Table Of ContentAdvances in Experimental Medicine and Biology 1155
Jianmin Hu
Fengyuan Piao
Stephen W. Schaffer
Abdeslem El Idrissi
Jang-Yen Wu Editors
Taurine 11
Advances in Experimental Medicine
and Biology
Volume 1155
Editorial Board
IRUN R. COHEN, The Weizmann Institute of Science, Rehovot, Israel
ABEL LAJTHA, N.S. Kline Institute for Psychiatric Research,
Orangeburg, NY, USA
JOHN D. LAMBRIS, University of Pennsylvania, Philadelphia, PA, USA
RODOLFO PAOLETTI, University of Milan, Milan, Italy
NIMA REZAEI, Tehran University of Medical Sciences, Children’s Medical
Center Hospital, Tehran, Iran
More information about this series at http://www.springer.com/series/5584
Jianmin Hu • Fengyuan Piao
Stephen W. Schaffer
Abdeslem El Idrissi • Jang-Yen Wu
Editors
Taurine 11
Editors
Jianmin Hu Fengyuan Piao
College of Animal Science and Veterinary Department of Occupational and
Medicine Environmental Health
Shenyang Agricultural University Dalian Medicine University
Shenyang, Liaoning, China Dalian, Liaoning, China
Stephen W. Schaffer Abdeslem El Idrissi
Department of Pharmacology, College of Department of Biology, Center for
Medicine Developmental Neuroscience
University of South Alabama College of Staten Island
Mobile, AL, USA Staten Island, NY, USA
Jang-Yen Wu
Department of Biomedical Science, Charles
E. Schmidt College of Medicine
Florida Atlantic University
Boca Raton, FL, USA
ISSN 0065-2598 ISSN 2214-8019 (electronic)
Advances in Experimental Medicine and Biology
ISBN 978-981-13-8022-8 ISBN 978-981-13-8023-5 (eBook)
https://doi.org/10.1007/978-981-13-8023-5
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Preface
The 21st International Taurine Meeting was held from May 20 to 26, 2018, in
Liaoning Province, China. Unique to this taurine meeting, the first half of the con-
ference was held in the historical, 2600-year-old, industrial city of Shenyang and
the second half in the modern, coastal city of Dalian. The participants of the meet-
ing, who came from 14 different countries, were exposed to the rich culture, ancient
history, and stunning beauty of this special region of China. The meeting featured
approximately 100 presentations covering 8 different taurine-related topics (metab-
olism, nutrition, organ dysfunction, heart health, cancer, antioxidation and antimi-
crobial activities, neuroprotection, and anti-inflammation). The aims of the meeting
were to spur interest in recent advances in the taurine field and to provide impetus
for further research and growth. Novel findings reported during the meeting sup-
ported new actions for taurine, including antianxiety and antitumor activity, modu-
lation of miRNA activity, promotion of thioredoxin-interacting protein expression,
potential use as a laxative, and potential benefit against immunosuppression. Also,
the identity of novel taurine containing derivatives with unique or undiscovered
activities opened up promising new avenues to study taurine.
Several presentations during the meeting focused on the importance of taurine in
minimizing the severity of various diseases, including alcohol liver disease, fragile
X, dementia, Down syndrome, diabetes, neurodegenerative diseases, and heart dis-
ease. Although taurine was approved several years ago for the treatment of conges-
tive heart failure, we await further research showing that taurine possesses clinical
value as a therapeutic agent in the treatment of several other diseases.
Another important application of taurine is its inclusion in nutritional supple-
ments. Because endurance exercise can damage muscle, protein and nutritional
supplementation have been commonly utilized to improve the outcome of exercise
training. One of the presentations during the meeting focused on the effect of
chronic taurine treatment on muscle mass and physical performance in subjects
receiving exercise training. Taurine supplementation was also found to improve
cognitive function in elderly women with dementia, a finding that may prove useful
in treating intractable diseases, such as Alzheimer’s disease. Because taurine plays
a fundamental role within cells, perinatal taurine supplementation is important for
v
vi Preface
the development of normal cellular and organ function, proper cellular differentia-
tion, and cell viability.
One of the hosts of the meeting was the Shenyang Agricultural University. It was
therefore timely that one of the presentations discussed a potential use of taurine in
agriculture. According to the Department for Environment, Food, and Rural Affairs
in London, England, heat stress is a major cause of reduced production and actual
loss of broilers during summer months. A study presented in the meeting reported
that taurine treatment protects broilers against the adverse effects of heat stress. In
future meetings, we await further studies about potential uses of taurine in aiding
the poultry industry. Additional studies should also clarify the value of taurine and
taurine derivatives from seafood sources in nutritional supplements.
We are deeply indebted to the sponsors of this meeting for their generous sup-
port. These include Red Bull GmbH4, Austria and Europe; Dong-A Group,
Korea;Suzhou Dong-A Beverage Corp, China (苏州东亚饮料有限公司, 中
国);Becton, Dickinson, and Company, USA; Shenyang Dequan VS Leica, China
(沈阳德泉仪器设备销售有限公司, 中国); and Chengdu Taimeng Software Co.,
Ltd, China (成都泰盟软件有限公司, 中国). We would also like to thank all the
participants of the meeting and the authors contributing to this volume.
Shenyang, Liaoning, China Jianmin Hu
Dalian, Liaoning, China Fengyuan Piao
Mobile, AL, USA Stephen W. Schaffer
Staten Island, NY, USA Abdeslem El Idrissi
Boca Raton, FL, USA Jang-Yen Wu
Contents
Part I Taurine and Metabolism
Effect of Aging on Taurine Transporter (TauT)
Expression in the Mouse Brain Cortex . . . . . . . . . . . . . . . . . . . . . . . . . . . . 3
Manoj Kumar Neog, Hyunju Chung, Min Joo Jang, Dong Jin Kim,
Sang Ho Lee, and Kyoung Soo Kim
Effect of Taurine on Intestinal Microbiota and Immune Cells
in Peyer’s Patches of Immunosuppressive Mice . . . . . . . . . . . . . . . . . . . . . 13
Hui Fang, Fanpeng Meng, Fengyuan Piao, Bo Jin, Ming Li,
and Wenzhe Li
Effects of Chronic Intake of a Low Concentration of Taurine
on Physical Strength and Body Composition in Mice . . . . . . . . . . . . . . . . 25
Kyung Suk Cho, Manoj Kumar Neog, Joo Young Kim,
Hyung-In Yang, and Kyoung Soo Kim
Influences of Taurine Deficiency on Bile Acids of the Bile
in the Cat Model . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 35
Teruo Miyazaki, Sei-ich Sasaki, Atsushi Toyoda, Mutsumi Shirai,
Tadashi Ikegami, Yasushi Matsuzaki, and Akira Honda
Inhibition of Renin-Angiotensin System from Conception
to Young Mature Life Induces Salt-Sensitive Hypertension
via Angiotensin II-Induced Sympathetic Overactivity
in Adult Male Rats . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 45
Tippaporn Bualeong, James Michael Wyss, and Sanya Roysommuti
Taurine Chloramine Inhibits Osteoclastic Differentiation
and Osteoclast Marker Expression in RAW 264.7 Cells . . . . . . . . . . . . . . 61
In Soon Kang and Chaekyun Kim
vii
viii Contents
Taurine Enhances the Protective Actions of Fish Oil Against
D-Galactosamine- Induced Metabolic Changes and Hepatic Lipid
Accumulation and Injury in the Rat . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 71
Yuanjun Shen and Cesar A. Lau-Cam
Taurine Improves the Actions of Metformin and Lovastatin
on Plasma Markers of Carbohydrate and Lipid Dysfunction
of Diabetic Rats . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 87
Kashyap Pandya and Cesar A. Lau-Cam
Taurine Supplementation Inhibits Cardiac and Systemic
Renin-Angiotensin System Overactivity After Cardiac
Ischemia/Reperfusion in Adult Female Rats Perinatally
Depleted of Taurine Followed by High Sugar Intake . . . . . . . . . . . . . . . . 101
Supaporn Kulthinee, James Michael Wyss, and Sanya Roysommuti
The Production of a Rat Model That Inhibits Phosphoenolpyruvate
Carboxykinase (PEPCK), a Rate-Limiting Enzyme of Hepatic
Gluconeogenesis . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 113
Hajime Ohmori, Masataka Matsumura, Shoichi Komine,
Haruki Kobayashi, Yusei Kobayashi, Jun Shiromoto,
and Sumpei Miyakawa
Preventive or Curative Administration of Taurine Regulates
Lipid Metabolism in the Liver of Rats with Alcoholic
Liver Disease . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 119
Riyi Tang, Qunhui Yang, Shumei Lin, Ying Feng, Jiancheng Yang,
Qiufeng Lv, Gaofeng Wu, and Jianmin Hu
Taurine Improves Lipid Metabolism and Skeletal Muscle
Sensitivity to Insulin in Rats Fed with High Sugar
and High Fat Diet . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 133
Dongdong Zhao, Qiufeng Lv, Jiancheng Yang, Gaofeng Wu, Mei Liu,
Qunhui Yang, Jie Han, Ying Feng, Shumei Lin, and Jianmin Hu
Taurine Inhibited Uric Acid Uptake in HK-2 Renal Tubular
Epithelial Cells . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 147
Ying Feng, Shumei Lin, Xiaoyan Zhao, Qunhui Yang, Gaofeng Wu,
Qiufeng Lv, Jiancheng Yang, and Jianmin Hu
Role of Taurine in Testicular Function in the Fragile x Mouse . . . . . . . . 155
Shumei Lin and Abdeslem El Idrissi
Effect of Taurine on Cell Function via TXNIP Induction
in Caco-2 Cells . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 163
Hideo Satsu, Yusuke Gondo, Hana Shimanaka, Kenji Watari,
Midori Fukumura, and Makoto Shimizu
Taurine Regulation of Peripheral Hemodynamics . . . . . . . . . . . . . . . . . . . 173
Francoise Sidime and Abdeslem El Idrissi
Contents ix
Part II Taurine and Nutrition
Antioxidant and Anti-Stress Effects of Taurine Against Electric
Foot-Shock- Induced Acute Stress in Rats . . . . . . . . . . . . . . . . . . . . . . . . . . 185
Dong-Sung Lee, Hee Geun Jo, Min Ji Kim, Hwan Lee,
and Sun Hee Cheong
Taurine Promotes In-vitro Follicle Development, Oocyte
Maturation, Fertilization and Cleavage of rats . . . . . . . . . . . . . . . . . . . . . 197
Teng Mu, Ying Feng, Yuchen Che, Qiufeng Lv, Jianmin Hu,
Qunhui Yang, and Jiancheng Yang
Consumption Patterns and Importance- Performance Analysis
of Home Meal Replacements by Level of Taurine-Related
Nutritional Knowledge in Korean Adults . . . . . . . . . . . . . . . . . . . . . . . . . . 205
So Hyun Park, Mi Ae Bae, So Hee Han, Si Yao Cheng,
Sung Hoon Kim, and Kyung Ja Chang
Demands for Development of Taurine- Containing Home
Meal Replacement for Prevention of Dementia According to Age . . . . . . 215
So Hyun Park, Mi Ae Bae, So Hee Han, Young Deok Seo,
Sung Hoon Kim, and Kyung Ja Chang
Dietary Taurine Intake and Its Food Sources in Korean Young
Adults Using 2015 Korea National Health and Nutrition
Examination Survey Data . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 223
So Hee Han, So Hyun Park, and Kyung Ja Chang
Effects of Dietary Taurine Supplementation on Blood
and Urine Taurine Concentrations in the Elderly Women
with Dementia . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 231
Ranran Gao, Mi Ae Bae, So Hee Han, Kyung Ja Chang,
and Sung Hoon Kim
Effects of Taurine on Eusociality of Ants . . . . . . . . . . . . . . . . . . . . . . . . . . 239
Ha Won Kim and Dong Hee Lee
Food Preference of the Elderly for the Development
of Taurine-Containing Elderly-Friendly Foods . . . . . . . . . . . . . . . . . . . . . 249
Mi Ae Bae, So Hyun Park, So Hee Han, Kyung Ja Chang,
and Sung Hoon Kim
Laxative Effects of Taurine on Loperamide-Induced
Constipation in Rats . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 261
Dong-Sung Lee, Hee Geun Jo, Min Ji Kim, Hwan Lee,
and Sun Hee Cheong
Positive Changes in Blood Lipid Profiles, Nutrition Knowledge,
and Dietary Taurine Intake After 8-Week Nutrition Education
Program in Low- Income Korean Children . . . . . . . . . . . . . . . . . . . . . . . . 273
So Hyun Park, Ji Won Shin, Sung Hoon Kim, and Kyung Ja Chang
