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TargetedDrugDelivery ochrane Germ
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EREGdd..MFiittooeadlrkniabenrylhsB,ooHlda.,rTdHim.Bmusecrhmmaannnn,H,J..vHaonlednezWaterbeemd,J.BondoHansen https://onlinelibrary.wiley.com
AFPllrzoeavw,iEoa.u(snEVddo.)MluimcreosorefathcetoSerrTieeschnology BInanchohvaavt,iYv.e(EdD.)osageFormsDesign /doi/ by ibrahim ragab - C
inMedicinalChemistry andDevelopmentatEarlyStage ochrane G
2019 erm
2IS0B2N2:978-3-527-34689-9 ISBN:978-3-527-34396-6 any , W
Vol.81 Vol.76 iley O
R(NaGSP2IVES0oünrorBed2ulob.dN2lsws8isc.s:)d0aEe,9mD7MsmS8esr.t-uen3ia(n-E-rg5tSdgg2ec.D7i)ho-nD3eafg4eev3Pfve3Vf7h,eli-oH9alroup.r,pmsmaemnaesdcenBentuutfstocaihcrnmaKdlannonw,Hn. GBSSE2IV2ISS00ioeptiBBp11lorr.NN88ipvug7ml::a5c,e99sWto77inuo88l.e--,,er33FJtec--u55i.-ucn22Lb77gl.Da--,a,33SrMsr44pu23eS.61idgw(i54Em--o50dDDksuir,.s)luVac.got(EivDodensisr.)sycoinvery nline Library on [23/11/2022]. See the Terms and Conditions (https://onlinelibrary.w
MSaoltlse,Ccouclreysstals,andPolymorphism GVoiol.r7d4anetto,F.(Ed.) iley.com/term
PT2IVS0olaBo2lr.N1wg7:9re9ig7t8hD-t3,-i5As2.cT7o.-3(v4Ee6d3r.5)y-6andValidation E2IVS0oaB1l.rN87l:y397D8-r3u-5g27D-3e41v4e9-l8opment s-and-conditions) on Wiley Online L
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Targeted Drug Delivery ochrane G
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Helmut Buschmann s and C
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EDdr.itYoorgeshwarBachhav ppArulolbdbliuoscohekedsr.pdNuoebnvloeisrthtwheedalrebrsaysn,WtaItuLhtEehYoi-nVrsfCo,Hremdairateotircosan,raenfudlly ochrane Germany , W
B401,No126 containedinthesebooks,includingthisbook, iley O
FTliolarkenNcaiogar tinobmeinfrdeethoaftesrtraotresm.Reneatsd,edrastaar,eilaludsvtirsaetdiotnosk,eep nline L
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4GDS5GDB02prrIee..A40errHJ87rmmöLbe96rlgeaa–mDArnnHwPuaüyyotOceslBhsegRenue1Tlsznd5cEhoLmrfAan&nCA.,S.A. dfBDTpNdrunaiheoabtubbemtlaiitl.ooDdisactcng-rheahnreautaeebliaptboB.Nsvdhincbraaiehicliti>tilnieiioaosn.bNgnthfhrloaaeaLelrtbfimioiDbioenbarn;eltatiudaiohroletytbnesth.ciaIepbhinkulleeitboedltrihsnbheiebektldailoitbsgy<trsathhtpthethpisi:c// s and Conditions (https://onlinelibrary.wiley.com
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photoprinting,microfilm,oranyother iley O
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Contents ochrane Germ
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APersonalForeword xiii nline L
1 KPBrsaehsfaiacmsceaofAT.xaDvrogsehtiedDrugDelivery 1 ibrary on [23/11/2022]. See the T
1.1 Introduction 1 erm
1.1.1 ConceptofBioavailabilityandTherapeuticIndex 2 s and C
11111.....33323...111..12 PRETStaanersrtahgsitcaieevuntgeelciodeTeesdaDnrfPdorgueorergttDmhinDreeguleaiglabilvTi4lSeairytryysgteaetnmi2ndg(RReEt3eSn)tSiyosnte(mEPR4)Effect 4 onditions (https://onlinelibrary.w
11..33..12.3 LAocctiavleizTeadrDgeetliinvgery5 4 iley.com/term
1111....4333...333..12 TUMPhhlatyergsraniascepoateuilucnTtFdaicrifegoAledrptiTfpnoalgrircgTaeat5tiriongnegstionf6gTa6rgetedDrugDelivery 6 s-and-conditions) on W
1.4.1 DiabetesManagement 6 iley O
1.4.2 NeurologicalDiseases 7 nline L
1111....5444...345 CRCTaeaarsrngpdceiierotreavdtIaonsDrdcyuuicDglaa-itrDsieoDeanlisissveeesars9ye9Psro8ducts 10 ibrary for rules of use; O
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111111......689676..12 PCACRSCcaeuohcasftnraeslirelvcirelv-leeenuuennTtspTcgiaSeoaeartsnsrngagetdaeutn1itC1sni6d1nhggPa1lra4lo1ensn2dpgeEecsPtsR1E31ff5ect 12 articles are governed by the applicable C
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vi 2Contents ADdrudgre-DsseilnivgeUrynmSyestteMmesd:icEamlpNheaesdissoUnsiNnganToamrgeedteicdine-Based https://onlinelibrary.w
AChpapnlidcraatkioanntssin2g1Pardeshi,RajuSonawane,andYogeshwarBachhav iley.com
22..12 ITnatrrgoedteudctDiornug-2D1eliverySystemsforUnmetMedicalNeeds 23 /doi/ by ibrahim
22..22..11.1 STmaragleltMingolLecigualnesdsasT2a5rgetingLigands 25 ragab - C
22..22..11..23 AApnttaibmoedrisesaassTTaargrgeteitninggLLigigaannddss 2278 ochrane Germ
2.2.1.4 LectinsasTargetingLigands 28 any , W
2.2.1.5 LactoferrinsasTargetingLigands 29 iley O
22222.....34222...222..12 RCLRTLDaioeeoissrcgfntgeeaucoaretllefitsauoineAtnsn-ocigBb-eorBbyasAnsraApeeasvdpens3ipdr9daToetTaFaciraotcugsrnhtegausetensirtneding3OC28gu9li2tnl93oi2coaklPe3r8spectives 35 nline Library on [23/11/2022]. See the T
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333..21 PNNaPDnraaeaesdnlnssiohvoiMvceicteaaraaycrrTrrDraioieeerm4rsgrsa5seo-it(BlieNnacgasuenAldeopsmTpaerrod4gai5ecctihneedes)D–r5uO0gveDrevliievweraynSdysRtoelmesin:STmaraglletedDrug s and Conditions (https://onlinelibrary.w
3.2.1 EnhancedPermeabilityandRetention-Effect-BasedTargeting 50 iley.com
3.3 ActiveTargetingApproaches 52 /term
3333....4444...231 pESRtHneimdzSoyutmxilmiSeRtuiSmeltisimupRoleuinsRlpsieioRvsneepssoTipvnaoesrngiTvseaeitvreTgedaeTrNteagCdregtsNeedtCe5Nds4CNs5C6s5557 s-and-conditions) on W
3.4.4 TemperatureStimuliResponsiveTargetedNCs 58 iley O
3.4.5 UltrasoundStimuliResponsiveTargetedNCs 59 nline L
33..54.6 CMReoafngecnrleeuntsiciceoFsniealn6d0dSFtiumtuurleiRPerospspoencstisveT6a0rgetedNCs 59 ibrary for rules of use; O
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4444...123 ILILRALnmiajiipapptgpryooohoosssJadr.ooovtuKmmmaechnneeetoditssopCrCanaaoosdC8mneT0.s6maMi9rdeguerenrctdaieataidlrogLnDia,srNnuindgees-DDctiaekepavlieevTleaornp7yem2jSaey,nsJatteyamensdshkCuh6m9aarracJ.teHraizdaiati,oanndof articles are governed by the applicable C
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44..33..21 DSerluegct:ioLnipoidfLRipatiidos 8810 Contents vii https://onlinelibrary.w
44..33..34 PLEigGanyldatAionncho8r2ing 83 iley.com
44..33..65 PDhruysgi-cLoocahdeimngicTaelcChhnairqaucetseriz8a4tion 85 /doi/ by ibrahim
44..33..78 MPraonduufcatcSttuarbinilgityPro8ce7ss 86 ragab - C
44..44.1 PTaasrgsievteedTaDregleitvienrgyof8L9iposomes 88 ochrane Germ
4.4.2 Active-TargetedDelivery 92 any , W
4.4.2.1 CancerCellTargeting 94 iley O
4444....7546.2.2 CRCSDFTyaueoaesccmnnltiteedcvoonmleirurdtsrssyaECIitnonleiflndsn11suo0i0ct8ea3ah1nnl0ecdT2liinrFuigumalttsuhTwreaeriCtgohlefitnPLiinricpogaoslpsToe9rcm8atnsessolfwaTtiitaohrngIeontfveLedsipLtioigpsaootismoonemasalfloL-rDipTeoalsirvogemertyeed nline Library on [23/11/2022]. See the T
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5 LRAARGaainpesjufpteteitlsboraihceofmandAPtcySribeao–ibnsdnDrghserhavu1vnig1ia1,,2tM2CSi7oouennngsijhlunKgaa1.DtP1e0ausnb:deDeye,y,avSenilddodSphamacehnnitnhtDaHnuedbjmeyady,RajeevTaliyan, s and Conditions (https://onlinelibrary.w
5.1 Introduction 127 iley.com
5.2 DesignofADCs 128 /term
5555....3222...123 MALPainneytckliohbeaaordndiys1m31031o22f9Action 133 s-and-conditions) on W
5.4 PharmacokineticConsiderationsforADCs 134 iley O
5.4.1 HeterogeneityofADCs 134 nline L
5555....4444....2333..21 DBPAhibiosastarornmirbapaultycitotoiionkcnainle1Ct13oi36cn6PsiadrearmateitoenrssfoofrAADDCCss 113365 ibrary for rules of use; O
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viii 55Co..55n..t11en..56ts PEonlfaotrutzuummaabbVVeeddootitnin-p1i4iq0 140 https://onlinelibrary.w
55..55..21.7 TUrsaestoufzAuDmCasbiDneRruhxetuemcaantoid14A0rthritis 141 iley.com
55..55..34 UUsseeooffAADDCCssiinnBOapchttehriaallmInolfoegctyion1s41141 /doi/ by ibrahim
55..76 RReegsiusltaatnocreyoAfsApDecCtsfo1r4A2DCs 143 ragab - C
55..77..12 RRoolleeooffOONBPDQA144143 ochrane Germ
5.8 ConclusionandFutureDirection 144 any , W
References 145 iley O
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66667....2324..23 TNOCRTareootirhfnpvgeeeclererlletu-eECnNsdcnaieeonzPgsnycarsmeotirdv1esre6s1u56Bfgo15rs6rei2aGnsDtOCEraPalnTDcerur1g(6T4DNeBliCve)ry161169 s and Conditions (https://onlinelibrary.w
MilicaMarkovic,ShimonBen-Shabat,andArikDahan iley.com
7.1 Introduction 169 /term
7777....2122...111.1 VCMPralooaladsdsceriyurccngvl,oAsTv.paiMrrpagorseodetae-eMcrdhneP-TPdraoiraordtgdreeurdtugiPngArgAopEdppnrpruzorgoyaamcAchechstiv1a171t71i70o1n 172 s-and-conditions) on W
77..22..11..32 APhnotisbpohdoyl,ipGaesneeA,a2-nMdeVdiirautes-dDPirreocdtreudgEAncztyivmaeti–oPnrod1r7u3g iley Online L
777...222...222..12 PTPMerhoopendtrioradupcegayTrAbraop1nxp7ysr5ploaoatrcetheTrTra1anrgspe1to7irn7tgerTTraynpsep1orte1r7s9 176 ibrary for rules of use; O
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77777.....45623.2.3 DFCRCBuieooilsftnmeceucurAprleesuucnsisPticdiaoreotnoTsniosrpanen11a1c88sl8tp24As3oparnptedrrosCaclihn1e8isc0ainlATpaprgliectaetdioPnrsodr1u8g3Design 181 articles are governed by the applicable C
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8 ECxaordsioamceInsdfiocratDiorungsDe1l9iv3eryApplicationsinCancerand Contents ix https://onlinelibrary.w
8.1 EAnxjtaralicPeallnudlayra,VSerseiecrlaens:jiAninPOulvaekrkvaite,wand1V9a3ndanaPatravale iley.com
88..11..21 EEvxoolsuotmioensoafsEDxeolsivoemryesVeh1i9c4lesforTherapeutics 195 /doi/ by ibrahim
88..11..22..12 EEnxodgoegneonuosuLsoLaodaidnigngMMetehtohdosds 191898 ragab - C
88..22.1 EInxflousoemnceesoafsDCoannocrerCTehllserap2e0u2tics 199 ochrane Germ
8.2.2 DifferentTherapeuticCargoExploredinCancerTherapy 202 any , W
8.2.2.1 DeliveryofProteinsandPeptides 203 iley O
8888888.......3234532....1222..32 DDECCEDxxloeeeioonlllniiissvvcvioocleeeummarrrlsyyyeeiEoooosBvnfffMaaCRClsouNahe2dardeA1ditmfiiD1iooeornpdut2srh0gwoae4tDniretadhceptlFiieCvvuuaeettrriuRdycriNeCfaoAcaArrTssCgapoarerg2cde0ti2ts7oi0nv4ga2sP1c0euplatirdDesisea2s0e8s 206 nline Library on [23/11/2022]. See the T
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9 ARASDCaoneecnmafkleignnvprhyeeolaarenwmyxPcleoaieFtstdfrotagNnrmmaPu2iac1euktl2n,liea,StitascwinoAadnrc2nsSi1daa2spn,a2gSr2rau1abcmhhaKaP.sSasaniRmy,NaAAl.Sa.nSdamnkReNt,ASu,UdispitnegeDas, s and Conditions (https://onlinelibrary.w
9.1 Introduction 221 iley.com
9.2 NA-BasedComplexDeliverySystem 228 /term
9999....2222....1111...132 PPLCoeilpaplyistdmsidi-cBeear-alB-sBNeaadsAseCe-dBdoCamNsoeApmdl-epCCxloeoNxmmANpplADleexexDlDiDevleeeilvlriiyvevreeSyrryyySstSySeysymtssettmeemm232023221299 s-and-conditions) on W
9.2.2 AdvancedNA-BasedComplexDeliverySystems 232 iley O
9.2.2.1 InorganicandHybridNPs 232 nline L
9999....2323...221..23 SAGEexpelonfp-solAoimcmsaseteeimEsondabnsiltediondfNgNNaAAn2o-N3CC5oaenmllospslter2xu3cD3tuelrievsery2S3y3stems 234 ibrary for rules of use; O
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x 1Co0ntents PArpapslhicaanttioSn.KohfaPrkRaOrTaAnCdTAetcuhlnLo.lJoagdhyainv DrugDevelopment 247 https://onlinelibrary.w
1100..21 DInetsriogdnuocftiPoRnOT2A47CS:ABriefOverview 252 iley.com
1100..33.1 TChanercaepreu2ti5c5ApplicationsofPROTACs 254 /doi/ by ibrahim
1100..33..23 NImeumruondeogloegniecraaltDivieseDaisseosrde2r6s3 261 ragab - C
1100..34.4 VChiraallleInnfgeecstiaonndsLi2m6i4tationsintheDevelopmentPROTACs 265 ochrane Germ
10.5 FuturePerspectives 266 any , W
References 266 iley O
11 MetalComplexesastheMeansortheEndofTargeted nline L
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11.2.2 DeliverytotheCellsorEnvironmentstoBeTargeted 275 erm
11.2.3 ReleasefromtheMetalWhereandWhenRequired 276 s and C
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1111..55..32 TpHhe-BEaPsRedETffaercgtetin2g83 282 iley.com
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References 289 iley O
12 FormulationofPeptidesforTargetedDelivery 299 nline L
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