Textbook of Biochemistry

1196 Pages·2011·45.22 MB·English

by  Devlin, Thomas M.

Textbook of Biochemistry with Clinical Correlations

Fourth Edition

Abberviations in Biochemistry

A (or Ade)
adenine

ACP
acyl carrier protein

ACTH
adrenocorticotropic hormone

acyl coA
acyl derivative of CoA

ADH
antidiuretic hormone

AdoMet
adenosylmethionine

Ala
alanine

ALA
aminolevulinic acid

AMP
adenosine monophosphate

cAMP
cyclic AMP

Arg
arginine

Asn
asparagine

Asp
aspartate

ATP
adenosine triphosphate

ATPase
adenosine triphosphatase

BMR
basal metabolic rate

BPG
D­2,3 hisphosphoglycerate

C (or Cyt)
cytosine

CDP
cytidine diphosphate

CMP
cytidine monophosphate

CTP
cytidine triphosphate

CoA or CoASH
coenzyme A

CoQ
coenzyme Q (ubiquinone)

cyclic AMP
adenosine 3 ,5 ­cyclic monophosphate

cyclic GMP
xuanosine 3 ,5 ­cyclic monophosphate

Cys
cysteine

d
2 ­deoxyriho

DNA
deoxyribonucleic acid

cDNA
complementary DNA

dopa
3,4­dihydroxyphenylalanine

EcoR1
EcoR1 restriction endonuclease

FAD
flavin adenine dinucleotide (oxidized form)

FADH2
flavin adenine dinucleotide (reduced form)

fMet
formylmethionine

FMN
flavin mononucleotide (oxidized form)

FMNH2
flavin mononucleotide (reduced form)

Fp
flavoprotein

G (or Gua)
guanine

GABA
g­aminobutyric acid

Gal
galactose

Glc
glucose

Gln
glutamine

Glu
glutamate

Gly
glycine

GDP
guanosine diphosphate

GMP
guanosine monophosphate

GTP
guanosine triphosphate

GSH
glutathione

Hb
hemoglobin

HbCO
carbon monoxide hemoglobin

HbO2
oxyhemoglobin

HDL
high density lipoprotein

HMG CoA
b­hydroxy­b­methylglutaryl CoA

Hyp
hydroxyproline

IDL
intermediate density lipoprotein

IgG
immunoglobulin G

Ile
isoleucine

IP3
inositol 1,4,5 trisphosphate

ITP
inosine triphosphate

Km
Michaelis–Menten constant

kb
kilo base pair

LDL
low density lipoprotein

Leu
leucine

Lys
lysine

Mb
myoglobin

MbO2
oxymyoglobin

Met
methionine

MetHb
methemoglobin

NAD+
nicotinamide adenine dinucleotide (oxidized form)

NADH
nicotinamide adenine dinucleotide (reduced form)

NADP+
nicotinamide adenine dinucleotide phosphate (oxidized form)

NADPH
nicotinamide adenine dinucleotide phosphate (reduced form)

NANA
N­acetylneuraminic acid

PEP
phosphoenolpyruvate

Phe
phenylalanine

Pi
inorganic orthophosphate

PG
prostaglandin

PPi
inorganic pyrophosphate

Pro
proline

PRPP
phosphoribosylpyrophosphate

Q
ubiquinone (CoQ)

RNA
ribonucleic acid

mRNA
messenger RNA

rRNA
ribosomal RNA

tRNA
transfer RNA

RNase
ribonuclease

RQ
respiratory quotient (CO2 production/O2 consumption)

S
Svedberg unit

SAM
S­adenosylmethionine

Ser
serine

SH
sulfhydryl

T (or Thy)
thymine

TCA
Tricarhoxylic acid cycle (Krebs cycle)

TG
triacylglycerol

THF
tetrahydrofolic acid

Thr
threonine

TPP
thiamine pyrophosphate

Trp
tryptophan

TTP
thymidine triphosphate

Tyr
tyrosine

U (or Ura)
uracil

UDP
uridine diphosphate

UDP­galactose
uridine diphosphate galactose

UDP­glucose
uridine diphosphate glucose

UMP
uridine monophosphate

UTP
uridine triphosphate

Val
valine

VLDL
very low density lipoprotein

Page iii

Textbook of Biochemistry with Clinical Correlations:

Fourth Edition

Edited by

Thomas M. Devlin, Ph.D.

Professor Emeritus

Department of Biochemistry

MCP∙Hahnemann School of Medicine

Allegheny University of the Health Sciences

Philadelphia, Pennsylvania

Page iv

Address All Inquiries to the Publisher
Wiley­Liss, Inc., 605 Third Avenue, New York, NY 10158­0012

Copyright © 1997 Wiley­Liss, Inc.

Printed in the United States of America.

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Cover Illustration: An artist's conception of the initiation of the DNA transcription mechanism catalyzed by RNA polymerase and involving protein transcription
factors.

Subject Editor: Stephanie Diment
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Illustrations and Cover: Page Two

This book was set in ITC Garamond Light by Bi­Comp Incorporated, and was printed and bound by Von Hoffmann Press.

Library of Congress Cataloging­in­Publication Data

Textbook of biochemistry: with clinical correlations/edited by
Thomas M. Devlin — 4th ed.
p. cm.
Includes bibliographical references and index.
ISBN 0­471­15451­2
1. Biochemistry. 2. Clinical biochemistry. I. Devlin, Thomas M.
[DNLM: 1. Biochemistry. QU 4 T355 1997]
QP514.2.T4 1997 97­1078
612'.015—dc21 CIP

10 9 8 7 6 5 4 3

Page v

To
Katie, Matthew, Ryan, and Laura

Page vii

Contributors

Stelios Aktipis, Ph.D.
Professor
Department of Molecular and Cellular Biochemistry
Stritch School of Medicine
Loyola University of Chicago
2160 S. First Avenue
Maywood, IL 60153

Carol N. Angstadt, Ph.D.
Professor
Department of Biomedical Sciences, M.S.# 456
Allegheny University of the Health Sciences
Broad and Vine Streets
Philadelphia, PA 19102­1192

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