise of increasing numbers of contributors, and in the current matology practice have not changed substantially, the understand-
edition, no fewer than six editors and more than 100 authors from 20 ing of their etiology and pathogenesis, contemporary management,
countries have presented a comprehensive review of the continually and outcomes has advanced significantly. The basic science chapters
expanding field of pediatric rheumatology. Once viewed as a study of provide insight into the complexities of genetics, inflammation, and
chronic arthritis in children, with a nod to diseases such as systemic immunology, which are illuminating our understanding of the clini-
lupus, dermatomyositis, and scleroderma, pediatric rheumatology has cal manifestations of rheumatic diseases. Clinical aspects of disease are
grown both in breadth and depth to encompass the fascinating and illustrated by the use of many photographs and figures. An apprecia-
challenging realm of the diverse chronic arthritides, connective tissue tion of clinical research approaches is provided in the chapters on trial
diseases, vasculitides, autoinflammatory diseases, and non-inflam- design and interpretation and health outcomes. The generous use of
matory pain syndromes. To optimally present and discuss up-to-date up-to-date references encourages the reader to further pursue details
information about these disorders, the clinical and scientific expertise of research studies.
of an excellent international group of authors has been recruited. The Every attempt has been made to provide the most up-to-date infor-
eighth edition of the Textbook of Pediatric Rheumatology has engaged mation and references, but thanks to the gratifyingly rapid changes in
the expertise of many new authors whose contributions have often both understanding of pathogenesis and application of new diagnostic
been built on the work of authors of the previous editions to whom and therapeutic advances, and the long gestation of a textbook, the
we are grateful. At the same time, these new authors have presented a reader is urged to be alert to the newest publications, particularly those
somewhat different and updated viewpoint. published since 2020.
The editors’ decision to recruit new authors and “retire” others We hope that this contribution will provide a reference for the stu-
has been difficult. We are indebted to authors of the seventh edition dent of pediatric rheumatology, will demonstrate the challenges and
whose contributions have been so important: Dr. Salvatore Albani, excitement of the specialty of pediatric rheumatology, and will facili-
Dr. Paul Babyn, Dr. Arvind Bagga, Dr. Susanne Benseler, Dr. Ruben tate optimal comprehensive management of children and adolescents
Burgos-Vargas, Dr. Jill Buyon, Dr. William Cole, Dr. Andrea Doria, with rheumatic diseases throughout the world.
Dr. Frank Dressler, Dr. Ciaran Duffy, Dr. Hans-Iko Huppertz, Dr. Ross E. Petty
Norman Ilowite, Dr. Adam Kirton, Ms. Gay Kuchta, Dr. Jerome Lane, Ronald M. Laxer
Dr. Steven Leeder, Dr. Elizabeth Legger, Dr. Daniel Lovell, Dr. Outi Carol B. Lindsley
Makitie, Dr. Frederick Miller, Dr. Kiem Oen, Dr. Peri Pepmueller, Lucy R. Wedderburn
Dr. Berent Prakken, Dr. Michael Rapoff, Dr. Lisa Rider, Dr. Ricardo Elizabeth D. Mellins
Russo, Dr. Rayfel Schneider, Dr. Robert Sundel, Dr. Susan Thompson, Robert C. Fuhlbrigge
Dr. Joris van Montfrans, Dr. Janitzia Vazques-Mellado, Dr. James
vi
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C O N T R I B U TO R S
Mario Abinun, MD, PhD Karyl Barron, MD Paul Brogan, PhD, FRCPCH
Emeritus Consultant Deputy Scientific Director Professor of Vasculitis and Honorary
Paediatric Immunology Division of Intramural Research Consultant Paediatric Rheumatologist
Great North Children’s Hospital; National Institute of Allergy and Infectious Infection Immunity And Rheumatology
Associate Lecturer Diseases Section
Translational and Clinical Research Institute National Institutes of Health UCL Institute of Child Health
Faculty of Medical Sciences Bethesda, Maryland, USA London, UK
Newcastle University
Newcastle upon Tyne, UK Julie Barsalou, MD, FRCPC, MSc Hermine I. Brunner, MD MSc
Pediatric Rheumatologist Professor of Pediatrics
Amita Aggarwal, MD, DM Rheumatology and Immunology Division of Rheumatology
Professor CHU Sainte-Justine; Cincinnati Children’s Hospital Medical
Department of Clinical Immunology and Clinical Assistant Professor of Pediatrics Center
Rheumatology Université de Montréal University of Cincinnati
Sanjay Gandhi Postgraduate Institute of Montreal, Quebec, Canada Cincinnati, Ohio, USA
Medical Sciences
Lucknow, Uttar Pradesh, India Mara L. Becker, MD, MSCE Jane C. Burns, MD
Professor of Pediatrics Professor of Pediatrics
Jonathan Akikusa, MBBS, FRACP Duke University/Duke Clinical Research Director
General Medicine, Rheumatology Service Institute Kawasaki Disease Research Center
Royal Children’s Hospital Durham, North Carolina, USA University of California San Diego School of
Melbourne, Victoria, Australia Medicine
Edward M. Behrens, MD La Jolla, California, USA
Roger Allen, MB BS, FRACP Associate Professor of Pediatrics
Department of Rheumatology Perelman School of Medicine at the Robert Busch, BSc, PhD
Royal Children’s Hospital University of Pennsylvania; Senior Lecturer
Melbourne, Victoria, Australia Joseph Lee Hollander Chair of Pediatric Department of Life Sciences
Rheumatology University of Rochampton
Khaled Alsaeid, MD The Children’s Hospital of Philadelphia London, UK
Professor of Pediatrics Philadelphia, Pennsylvania, USA
Kuwait University David A. Cabral, MBBS
Jabryah, Kuwait Michael W. Beresford, MBChB, PhD Ross Petty Chair and Clinical Professor
Professor of Child Health Division of Rheumatology
Tadej Avčin, MD, PhD Institute of Life Course and Medical Department of Pediatrics
Professor of Pediatrics Sciences British Columbia Children’s Hospital and
Department of Allergology, Rheumatology University of Liverpool; University of British Columbia
and Clinical Immunology Honorary Consultant Paediatric Vancouver, British Columbia, Canada
Children’s Hospital, University Medical Rheumatologist
Center Ljubljana Alder Hey Children’s NHS Foundation Scott W. Canna, MD
Ljubljana, Slovenia Trust Assistant Professor
Liverpool, UK Pediatrics and Immunology
Stephen Balevic, MD, MHS University of Pittsburgh, UPMC Children’s
Assistant Professor Timothy Beukelman, MD, MSCE Hospital of Pittsburgh
Internal Medicine and Pediatrics Associate Professor Pittsburgh, Pennsylvania, USA
Duke University/Duke Clinical Research Department of Pediatrics, Division of
Institute Rheumatology Sharon Choo, MBBS, FRACP, FRCPA
Durham, North Carolina, USA University of Alabama at Birmingham Allergy and Immunology
Birmingham, Alabama, USA Laboratory Services
Brenda Banwell, MD, FRCPC, FAAN The Royal Children’s Hospital
Chief of Neurology Linda K. Bockenstedt, MD Melbourne, Victoria, Australia
Children’s Hospital of Philadelphia; Harold W. Jockers Professor of Medicine
Professor of Neurology and Pediatrics Internal Medicine/Rheumatology Rolando Cimaz, MD
Perelman School of Medicine Yale University School of Medicine Professor of Rheumatology
University of Pennsylvania New Haven, Connecticut, USA University of Milano
Philadelphia, Pennsylvania, USA Milan, Italy
vii
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viii CONTRIBUTORS
Coziana Ciurtin, PhD, FRCP Brian Michael Feldman, MD, MSc, Alexei A. Grom, MD
Associate Professor in Rheumatology FRCPC Professor of Pediatrics
Consultant Rheumatologist Professor University of Cincinnati, College of
Centre for Adolescent Rheumatology Departments of Pediatrics, Medicine;
University College London Medicine, and the Institute of Health Attending Physician
London, UK Policy, Management, and Rheumatology
Evaluation Cincinnati Children’s Hospital Medical
Jacqui Clinch, MBBS, MRCP, FRCPCH The Hospital for Sick Children, University Center
Consultant in Paediatric Rheumatology of Toronto Cincinnati, Ohio, USA
Paediatric Rheumatology Toronto, Ontario, Canada
Bristol Royal Hospital for Children Liora Harel, MD
Bristol, UK; Polly J. Ferguson, BS, MD Director
Consultant in Paediatric Pain Professor of Pediatrics Pediatric Rheumatology Unit
Bath Centre for Pain Services University of Iowa Carver College of Schneider Children’s Medical Center
Royal National Hospital for Rheumatic Medicine Israel;
Diseases Iowa City, Iowa, USA Associate Professor of Pediatrics
Bath, UK Sackler School of Medicine, Tel Aviv University
Tel Aviv, Israel
Helen Elisabeth Foster, MBBS
Robert A. Colbert, MD, PhD (Hons), FRCP, FRCPCH, DCH, MD, Philip J. Hashkes, MD, MSc
Senior Investigator Cert Med Ed
Head, Pediatric Rheumatology Unit
National Institute of Arthritis, Professor, Paediatric Rheumatology Department of Pediatrics
Musculoskeletal and Skin Diseases Newcastle University; Shaare Zedek Medical Center;
National Institutes of Health Honorary Consultant Paediatric Associate Professor of Pediatrics
Bethesda, Maryland, USA Rheumatologist Hebrew University Hadassah School of
Great North Children’s Hospital Medicine
Alessandro Consolaro, MD, PhD Newcastle Hospitals NHS Foundation Jerusalem, Israel
Assistant Professor of Pediatrics Trust
IRCCS Istituto Giannina Gaslini Newcastle upon Tyne, UK Christian Michael Hedrich, MD, PhD
University of Genova
Professor
Genova, Italy
Robert C. Fuhlbrigge, MD, PhD Department of Women’s and Children’s Health
Professor of Pediatrics Institute of Life Course and Medical
Jennifer C. Cooper, PharmD, MD
University of Colorado; Sciences, University of Liverpool
Assistant Professor
Chair of Rheumatology Liverpool, Merseyside, UK
Pediatrics, Section of Rheumatology
Children’s Hospital Colorado
University of Colorado School of Medicine
Aurora, Colorado, USA Gerd Horneff, MD
Aurora, Colorado, USA
Director
Ryan S. Funk, PharmD, PhD General Pediatrics and Neonatology
Randy Q. Cron, MD, PhD
Professor Asklepios Clinic Sankt Augustin
Professor of Pediatrics and Medicine
Pharmacy Practice Sankt Augustin, Germany
Pediatrics
University of Kansas
University of Alabama at Birmingham
Kansas City, Kansas, USA Kristin Michelle Houghton, MD, MSc,
School of Medicine;
FRCPC, Diploma Sports Medicine
Director of Pediatric Rheumatology
Marco Gattorno, MD Clinical Associate Professor of Pediatrics
Pediatrics
Center for Autoinflammatory diseases and British Columbia Children’s Hospital
Children’s Hospital of Alabama
Immunedeficiencies University of British Columbia
Birmingham, Alabama, USA
IRCCS G. Gaslini Vancouver, British Columbia, Canada
Genova, Italy
Iris Davidson, BSR Edgar Jaeggi, MD, FRCPC
Physical Therapist Gabriella Giancane, MD, PhD Cardiologist
Division of Rheumatology Assistant Professor of Pediatrics Head, Fetal Cardiac Program;
BC Children’s Hospital IRCCS Istituto Giannina Gaslini Professor of Pediatrics
Vancouver, British Columbia, Canada University of Genova The Hospital for Sick Children, University
Genova, Italy of Toronto
Perrine Dusser, MD Toronto, Ontario, Canada
Pediatric Rheumatology Anne M. Griffiths, MD, FRCPC
CHU Kremlin Bicêtre Professor of Pediatrics Mehul Jariwala, MBBS, DNB (Pediatrics)
Paris, France University of Toronto Temerty Faculty of Assistant Professor
Medicine Division of Rheumatology, Department of
Despina Eleftheriou, MBBS, PhD Division of Gastroenterology, Hepatology Pediatrics
Professor of Paediatric Rheumatology and Nutrition University of Saskatchewan
UCL The Hospital for Sick Children Saskatoon, Saskatchewan, Canada
London, UK Toronto, Ontario, Canada
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CONTRIBUTORS ix
Jordan T. Jones, DO, MS Suzanne C. Li, MD, PhD Peter A. Nigrovic, MD
Assistant Professor of Pediatrics Professor of Pediatrics Associate Professor of Medicine
Children’s Mercy Kansas City Hackensack Meridian School of Medicine; Harvard Medical School;
University of Missouri-Kansas City School Senior Attending, Pediatrics Chief, Division of Immunology
of Medicine; Joseph M Sanzari Children’s Hospital Boston Children’s Hospital;
Clinical Assistant Professor of Pediatrics Hackensack University Medical Center Director, Center for Adults with Pediatric
University of Kansas School of Medicine Hackensack, New Jersey, USA; Rheumatic Illness
Kansas City, Kansas, USA Associate Professor of Pediatrics Division of Rheumatology, Inflammation,
Rutgers New Jersey Medical School and Immunity
Daniel L. Kastner, MD, PhD Newark, New Jersey, USA Brigham and Women’s Hospital
Scientific Director Boston, Massachusetts, USA
Division of Intramural Research Carol B. Lindsley, MD
National Human Genome Research Institute Professor Emerita Kerstin A. Nott, Dr.med.
National Institutes of Health Pediatrics Paediatric Rheumatology
Bethesda, Maryland, USA University of Kansas Medical Center Great Ormond Street Hospital for Children
Kansas City, Kansas, USA NHS Foundation Trust
Yukiko Kimura, MD London, UK
Professor of Pediatrics Alberto Martini, MD
Hackensack Meridian School of Medicine Professor Emeritus Kathleen M. O’Neil, MD
Nutley, New Jersey, USA; University of Genoa Professor Emerita
Division Chief, Pediatric Rheumatology Genoa, Italy Clinical Pediatrics
Joseph M Sanzari Children’s Hospital Indiana University School of Medicine;
Hackensack University Medical Center Elizabeth D. Mellins, MD Pediatric Rheumatology
Hackensack, New Jersey, USA Professor of Pediatrics Riley Hospital for Children at IU Health
Program in Immunology Indianapolis, Indiana, USA
Marisa S. Klein-Gitelman, MD, MPH Stanford University
Professor of Pediatrics Stanford, California, USA Michael J. Ombrello, MD
Northwestern University Feinberg School Principal Investigator
of Medicine; Kimberly A. Morishita, MD, MHSc National Institute of Arthritis and
Head, Division of Rheumatology Clinical Associate Professor of Pediatrics Musculoskeletal and Skin Diseases
Ann and Robert H. Lurie Children’s University of British Columbia and BC National Institutes of Health
Hospital of Chicago Children’s Hospital Bethesda, Maryland, USA
Chicago, Illinois, USA Vancouver, British Columbia, Canada
Lisa Orme, MB BS, FRACP
Isabelle Koné-Paut, MD Eyal Muscal, MD, MS Children’s Cancer Centre
Professor of Pediatrics Section Chief, Rheumatology Royal Children’s Hospital
Pediatric Rheumatology and National Associate Professor, Department of Parkville, Victoria, Australia
Reference Center for Autoinflammatory Pediatrics
Diseases and Inflammatory Amyloidosis Co-appointment in Pediatric Seza Ozen, MD
CEREMAIA Neurology and Developmental Professor of Pediatrics
APHP, hôpital Bicêtre, University of Paris Neuroscience Hacettepe University Faculty of Medicine
Sud Saclay Baylor College of Medicine Ankara, Turkey
Paris, France Houston, Texas, USA
Ross E. Petty, MD, PhD, DSc (Hon), FRCPC
Ronald M. Laxer, MDCM, FRCPC Jane W. Newburger, MD, MPH Professor Emeritus
Professor of Pediatrics and Medicine Associate Cardiologist-in-Chief for Department of Pediatrics
University of Toronto Academic Affairs University of British Columbia
Temerty Faculty of Medicine Department of Cardiology Vancouver, British Columbia, Canada
Division of Rheumatology Boston Children’s Hospital;
The Hospital for Sick Children Commonwealth Professor Clarissa A. Pilkington, MBBS, BSc,
Toronto, Ontario, Canada of Pediatrics FRCP (Paeds)
Harvard Medical School Honorary Lecturer
Claire Marie Anne LeBlanc, MD, FRCPC, Boston, Massachusetts, USA Institute of Child Health
Diploma Sports Medicine University College London Medical School;
Associate Professor, Pediatrics McGill Consultant in Paediatric and Adolescent
University; Rheumatology
Head, Rheumatology Division Great Ormond Street Hospital NHS Trust
Montreal Children’s Hospital London, UK
Montreal Quebec, Canada
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x CONTRIBUTORS
Elena Pope, MD, MSc Sarah Ringold, MD, MS Johannes Roth, Prof. Dr. med.
Head, Section of Pediatric Dermatology Associate Professor of Pediatrics Professor of Immunology
Department of Pediatrics Seattle Children’s Hospital Institute of Immunology
The Hospital for Sick Children; Seattle, Washington, USA University of Münster
Professor of Pediatrics Münster, Germany
University of Toronto James Todd Rosenbaum, AB, MD
Toronto, Ontario, Canada Professor Nicolino Ruperto, MD, MPH
Ophthalmology, Medicine, and Cell Director, Clinical Trials Unit
Sampath Prahalad, MD, MSc Biology Clinica Pediatrica e Reumatologia - PRINTO
Marcus Professor of Pediatric Rheumatology Oregon Health and Science University; IRCCS Istituto Giannina Gaslini
Professor of Pediatrics and Human Genetics Chair of Ophthalmology Emeritus Genoa, Italy
Emory University School of Medicine; Legacy Devers Eye Institute
Director, Division of Rheumatology Portland, Oregon, USA Grant Schulert, MD, PhD
Children’s Healthcare of Atlanta Assistant Professor, Pediatrics
Atlanta, Georgia, USA Alan M. Rosenberg, MD, FRCP(C) Division of Rheumatology
Professor Cincinnati Children’s Hospital Medical
Steven A. Prescott, MD, PhD Division of Rheumatology, Department of Center
Senior Scientist Pediatrics University of Cincinnati
Neurosciences and Mental Health University of Saskatchewan Cincinnati, Ohio, USA
Hospital for Sick Children; Saskatoon, Saskatchewan, Canada
Professor Christiaan Scott, MBChB, FCPaed (SA),
Physiology and Biomedical Engineering Karen Rosendahl, MD, PhD Grad Cert Paed Rheum (UWA)
University of Toronto Consultant Paediatric Radiologist Associate Professor
Toronto, Ontario, Canada Radiology Paediatric Rheumatology
University Hospital North Norway; University of Cape Town
Markus Pääkkönen, MD, PhD Professor Cape Town, South Africa
Orthopedic Surgery and Traumatology Institute of Clinical Medicine (IKM)
Turku University Hospital and The UiT the Arctic University of North Ethan S. Sen, BA (Hons), BM BCh, PhD,
University of Turku Norway FRCPCH
Turku, Finland Tromsø, Norway Consultant Paediatric Rheumatologist
Department of Paediatric Rheumatology
C. Egla Rabinovich, MD, MPH Elizabeth C. Rosser, BSc, PhD Great North Children’s Hospital;
Professor of Pediatrics Centre for Adolescent Rheumatology Associate Clinical Lecturer
Duke University Versus Arthritis at University College Faculty of Medical Sciences
Durham, North Carolina, USA London Newcastle University
University College London Hospital and Newcastle upon Tyne, UK
Athimalaipet V. Ramanan, FRCPCH, Great Ormond Street Hospital
FRCP University College London David D. Sherry, MD
Professor of Paediatric Rheumatology London, UK Rheumatology Attending
Paediatric Rheumatology Pediatrics
Bristol Royal Hospital for Children Carlos Daniel Rosé, MD, CIP The Children’s Hospital of Philadelphia;
Bristol, UK Division Chief (Ex) Professor of Pediatrics
Division of Rheumatology, Department of Pediatrics
Angelo Ravelli, MD Pediatrics Perelman School of Medicine at the
Professor of Pediatrics duPont Children’s Hospital, Thomas University of Pennsylvania;
IRCCS Istituto Giannina Gaslini Jefferson University Director
University of Genova Wilmington, Delaware, USA Amplified Pain Program
Genova, Italy The Children’s Hospital of Philadelphia
Johannes Roth, MD, PhD, FRCPC, Philadelphia, Pennsylvania, USA
Amanda Ricciuto, MD, PhD, FRCPC RhMSUS
Assistant Professor Professor Earl D. Silverman, MD, FRCPC
Department of Pediatrics Department of Pediatrics Professor Emeritus
University of Toronto Temerty Faculty of University of Ottawa; Department of Pediatrics
Medicine Division Chief University of Toronto Temerty Faculty of
Division of Gastroenterology, Hepatology Pediatric Dermatology and Rheumatology Medicine
and Nutrition Children’s Hospital of Eastern Ontario Division of Rheumatology and Senior
The Hospital for Sick Children Ottawa, Ontario, Canada Associate Scientist
Toronto, Ontario, Canada The Hospital for Sick Children;
Editor-in -Chief
Journal of Rheumatology
Toronto, Ontario, Canada
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CONTRIBUTORS xi
Mary Beth F. Son, MD Shirley ML. Tse, MD, FRCPC Leanne M. Ward, MD, FRCPC, FAAP
Director, Rheumatology Program Associate Professor Professor of Pediatrics and Research Chair
Division of Immunology Department of Pediatrics in Pediatric Bone Disorders
Boston Children’s Hospital University of Toronto Temerty Faculty of University of Ottawa
Boston, Massachusetts, USA Medicine; Division of Pediatric Endrocrinology
Program Director and Staff Rheumatologist Children’s Hospital of Eastern Ontario
Watchareewan Sontichai, MD Division of Rheumatology Ottawa, Ontario, Canada
Assistant Professor of Pediatrics The Hospital for Sick Children
Faculty of Medicine, Chiang Mai University Toronto, Ontario, Canada Lucy R. Wedderburn, MD, MA, PhD,
Chiang Mai, Thailand FRCP
Lori Tucker, MD Professor in Paediatric Rheumatology
Anne M. Stevens, MD, PhD Clinical Professor in Pediatrics UCL GOS Institute of Child Health
Professor of Pediatrics Pediatric Rheumatology University College London;
University of Washington, BC Children’s Hospital, University of British Consultant in Paediatric Rheumatology
Seattle Children’s Hospital Columbia Great Ormond Street Hospital
Seattle, Washington, USA Vancouver, British Columbia, Canada NHS Trust
London, UK
Jennifer N. Stinson, RN, PhD Sheila Unger, MD, FRCPC
Senior Scientist Medical Geneticist Pamela F. Weiss, MD, MSCE
Child Health Evaluative Sciences Division of Genetic Medicine Associate Professor of Pediatrics
Hospital for Sick Children; Lausanne University Hospital Perelman School of Medicine
Professor Lausanne, Switzerland University of Pennsylvania;
Lawrence S. Bloomberg Faculty of Nursing Attending Physician
University of Toronto Yosef Uziel, MD, MSc Division of Rheumatology
Toronto, Ontario, Canada Professor of Pediatrics Children’s Hospital of Philadelphia
Head of the Pediatric Rheumatology Unit Philadelphia, Pennsylvania, USA
Matthew L. Stoll, MD, PhD, MSCS Department of Pediatrics
Associate Professor of Pediatrics Meir Medical Center Carine Helena Wouters, MD, PhD
University of Alabama at Birmingham Kfra-Saba, Israel; Professor
Birmingham, Alabama, USA Sackler School of Medicine, Tel-Aviv Pediatric Rheumatology
University Leuven University Hospital
Kathleen Sullivan, MD, PhD Tel-Aviv, Israel Leuven, Belgium
Professor of Pediatrics
The Children’s Hospital of Philadelphia, Janjaap van der Net, PhD, BSc Lawrence Zemel, MD
University of Pennsylvania Perelman Associate Professor Professor of Pediatrics
School of Medicine Child Development and Exercise Center University of Connecticut School of
Philadelphia, Pennsylvania, USA University Children’s Hospital “Het Medicine
Wilhelmina Kinderziekenhuis”, UMC Farmington, Connecticut, USA;
Tim Takken, PhD Utrecht; Division Head
Exercise Physiologist Associate Professor Pediatric Rheumatology
Child Development and Exercise Center Clinical Health Sciences Connecticut Children’s Medical Center
UMC Utrecht Utrecht University Hartford, Connecticut, USA
Utrecht, Netherlands Utrecht, Netherlands
Kathryn S. Torok, MD Sebastiaan J. Vastert, MD, PhD
Associate Professor Pediatric Rheumatologist
Pediatric Rheumatology Pediatric Rheumatology and Immunology
University of Pittsburgh Wilhelmina’s Children Hospital, University
Children’s Hospital of Pittsburgh Medical Center Utrecht
Pittsburgh, Pennsylvania, USA Utrecht, Netherlands
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