Textbook of Pediatric Hematology & Hemato-Oncology

541 Pages·2016·54.6 MB·English

by  coll.

Textbook of
Pediatric Hematology and
Hemato-Oncology

Textbook of
Pediatric Hematology and
Hemato-Oncology
Editor-in-Chief
MR Lokeshwar
Consultant Pediatrician and Pediatric Hematologist Oncologist
Shushrusha Citizens Co-operative Hospital and
Lilavati Hospital and Research Centre, Mumbai, India
Editors
Nitin K Shah Bharat R Agarwal
President, Indian Academy of Pediatrics, 2006 Head
Consultant Pediatrician, PD Hinduja Hospital, Mumbai, India Department of Pediatric Hematology and Oncology
Hon. Pediatric Hematologist Oncologist BJ Wadia Hospital for Children Institute of Child Health
BJ Wadia Hospital and Lions Hospital, Mumbai, India and Research Centre, Mumbai, India
Co-editors
Mamta Vijay Manglani Anupam Sachdeva
Professor and Head Director, Pediatric Hematology-Oncology and
Department of Pediatrics Bone Marrow Transplantation, Institute for Child Health
Chief, Division of Hematology-Oncology Sir Ganga Ram Hospital, New Delhi, India
Program Director, Pediatric Center of Excellence for HIV Care Recipient, Dr BC Roy Award
Lokmanya Tilak Municipal Medical College and Recipient, Silver Jubilee Research Award
General Hospital, Mumbai, India
Publication Editor
Asha Pillai
Medical Officer
Kashyap Nursing Home
Mumbai, India
Forewords
SS Kamath
Vijay N Yewale
The Health Sciences Publisher
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Textbook of Pediatric Hematology and Hemato-Oncology
First Edition: 2016
ISBN: 978-93-5152-143-3
Printed at
Dedicated to
Zinet Currimbhoy
Teacher of Teachers
in Pediatric Hematology and Oncology
for whom
Children with blood disorders and cancer were the greatest teachers!

Contributors
Aditya Kumar Gupta Anand Deshpande
MD FNB (Pediatric Hematology Oncology, SGRH) Consultant
Assistant Professor Hematopathologist and In-Charge
Division of Pediatric Hematology- Transfusion Medicine
Oncology PD Hinduja National Hospital
Department of Pediatrics Mumbai, India
Institute of Medical Sciences [email protected]
Banaras Hindu University
Varanasi, India
Anupa A Joshipura
[email protected]
Fellow Pediatric Hemato-Oncology
BJ Wadia Hospital for Children
Ajay Kumar
Institute of Child Health and Research Centre
Senior Specialist
Mumbai, India
Department of Neonatology
[email protected]
Lady Hardinge Medical College
and Kalawati Saran Children’s Hospital
New Delhi, India Anupama S Borker
[email protected] Consultant Pediatric Oncologist
Somaiya Ayurvihar
Aman Chauhan Asian Institute of Oncology
Internal Medicine and Pediatrics KJ Somaiya Hospital Campus
Combined Resident Mumbai, India
Louisiana State University Health Science [email protected]
Center
New Orleans, USA
Anupam Sachdeva
[email protected]
Director
Pediatric Hematology-Oncology and
Ambreen Pandrowala
Bone Marrow Transplantation
Clinical Associate
Institute for Child Health
Lilavati Hospital
Sir Ganga Ram Hospital, New Delhi, India
Mumbai, India
Recipient, Dr BC Roy Award
[email protected]
Recipient, Silver Jubilee Research Award
[email protected]
Amol Dongre Aparna Vijayaraghavan
Assistant Professor Registrar
Department of Medical Oncology Department of Pediatrics
Jawaharlal Nehru Medical College Chennai, India
Wardha, India [email protected]
[email protected]
viii Textbook of Pediatric Hematology and Hemato-Oncology
AP Dubey Brijesh Arora
Director Professor
Professor and Head Division of Pediatric Oncology
Department of Pediatrics Tata Memorial Hospital
Maulana Azad Medical College and Mumbai, India
Associated Lok Nayak Hospital [email protected]
New Delhi, India
[email protected] Deepak K Changlani
Pediatric Interventional Cardiologist
Lilavati Hospital and Research Centre
Arvind Saili
Mumbai, India
Director
[email protected]
Professor and Head
Department of Neonatology
Lady Hardinge Medical College and
Kalawati Saran Children’s Hospital Dilraj Kaur Kahlon
New Delhi, India Consultant Pediatric Hemato-Oncologist
[email protected] Amandeep Hospital
Amritsar, India
[email protected]
ATK Rau
Pediatric Hematologist-Oncologist
Professor, Department of Pediatrics
Dinesh Yadav MD
MS Ramaiah Medical College
Consultant Pediatrician
Bengaluru, India
Vivekanand Hospital, Bhadra, India
[email protected]
Formerly Assistant Professor
Department of Pediatrics
Sri Aurobindo Institute of Medical
Bharat R Agarwal
Sciences, Indore, India
Head
[email protected]
Department of Pediatric Hematology and
Oncology
Farah Jijina
BJ Wadia Hospital for Children
Consultant Hematologist
Institute of Child Health and Research
PD Hinduja Hospital, Mahim, India
Centre, Mumbai, India
Professor
[email protected]
Department of Hematology
Seth GS Medical College and
Bhavna Dhingra KEM Hospital, Mumbai, India
Assistant Professor [email protected]
Department of Pediatrics
All India Institute of Medical Sciences Gaurav Narula
Bhopal, India Associate Professor (Pediatric-Oncology)
[email protected] Department of Medical Oncology
Tata Memorial Hospital
Mumbai, India
Bipin P Kulkarni [email protected]
Scientist ‘B’
National Institute of
Girish Chinnaswamy
Immunohaematology (Indian Council of
Associate Professor (Pediatric-Oncology)
Medical Research, ICMR)
Department of Medical Oncology
KEM Hospital Campus
Tata Memorial Hospital
Mumbai, India
Mumbai, India
[email protected]
[email protected]
www.niih.org.in
Contributors ix
Jagdish Chandra Malobika Bhattacharya
Director-Professor of Pediatrics Consultant Pediatrics
In-Charge, Pediatric Hematology and Kailash Hospital
Thalassemia Day Care Centre Greater Noida, India
Programme Director, Pediatric Centre of [email protected]
Excellence (HIV)
Lady Hardinge Medical College and
Kalawati Saran Children’s Hospital
Mamta Vijay Manglani
New Delhi, India
Professor and Head
[email protected]
Department of Pediatrics
Chief, Division of Hematology-Oncology
Jayashree Mondkar
Program Director, Pediatric Center of
Professor and Head
Excellence for HIV Care, Lokmanya Tilak
Department of Neonatology
Municipal Medical College and General
Director
Hospital, Mumbai, India
Human Milk Bank
[email protected]
Lokmanya Tilak Municipal Medical
College and General Hospital
Mumbai, India Manas Kalra
[email protected] Fellowship
Pediatric Oncology and BMT-Sydney
Kana Ram Jat Consultant, Pediatric Hematologist
Assistant Professor Oncologist and BMT Unit
Department of Pediatrics Sir Ganga Ram Hospital
All India Institute of Medical Sciences New Delhi, India
New Delhi, India [email protected]
[email protected]
Maya Prasad
K Ghosh Assistant Professor
Director Department of Medical Oncology
National Institute of (Pediatrics)
Immunohaematology (ICMR) Tata Memorial Hospital, Mumbai, India
KEM Hospital Campus [email protected]
Mumbai, India
[email protected]
MMA Faridi
Professor and Head
KN Aggarwal MD FIAP FAMS FNA
Department of Pediatrics
Former Professor and Director
In-Charge
Institute of Medical Sciences
Division of Neonatology
Banaras Hindu University
University College of Medical Sciences
Varanasi, India
Guru Teg Bahadur Hospital
Former Director
New Delhi, India
SGPGIMS, Lucknow, India
[email protected]
Professor
Department of Pediatrics
UCMS, Bhairwah, Nepal MR Lokeshwar
Consultant Pediatrician and Pediatric
Madhulika Kabra Hematologist Oncologist
Professor, Division of Genetics Shushrusha Citizens
All India Institute of Medical Sciences Co-operative Hospital and Lilavati
New Delhi, India Hospital and Research Centre
[email protected] Mumbai, India
[email protected] [email protected]
x Textbook of Pediatric Hematology and Hemato-Oncology
Mukesh M Desai MD Nirmalya D Pradhan
Hon. Hematologist Oncologist and Senior Pediatric Oncologist
Immunologist Department of Pediatric Oncology
Professor Tata Memorial Hospital
Department of Pediatric Hematology- Mumbai, India
Oncology (DNB) [email protected]
Department of PHO
Chief Division of Immunology
Nita Radhakrishnan
BJ Wadia Hospital for Children
Consultant Pediatric Hematology
Honorary Consultant Hematologist
Oncology
B Nanavati Hospital
Institute of Child Health
Sir HN Hospital
Sir Ganga Ram Hospital
Saifee Hospital
New Delhi, India
Asian Heart Institute, India
[email protected]
[email protected]
Nitin K Shah
Narendra Chaudhary
President
Assistant Professor
Indian Academy of Pediatrics, 2006
Pediatric Hematology-Oncology
Consultant Pediatrician
Department of Child Health
PD Hinduja Hospital, Mumbai, India
Christian Medical College
Hon. Pediatric Hematologist Oncologist
Tamil Nadu, India
BJ Wadia Hospital and Lions Hospital
[email protected]
Mumbai, India
[email protected]
Neerja Gupta
Assistant Professor Pankaj Dwivedi
Division of Genetics Fellow in Pediatric, Hematology and
Department of Pediatrics Oncology
All India Institute of Medical Sciences Hospital for Sick Children
New Delhi, India Toronto, Canada
[email protected] [email protected]
Neha Vilas Dighe
Pooja Balasubramanian
Fellow
Clinical Associate
Department of Pediatrics
Lilavati Hospital and Research Centre
BJ Wadia Hospital for Children
Mumbai, India
Institute of Child Health and Research Centre
[email protected]
Mumbai, India
[email protected]
Pooja Dewan
Nirav Buch MD FNB
Assistant Professor
Pediatric Hematologist-Oncologist
Department of Pediatrics
[email protected]
University College of Medical Sciences
[email protected]
Guru Teg Bahadur Hospital
Delhi, India
[email protected]
Nirav Thacker Priti Desai
Senior Registrar Pediatric Oncology Associate Professor
Department of Pediatric Oncology Department of Transfusion Medicine
Tata Memorial Hospital Tata Memorial Hospital
Mumbai, India Mumbai, India
[email protected] [email protected]