Taurine and the Heart: Proceedings of the Symposium Annexed to the 10th Annual Meeting of the Japanese Research Society on Sulfur Amino Acids Osaka, Japan, September 10, 1987

179 Pages·1989·4.32 MB·English

by  N. Sperelakis

TAURINE AND THE HEART
DEVELOPMENTS IN CARDIOVASCULAR MEDICINE
Roelandt, J., Hugenholtz, P. G., eds.: Long-term ambulatory electrocardiography. 1982. ISBN 90-247-2664-8.
Adgey, A.J., ed.: Acute phase of ischemic heart disease and myocardial infarction. 1982. ISBN 90-247-2675-1.
Hanrath, P., Bleifeld, W., Souquet, eds.: Cardiovascular diagnosis by ultrasound. Transesophageal,
computerized, contrast, Doppler echocardiography. 1982. ISBN 90-247-2692-1.
Roelandt, J., ed.: The practice ofM-mode and two-dimensional echocardiography. 1983. ISBN 90-247-2745-6.
Meyer, J., Schweizer, P., Erbel, R., eds.: Advances in noninvasive cardiology. 1983. ISBN 0-89838-576-8.
Morganroth, Joel, Moore, E.N., eds.: Sudden cardiac death and congestive heart failure: Diagnosis and
treatment. 1983. ISBN 0-89838-580-6.
Perry, H.M., ed.: Lifelong management of hypertension. ISBN 0-89838-582-2.
Jaffe, E.A., ed.: Biology of endothelial cells. ISBN 0-89838-587-3.
Surawicz, B., Reddy c.P., Prystowsky, E.N., eds.: Tachycardias. 1984. ISBN 0-89838-588-1.
Spencer, M.P., ed.: Cardiac Doppler diagnosis. ISBN 0-89838-591-1.
Villareal, H. V., Sambhi, M.P., eds.: Topics in pathophysiology of hypertension. ISBN 0-89838-595-4.
Messerli, F.H., ed.: Cardiovascular disease in the elderly. 1984. ISBN 0-89838-596-2.
Simoons, M.L., Reiber, I.H.C., eds.: Nuclear imaging in clinical cardiology. ISBN 0-89838-599-7.
Ter Keurs, H.E.D.J., Schipperheym, ].T., eds.: Cardiacleft ventricular hypertrophy. ISBN 0-89838-612-8.
Sperelakis, N., ed.: Physiology and pathophysiology of the heart. ISBN 0-89838-615-2.
Messerli, F. H., ed.: Kidney in essential hypertension. 1983. ISBN 0-89838-616-0.
Sambhi, M.P., ed.: Fundamental fault in hypertension. ISBN 0-89838-638-1.
Marchesi, D., ed.: Ambulatory monitoring: Cardiovascular system and allied applications.
ISBN 0-89838-642-X.
Kupper, W., Macalpin, R.N., Bleifeld, W., eds.: Coronary tone in ischemic heart disease.
ISBN 0-89838-646-2.
Sperelakis, N., Caulfield, J. B., eds.: Calcium antagonists: Mechanisms of action on cardiac muscle and vascular
smooth muscle. ISBN 0-89838-655-1.
Godfraind, T., Herman, A.S., Wellens, D., eds.: Entry blockers in cardiovascular and cerebral dysfunctions.
ISBN 0-89838-658-6.
Morganroth, I., Moore, E. N., eds.: Interventions in the acute phase of myocardial infarction.
ISBN 0-89838-659-4.
Abel, F.L., Newman, W.H., eds.: Functional aspects of the normal, hypertrophied, and failing heart.
ISBN 0-89838-665-9.
Sideman, S., and Beyar, R., eds.: Simulation and imaging of the cardiac system. ISBN 0-89838-687-X.
van de Wall, E., Lie, K.I., eds.: Recent views on hypertrophic cardiomyopathy. ISBN 0-89838-694-2.
Beamish, R. E., Singal, P.K., Dhalla, N. S., eds.: Stress and heart disease. ISBN 0-89838-709-4.
Beamish, R. E., Panagia, V., Dhalla, N. S., eds.: Pathogenesis of stress-induced heart disease.
ISBN 0-89838-710-8.
Morganroth, J., Moore, E.N., eds.: Cardiac arrhythmias: New therapeutic drugs and devices.
ISBN 0-89838-716-7.
Mathes, P., ed.: Secondary prevention in coronary artery disease and myocardial infarction.
ISBN 0-89838-736-1.
Stone, H. Lowell, Weglicki, W.B., eds.: Pathology of cardiovascular injury. ISBN 0-89838-743-4.
Meyer, J., Erbel, R., Rupprecht, H.J., eds.: Improvement of myocardial perfusion. ISBN 0-89838-748-5.
Reiber, J. H. C., Serruys, P. W., Slager, c.J.: Quantitative coronary and left ventricular cineangiography. ISBN
0-89838-760-4.
Fagard, R.H., Bekaert, I.E., eds.: Sports cardiology. ISBN 0-89838-782-5.
ReIber, J.H.C., Serruys, P. W., eds.: State of the art in quantitative coronary arteriography.
ISBN 0-89838-804-X.
Roelandt, J., ed.: Color doppler flow imaging. ISBN 0-89838-806-6.
van de Wall, E.E., ed.: Noninvasive imaging of cardiac metabolism. ISBN 0-89838-812-0.
Liebman, J., Plonsey, R., Rudy, Y., eds.: Pediatric and fundamental electrocardiography. ISBN 0-89838-815-5.
Higler, H., Hombach, V., eds.: Invasive cardiovascular therapy. ISBN 0-89838-818-X.
Serruys, P. W., Meester, G. T., eds.: Coronary angioplasty: a controlled model for ischemia.
ISBN 0-89838-819-8.
Tooke, J.E., Smaje, L.H., eds.: Clinical investigation of the microcirculation. ISBN 0-89838-833-3.
van Dam, Th., van Oosterom, A., eds.: Electrocardiographic body surface mapping. ISBN 0-89838-834-1.
Spencer, M.P., ed.: Ultrasonic diagnosis of cerebrovascular disease. ISBN 0-89838-836-8.
Legato, M.J., ed.: The stressed heart. ISBN 0-89838-849-X.
Safar, M.E., ed.: Arterial and venous systems in essential hypertension. ISBN 0-89838-857-0.
Roelandt, J., ed.: Digital techniques in echocardiography. ISBN 0-89838-861-9.
Dhalla, N.S., Singal, P.K., Beamish, R.E., eds.: Pathophysiology of heart disease. ISBN 0-89838-864-3.
Dhalla, N.S., Pierce, G.N., Beamish, R.E., eds.: Heart function and metabolism. ISBN 0-89838-865-1.
Dhalla, N.S., Innes, I.R., Beamish, R.E., cds.: Myocardial ischemia. ISBNO-89838-866-X.
Beamish, R. E., Panagia, V., Dhalla, N.S., eds.: Pharmacological aspects of heart disease. ISBN 0-89838-867-8.
Ter Keurs, H.E.D.J., Tyberg,J.V., eds.: Mechanics ofche circulation. ISBN 0-89838-870-8.
Sideman, S., Beyar, R., eds.: Activation metabolism and perfusion of the heart. ISBN 0-89838-871-6.
Aliot, E., Lazzara, R., eds.: Ventricular tachycardias. ISBN 0-89838-881-3.
Schneeweiss, A., Schettler, G.: Cardiovascular drug therapy in the elderly. ISBN 0-89838-883-X.
Chapman,J. V., Sgalambro, A., eds.: Basic concepts in doppler echo cardiography. ISBN 0-89838-888-0.
Chien, S., Dormandy, J., Ernst, E., Matrai, A., eds.: Clinical hemorheology. ISBN 0-89838-807-4.
Morganroth, J., Moore, E. Neil, eds.: Congestive heart failure. ISBN 0-89838-955-0.
Heintzen, P.H., Bursch, I.H., eds.: Progress in digital angiocardiography. ISBN 0-89838-965-8.
Scheinman, M., ed.: Catheter ablation of cardiac arrhythmias. ISBN 0-89838-967-4.
Spaan, lA.E., Bruschke, A. V. G., Gittenberger, A. c., eds.: Coronary circulation. ISBN 0-89838-978-X.
Bayes de Luna, A., ed.: Therapeutics in cardiology. ISBN 0-89838-981-X.
Mirvis, D.M., ed.: Body Surface Electrocardiographic Mapping. ISBN 0-89838-983-6.
Visser, c., Kan, G., Meltzer, R., eds.: Echocardiography in Coronary Artery Disease. ISBN 0-89838-979-8.
Singal, P.K., ed.: Oxygen Radicals in the Pathophysiology of Heart Disease. ISBN 0-89838-375-7.
TAURINE AND THE HEART
PROCEEDINGS OF THE SYMPOSIUM ANNEXED TO THE
10TH ANNUAL MEETING OF THE JAPANESE RESEARCH
SOCIETY ON SULFUR AMINO ACIDS
OSAKA, JAPAN, SEPTEMBER 10, 1987
Edited by
HEITAROH IWATA
JOHN B. LOMBARDINI
TOMIO SEGAWA
.....
"
KLUWER ACADEMIC PUBLISHERS
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Taurine and the heart: proceedings of the symposium annexed to the 10th Annual Meeting of the
Japanese Research Society on Sulfur Amino Acids, Osaka, Japan, September 10, 19871 editors,
Heitaroh Iwata, John B. Lombardini, Tomio Segawa.
p. cm.-(Developments in cardiovascular medicine)
Includes bibliographies and index.
ISBN-13: 978-1-4612-8915-9 e-ISBN-13: 978-1-4613-1647-3
DOl: 10.1007/978-1-4613-1647-3
1. Taurine-Therapeutic use-Testing-Congresses. 2. Congestive heart failure
Chemotherapy-Congresses. 3. Taurine-Physiological effect-Congresses. I. Iwata,
Heitar6,1927- II. Lombardini,J. Barry. III. Segawa, Tomio, 1927-
IV. Japanese Research Society on Sulfur Amino Acids. Meeting (10th: 1987: Osaka, Japan)
V. Series.
[DNLM: 1. Heart-drug effects-congresses. 2. Heart Diseases-drug therapy
congresses. 3. Taurine-pharmacology-congresses. 4. Taurine-therapeutic use
congresses. WI DE997VME 1 WG T2271987]
RC685.C53T38 1988
615'.71-dc19
DNLM/DLC
for Library of Congress 88-13004
CIP
Copyright 1989 by Kluwer Academic Publishers
Softcover reprint of the hardcover 1s t edition 1989
All rights reserved. No part of this publication may be reproduced, stored in a retrieval system or
transmitted in any form or by any means, mechanical, photocopying, recording, or otherwise,
without the prior written permission of the publisher, Kluwer Academic Publishers, 101 Philip
Drive, Assinippi Park, Norwell, Massachusetts 02061.
CONTENTS
List of contributors vn
Preface XIV
HEITAROH IWATA
Introduction XIX
Y. YAMAMURA
1. Taurine effects on action potentials and ionic currents in chick myocardial cells
N. SPERELAKIS, T. YAMAMOTO, G. BKAILY, H. SADA, A. SAWAMURA,
and]. AZUMA
2. Taurine's modulation ofinotropism in guinea pig heart 21
FLAVIA FRANCONI, PAOLA FAILLI, FEDERICO BENNARDINI, ROSANNA MATUCCI,
ALESSANDRO FAZZINI, ISABELLA STENDARDI, and ALBERTO GIOTTI
3. Taurine and the heart: The phospholipid connection 31
RYAN]. HUXTABLE and LESLIE A. SEBRING
4. Mechanism underlying the membrane-stabilizing activity of taurine 43
s. W. SCHAFFER, S. ALLO, H. HARADA, W. STROO, J. AZUMA, and T. HAMAGUCHI
:l. Modulation of myocardial contractility by taurine: Absence of its interactions with
the effects oflow [Ca2+)o, verapamil, Bay k 8644, and a-and f3-adrenoceptor
agonists in the rabbit papillary muscle 51
MASAO ENDOH, KAZUHIRO OHKUBO, HIROSHI KUSHIDA, and TETSUYA HIRAMOTO
6. Clinical evaluation of taurine in congestive heart failure-A double-blind
comparative study using CoQJO as a control drug 75
]UNICHI AZUMA
v
vi Contents
7. Taurine and NaCI: Untoward effects and a possible role for the heart 99
M.J. MCBROOM, M.S. RINAUDO, D.L. CLOUGH, G.P. MUELLER, and F.J. HADDY
8. Taurine modifies calcium ion uptake and protein phosphorylation in rat heart 117
JOHN B. LOMBARDINI and STEPHEN M. LIEBOWITZ
9. Taurine and receptor mechanisms in the heart: Possible correlates with the
occurrence of ischemic myocardial damages 139
KINYA KURIYAMA, TSUNEICHI HASHIMOTO, MISA KIMORI, and YOSHIKO NAKAMURA
LIST OF CONTRIBUTORS
S. ABo
Department of Pharmacology
University of South Alabama School of Medicine
Mobile, Alabama 36688
Nobuhisa Awata
Third Department ofInternal Medicine
Osaka University Medical School
Osaka, Japan
Junichi Azuma
Third Department ofInternal Medicine
Osaka University Medical School
1-1-50, Fukushima
Fukushima-Ku, Osaka 553
Japan
Federico Bennardini
Dipartimento di Farmacologia
Preclinica e Clinica
"Mario Aiazzi Manchini"
Universita di Firenze
Firenze, Italy
vii
viii List of contributors
G. Bkaily
Department of Physiology and Biophysics
University of Cincinnati
Cincinnati, Ohio 45267
and
Department of Biophysics
University ofSherbrooke
Sherbrooke, Quebec
Canada
D.L. Clough
Department of Physiology
Uniformed Services University of the Health Sciences
4301 Jones Bridge Road
Bethesda, Maryland 20814
Masao Endoh
Department of Pharmacology
Yamagata University School of Medicine
Nishinomae, Zao-iida
990-23 Yamagata
Japan
Paola Failli
Dipartimento di Farmacologia
Preclinica e Clinica
"Mario Aiazzi Mancini"
Universita di Firenze
Firenze, Italy
Alessandro Fazzini
Dipartimento di Farmacologia
Preclinica e Clinic a
"Mario Aiazzi Mancini"
Universita di Firenze
Firenze, Italy
Flavia Franconi
Instituto di Biochimica
Facolta di Farmacia
Via Muroni, 23
Universita di Sassari
Sassari, Italy
ix
Keizo Furukawa
Second Department ofInternal Medicine
Kyoto Prefectural University of Medicine
Kyoto,Japan
Alberto Giotti
Dipartimento di Farmacologia
Preclinica c Clinica
"Mario Aiazzi Mancini"
Univcrsita di Firenze
Firenze, Italy
F.J. Haddy
Department of Physiology
Uniformed Services University of the Health Sciences
4301 Jones Bridge Road
Bethesda, Maryland 20814
T. Hamaguchi
Third Department ofInternal Medicine
Osaka University Medical School
Osaka, Japan
H. Harada
Department of Pharmacology
University of South Alabama School of Medicine
Mobile, Alabama 36688
and
The Third Department ofInternal Medicine
Osaka University Medical School
Osaka, Japan
Tsuneichi, Hashimoto
Department of Pharmacology
Kyoto Prefectural University of Medicine
Kamikyo-Ku, Kyoto 602
Japan
Tetsuya Hiramoto
Department of Pharmacology
Yamagata University School of Medicine
Nishinomae, Zao-iida
990-23 Yamagata
Japan
x List of contributors
RyanJ. Huxtable
Department of Pharmacology
College of Medicine
University of Arizona
Tucson, Arizona 85724
Hyoe Ishikawa
First Department ofInternal Medicine
Nara Medical University
Nara,Japan
Taro Ishiyama
Department ofInternal Medicine
National Senboku Hospital
Osaka, Japan
Hietaroh Iwata
Department of Pharmacology
Faculty of Pharmaceutical Sciences
Osaka, Japan
Tadashi Kagoshima
First Department ofInternal Medicine
Nara Medical University
Nara,Japan
Hiroshi Katsume
Second Department ofInternal Medicine
Kyoto Prefectural University of Medicine
Kyoto, Japan
Misa Kimori
Department of Pharmacology
Kyoto Prefectural University of Medicine
Kamikyo-Ku, Kyoto 602
Japan
Susumu Kishimoto
Third Department ofInternal Medicine
Osaka University Medical School
Osaka, Japan