Table Of ContentAcademic Press Rapid Manuscript Reproduction
Proceedings of the 1979 ICN-UCLA Symposia on
Molecular and Cellular Biology held in Keystone,
Colorado, March 25-30,1979
ICN-UCLA Symposia on Molecular and Cellular Biology
Volume XVI, 1979
Τ A ND Β L Y M P H O C Y T E S:
RECOGNITION A ND
F U N C T I ON
edited by
FRITZ H. BACH
Immunology Research Center
University of Wisconsin
Madison, Wisconsin
BENJAMIN BONA VIDA
Department of Microbiology and Immunology
University of California, Los Angeles
Los Angeles, California
ELLEN S. VITETTA
Department of Microbiology
University of Texas Southwestern Medical School
Dallas, Texas
C. FRED FOX
Department of Microbiology and Molecular Biology
University of California, Los Angeles
Los Angeles, California
ACADEMIC PRESS 1979
A Subsidiary of Harcourt Brace Jovanovich, Publishers
New York London Toronto Sydney San Francisco
COPYRIGHT © 1979, BY ACADEMIC PRESS, INC.
ALL RIGHTS RESERVED.
NO PART OF THIS PUBLICATION MAY BE REPRODUCED OR
TRANSMITTED IN ANY FORM OR BY ANY MEANS, ELECTRONIC
OR MECHANICAL, INCLUDING PHOTOCOPY, RECORDING, OR ANY
INFORMATION STORAGE AND RETRIEVAL SYSTEM, WITHOUT
PERMISSION IN WRITING FROM THE PUBLISHER.
ACADEMIC PRESS, INC.
Ill Fifth Avenue, New York, New York 10003
United Kingdom Edition published by
ACADEMIC PRESS, INC. (LONDON) LTD.
24/28 Oval Road, London NW1 7DX
ISBN 0-12-069850-1
PRINTED IN THE UNITED STATES OF AMERICA
79 80 81 82 9 8 7 6 5 4 3 2 1
CONTRIBUTORS
Numbers in parentheses refer to chapter numbers
ACTON, RONALD T. (52), Department of Microbiology, University of Alabama, Birmingham,
Alabama 35294
ADORINI. LUCIANO (21, 44), Department of Microbiology, University of California, Los
Angeles, California 90024
AHMANN, GERALD B. (35), National Cancer Institute, Bethesda, Maryland 20205
AHMED, AFTAB (12, 13), Naval Medical Research Institute, Bethesda, Maryland 20014
ALTER, BARBARA J. (56), Immunobiology Research Center, University of Wisconsin, Madison,
Wisconsin 53706
AMOS, D. BERNARD (66), Duke University Medical Center, Durham, North Carolina 27710
ANDERSSON R. (47), Department of Immunology, Uppsala University Biomedical Center,
Uppsala, S-751 23, Sweden
ASHMAN, ROBERT F. (20, 22), Department of Microbiology and Immunology, University of
California, Los Angeles, California 90024
ASOFSKY, RICHARD (11), National Institutes of Health, Bethesda, Maryland 20205
BACH, BRUCE ALLEN (38), Department of Pathology, Harvard Medical School, Boston,
Massachusetts 02115
BACH, FRITZ H. (5, 10, 56), Immunobiology Research Center, University of Wisconsin, Madison,
Wisconsin 53706
BAKER, P. E. (68), Hematology Research Laboratory, Dartmouth Medical School, Hanover, New
Hampshire 03755
BALDWIN, R. W. (64), Cancer Research Campaign Laboratories, University of Nottingham,
England
BENACERRAF, BARUJ (38), Department of Pathology, Harvard Medical School, Boston,
Massachusetts
BENJAMIN, CHRISTOPHER D. (44), Department of Microbiology, University of California,
Los Angeles, California 90024
BENJAMIN, DAVID (58), Department of Biology, City of Hope National Medical Center, Duarte,
California 91010
xiii
xiv CONTRIBUTORS
BINZ, H. (47), Institute of Medical Mikrobiologie, University of Zurich, Zurich, Switzerland
BLACK, PAUL L. (51), Department of Microbiology, University of Texas Health Science Center,
Dallas, Texas 75235
BONA, COSTANTIN (45, 46), Laboratory of Immunology, National Institutes of Health,
Bethesda, Maryland 20014
BONAVIDA, BENJAMIN (49, 60), Department of Microbiology and Immunology, University of
California, Los Angeles, California 90024
BRENAN, MARY (58), Transplantation Biology Unit, Clinical Research Center, Watford Road,
Harrow, Middlesex HAI 3UJ, England
BRENNAN, CAROLEQ6), National Institutes of Health, Bethesda, Maryland 20014
BROV^N, ALAN R. (38), Department of Pathology, Brandeis University, Waltham, Massachusetts
02154
BURAKOFF, S. (65), Department of Pathology, Harvard Medical School, Boston, Massachusetts
02115
BYERS, V. S. (64), Department of Dermatology, University of California, School of Medicine, San
Francisco, California 94143
CAPRA, J. DONALD (4, 6), Department of Microbiology, University of Texas, Southwestern
Medical School, Dallas, Texas 75235
CECKA, J. MICHAEL (37), Department of Zoology, University College, London WC1, England
CHAN, CHRISTINA (43), Laboratory of Immunology, National Institutes of Health, Bethesda,
Maryland 20205
CHEN, C. (28), National Institutes of Health, Bethesda, Maryland 20014
CHRISTADOSS, PREMKUMAR (26), Department of Immunology, Mayo Clinic, Rochester,
Minnesota 55901
CLARKE, JESSICA ANNE (21), Department of Microbiology, University of California, Los
Angeles, California 90024
CLEMENT, LOR AN (43), Laboratory of Immunology, National Institutes of Health, Bethesda,
Maryland 20205
COLLAVO, DINO (71), Genetics Unit, Institute of Pathological Anatomy, University of Padua,
Padua, Switzerland
COOK, RICHARD G. (4), Department of Microbiology, University of Texas, Southwestern
Medical School, Dallas, Texas 75235
COSENZA, HUMBERTO (37), Basel Institute for Immunology, Basel, Switzerland
COUDERC, JACQUES (21), Department of Microbiology, University of California, Los Angeles,
California 90024
CRUMPTON, MICHAEL J. (1), National Institute for Medical Research, Mill Hill, London NW7
1AA, United Kingdom
CUNNINGHAM, ALAST AIR J. (27), Ontario Cancer Institute, University of Toronto, Toronto,
Ontario, Canada M4X 1K9
DAVID, CHELLA S. (26, 37), Department of Immunology, Mayo Clinic, Rochester, Minnesota
55901
DENNERT, GUNTHER (69), Department of Cancer Biology, The Salk Institute for Biological
Studies, San Diego, California 92112
CONTRIBUTORS xv
DIENER, ERWIN (23, 41), Department of Immunology, University of Alberta, Edmonton,
Alberta, Canada T6G 1H7
DOCKRELL, HAZEL (18), Department of Immunology, Middlesex Hospital Medical School,
London, England
DOHERTY, PETER C. (55), The Wistar Institute, Philadelphia, Pennsylvania 19104
DUTTON, R. W. (34), Department of Biology, University of California, at San Diego, La Jolla,
California 92093
EL-GAMIL, MONA (2), Immunology Branch, National Cancer Institute, Bethesda, Maryland
20205
ENGERS, HOWARD (71), Department of Immunology, Swiss Institute for Experimental Cancer
Research, CH-1066 Epalinges Lausanne, Switzerland
ERB, PETER (37), Institute of Medical Microbiology, University of Basel, Basel, Switzerland
FATHMAN, C. G. (61), Department of Immunology, Mayo Clinic, Rochester, Minnesota 55901
FELDMANN, MARC (37), Department of Zoology, University College, London WC1, England
FESTENSTEIN, HILLIARD (63), Department of Immunology, London Hospital Medical
College, London El 2AD, England
FINBERG, R. (65), Department of Pathology, Harvard Medical School, Boston, Massachusetts
02115
FISCHER LINDAHL, KIRSTEN (63), Basel Institute for Immunology, Grenzacherstrasse 487,
CH-4058 Basel, Switzerland
FLIEGER, Ν. (54), Irvington House Institute, New York University Medical Center, New York,
New York 10016
FORM AN, J. (51), Department of Microbiology, University of Texas, Health Science Center,
Dallas, Texas 75235
FRISCHKNECHT, Η. (47), Institute of Medical Microbiologie, University of Zurich, Zurich,
Switzerland
GERSHON, R. K. (62), Section of Comparative Medicine, Yale University School of Medicine,
New Haven, Connecticut 06510
GILLIS, STEVEN (68), Hematology Research Laboratory, Dartmouth Medical School, Hanover,
New Hampshire 03755
GIORGI, JANIS V. (72), Immunobiology Laboratories, University of New Mexico, Albuquerque,
New Mexico 87131
GIVOL, DAVID (50), Department of Chemical Immunology, Weizmann Institute, Rehovot, Israel
GOLUB, SID (63), Department of Bacteriology, University of California, Los Angeles, California
90024
GOODMAN, JOEL W. (48), Department of Microbiology and Immunology, University of
California, San Francisco, California 94143
GRANGER, G. A. (49), Department of Microbiology and Immunology, University of California,
Los Angeles, California 90024
GREENE, MARK IRWIN (38), Department of Pathology, Harvard Medical School, Boston,
Massachusetts 02115
GRONOWICZ, EVA (19), Immunology Division, Stanford University, Stanford, California
HAAS, WERNER (71), Basel Institute of Immunology, Basel, Switzerland
xvi CONTRIBUTORS
HARVEY, M. A. (44), Department of Microbiology, University of California, Los Angeles,
California 90024
HATHCOCK, KAREN S. (35), National Cancer Institute, Bethesda, Maryland 20205
H AY AKAW A, KYOKO (32,40), Department of Immunology, University of Tokyo, Tokyo, Japan
HAYES, COLLEEN E. (10), Immunobiology Research Center, University of Wisconsin, Madison,
Wisconsin 53706
HENGARTNER, H. (61), Department of Immunology, Mayo Clinic, Rochester, Minnesota 55901
HENGARTNER HANS (71), Basel Institute of Immunology, Basel, Switzerland
HENKART, PIERRE (67), Immunology Branch National Institutes of Health, Bethesda,
Maryland 20205
HOWIE, SARAH (37), Basel Institute for Immunology, Basel, Switzerland
HENLEY, SUSANNE L. (52), Department of Microbiology, University of Alabama, Birmingham,
Alabama 35294
HISERODT, JOHN C. (49), Department of Microbiology and Immunology, University of
California, Los Angeles, California 90024
HODES, RICHARD J. (35), National Cancer Institute, Bethesda, Maryland 20205
HORNBECK, PETER V. (48), Department of Microbiology and Immunology, University of
California, San Francisco, California 94143
JAMES, ROGER (37), Department of Zoology, University College, London WC1, England
JANEWAY, CHARLES A. (18, 36, 62), Department of Pathology, Yale University School of
Medicine, New Haven, Connecticut 06510
JOHNSTONE, ALAN P. (1), National Institute for Medical Research, Mill Hill, London NW7
1AA, England
JONES, BARRY (18), Department of Pathology, Yale University, New Haven, Connecticut 06510
JOHSSON, B. (47), Department of Immunology, Uppsala University Biomedical Center, Uppsala,
S-751 23, Sweden
KANELLOPOULOS-LANGEVIN, COLETTE (11), Laboratory of Microbiological Immunity,
National Institutes of Health, Bethesda, Maryland 20205
KANG, C.-Y. (51), Department of Microbiology, University of Texas Health Science Center,
Dallas, Texas 75235
KANOWITH-KLEIN, SUSAN (20), Department of Microbiology and Immunology, University of
California, Los Angeles, California 90024
KAPPLER, JOHN W. (39), Department of Microbiology, University of Rochester, Rochester, New
York 14642
KATZ, DAVID H. (33), Scripps Clinic and Research Foundation, La Jolla, California 92037
KELLER, DANIEL M. (39), Department of Microbiology, University of Rochester, Rochester,
New York 14642
KESSLER, STEVEN (12), Naval Medical Research Institute, Bethesda, Maryland 20014
KIM, K. JIN (11), National Institutes of Health, Bethesda, Maryland 20205
KISZKISS, PATRICIA (2), Immunology Branch, National Cancer Institute, Bethesda, Maryland
20205
KOHLER, H. (8), La Ribida University of Chicago Institute, Chicago, Illinois 60649
CONTRIBUTORS xvii
KONTIAINEN, SIRKKA (37), Department of Bacteriology and Immunology, University of
Helsinki, Helsinki, Finland
LAMBERT, EDWARD H. (26), Department of Immunology, Mayo Clinic, Rochester, Minnesota
55901
LAS ARO W, ELISABETH H. (27), Department of Microbiology and Immunology, University of
California, Los Angeles, California 90024
LENNON, VANDA A. (26), Department of Immunology, Mayo Clinic, Rochester, Minnesota
55901
LEWIS, GEORGE K. (48), Department of Microbiology and Immunology, University of
California, San Francisco, California 94143
LILLY, FRANK (57), Department of Genetics, Albert Einstein College of Medicine, Bronx, New
York 10461
LIPSKY, PETER E. (30), Department of Internal Medicine, University of Texas Health Science
Center, Dallas, Texas 75235
LUCAS, DAVID (19), Department of Microbiology, University of Arizona, Tucson, Arizona 85724
LUNNEY, JOAN K. (2), National Cancer Institute, Building 10, Room 4B17, Bethesda, Maryland
20205
MACY, ERIC M. (17), Department of Microbiology and Immunology, University of California,
Los Angeles, California 90024
MAKELA, OLLI (16), National Institutes of Health, Bethesda, Maryland 20014
MANN, DEAN L. (2, 3), National Cancer Institute, Bethesda, Maryland 20205
MARCHALONIS, JOHN J. (50), Cancer Biology Program, Frederick Cancer Research Center,
Frederick, Maryland 21701
MARGOLIASH, E. (28), National Institutes of Health, Bethesda, Maryland 20014
M ARRACK, PHILIPPA (39), Department of Microbiology, University of Rochester, Rochester,
New York 14642
MATSUNAGA, TAKESHI (58), Department of Biology, City of Hope, National Medical Center,
Duarte, California 91010
MAURER, P. H. (28), National Institutes of Health, Bethesda, Maryland 20014
MAURER, PAUL (37), Department of Biochemistry, Jefferson Medical College, Philadelphia,
Pennsylvania 19107
McCONNEL, HARDEN M. (67), Department of Chemistry, Stanford University, Stanford,
California 94305
McDEVITT, H. O. (54), Irvington House Institute, New York University Medical Center, New
York, New York 10016
McKEAN, DAVID J. (7), Department of Immunology, Mayo Clinic, Rochester, Minnesota 55901
MCKENZIE, IAN F. C. (37, 71), Department of Medicine, Austin Hospital, Melbourne, Australia
MELCHERS, FRITZ (19), Institute for Immunology, Basel, Switzerland
MERRILL, JEAN E. (20), Department of Virology, Karolinska Institute, Stockholm, Sweden
MERRYMAN, C. F. (28), National Institutes of Health, Bethesda, Maryland 20014
MERUELO, DANIEL (54), Irvington House Institute, New York University Medical Center, New
York, New York 10016
xviii CONTRIBUTORS
MESCHER, MATTHEW F. (65), Department of Pathology, Harvard Medical School, Boston,
Massachusetts 02115
MILLER, ALEXANDER (21,22,44), Department of Microbiology, University of California, Los
Angeles, California 90024
MITCHISON, N. A. (31), University College, Department of Tumor Biology, London WC1 6BT,
England
MOCHIZUKI, DIANE (14), Department of Microbiology, University of California, Irvine,
California 92717
MOLLER, GORAN (19), Immunobiology, Karolinska Institute, Stockholm, Sweden
MOND, JAMES J. (16), National Institutes of Health, Bethesda, Maryland 20014
NABHOLZ, MARKUS (71), Swiss Institute for Experimental Cancer Research, CH-1066
Epalinges Lausanne, Switzerland
NADLER, PAUL I. (35), National Cancer Institute, Bethesda, Maryland 20205
NAKOINZ, ILONA (15), Sloan-Kettering Institute, Rye, New York 10580
NATHENSON, STANLEY G. (6), Albert Einstein College of Medicine, Bronx, New York 10461
NISONOFF, ALFRED (38), Department of Pathology, Brandeis University, Waltham,
Massachusetts 02154
NONAKA, M. (40), Department of Immunology, University of Tokyo, Hongo, Tokyo, Japan
NORTH, MARCEL (71), Genetics Unit, Swiss Institute for Experimental Cancer Research, CH-
1066 Epalinges Lausanne, Switzerland
OI, VERNON T. (73), Department of Genetics, Stanford University School, Stanford, California
94305
OKUMURA, KO (32,40), Department of Immunology, University of Tokyo, Hongo, Tokyo, Japan
OTOOLE, MARGOT (29), Department of Pathology, Tufts University School of Medicine,
Boston, Massachusetts 02111
OWENS, MICHAEL J. (1), National Institute for Medical Research, Mill Hill, London NW7 1AA,
England
OZATO, KEIKO (2), National Cancer Institute, Bethesda, Maryland 20205
PAIGE, CHRISTOPHER J. (15), Sloan-Kettering Institute, Rye, New York 10580
PANFILI, P. R. (34), Department of Biology, University of California at San Diego, La Jolla,
California 92093
PARISH, CHRIS (37), Department of Microbiology, John Curtin School of Medical Research,
Canberra, Australia
PARKS, D. ELLIOT (24), Department of Immunopathology, Scripps Clinic and Research
Foundation, La Jolla, California 92037
PAUL, W. E. (16), National Institutes of Health, Bethesda, Maryland 20014
PLATA, FERNANDO (57), Department of Genetics, Albert Einstein College of Medicine, Bronx,
New York 105461
POTTER, MICHAEL(7), National Cancer Institute, Bethesda, Maryland 20014
RALPH, PETER (15), Sloan-Kettering Institute, Rye, New York 10580
REES, ANNE (37), Department of Zoology, University College, London WC1, England
SACHS, DAVID H. (2, 11, 59), Immunology Branch, National Cancer Institute, Bethesda,
Maryland 20205
CONTRIBUTORS xix
SAITO, T. (70), Laboratory for Immunology, Chiba University, Chiba, Japan
SCHER, IRWIN (12), Naval Medical Research Institute, Bethesda, Maryland 20014
SCHWARTZ, ANTHONY (62), Section of Comparative Medicine, Yale University School of
Medicine, New Haven, Connecticut 06510
SCHWARTZ, RONALD (28), National Institute of Allergy and Infectious Diseases, National
Institutes of Health, Bethesda, Maryland 20014
SERCARZ, ELI E. (21, 44), Department of Microbiology, University of California, Los Angeles,
California 90024
SHEARER, GENE (60), Immunology Branch, National Cancer Institute, Bethesda, Maryland
20205
SHEN, F. W. (47), Sloan-Kettering Cancer Center, New York, New York 10021
SHERMAN, LINDA(65), Department of Cellular and Developmental Immunology, Scripps Clinic
and Research Foundation, La Jolla, California 92037
SHEVACH, ETHAN M. (43), Laboratory of Immunology, National Institutes of Health, Bethesda,
Maryland 20205
SHINOHARA, NOBUKATA, (2, 59), National Cancer Institute, Bethesda, Maryland 20205
SHIOZAWA, CHIAKI (391), Department of Immunology, University of Alberta, Edmonton,
Alberta, Canada T6G 1H7
SIEGELM AN, MARK H. (4), Department of Microbiology, University of Texas Southwestern
Medical School, Dallas, Texas 75235
SIMPSON, ELIZABETH (58, 73), Transplantation Biology Unit, Clinical Research Center,
Watform Road, Harrow, Middlesex HAI 3UJ, England
SINGER, ALFRED(35), National Cancer Institute, Bethesda, Maryland 20205
SINGH, BHAGIRATH (23, 41), University of Alberta, Medical Science Building, Edmonton,
Alberta, Canada T6G 2H7
SLAVIN, SHIMON (25), Department of Medicine, Hadassah Hebrew University School of
Medicine, Jerusalem, Israel
SMITH, D. (54), Irvington House Institute, New York University Medical Center, New York, New-
York 10016
SMITH, K. A. (68), Hematology Research Laboratory, Dartmouth Medical School, Hanover, New
Hampshire 03755
SOLINGER, A. M. (28), National Institutes of Health, Bethesda, Maryland 20014
SONIK, SIKANDER (41), Department of Immunology, University of Alberta, Edmonton,
Alberta, Canada T6G 2H7
STEIN, KATHRYN E. (16), Laboratory of Immunology, National Institutes of Health, Bethesda,
Maryland 20014
STEVENS, RONALD H. (17), Department of Microbiology and Immunology, University of
California, Los Angeles, California 90024
STIMPFLING, J. H. (28), National Institutes of Health, Bethesda, Maryland 20014
STROBER, SAMUEL (13, 25), Stanford University School of Medicine, Stanford, California
94305
STUTMAN, OSIAS (9), Sloan-Kettering Institute for Cancer Research, New York, New York
10021
